Affiliations 

  • 1 Division of Clinical Dentistry, School of Dentistry, International Medical University, Kuala Lumpur, 57000, Malaysia
  • 2 School of Dentistry, DY Patil University, Navi Mumbai, 400706, India
  • 3 Centre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia
  • 4 Modern Dental College, Indore, 453112, Madhya Pradesh, India
  • 5 School of Pharmacy, Faculty of Health and Medical Science, Taylor's University, Subang Jaya, 47500, Selangor, Malaysia
  • 6 School of Pharmacy, Department of Pharmaceutical Technology, International Medical University, 57000, Kuala Lumpur, Malaysia
  • 7 Division of Oral Diagnostic and Surgical Sciences, School of Dentistry, International Medical University, Kuala Lumpur, 57000, Malaysia
  • 8 Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India
Heliyon, 2019 Oct;5(10):e02544.
PMID: 31687479 DOI: 10.1016/j.heliyon.2019.e02544

Abstract

Dendrimers are hyperbranched nanoparticle structures along with its surface modifications can to be used in dental biomaterials for biomimetic remineralisation of enamel and dentin. The review highlights the therapeutic applications of dendrimers in the field of dentistry. It addresses the possible mechanisms of enhancement of mechanical properties of adhesives and resins structure. Dendrimers due to its unique construction of possessing inner hydrophobic and outer hydrophilic structure can act as drug carrier for delivery of antimicrobial drugs for treatment of periodontal diseases and at peripheral dental implant areas. Dendrimers due to its hyperbranched structures can provides a unique drug delivery vehicle for delivery of a drug at specific site for sustained release for therapeutic effects. Thus, dendrimers can be one of the most important constituents which can be incorporated in dental biomaterials for better outcomes in dentistry.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.