Long-term impact of bariatric surgery in diabetic nephropathy

Young L 1 , Nor Hanipah Z 2 , Brethauer SA 1 , Schauer PR 1 , Aminian A 3

Affiliations 

  • 1 Cleveland Clinic Lerner of College of Medicine, Cleveland, OH, USA
  • 2 Department of General Surgery, Bariatric and Metabolic Institute, Cleveland Clinic, Mail Code M61, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
  • 3 Cleveland Clinic Lerner of College of Medicine, Cleveland, OH, USA. AMINIAA@ccf.org
Surg Endosc, 2019 05;33(5):1654-1660.
PMID: 30251143 DOI: 10.1007/s00464-018-6458-8

Abstract

BACKGROUND: Bariatric surgery has been shown to improve and resolve diabetes. However, limited literature about its impact on end-organ complications of diabetes is available. The aim of this study was to examine the long-term effect of bariatric surgery on albuminuria.

METHODS: We studied 101 patients with pre-operative diabetes and albuminuria [defined as urine albumin:creatinine ratio (uACR) > 30 mg/g] who underwent bariatric surgery at an academic center from 2005 to 2014.

RESULTS: Fifty-seven patients (56%) were female with a mean age of 53 (± 11) years. The mean pre-operative BMI and glycated hemoglobin (HbA1c) were 43.1 (± 7.6) kg/m2 and 8.4 (± 1.8)%, respectively. The median pre-operative uACR was 80.0 (45.0-231.0) mg/g. Bariatric procedures included Roux-en-Y gastric bypass (n = 75, 74%) and sleeve gastrectomy (n = 26, 26%). The mean follow-up period was 61 (± 29) months. At last follow-up, the mean BMI was 33.8 (± 8.3) kg/m2. The overall glycemic control improved after bariatric surgery. At last follow-up, 73% had good glycemic control (HbA1c 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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