Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds

Wu YX 1 , Kim YJ 2 , Kwon TH 3 , Tan CP 4 , Son KH 5 , Kim T 2

Affiliations 

  • 1 College of Life and Environment Science, Huangshan University, Huangshan, PR China
  • 2 Department of Food Science and Biotechnology, Andong National University, Andong, Korea
  • 3 Chuncheon Bioindustry Foundation, Chuncheon, Korea
  • 4 Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang, Malaysia
  • 5 Department of Food and Nutrition, Andong National University, Andong, Korea
Nat Prod Res, 2020 Jun;34(12):1786-1790.
PMID: 30470128 DOI: 10.1080/14786419.2018.1527832

Abstract

Mulberry (Morus alba L.) root bark (MRB) was extracted using methanol and the extracts were subjected to tests of anti-inflammatory effects. The ethyl acetate fraction demonstrated the best anti-inflammatory effects. Purified compounds, sanggenon B, albanol B and sanggenon D, showed inhibitory effects on NO production in LPS-stimulated RAW264.7 cells and albanol B demonstrated the best anti-inflammatory effects. Regarding the underlying molecular mechanisms, further investigations showed that treatments with Albanol B reduced production of pro-inflammatory cytokines and decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). These results would contribute to development of novel anti-inflammatory drugs from MRB.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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