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Anti-inflammatory potential of ellagic acid, gallic acid and punicalagin A&B isolated from Punica granatum

BenSaad LA 1 , Kim KH 2 , Quah CC 1 , Kim WR 3 , Shahimi M 4

Affiliations 

  • 1 Department of Physiology, Faculty of Medicine, Malaysia Institute of Medical Research, Kuala Lumpur, 50603, Malaysia
  • 2 Department of Physiology, Faculty of Medicine, Malaysia Institute of Medical Research, Kuala Lumpur, 50603, Malaysia. kimkh@um.edu.my
  • 3 Malaysia Institute of Medical Research, Kuala Lumpur, 50603, Malaysia
  • 4 University College Lincoln, Petaling Jaya, 47301, Malaysia
BMC Complement Altern Med, 2017 Jan 14;17(1):47.
PMID: 28088220 DOI: 10.1186/s12906-017-1555-0

Abstract

Punica granatum (pomegranate), an edible fruit originating in the Middle East, has been used as a traditional medicine for treatment of pain and inflammatory conditions such as peptic ulcer. The numerous risks associated with nonsteroidal anti-inflammatory drugs (NSAIDs) for treatment of pain and inflammation give rise to using medicinal herbs as alternative therapies. This study aimed to evaluate the anti-inflammatory effect of isolated compounds from the ethyl acetate (EtOAc) fraction of P. granatum by determination of their inhibitory effects on lipopolysaccharide (LPS), stimulated nitric oxide (NO), prostaglandin E2 (PGE-2), interleukin-6 (IL-6) and cyclooxxgenase-2 (COX-2) release from RAW264.7 cells.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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