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The roles of circular RNAs in human development and diseases

Lee ECS 1 , Elhassan SAM 2 , Lim GPL 3 , Kok WH 4 , Tan SW 5 , Leong EN 6 Show all authors , Tan SH 7 , Chan EWL 8 , Bhattamisra SK 9 , Rajendran R 10 , Candasamy M 11

Affiliations 

  • 1 School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia. Electronic address: ericlee94@live.com
  • 2 School of Postgraduate Studies, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia. Electronic address: safaabdo44@hotmail.com
  • 3 School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia. Electronic address: gracelim95@gmail.com
  • 4 School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia. Electronic address: wenghong19960205@gmail.com
  • 5 School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia. Electronic address: tanszewei1996@hotmail.com
  • 6 School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia. Electronic address: eeneng07291995@gmail.com
  • 7 School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia. Electronic address: seantsh31@hotmail.com
  • 8 Institute of Research, Development and Innovation, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia. Electronic address: elainechan@imu.edu.my
  • 9 Department of Life Sciences, School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia. Electronic address: subratkumar@imu.edu.my
  • 10 Department of Life Sciences, School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia. Electronic address: ramkumar.rajendran@gmail.com
  • 11 Department of Life Sciences, School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia. Electronic address: mayurencandasamy@imu.edu.my
Biomed Pharmacother, 2019 Mar;111:198-208.
PMID: 30583227 DOI: 10.1016/j.biopha.2018.12.052

Abstract

For many years, circular ribonucleic acids (circRNAs) have been counted as aberrant splicing by-products. Advanced bioinformatics analysis and deep sequencing techniques have allowed researchers to discover more interesting facts about circRNAs. Intriguing evidence has shed light on the functions of circRNAs in many tissues. Furthermore, emerging reports showed that circRNAs are found abundantly in saliva and blood samples, suggesting that circRNAs are potential clinical biomarkers for human embryonic development, diseases progression and prognosis, in addition to its role in organogenesis and pathogenesis. The implementation of circRNAs in human developmental stages and diseases would be a tremendous discovery in the science and medical field. Therefore, circRNAs have been studied for its biological function as well as its implication in various human diseases. The aim of this review is to highlight the importance of circRNAs in cardiac, respiratory, nervous, endocrine and digestive systems. In addition, the role and impact of circRNAs in, cardiogenesis, neurogenesis and cancer have been discussed.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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