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Diabetic endothelial colony forming cells have the potential for restoration with glycomimetics

Langford-Smith AWW 1 , Hasan A 2 , Weston R 1 , Edwards N 1 , Jones AM 3 , Boulton AJM 2 Show all authors , Bowling FL 2 , Rashid ST 2 , Wilkinson FL 4 , Alexander MY 1

Affiliations 

  • 1 Cardiovascular Science, The Centre for Bioscience, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK
  • 2 Diabetes Research Group, University of Manchester, Manchester, UK
  • 3 School of Pharmacy, University of Birmingham, Edgbaston, UK
  • 4 Cardiovascular Science, The Centre for Bioscience, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK. f.wilkinson@mmu.ac.uk
Sci Rep, 2019 02 19;9(1):2309.
PMID: 30783159 DOI: 10.1038/s41598-019-38921-z

Abstract

Endothelial colony forming progenitor cell (ECFC) function is compromised in diabetes, leading to poor vascular endothelial repair, which contributes to impaired diabetic foot ulcer healing. We have generated novel glycomimetic drugs with protective effects against endothelial dysfunction. We investigated the effect of glycomimetic C3 on the functional capacity of diabetic ECFCs. ECFCs were isolated from healthy controls and patients with diabetes with neuroischaemic (NI) or neuropathic (NP) foot ulcers. Functionally, diabetic ECFCs demonstrated delayed colony formation (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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