Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation

Chellappan DK 1 , Yee NJ 2 , Kaur Ambar Jeet Singh BJ 2 , Panneerselvam J 3 , Madheswaran T 3 , Chellian J 1 Show all authors , Satija S 4 , Mehta M 4 , Gulati M 4 , Gupta G 5 , Dua K 6

Affiliations 

  • 1 Department of Life Sciences, International Medical University, Kuala Lumpur, Malaysia 57000
  • 2 School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia 57000
  • 3 Department of Pharmaceutical Technology, International Medical University, Kuala Lumpur, Malaysia 57000
  • 4 School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara-144411, Punjab, India
  • 5 School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Mahal Road, 302017, Jaipur, India
  • 6 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia
Ther Deliv, 2019 May 01;10(5):281-293.
PMID: 31094299 DOI: 10.4155/tde-2019-0019

Abstract

Aim: Our aim was to develop and characterize a nanogel formulation containing both glibenclamide and quercetin and to explore the permeation profile of this combination. Methods: Drug-loaded nanogel was prepared by ionic gelation. In addition, optimum encapsulation efficiencies of glibenclamide and quercetin were also obtained. The average nanoparticle size at optimum conditions was determined by Zetasizer. Results: The particle size of the nanogel was found to be 370.4 ± 4.78 nm with a polydispersity index of 0.528 ± 0.04, while the λ potential was positive in a range of 17.6 to 24.8 mV. The percentage cumulative drug release also showed favorable findings. Conclusion: The chitosan nanogel could be a potential alternative for delivering glibenclamide and quercetin through skin.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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