The effect of season on yield and quality of organic solvent extracts from Gracilaria changii was determined. The sustainability of the bioactive compound of G. changii from Malaysia was investigated by using the TLC and FTIR standards methods. Studies was carried out to examine the sustainability of the bioactive compound in the various extract obtained from G. changii collected from Pantai Morib, Beach Selangor Malaysia on bimonthly for a period of one year in 2003. This study revealed that the bioactive compounds was present all over the year but with different quantities. In general the variation in yield or quantities of bioactive compound was related to environment. G. changii can be considered a candidate for drug development since it retained the number of bioactive compound.