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Engineering artificial machines from designable DNA materials for biomedical applications

Qi H 1 , Huang G 2 , Han Y 2 , Zhang X 2 , Li Y 2 , Pingguan-Murphy B 3 Show all authors , Lu TJ 4 , Xu F 2 , Wang L 2

Affiliations 

  • 1 1Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin, P.R. China
  • 2 3MOE Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, P.R. China
  • 3 5Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia
  • 4 4Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, P.R. China
Tissue Eng Part B Rev, 2015 Jun;21(3):288-97.
PMID: 25547514 DOI: 10.1089/ten.TEB.2014.0494

Abstract

Deoxyribonucleic acid (DNA) emerges as building bricks for the fabrication of nanostructure with complete artificial architecture and geometry. The amazing ability of DNA in building two- and three-dimensional structures raises the possibility of developing smart nanomachines with versatile controllability for various applications. Here, we overviewed the recent progresses in engineering DNA machines for specific bioengineering and biomedical applications.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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