Affiliations 

  • 1 Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Jalan Jalil Perkasa, Bukit Jalil, Kuala Lumpur, Malaysia
Asian Pac J Cancer Prev, 2019 07 01;20(7):2181-2194.
PMID: 31350983 DOI: 10.31557/APJCP.2019.20.7.2181

Abstract

Controlled release delivery system of chemotherapeutic agents at the site of colon endorses modern drug-entrapped
delivery tools, which release the entrappedagents at a controlled rate for anextended period providing patient compliance
and additional protection from the degradinggastric environment. Thus, the present study was aimed to develop
and optimize a novel polymeric microsphere of 5-fluorouracil (5-FU) using natural gum katira to obtain an optimal
therapeutic response at the colon. Due course of experimentation, in-vivo safety profile of the gum katira in an animal
model was established. Modified solvent extraction/evaporation technique wasemployed to encapsulate 5-FU in the
natural polymeric microsphere and was characterized using in-vitro studies to investigate particle size, morphology,
encapsulation efficiency and release of the drug from developed formulation. Formulated and optimized polymeric
microsphere of 5-FU using gum katira polymer own optimal physicochemical characteristics with a fine spherical particle
with size ranged from 210.37±7.50 to 314.45±7.80 μm.Targeted microsphere exhibited good cytotoxicity and also has
high drug entrapment efficiency, and satisfactory release pattern of the drug within a time frame of 12 h. Finally, we
foresee that the optimized polymeric gum katiramicrosphere of 5-FU could be a promising micro-carrier for efficient
colon drug targeting delivery tool with improved chemotherapeutic efficacy against colon cancer.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.