Insights on the synthesis of asymmetric curcumin derivatives and their biological activities

Khor PY 1 , Mohd Aluwi MFF 2 , Rullah K 3 , Lam KW 4

Affiliations 

  • 1 Faculty Pharmacy and Health Sciences, Universiti Kuala Lumpur, Royal College of Medicine Perak, 3, Jalan Greentown, 30450, Ipoh, Perak, Malaysia; Drugs and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia. Electronic address: pykhor@unikl.edu.my
  • 2 Faculty of Industrial Science & Technology, Universiti Malaysia Pahang Lebuhraya Tun Razak, 26300, Gambang, Pahang, Malaysia. Electronic address: fasihi@ump.edu.my
  • 3 Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Bandar Indera Mahkota, 25200, Kuantan, Pahang, Malaysia. Electronic address: kamalrullah@iium.edu.my
  • 4 Drugs and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia. Electronic address: david_lam@ukm.edu.my
Eur J Med Chem, 2019 Dec 01;183:111704.
PMID: 31557608 DOI: 10.1016/j.ejmech.2019.111704

Abstract

Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications