Looking into dental pulp stem cells in the therapy of photoreceptors and retinal degenerative disorders

Alsaeedi HA 1 , Lam C 2 , Koh AE 3 , Teh SW 3 , Mok PL 4 , Higuchi A 5 Show all authors , Then KY 2 , Bastion MC 2 , Alzahrani B 6 , Farhana A 6 , Muthuvenkatachalam BS 7 , Samrot AV 8 , Swamy KB 9 , Marraiki N 10 , Elgorban AM 11 , Subbiah SK 12

Affiliations 

  • 1 Department of Medical Microbiology and Parasitology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
  • 2 Department of Ophthalmology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000 Cheras, Kuala Lumpur, Malaysia
  • 3 Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
  • 4 Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Genetics and Regenerative Medicine Research Center, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Department of Clinical Laboratory Sciences, College of Applied Medical Science, Jouf University, Sakaka 72442, Aljouf Province, Saudi Arabia
  • 5 Department of Chemical and Materials Engineering, National Central University, Jhong-li, Taoyuan 32001, Taiwan; Department of Reproduction, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan
  • 6 Department of Clinical Laboratory Sciences, College of Applied Medical Science, Jouf University, Sakaka 72442, Aljouf Province, Saudi Arabia
  • 7 Department of Biochemistry, Faculty of Medicine, AIMST University, Jalan Bedong-Semeling, 08100 Bedong, Kedah, Malaysia
  • 8 Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Jeppiaar Nagar, Rajiv Gandhi Salai, Sholinganallur, Chennai 600119, Tamil Nadu, India; Department of Biomedical Sciences, Faculty of Medicine and Biomedical Sciences, MAHSA University, Jalan SP2, Bandar Saujana Putra, 42810 Jenjarom, Selangor, Malaysia
  • 9 Faculty of Medicine, Lincoln University College, Wisma Lincoln, No. 12-18, Jalan SS 6/12, 47301 Petaling Jaya, Selangor Darul Ehsan, Malaysia
  • 10 Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
  • 11 Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; Centre of Excellence in Biotechnology Research, King Saud University, P.O Box 2455, Riyadh 11451, Saudi Arabia
  • 12 Department of Medical Microbiology and Parasitology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Genetics and Regenerative Medicine Research Center, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; UPM-MAKNA Cancer Research Centre, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. Electronic address: sureshkudsc@gmail.com
J. Photochem. Photobiol. B, Biol., 2020 Jan;203:111727.
PMID: 31862637 DOI: 10.1016/j.jphotobiol.2019.111727

Abstract

Blindness and vision impairment are caused by irremediable retinal degeneration in affected individuals worldwide. Cell therapy for a retinal replacement can potentially rescue their vision, specifically for those who lost the light sensing photoreceptors in the eye. As such, well-characterized retinal cells are required for the replacement purposes. Stem cell-based therapy in photoreceptor and retinal pigment epithelium transplantation is well received, however, the drawbacks of retinal transplantation is the limited clinical protocols development, insufficient number of transplanted cells for recovery, the selection of potential stem cell sources that can be differentiated into the target cells, and the ability of cells to migrate to the host tissue. Dental pulp stem cells (DPSC) belong to a subset of mesenchymal stem cells, and are recently being studied due to its high capability of differentiating into cells of the neuronal lineage. In this review, we look into the potential uses of DPSC in treating retinal degeneration, and also the current data supporting its application.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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