Biogenic integrated ZnO/Ag nanocomposite: Surface analysis and in vivo practices for the management of type 1 diabetes complications

Rahim Pouran S 1 , Bayrami A 2 , Mohammadi Arvanag F 3 , Habibi-Yangjeh A 4 , Darvishi Cheshmeh Soltani R 5 , Singh R 6 Show all authors , Abdul Raman AA 7 , Chae KH 8 , Khataee A 9 , Kang HK 8

Affiliations 

  • 1 Centre of Advanced Manufacturing and Materials Processing, Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: sh.rahimpooran@um.edu.my
  • 2 Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, P.O. Box 179, Ardabil, Iran. Electronic address: a_bayrami@uma.ac.ir
  • 3 Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, P.O. Box 179, Ardabil, Iran
  • 4 Department of Chemistry, Faculty of Science, University of Mohaghegh Ardabili, P.O. Box 179, Ardabil, Iran
  • 5 Department of Environmental Health Engineering, School of Health, Arak University of Medical Sciences, Arak, Iran
  • 6 Centre of Advanced Manufacturing and Materials Processing, Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia; Department of Mechanical Engineering, Faculty of Engineering, Universiti Teknologi Brunei, Tunku Highway, Gadong BE1410, Brunei Darussalam
  • 7 Chemical Engineering Department, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 8 Advanced Analysis Centre, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea
  • 9 Research Laboratory of Advanced Water and Wastewater Treatment Processes, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, 51666-16471 Tabriz, Iran; Department of Materials Science and Nanotechnology Engineering, Faculty of Engineering, Near East University, 99138 Nicosia, TRNC, Mersin 10, Turkey
Colloids Surf B Biointerfaces, 2020 May;189:110878.
PMID: 32087528 DOI: 10.1016/j.colsurfb.2020.110878

Abstract

In this research, a milk thistle seed extract (MTSE)-rich medium was used as a capping and reducing agent for the one-pot biosynthesis of ZnO/Ag (5 wt%) nanostructure. The sample was systematically characterized through various techniques and its strong biomolecule‒metal interface structure was supported by the results. The efficacy of the derived nanostructure (MTSE/ZnO/Ag) was evaluated in vivo on the basis of its therapeutic effects on the main complications of Type 1 diabetes (hyperglycemia, hyperlipidemia, and insulin deficiency). For this purpose, the changes in the plasma values of fasting blood glucose, total cholesterol, total triglyceride, high-density lipoprotein cholesterol, and insulin in alloxan-diabetic Wistar male rats were compared with those in healthy and untreated diabetic controls after a treatment period of 16 days. The antidiabetic results of MTSE/ZnO/Ag were compared with those obtained from pristine ZnO, MTSE, and insulin therapies. The health conditions of the rats with Type 1 diabetes were significantly enhanced after treatment with MTSE/ZnO/Ag (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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