Reduced neonatal regulatory T cell response to microbial stimuli associates with subsequent eczema in high-risk infants

Ismail IH 1 , Boyle RJ , Mah LJ , Licciardi PV , Tang ML

Affiliations 

  • 1 Allergy and Immune Disorders, Murdoch Children's Research Institute, Melbourne, Vic., Australia; Department of Paediatrics, University of Melbourne, Melbourne, Vic., Australia; Department of Paediatrics, Universiti Putra Malaysia, Selangor, Malaysia
Pediatr Allergy Immunol, 2014 Nov;25(7):674-84.
PMID: 25376403 DOI: 10.1111/pai.12303

Abstract

Regulatory T cells (Treg) play an essential role in early immune programming and shaping the immune response towards a pro-allergic or tolerant state. We evaluated cord blood Treg and cytokine responses to microbial and non-microbial stimuli in infants at high risk of allergic disease and their associations with development of allergic disease in the first year.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications