Precast concrete panel is one of the Industrial Building System (IBS) components currently used in modern construction industry, especially, in a highly populated urban area in Malaysia, owing to its cost and time efficiency in a project completion. However, the constraints lie in Musculoskeletal Disorders (MSDs) when IBS workers manually lift the concrete panel repeatedly. The aim of this study is to analyze the recommended weight limit (RWL), lifting index (LI) and physiological experience among workers while lifting precast concrete panel with 3300mm x 600mm size and compressive strength of 40MPa. The methods involved include a survey through the Nordic questionnaires, interview sessions, NIOSH lifting index calculation, recommended work limit calculation, Rapid Upper Limb Assessment (RULA) and video recording. The results yielded the MSDs problem. The guidelines of recommended weight limit and lifting index are produced. They benefit workers and increase their awareness on the MSDs issues.