A new xanthone dimer and cytotoxicity from the stem bark of Calophyllum canum

Taher M 1 , Salleh WMNHW 2 , Alkhamaiseh SI 1 , Ahmad F 3 , Rezali MF 4 , Susanti D 5 Show all authors , Hasan CM 6

Affiliations 

  • 1 Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200, Kuantan, Pahang, Malaysia
  • 2 Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris (UPSI), Tanjung Malim, 35900, Perak, Malaysia
  • 3 Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia
  • 4 SIRIM Berhad (National Metrology Laboratory), Lot PT 4803, Bandar Baru Salak Tinggi, 43900, Sepang, Selangor, Malaysia
  • 5 Department of Chemistry, Faculty of Science, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200, Kuantan, Pahang, Malaysia
  • 6 Departmnet of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, 1000, Dhaka, Bangladesh
Z Naturforsch C J Biosci, 2021 Jan 27;76(1-2):87-91.
PMID: 32931451 DOI: 10.1515/znc-2020-0089

Abstract

A phytochemical investigation of the stem bark of Calophyllum canum resulted in the isolation of a new xanthone dimer identified as biscaloxanthone (1), together with four compounds; trapezifoliaxanthone (2), trapezifolixanthone A (3), taraxerone (4) and taraxerol (5). The structures of these compounds were determined via spectroscopic methods of IR, UV, MS and NMR (1D and 2D). The cytotoxicity of compounds 1-3 were screened against A549, MCF-7, C33A and 3T3L1 cell lines, wherein weak cytotoxic activities were observed (IC50 > 50 μm).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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