A lignan with glucose uptake activity in 3T3-L1 adipocytes from the stem bark of Knema patentinervia

Taher M 1 , Amiroudine MZAM 1 , Jaffri JM 1 , Amri MS 1 , Susanti D 2 , Abd Hamid S 2 Show all authors , Rezali MF 3 , Hassan CM 4 , Read RW 5 , Ahmed Q 6 , Ahmad F 7

Affiliations 

  • 1 Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang, Malaysia
  • 2 Department of Chemistry, Faculty of Science, International Islamic University Malaysia, Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang, Malaysia
  • 3 SIRIM Berhad (National Metrology Laboratory), Lot PT, Bandar Baru Salak Tinggi, Sepang, Selangor, Malaysia
  • 4 Manarat International University, Road No 106, Gulshan-2, Dhaka, Bangladesh
  • 5 The School of Chemistry, The University of New South Wales, UNSW Sydney NSW, Australia
  • 6 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang, Malaysia
  • 7 Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia
Pak J Pharm Sci, 2017 Jul;30(4):1335-1339.
PMID: 29039334

Abstract

A new naturally occurring dibenzylbutyrolactone lignan named isocubebinic ether has been isolated from Knema patentinervia. The structure was established by spectroscopic methods, which include Ultraviolet, Infrared, Nuclear Magnetic Resonance and Mass Spectrometry. The compound showed activity in the stimulation of glucose uptake by 3T3-L1 adipocytes.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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