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Chronic airflow obstruction and ambient particulate air pollution

Amaral AFS 1 , Burney PGJ 2 , Patel J 2 , Minelli C 2 , Mejza F 3 , Mannino DM 4 Show all authors , Seemungal TAR 5 , Mahesh PA 6 , Lo LC 7 , Janson C 8 , Juvekar S 9 , Denguezli M 10 , Harrabi I 10 , Wouters EFM 11 , Cherkaski H 12 , Mortimer K 13 , Jogi R 14 , Bateman ED 15 , Fuertes E 2 , Al Ghobain M 16 , Tan W 17 , Obaseki DO 18 , El Sony A 19 , Studnicka M 20 , Aquart-Stewart A 21 , Koul P 22 , Lawin H 23 , Nafees AA 24 , Awopeju O 18 , Erhabor GE 18 , Gislason T 25 , Welte T 26 , Gulsvik A 27 , Nielsen R 27 , Gnatiuc L 28 , Kocabas A 29 , Marks GB 30 , Sooronbaev T 31 , Mbatchou Ngahane BH 32 , Barbara C 33 , Buist AS 34 , BOLD (Burden of Obstructive Lung Disease) Collaborative Research Group , BOLD (Burden of Obstructive Lung Disease) Collaborative Research Group members

Affiliations 

  • 1 National Heart and Lung Institute, Imperial College London, London, UK a.amaral@imperial.ac.uk
  • 2 National Heart and Lung Institute, Imperial College London, London, UK
  • 3 Centre for Evidence Based Medicine, 2nd Department of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland
  • 4 Preventive Medicine and Environmental Health, University of Kentucky, Lexington, Kentucky, USA
  • 5 Clinical Medical Sciences, The University of the West Indies at St Augustine, Saint Augustine, Tunapuna-Piarco, Trinidad and Tobago
  • 6 Respiratory Medicine, JSS Medical College and Hospital, Mysore, Karnataka, India
  • 7 Department of Medicine, RCSI & UCD Malaysia Campus, Georgetown, Pulau Pinang, Malaysia
  • 8 Respiratory, Allergy and Sleep Research, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
  • 9 Vadu Rural Health Program, King Edward Memorial Hospital Pune, Pune, Maharashtra, India
  • 10 Laboratoire de Physiologie et des Explorations Fonctionnelles, Universite de Sousse Faculte de Medecine de Sousse, Sousse, Tunisia
  • 11 Department of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
  • 12 Service de Epidemiologie et Medecine Preventive, Universite Badji Mokhtar Annaba Faculte de Medecine, Annaba, Algeria
  • 13 Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK
  • 14 Lung Clinic, Tartu University Hospital, Tartu, Estonia
  • 15 Division of Respiratory Medicine, University of Cape Town, Rondebosch, Western Cape, South Africa
  • 16 Department of Medicine, King Saud bin Abdulaziz University for Health Sciences & King Abdullah International Medical Research Centre, Riyadh, Saudi Arabia
  • 17 iCAPTURE Centre, The University of British Columbia, Vancouver, Ontario, Canada
  • 18 Medicine, Obafemi Awolowo University, Ile-Ife, Osun, Nigeria
  • 19 Director, Epi-Lab, Khartoum, Sudan
  • 20 Department of Pulmonary Medicine, Paracelsus Medical University Salzburg, Salzburg, Austria
  • 21 Department of Internal Medicine, The University of the West Indies at Mona, Mona, Saint Andrew, Jamaica
  • 22 Pulmonary Medicine, SKIMS, Srinagar, Jammu and Kashmir, India
  • 23 Occupational and Environmental Health, University of Abomey-Calavi, Cotonou, Littoral, Benin
  • 24 Community Health Sciences, Aga Khan University, Karachi, Pakistan
  • 25 Department of Sleep, Landspitali University Hospital, Reykjavik, UK
  • 26 Respiratory Medicine, Medizinische Hochschule Hannover, Hannover, Germany
  • 27 Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway
  • 28 Nuffield Department of Population Health, Oxford University, Oxford, UK
  • 29 Department of Chest Disease, Cukurova University, School of Medicine, Adana, Turkey
  • 30 Respiratory and Environmental Epidemiology, Woolcock Institute of Medical Research, Glebe, New South Wales, Australia
  • 31 Department of Respiratory Medicine, National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyzstan
  • 32 Internal Medicine, Douala General Hospital, Douala, Cameroon
  • 33 Institute of Environmental Health, Lisbon Medical School, Lisbon University, Lisboa, Portugal
  • 34 Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, Oregon, USA
Thorax, 2021 12;76(12):1236-1241.
PMID: 33975927 DOI: 10.1136/thoraxjnl-2020-216223

Abstract

Smoking is the most well-established cause of chronic airflow obstruction (CAO) but particulate air pollution and poverty have also been implicated. We regressed sex-specific prevalence of CAO from 41 Burden of Obstructive Lung Disease study sites against smoking prevalence from the same study, the gross national income per capita and the local annual mean level of ambient particulate matter (PM2.5) using negative binomial regression. The prevalence of CAO was not independently associated with PM2.5 but was strongly associated with smoking and was also associated with poverty. Strengthening tobacco control and improved understanding of the link between CAO and poverty should be prioritised.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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