Affiliations 

  • 1 Centre for Drug Research, Universiti Sains Malaysia, Penang, Malaysia (DS, BV); School of Social Sciences, Universiti Sains Malaysia, Penang, Malaysia (SN); Department of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, IL(WCP); National Institute on Drug Abuse Intramural Research Program, Baltimore, MD (KES); Department of Clinical, Pharmaceutical and Biological Sciences, School of Life and Medical Sciences, College Lane, Hatfield, United Kingdom (OC); Pinney Associates, Bethesda, MD and Johns Hopkins University School of Medicine, Baltimore, MD (JEH); Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL (OG)
J Addict Med, 2021 5 19;16(2):223-228.
PMID: 34001777 DOI: 10.1097/ADM.0000000000000876

Abstract

OBJECTIVES: Kratom (Mitragyna speciosa Korth.), an indigenous medicinal plant, has been widely used as a traditional remedy in Southeast Asia. However, its combined consumption with other substances has received scarce attention. This study investigates the use of kratom among adults with a history of using heroin and methamphetamine in Malaysia.

METHODS: A total of 332 patients who were mandated to undergo drug rehabilitation participated in this cross-sectional study. The study data were collected through face-to-face interviews using a semi-structured questionnaire.

RESULTS: The majority were males (95%, n = 314/332) and Malays (98%, n = 325/332) with a mean age of 32.3 years (SD = 9.16). Over two thirds of the respondents used kratom to alleviate heroin withdrawal symptoms and to reduce methamphetamine intake; 59% used it as a substitute for heroin and methamphetamine. A similar proportion used kratom to reduce heroin intake (58%), while only 15% used it for its euphoric effects. Multivariate analysis showed that previous attendees of government rehabilitation programs had lower odds of using kratom as a heroin substitute.

CONCLUSIONS: The potential of kratom to alleviate heroin withdrawal symptoms, and to reduce methamphetamine and heroin intake, among people who co-use heroin and methamphetamine warrants further research.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.