Affiliations 

  • 1 Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang, 26300 Gambang, Pahang, Malaysia
  • 2 Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, 50603 Kuala Lumpur, Malaysia; Centre for Natural Products Research and Drug Discovery (CENAR), Universiti Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: syedmahmood@um.edu.my
  • 3 Faculty of Health Sciences, Department of Medical Science and Technology, PICOMS International University College of Medical Sciences, 68100 Kuala Lumpur, Malaysia
  • 4 Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, UCSI University, 56000, Kuala Lumpur, Malaysia
  • 5 Faculty of Pharmacy, Jamia Hamdard, 110062 New Delhi, India
Int J Biol Macromol, 2021 Aug 31;185:832-848.
PMID: 34237361 DOI: 10.1016/j.ijbiomac.2021.07.023

Abstract

Over the last few years, several attempts have been made to replace petrochemical products with renewable and biodegradable components. The most challenging part of this approach is to obtain bio-based materials with properties and functions equivalent to those of synthetic products. Various naturally occurring polymers such as starch, collagen, alginate, cellulose, and chitin represent attractive candidates as they could reduce dependence on synthetic products and consequently positively impact the environment. Chitosan is also a unique bio-based polymer with excellent intrinsic properties. It is known for its anti-bacterial and film-forming properties, has high mechanical strength and good thermal stability. Nanotechnology has also applied chitosan-based materials in its most recent achievements. Therefore, numerous chitosan-based bionanocomposites with improved physical and chemical characteristics have been developed in an eco-friendly and cost-effective approach. This review discusses various sources of chitosan, its properties and methods of modification. Also, this work focuses on diverse preparation techniques of chitosan-based bionanocomposites and their emerging application in various sectors. Additionally, this review sheds light on future research scope with some drawbacks and challenges to motivate the researchers for future outstanding research works.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.