Affiliations 

  • 1 Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 26666, United Arab Emirates
  • 2 Department of Biological Sciences, Sunway University, Petaling Jaya 47500, Selangor, Malaysia
  • 3 Centre for Discovery Brain Science, Edinburgh Medical School, Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9YL, UK
  • 4 Centre of Medical Laboratory Technology, Faculty of Health Sciences, Puncak Alam Campus, Universiti Teknologi MARA, Kuala Selangor 42300, Selangor, Malaysia
  • 5 College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates
Molecules, 2021 Aug 18;26(16).
PMID: 34443585 DOI: 10.3390/molecules26164999

Abstract

Crocodiles are remarkable animals that have the ability to endure extremely harsh conditions and can survive up to a 100 years while being exposed to noxious agents that are detrimental to Homo sapiens. Besides their immunity, we postulate that the microbial gut flora of crocodiles may produce substances with protective effects. In this study, we isolated and characterized selected bacteria colonizing the gastrointestinal tract of Crocodylusporosus and demonstrated their inhibitory effects against three different cancerous cell lineages. Using liquid chromatography-mass spectrometry, several molecules were identified. For the first time, we report partial analyses of crocodile's gut bacterial molecules.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.