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Factors associated with bone health status of Malaysian pre-adolescent children in the PREBONE-Kids Study

Chang CY 1 , Arasu K 1 , Wong SY 1 , Ong SH 1 , Yang WY 1 , Chong MHZ 1 Show all authors , Mavinkurve M 2 , Khoo EJ 2 , Chinna K 3 , Weaver CM 4 , Chee WSS 5

Affiliations 

  • 1 Department of Nutrition & Dietetics, School of Health Sciences, International Medical University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia
  • 2 Department of Paediatrics, School of Medicine, International Medical University, Jalan Rasah, Negeri Sembilan, 70300, Seremban, Malaysia
  • 3 Faculty of Health & Medical Sciences, School of Medicine, Taylor's University, No 1, Jalan Taylor's, 47500, Subang Jaya, Selangor, Malaysia
  • 4 Purdue University, West Lafayette, Indiana, USA
  • 5 Department of Nutrition & Dietetics, School of Health Sciences, International Medical University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia. winnie_chee@imu.edu.my
BMC Pediatr, 2021 09 03;21(1):382.
PMID: 34479539 DOI: 10.1186/s12887-021-02842-6

Abstract

BACKGROUND: Modifiable lifestyle factors and body composition can affect the attainment of peak bone mass during childhood. This study performed a cross-sectional analysis of the determinants of bone health among pre-adolescent (N = 243) Malaysian children with habitually low calcium intakes and vitamin D status in Kuala Lumpur (PREBONE-Kids Study).

METHODS: Body composition, bone mineral density (BMD), and bone mineral content (BMC) at the lumbar spine (LS) and total body (TB) were assessed using dual-energy X-ray absorptiometry (DXA). Calcium intake was assessed using 1-week diet history, MET (metabolic equivalent of task) score using cPAQ physical activity questionnaire, and serum 25(OH) vitamin D using LC-MS/MS.

RESULTS: The mean calcium intake was 349 ± 180 mg/day and mean serum 25(OH)D level was 43.9 ± 14.5 nmol/L. In boys, lean mass (LM) was a significant predictor of LSBMC (β = 0.539, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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