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Detection of Mycobacterium tuberculosis complex antibodies in free-ranged wild boar and wild macaques in selected districts in Selangor and reevaluation of tuberculosis serodetection in captive Asian elephants in Pahang, Peninsular Malaysia

Lekko YM 1 , Che-Amat A 1 , Ooi PT 1 , Omar S 2 , Mohd-Hamdan DT 1 , Linazah LS 1 Show all authors , Zakaria Z 1 , Ramanoon SZ 3 , Mazlan M 2 , Jesse FFA 1 , Abdul-Razak MFA 4 , Jasni S 5 , Abdul-Hamid N 6

Affiliations 

  • 1 Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
  • 2 Department of Veterinary Pathology & Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
  • 3 Department of Farm and Exotic Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
  • 4 Department of Wildlife and National Parks Peninsular Malaysia, 56100 Kuala Lumpur, Malaysia
  • 5 Department of Paraclinical, Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, 16100 Kota Bharu, Kelantan, Malaysia
  • 6 Selangor State Veterinary Services Department, Lot 2, Jalan Utas 15/7, Seksyen 15, 40630 Shah Alam, Selangor, Malaysia
J Vet Med Sci, 2021 Oct 31;83(11):1702-1707.
PMID: 34544936 DOI: 10.1292/jvms.21-0144

Abstract

Tuberculosis (TB) is a chronic inflammatory and zoonotic disease caused by Mycobacterium tuberculosis complex (MTBC) members, affecting several domestic animals, wildlife species and humans. The preliminary investigation was aimed to detect antibody against MTBC among indigenous wildlife which are free-ranged wild boar, free-ranged wild macaques and captive Asian elephants in selected areas of Selangor and elephant conservation centre in Pahang, respectively. The results indicate that MTBC serodetection rate in wild boar was 16.7% (7.3-33.5 at 95% confidence interval (CI)) using an in-house ELISA bPPD IgG and 10% (3.5-25.6 at 95% CI) by DPP®VetTB assay, while the wild macaques and Asian elephant were seronegative. The univariate analysis indicates no statistically significant difference in risk factors for sex and age of wild boar but there was a significant positive correlation (P<0.05) between bovine TB in dairy cattle and wild boar seropositivity in the Sepang district.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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