Affiliations 

  • 1 Integrative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 13200 Bertam Kepala Batas, Penang, Malaysia; Department of Chemistry, University of British Columbia, Vancouver V6T 1Z1, BC, Canada. Electronic address: noorfatimah@usm.my
  • 2 Department of Chemistry, University of British Columbia, Vancouver V6T 1Z1, BC, Canada
  • 3 Department of Chemistry, University of British Columbia, Vancouver V6T 1Z1, BC, Canada; College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China
  • 4 Department of Chemistry, University of British Columbia, Vancouver V6T 1Z1, BC, Canada. Electronic address: chen@chem.ubc.ca
Food Chem, 2022 Mar 15;372:131220.
PMID: 34607048 DOI: 10.1016/j.foodchem.2021.131220

Abstract

A simple and sensitive method for the determination of bisphenol A and its analogues at the ng/mL level in bottled tea beverages is presented. This method utilized a dynamic pH junction to focus the analyte into a more concentrated zone, based on the electrophoretic mobility difference of analytes in the sample matrix and background electrolytes in capillary electrophoresis coupled to mass spectrometry (CE-MS). The optimised analyte focusing led to enhanced signal detection with average peak heights for five bisphenols of 53-170 folds higher than conventional injections. Under optimised conditions, the method showed good linearity in the range of 0.1-100 ng/mL, excellent limits of detection (0.03-0.04 ng/mL), good analyte recovery (80.3-118.1%) with acceptable relative standard deviations (<12%). The limits of quantifications were below the maximum permissible content of bisphenol A set by the European Commission for this product. This method was used to quantitatively analyse bisphenols in six different kinds of bottled tea beverages, making it a promising tool for practical applications.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.