Protein and peptide delivery to lungs by using advanced targeted drug delivery

Chellappan DK 1 , Prasher P 2 , Saravanan V 3 , Vern Yee VS 3 , Wen Chi WC 3 , Wong JW 3 Show all authors , Wong JK 3 , Wong JT 3 , Wan W 3 , Chellian J 4 , Molugulu N 5 , Prabu SL 6 , Ibrahim R 7 , Darmarajan T 7 , Candasamy M 4 , Singh PK 8 , Mishra V 9 , Shastri MD 10 , Zacconi FC 11 , Chakraborty A 12 , Mehta M 13 , Gupta PK 14 , Dureja H 15 , Gulati M 9 , Singh SK 9 , Gupta G 16 , Jha NK 17 , George Oliver BG 18 , Dua K 19

Affiliations 

  • 1 Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia. Electronic address: dinesh_kumar@imu.edu.my
  • 2 Department of Chemistry, UGC-Sponsored Centre for Advanced Studies, Guru Nanak Dev University, Amritsar 143005, India; Department of Chemistry, University of Petroleum & Energy Studies, Dehradun 248007, India
  • 3 School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia
  • 4 Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia
  • 5 School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia
  • 6 Department of Pharmaceutical Technology, University College of Engineering (BIT Campus), Anna University, Tiruchirappalli 620024, India
  • 7 School of Health Sciences, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia
  • 8 Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana 500037, India
  • 9 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India
  • 10 School of Pharmacy and Pharmacology, University of Tasmania, Hobart, Australia
  • 11 Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica deChile, Av. Vicuña Mackenna 4860, Macul, Santiago 7820436, Chile; Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile
  • 12 Department of Pharmacology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia
  • 13 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia
  • 14 Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Knowledge Park III, Greater Noida - 201310, Uttar Pradesh, India
  • 15 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak - 124001, India
  • 16 School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, India
  • 17 Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, Uttar Pradesh, 201310, India
  • 18 School of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia; Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia. Electronic address: Brian.Oliver@uts.edu.au
  • 19 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia. Electronic address: Kamal.Dua@uts.edu.au
Chem Biol Interact, 2022 Jan 05;351:109706.
PMID: 34662570 DOI: 10.1016/j.cbi.2021.109706

Abstract

The challenges and difficulties associated with conventional drug delivery systems have led to the emergence of novel, advanced targeted drug delivery systems. Therapeutic drug delivery of proteins and peptides to the lungs is complicated owing to the large size and polar characteristics of the latter. Nevertheless, the pulmonary route has attracted great interest today among formulation scientists, as it has evolved into one of the important targeted drug delivery platforms for the delivery of peptides, and related compounds effectively to the lungs, primarily for the management and treatment of chronic lung diseases. In this review, we have discussed and summarized the current scenario and recent developments in targeted delivery of proteins and peptide-based drugs to the lungs. Moreover, we have also highlighted the advantages of pulmonary drug delivery over conventional drug delivery approaches for peptide-based drugs, in terms of efficacy, retention time and other important pharmacokinetic parameters. The review also highlights the future perspectives and the impact of targeted drug delivery on peptide-based drugs in the coming decade.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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