Displaying publications 1 - 20 of 109 in total

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  1. More women marrying late
    Aziz NL
    Bul Keluarga, 1980 May.
    PMID: 12336570
  2. Fulltext Ex-situ experimental set-up for pink guava juice fouling deposit study
    Ong, C.A., Abdul Aziz, N., Taip, F.S., Ibrahim M.N.
    Pertanika Journal of Science & Technology, 2012;20(1):109-119.
    MyJurnal
    A study has been conducted on pink guava juice (PGJ) fouling deposit. Several ex-situ experimental rigs were set-up to obtain PGJ fouling deposit, while the best ex-situ experimental rig was also selected. PGJ was heated at 93°C and its fouling deposit was obtained after 1 hour of heating. Then, it was used for the ex-situ cleaning study at 1 litre min-1, at several temperatures (70, 80 and 90°C), and in some chemical concentrations (1.6 v/v% of Maxiclean CP6 or 0.325 % OH-; 1.8 v/v% of Maxiclean CP6 or 0.369 % OH-; 2.0 v/v% of Maxiclean CP6 or 0.44 % OH-). The best cleaning combinations were investigated. Carbohydrate is the main content in the fouling deposit. The morphology of the deposit was studied using SEM and it showed an aggregated structure. The cleaning process improved as the temperature increased with the increasing of the chemical solution concentration. The shortest cleaning time was 40 minutes, for cleaning using 2.0 v/v % of Maxiclean CP6 (0.44 % OH-) at 90°C.
  3. Fulltext The effects of airflow on oven temperatures and cakes qualities
    Shahapuzi, N.S., Taip, F. S., Aziz, N., Ahmedov, A.
    Pertanika Journal of Science & Technology, 2015;23(2):339-350.
    MyJurnal
    The presence of airflow during heating process is expected to increase heat uniformity in a closed heating chamber. Circulation of hot air increases the percentage of convective heat transfer. In this study effects of airflow on oven temperature, cake temperature and several cake qualities were investigated. Experimental studies were conducted in convective oven using two different baking modes; with and without airflow. During baking, oven temperatures and internal cake temperature were measured, and images of cake expansion were captured. Results of the study showed that the presence of airflow could maintain the oven temperature within a small range of set point temperature. Temperature in the oven exhibited ±5.5°C fluctuation, approximately 3.5% overshoot that occurred continuously during baking with airflow. On the contrary, higher overshoot (ranging from 15 to 30%) was observed in oven temperature without airflow. Airflow also showed a significant effect (p
  4. Fulltext Drying performances and milling quality of rice during industrial fluidized bed drying of paddy in Malaysia
    Ibrahim, M.N., Sarker, M.S.H., Ab. Aziz N., Mohd Salleh, P
    Pertanika Journal of Science & Technology, 2015;23(2):297-309.
    MyJurnal
    Field investigation on the operation of an industrial fluidized bed paddy dryer of 25 t/h capacity available in a processing complex of Padiberas Nasional Berhad (BERNAS) of Malaysia was carried out to assess its drying characteristics, energy consumption and quality of product during two paddy harvesting seasons. A grain drying simulation model was used to predict dryer performance which can be used as a basis for improving drying operations. For the first season (August-September), average drying rate was found to be 538 kg moisture/h to reduce moisture content (mc) from 36.98± 0.89% dry basis (db) to 27.58±0.79% (db) at 100-120°C of drying air temperature with a feed rate (capacity) of 7.75 t/h. In the second season (February-March), average drying rate was found to be 435 kg moisture/h to reduce mc from 28.14 ±0.68% (db) to 22.54 ± 0.69% (db) at 78-90°C drying air temperature with a feed rate of 9.5 t/h. The thermal and electrical energy consumptions were obtained as 7.57 and 0.97 MJ/kg water removed, respectively, for the first season, while 5.92 and 1.2 MJ/kg water removed for the second season. Higher head rice yield and whiteness and lower milling recovery were achieved during the first season than the second season at acceptable milling degree and transparency. Meanwhile, simulation results indicated that the dryer performed better in terms of increased drying capacity during the second than the first season; the dryer could be operated at 150°C to achieve almost double throughput capacity up to 20 t/h for the second season, while for the first season, high mc hindered the capacity to be at or below 7.75 t/h even when using higher a temperature of 160°C to reduce moisture to the desired final moisture of 24-25% (db). Proportion of slower vehicles based on users' opinion poll
  5. East Asia review, 1976-7: Malaysia
    Aziz NL
    Stud Fam Plann, 1978 Sep;9(9):41-2.
    PMID: 734714 DOI: 10.2307/1965636
  6. Fulltext Potential of fermented papaya beverage in the prevention of foodborne illness incidence
    Koh, S.P., Aziz, N., Sharifudin, S.A., Abdullah, R., Hamid, N.S.A., Sarip, J.
    Food Research, 2017;1(4):109-113.
    MyJurnal
    Foodborne illness is recognized as an emerging infectious disease. The incidence of foodborne
    infections is common and the majority cases are undiagnosed or unreported. Apart from some
    diarrhea or minor gastrointestinal problem, some foodborne pathogenic microbes may cause
    death, particularly to those people with weakened immune system. In this study, we have
    developed a new fermented papaya beverage using symbiotic culture of yeast and acetic acid
    bacteria under controlled biofermentation process. An in-vitro assessment of fermented papaya
    beverage against few foodborne pathogenic microorganism was conducted to determine
    its minimum bactericidal concentration (MBC>99). Three types of foodborne pathogen:
    Escherichia coli O157, Salmonella enterica serovar Typhimurium ATCC 53648, Salmonella
    enterica serovar Enteritidis (isolated from infectious chicken) were selected. From minimum
    bactericidal concentration (MBC>99) assay, both fermented papaya pulp and leaves beverages
    have shown 100% killing rate against three selected foodborne pathogenic microbes. Inversely,
    non-fermented papaya pulp and leaves beverages indicated no inhibition at all. In fact, further
    dilution of fermented papaya pulp and leaves beverages demonstrated different degree of
    MBC>99 and brix value, but the pH value remained less than 3.5. These findings indicated
    the combination of soluble solid compounds presents in both fermented papaya beverage and
    product acidity play an important role in the inhibition of pathogenic microorganisms. The
    preliminary promising results of this work have shown that the great potential of fermented
    papaya beverages as a preventive measure to reduce the incidence of foodborne illness.
  7. Heparin-induced thrombocytopenia and recent advances in its therapy
    Hassan Y, Awaisu A, Aziz NA, Aziz NH, Ismail O
    J Clin Pharm Ther, 2007 Dec;32(6):535-44.
    PMID: 18021330
    To highlight therapeutic controversies, and present a critical review of the most recent evidence on the management of heparin-induced thrombocytopenia (HIT).
  8. Fulltext Cholesterol and alpha-tocopherol contents of fish and other seafood from the Straits of Malacca
    Azrina, A., Abd Aziz, N., Khoo, H. E., Amin, I., Al-Sheraji, S. H., Muhammad Rizal, R.
    International Food Research Journal, 2015;22(4):1494-1500.
    MyJurnal
    This study was conducted to determine the cholesterol and alpha-tocopherol contents of 20 marine fish and four other seafood from the Straits of Malacca. Cholesterol and alphatocopherol contents of the fish and other seafood were determined using high-performance liquid chromatography. The results showed that most of the fish contained low amounts of cholesterol, except sixbar grouper (Epinephelus fasciatus), long-tailed butterfly ray (Gymnura sp.), yellowstripe scad (Selaroides leptolepis), cuttlefish (Sepia officinalis), large-scale tongue sole (Cynoglossus arel), and longtail shad (Hilsa macrura) that contained high amounts of cholesterol (119.39-353.97 mg/100 g wet samples). Indian mackerel (Rastrelliger kanagurta), giant seaperch (Lates calcarifer), prawn (Metapenaeus affinis), and moonfish (Trachinotus blochii) had high alpha-tocopherol contents (462-989 μg/100 g wet sample). Regular consumption of fish and other seafood is highly recommended partly due to the high alphatocopherol content. Due to the high cholesterol in certain types of fish, consumption of the fish fillets of sixbar grouper, long-tailed butterfly ray, yellowstripe scad, cuttlefish, and large scale tongue sole should be < 100 g per day and < 50 per day for longtail shad. Validation of the analytical method also showed a high accuracy and reproducibility of the HPLC method.
  9. Development of oncolytic viruses for cancer therapy
    Abd-Aziz N, Poh CL
    Transl Res, 2021 11;237:98-123.
    PMID: 33905949 DOI: 10.1016/j.trsl.2021.04.008
    Oncolytic virotherapy is a therapeutic approach that uses replication-competent viruses to kill cancers. The ability of oncolytic viruses to selectively replicate in cancer cells leads to direct cell lysis and induction of anticancer immune response. Like other anticancer therapies, oncolytic virotherapy has several limitations such as viral delivery to the target, penetration into the tumor mass, and antiviral immune responses. This review provides an insight into the different characteristics of oncolytic viruses (natural and genetically modified) that contribute to effective applications of oncolytic virotherapy in preclinical and clinical trials, and strategies to overcome the limitations. The potential of oncolytic virotherapy combining with other conventional treatments or cancer immunotherapies involving immune checkpoint inhibitors and CAR-T therapy could form part of future multimodality treatment strategies.
  10. Fulltext Mammography screening uptake among hospital personnel in Kuala Lumpur tertiary hospital
    Abdullah NN, Aziz NA, Rampal S, Al-Sadat N
    Asian Pac J Cancer Prev, 2011;12(10):2643-7.
    PMID: 22320967
    BACKGROUND: Breast cancer is the most common cancer among women in Malaysia. Of the total cancer cases registered in the National Cancer Registry for 2006, 3,525 were female breast cancer cases. The overall age standardized rate was 39.3 per 100,000 population in 2006. An estimated 30%-40% were diagnosed in the late stages and this had resulted in poor survival rates. The purpose of the study was to determine the factors and barriers related to mammography screening uptake among hospital personnel.

    METHODS: This mixed method explanatory study was carried out on a universal sampling of 707 female personnel aged 40 and above, from June 2007 until November 2007. The study was conducted at University Malaya Medical Centre, a tertiary hospital in Kuala Lumpur. Pre-tested self-administered questionnaires were mailed to eligible personnel.

    RESULTS: The prevalence of mammography screening uptake was 80.3% (95%CI: 76.8%,83.5%) among 534 respondents. Personnel who had physician recommendation had significantly higher odds of mammography screening uptake compared to those who did not have recommendation, adjusted odds ratio of 21.25 (95%CI:12.71,36.56). Reported barriers can be grouped into several themes; negative perception of the procedure like embarrassment due to the presence of male technicians/radiographers; low confidence with radiologist/radiographers in detecting abnormality; lack of coping skills in dealing with expected results and pain during procedure.

    CONCLUSIONS: The findings of this study highlighted that 20% of personnel did not undertake mammography screening although there is no cost incurred and the procedure is fully accessible to them. Opportunistic recommendation by physician and concerns on the procedure should be addressed.
  11. Fulltext Drug reaction with herbal supplement: a possible case of drug induced lupus erythematosus
    Muthupalaniappen L, Jamani N, Muhammad M, Adawiyah J, Aziz N
    Malays Fam Physician, 2010;5(2):99-100.
    PMID: 25606196 MyJurnal
    A 24-year-old lady presented with four days history of fever, non-pruritic rash, ankle pain and swelling. She had consumed herbal supplement five days before the onset of symptoms. Examinations revealed erythematous maculo-papular lesions of varying sizes on sun exposed areas. Patient was suspected to have Drug Induced Lupus Erythematosus (DILE) and subsequently symptoms subsided rapidly on withholding the herbal medication.
  12. Fulltext Predictive value of thrombocytopaenia in the diagnosis of dengue infection in outpatient settings
    Tong SF, Aziz NA, Chin GL
    Med J Malaysia, 2007 Dec;62(5):390-3.
    PMID: 18705473 MyJurnal
    Thrombocytopaenia is often relied upon as an important criterion for the diagnosis of dengue infection among patients presenting with an acute non-specific febrile illness. This study was aimed to assess usefulness of thrombocytopaenia in the diagnosis of acute dengue virus infection. This was a clinic based prospective cohort study from May to November 2003. Consecutive patients presenting with acute non-specific febrile illness of less than two weeks were selected from two urban primary care centres. We did full blood count examination (FBC) on the day of visit and dengue serology on day five of illness for all patients enrolled. We repeated the FBC examination for patients who had initial normal platelet counts. Thrombocytopaenia was defined as platelet count < 150 X 10(9)/L. Eighty-seven patients enrolled in the study. Complete data was available for 73 patients. The prevalence of acute dengue virus infection was 27.6%. The sensitivity and specificity were 88% and 71% respectively. The likelihood of acute dengue infection in the presence of thrombocytopaenia was 2.52 and likelihood of not having dengue infection in normal platelet count patients was 5.22. Thrombocytopaenia has fair predictive value in diagnosing acute dengue virus infection. It was more useful to exclude than to diagnose dengue infection.

    Study site: Primary Care Centre of Hospital Universiti
    Kebangsaan Malaysia (HUKM) and Batu 9 Health Clinic Hulu Langat,
  13. Adsorption of direct dye on palm ash: kinetic and equilibrium modeling
    Ahmad AA, Hameed BH, Aziz N
    J Hazard Mater, 2007 Mar 6;141(1):70-6.
    PMID: 16887263
    Palm ash, an agriculture waste residue from palm-oil industry in Malaysia, was investigated as a replacement for the current expensive methods of removing direct blue 71 dye from an aqueous solution. The experimental data were analyzed by the Langmuir and Freundlich models of adsorption. Equilibrium data fitted well with Freundlich model in the range of 50-600mg/L. The equilibrium adsorption capacity of the palm ash was determined with the Langmuir equation and found to be 400.01mg dye per gram adsorbent at 30 degrees C. The rates of adsorption were found to conform to the pseudo-second-order kinetics with good correlation. The results indicate that the palm ash could be employed as a low-cost alternative to commercial activated carbon.
  14. The impact of pharmacist-initiated interventions in improving acute coronary syndrome secondary prevention pharmacotherapy prescribing upon discharge
    Hassan Y, Kassab Y, Abd Aziz N, Akram H, Ismail O
    J Clin Pharm Ther, 2013 Apr;38(2):97-100.
    PMID: 23441979 DOI: 10.1111/jcpt.12027
    Pharmacists have the knowledge regarding optimal use of medications and the ability to influence physician prescribing. Successful interventions by a pharmacist to implement cardioprotective medications to a coronary artery disease patient's regimen would not only improve the patient's quality of care but may also increase his or her likelihood of survival. Therefore, the aim of this study was to (i) evaluate the effectiveness of pharmacist initiated interventions in increasing the prescription rates of acute coronary syndrome (ACS) secondary prevention pharmacotherapy at discharge, and to (ii) evaluate the acceptance rate of these interventions by prescribers.
  15. Comprehension of antibiotic instructions in an outpatient Malaysian practice
    Hassan Y, Abd Aziz N, Sarriff A, Darwis Y, Ibrahim P
    Hosp Pharm, 1994 Jan;29(1):48-50, 53.
    PMID: 10131493
    Patients may not comply with antibiotic instructions because they do not understand them. The aim of this study was to assess outpatients' ability to comprehend their antibiotic prescription labels. Two hundred and five subjects on oral antibiotic regimens from an outpatient clinic and pharmacy of a district hospital were selected in this survey. All patients were interviewed by trained clinical pharmacy students. They were asked to read the labels and then how they would take their antibiotics. The results show that 119 (58.1%) patients could interpret the label. Forty-nine (23.9%) patients knew the name of antibiotics and interpreted the directions of use correctly. One hundred sixteen (56.6%) subjects were able to recall the auxiliary information. However, only 44 (21.4%) patients were able to comprehend complete antibiotic instruction. This study demonstrates that a significant proportion of patients could not interpret the labeling instruction. The comprehension level of patients was low and significantly associated (P < 0.05) with the ability of patient to read the label contents. These observations illustrate the need for physicians and pharmacists to provide antibiotic instructions and review these instructions with the patient.

    Study site: outpatient clinic and pharmacy of a district hospita
  16. A study of patients' self-interpretation of prescription instructions
    Sarriff A, Aziz NA, Hassan Y, Ibrahim P, Darwis Y
    J Clin Pharm Ther, 1992 Apr;17(2):125-8.
    PMID: 1583080
    This study examined out-patients' interpretation of prescription instructions at a community hospital. The results showed a wide range of misinterpretation with respect to drug name, dose schedule, and auxiliary labels. Age level, education and financial status emerged as the most significant variables associated with the patient's response. Therefore, both physicians and pharmacists may wish to review their traditional prescribing and dispensing procedures to help out-patients make better use of potent medication.
  17. An analysis of clinical pharmacist interventions in an intensive care unit
    Hassan Y, Aziz NA, Awang J, Aminuldin AG
    J Clin Pharm Ther, 1992 Dec;17(6):347-51.
    PMID: 1287026
    In a 6-month study period, 170 pharmacist interventions in an intensive care unit (ICU) were analysed. Of the interventions, 68.8% were solicited and 31.2% were initiated by the pharmacists. The majority of the interventions were initiated by specialists (69.4%) followed by the medical officers (15.9%) and nurses (9.4%). Most of the interventions occurred during the grand rounds (75.9%), followed by ward visits (12.9%) and communication through the satellite pharmacy (10.5%). The most frequent type of intervention made was for indication or therapeutic efficacy followed by general product information, drug regimen, laboratory assessment, disease state, pharmaceutical availability and adverse drug reaction or side effect. It was also found that 83.7% of pharmacists' suggestions were accepted, 6.4% were accepted with changes, and 9.9% were not accepted. The majority of the interventions were made by direct verbal communications followed by telephone and written communications. In conclusion the study indicates that pharmacist therapeutic recommendations form an important integral element of patient care in an ICU.
  18. East Asia review 1978-79. Malaysia
    Aziz NL, Tey NP, Ramli O
    Stud Fam Plann, 1980 Nov;11(11):330-4.
    PMID: 7456109 DOI: 10.2307/1966036
    PIP: While Malaysia's National Family Planning Board is primarily responsible for family planning activities, several organizations and ministries, both governmental and voluntary, participate in various service programs. Current population policy attempts to go beyond family planning. Population education, treatment of infertility, and cancer screening are offered as well as family planning, to make the program more useful to greater numbers of people. The government also wishes to improve the status of women thereby giving them alternative choices of lifestyle. Rural women are reached through the Ministry of Agriculture's community development program. While the National Family Planning Board receives only 0.12% of the national budget, this figure is not expected to increase. Tables giving vital rates show that population fell below the 30 per 1000 mark for the first time in 1977. A higher rate of fertility decline has taken place between 1967 - 1977 than occurred from 1957 - 1967. Current demographic objectives are to reduce crude birthrate to 28.2 per 1000 by 1980. This goal would require 817,963 new acceptors. While the pill accounts for 80% of acceptor's choice, the proportion using condoms has increased from 1.4% during 1969 - 1970 to 11.4% in 1979. Despite reported side effects with the pill and the illegality of induced abortions, virtually all acceptors are well satisfied with the program in its current form.
  19. Development of MicroRNAs as Potential Therapeutics against Cancer
    Abd-Aziz N, Kamaruzman NI, Poh CL
    J Oncol, 2020;2020:8029721.
    PMID: 32733559 DOI: 10.1155/2020/8029721
    MicroRNAs (miRNAs) are small noncoding RNAs that function at the posttranscriptional level in the cellular regulation process. miRNA expression exerts vital effects on cell growth such as cell proliferation and survival. In cancers, miRNAs have been shown to initiate carcinogenesis, where overexpression of oncogenic miRNAs (oncomiRs) or reduced expression of tumor suppressor miRNAs has been reported. In this review, we discuss the involvement of miRNAs in tumorigenesis, the role of synthetic miRNAs as either mimics or antagomirs to overcome cancer growth, miRNA delivery, and approaches to enhance their therapeutic potentials.
  20. Safety and effectiveness of a biosimilar biphasic insulin in the management of diabetes mellitus during routine clinical practice in Asian patients
    Hussein Z, Aziz NA, Dhanaraj E, Brahmachari B, Kothekar M
    Med J Malaysia, 2020 07;75(4):372-378.
    PMID: 32723997
    INTRODUCTION: Biosimilar insulins have the potential to increase access to treatment among patients with diabetes mellitus (DM), reduce treatment costs, and expand market competition. There are no published studies evaluating the performance of biosimilar insulins in routine clinical practice in Asia. This study assessed the safety and effectiveness of biphasic isophane insulin injection in Malaysian DM patients.

    MATERIALS AND METHODS: In this open label, single-arm, observational, post marketing study, patients received biphasic isophane insulin injection as per the Prescribing Information; and were assessed for safety (adverse events including hypoglycaemia), effectiveness (glycosylated haemoglobin [HbA1c]; fasting blood sugar, [FBS]; and patient's condition by patient and physician) over a period of 24 weeks.

    RESULTS: Adult male and female diabetes patients (N=119; type 2 DM, n=117) with a mean (SD) diabetes duration of 13 years were included. No new safety signals have been identified. Significant reduction in HbA1c was observed at weeks 12 and 24 (mean [SD] - baseline: 9.6% [1.9]; Week 12: 9.0% [1.7] and at Week 24: 9.1% [1.7]; p < 0.001). There were 10 serious and 9 non-serious adverse events reported in the study. Expected mild events included hypoglycaemia and injection site pruritus. However, the majority of the adverse events were non-study drug related events. No deaths were reported during the study.

    DISCUSSION: Biphasic isophane insulin injection was well tolerated with no new safety concerns. It was found effective in post- marketing studies conducted in routine clinical settings when administered in DM patients in this study.

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