MyMedR

Fulltext Congenital vallecular cyst with polydactyly - A rare cause of stridor and failure to thrive

Khode SR, Gosrani N, Golhar S, Vedi J

Med J Malaysia, 2014 Apr;69(2):101-2.

Congenital vallecular cyst is an uncommon, benign but potentially dangerous condition causing respiratory distress and stridor. It is associated with sudden upper airway obstruction resulting in death due to its anatomical location in neonates and infants. We reported a rare case of 2 months old male infant presented with respiratory obstruction with failure to thrive with polydactyly (rarest finding) and managed timely with appropriate surgical marsupialization.

Matched MeSH terms: Infant; Infant, Newborn

Effect of current breastfeeding on sleep patterns in infants from Asia-Pacific region

Ramamurthy MB, Sekartini R, Ruangdaraganon N, Huynh DH, Sadeh A, Mindell JA

J Paediatr Child Health, 2012 Aug;48(8):669-74.

PMID: 22616943 DOI: 10.1111/j.1440-1754.2012.02453.x

AIM:
The aim of this study was to assess the relationship between breastfeeding and sleep patterns in infants from Asia-Pacific region.

METHODS:
Parents of 10 321 infants (0-11 months) from Australia, China, Hong Kong, India, Indonesia, Korea, Japan, Malaysia, New Zealand, the Philippines, Singapore, Taiwan, Thailand and Vietnam completed an expanded version of the Brief Infant Sleep Questionnaire.

RESULTS:
Overall, 4714 (45.72%) were currently being breastfed; 61.3% of those between 0 and 5 months and 36.6% of those between 6 and 11 months. Currently breastfed infants, when compared with not currently breastfed infants, had a significant increase in the number and duration of night-time wakings and less consolidated sleep. Interestingly, currently breastfed infants less than 6 months also showed longer duration of daytime sleep and obtained more sleep overall. Of note, of those who were currently breastfed, those infants who were nursed back to sleep during night, woke up more often at night (2.41 vs. 1.67 times) and had shorter continuous night-time sleep period (5.58 vs. 6.88 h; P < 0.001). There was no significant difference between breastfeeding and non-breastfeeding infants in the number of night wakings, when the nursing to sleep variable was controlled for in the analysis of variance.

CONCLUSION:
Breastfeeding is associated with reduced sleep consolidation in infants. This relationship, however, may be moderated by parenting practices of nursing to sleep and back to sleep during the night. Thus, parents of infants with night waking problems should be encouraged to limit the association between nursing and falling to sleep, to improve sleep while maintaining breastfeeding.

Matched MeSH terms: Infant; Infant, Newborn

Fulltext Infantile myofibromatosis

Ariffin H, Teh KH, Looi LM, Ariffin WA, Lin HP

Med J Malaysia, 2001 Dec;56(4):497-9.

PMID: 12014771

Infantile myofibromatosis (IMF) is a rare tumour with a wide spectrum of disease activity ranging from a solitary cutaneous nodule through to a multicentric form with widespread visceral involvement. It is characterised by its unique ability to spontaneously regress and has a typical histological appearance of actin-positive fibroblasts arranged in whorls or fascicles and vessels in a pericytomatous pattern. A male infant with multiple lesions involving the subcutaneous tissue and bone from birth is described and followed-up for two years. Treatment of IMF is dependent on the location of the tumour/s with surgery or chemotherapy reserved for rapidly progressive or symptomatic disease. However, due to the low rate of recurrence and the possibility of spontaneous tumoral regression, therapeutic abstention, as practised in our patient, is justified.

Matched MeSH terms: Infant; Infant, Newborn

Fulltext Congenital cytomegalovirus infection in Malaysia

Ho J

Med J Malaysia, 1994 Dec;49(4):429.

PMID: 7674985

Matched MeSH terms: Infant; Infant, Newborn

Fulltext Immunization: acceptance rates in a military community

Supramaniam V

Med J Malaysia, 1985 Jun;40(2):95-7.

PMID: 3834292

An immunization survey was carried out in early 1983 in a military community. The survey covered 192 children from 147 families. 98% had BCG scars. and 94% had completed their primary course of immunization against diphtheria, pertussis, tetanus and poliomyelitis. The acceptance rate for booster was however low. The time frame for the immunization was also not adhered to strictly. An immunization register has been started in all centres for recall of defaulters. Publicity has also been mounted to ensure all are aware of the immunization programme.

Matched MeSH terms: Infant; Infant, Newborn

Fulltext Serum IgM-globulin in Malaysian normal and defective infants

Tan DSK

Med J Malaysia, 1983 Mar;38(1):15-8.

PMID: 6633327

The IgM-globulin levels were determined for 5,167 cord-sera of apparently normal infants and 281 sera of defective infants aged 4 months and younger. The significant level for IgM-globulin in neonates was found to be 20 mgm/dl (2 SD above mean of the normal) above which the level was regarded as abnormally raised. Significant levels of IgM-globulin were found in 0.2% (11/5, 167) ofnormal neonates and in 40.6% (114/281) of defective infants which is more than 200 times the normal value. Combining the normal and abnormal rates, an overall figure of 23 intrauterine infections per 1,000 live births were obtained for Malaysia. The advantages and disadvantages of the use of serum IgM-globulin elevations for the diagnosis of intrauterine infections were discussed.

Matched MeSH terms: Infant; Infant, Newborn

Fulltext Bacteraemic enteritis due to Campylobacter jejuni

Puthucheary SD, Lin HP

Med J Malaysia, 1982 Dec;37(4):378-80.

PMID: 7167093

Campylobacter Jejuni is being increasingly recognised as a cause of bacteraemia enteritis and two infants with this condition are described. Awareness of the organism. as a possible cause of septicaemia is important because it has special growth requirements and delay in the diagnosis can be detrimental in a disease which usually only responds to erythromycin, gentamicin and chloramphenicol.

Matched MeSH terms: Infant; Infant, Newborn

Fulltext Lethal neonatal dwarfism: a case of achondrogenesis

Afzal MK, Choo KE

Med J Malaysia, 1980 Sep;35(1):64-7.

PMID: 7254002

Achondrogenesis is a lethal neonatal chondrodysplasia with extreme micromelia and marked discrepancy between the relatively large head and the decreased trunk length. The affected neonates are usually delivered prematurely, and are stillborn or die soon after birth. Polyhydramnios is frequently present. It is an inherited autosomal recessive disease. The radiographic features are diagnostic.

Matched MeSH terms: Infant, Newborn; Infant, Premature

Malaysian childhood leukemia: a 13 year review at the University Hospital, Kuala Lumpur

Sinniah D, Peng LH

Leuk. Res., 1981;5(3):271-8.

PMID: 7266021

Matched MeSH terms: Infant; Infant, Newborn

Fulltext A study of liver reserves of vitamin A in Malaysians

Chandrasekharan N

Malays J Pathol, 1981 Aug;4:43-7.

PMID: 7186602

Matched MeSH terms: Infant; Infant, Newborn

Phototherapy in neonatal jaundice

Sinniah D, Lee EL

Med J Malaysia, 1977 Jun;31(4):328-30.

PMID: 562970

Matched MeSH terms: Infant; Infant, Newborn

Screening for G. 6-P.D. deficiency

Robinson MJ, Lau KS, Lin HP, Chan GL

Med J Malaysia, 1976 Jun;30(4):287-90.

PMID: 979730

Matched MeSH terms: Infant; Infant, Newborn

A report on beriberi as discovered in the rural maternity and child welfare centres, Singapore and steps taken to combat it

Faris DWG

Journal of the Malaya Branch of the British Medical Association, 1938;2:124-31.

Matched MeSH terms: Infant; Infant Nutrition Disorders

Fulltext A case series of hereditary congenital cataract

Nurul Faaiqah Jainuddin, Azlindarita Aisyah Mohd Abdullah, Visvaraja Subrayan, Norlina Ramli, Nurliza Khaliddin

Malaysian Journal of Medicine and Health Sciences, 2020;16(2):336-338.

MyJurnal

Congenital cataract is a major cause of preventable blindness in children. It can be either hereditary or non-hereditary. In this case series, we present three cases of congenital cataract with a strong family history. The grandparents
and parents of these patients had cataract diagnosed in late childhood whilst the patients in this case series were
diagnosed with congenital cataract earlier. There was no history of consanguineous marriage in any of the families.
These cases show that, in the presence of a strong family history, a child will present with congenital cataract earlier
in their life. Hence, babies from such families should be screened at birth and at regular intervals within the first
year of life to enable early diagnosis and subsequent surgical intervention to reduce the incidence and burden of
amblyopia.

Matched MeSH terms: Infant; Infant, Newborn

A retrospective analysis of oral and maxillofacial biopsied specimens in Malaysian newborns and infants

Binti Shuhairi NN, Bt Abdul Jalil A, Lau SH, Bt Mohd Ghazali S, Kee CC

Int J Paediatr Dent, 2021 Jul;31(4):496-503.

PMID: 32815206 DOI: 10.1111/ipd.12719

BACKGROUND: Globally, research on oral and maxillofacial lesions among newborns and infants remains limited.

AIM: To describe demographic patterns, histopathological findings, and locations of oral and maxillofacial lesions in newborns (birth-1 month) and infants (>1 month-2 years) reported over 51 years.

DESIGN: A retrospective cross-sectional study on histopathological records of newborns and infants was conducted. Patients' demographic characteristics (age, gender, and race), histopathological diagnosis, and lesion's location were gathered. Pearson's chi-square or Fisher's exact test was performed to determine associations between demographic characteristics and different categories of lesions.

RESULTS: Out of 66,546 specimens received, 0.44% (290 specimens) were from patients aged 2 years and younger (27 newborns and 263 infants). The most common category was inflammatory/reactive (44.2%), followed by tumour/tumour-like (42.0%), cystic/pseudocystic (6.6%), and miscellaneous lesions (5.5%). Mucous extravasation cysts (23.4%) and Langerhans cell histiocytosis (7.2%) were the most common histopathological diagnoses. Tumour/tumour-like lesions were significant in newborns (P = .021), and majority were congenital epulis (40.7%). Inflammatory/reactive lesions were significantly higher in male (P = .025) and infants (P = infants are the key to early detection of lesions.

Matched MeSH terms: Infant; Infant, Newborn

Spontaneous neonatal scrotal haematoma: an early manifestation of severe haemophilia

Lee JS, Chieng CH, Martin M, Toh TH

BMJ Case Rep, 2021 Apr 28;14(4).

PMID: 33910804 DOI: 10.1136/bcr-2020-241482

We report a term newborn who presented on day 3 of life with unilateral, tender scrotal swelling with skin discolouration, which was subsequently diagnosed as haemophilia A at about 6 months of age. He received intramuscular vitamin K and hepatitis B vaccine at birth uneventfully. The scrotal swelling was treated as an infected hydrocoele, considering the absence of a family history of bleeding disorder and other risks of bleeding tendency, as well as the ultrasonographic features. He also had congenital pneumonia requiring venepuncture, non-invasive oxygen supplementation and intravenous antibiotics, without any complication. The swelling slowly improved over 2 months. He later developed post-trial vaccine injection haematoma at 4 months of age, and multiple non-traumatic bruises when he was 6 months old, leading to the diagnosis. This case demonstrates an uncommon, but a possible, early manifestation of haemophilia A at birth with a unilateral scrotal haematoma.

Matched MeSH terms: Infant; Infant, Newborn

Fulltext CT findings of congenital neonatal pyriform aperture stenosis

Sidek HAB, Teh YG, Tangaperumal A, Zaki FM, Kew TY

Oxf Med Case Reports, 2021 May;2021(5):omab018.

PMID: 34055355 DOI: 10.1093/omcr/omab018

Congenital neonatal pyriform aperture stenosis (CNPAS) is a rare but potentially lethal condition that causes respiratory distress. The characteristic narrowing of the pyriform aperture along with other associated craniofacial dysmorphism is diagnosed using cross-sectional imaging such as computed tomography (CT) and magnetic resonance imaging. CT scan is the imaging of choice for confirming and characterizing CNPAS. Infants are obligate nasal breathers in the first 5 months of life. Hence, a high degree of clinical suspicion, prompt imaging diagnosis and adequate respiratory support is critical to help reduce the morbidity of this condition.

Matched MeSH terms: Infant; Infant, Newborn

Randomised controlled trial: Shoulder-umbilicus length versus body weight measurement for optimal endotracheal tube depth estimation in ventilated infants

Mat Ali AAB, Nasir A, Ramli N, Ibrahim NR, Van Rostenberghe H

J Paediatr Child Health, 2020 05;56(5):704-709.

PMID: 31821664 DOI: 10.1111/jpc.14705

AIM: The optimal placement of the endotracheal tube (ETT) in ventilated infants is essential, but birthweight may be not the best parameter to predict it. The aim of this study was a direct comparison of shoulder-umbilical length (experimental group) versus birthweight (control group) as predictor of optimal ETT placement in Malaysian ventilated infants.

METHODS: All infants requiring ventilation in the neonatal intensive care unit of a tertiary hospital in Malaysia during the 4-month study period were eligible to enter this randomised controlled trial. All participants were randomised into two groups: experimental and control group. The main outcome measure was malposition of the ETT (requiring adjustment), as seen on the chest X-ray performed within 1 h after intubation. Tube placement was assessed by two neonatologists, blinded to the allocation.

RESULTS: One hundred and ten infants were randomised, 55 in each group. The ETT was malpositioned in 13 of 55 infants (23%) for the experimental group and 22 of 55 infants (40%) in the control group (P = 0.06).

CONCLUSION: In the experimental group, fewer infants showed a need for tube adjustment than in the control group. While a larger study may be necessary to show statistical significance, the difference shown in this study may be large enough to be of clinical significance.

Matched MeSH terms: Infant; Infant, Newborn

Fulltext C-reactive protein/albumin ratio is a prognostic indicator for predicting surgical intervention and mortality in neonates with necrotizing enterocolitis

Mohd Amin AT, Zaki RA, Friedmacher F, Sharif SP

Pediatr Surg Int, 2021 Jul;37(7):881-886.

PMID: 33779823 DOI: 10.1007/s00383-021-04879-1

PURPOSE: The role of hypoalbuminemia and raised C-reactive protein (CRP) levels in predicting critical prognosis has been described extensively in adult literature. However, there are limited studies in pediatrics, particularly neonates. The CRP/albumin (CRP/ALB) ratio is often associated with higher mortality, organ failure and prolonged hospital stay. We hypothesized that the serum CRP/ALB ratio has a prognostic value in predicting surgery and mortality in neonates with necrotizing enterocolitis (NEC).

METHODS: Retrospective review of all neonates with clinical and radiological evidence of non-perforated NEC that were treated in a tertiary-level referral hospital between 2009 and 2018. General patient demographics, laboratory parameters and outcomes were recorded. Receiver operating characteristics analysis was performed to evaluated optimal cut-offs and area under the curve (AUC) with 95% confidence intervals (CI).

RESULTS: A total of 191 neonates were identified. Of these, 103 (53.9%) were born at ≤ 28 weeks of gestation and 101 (52.9%) had a birth weight of ≤ 1000 g. Eighty-four (44.0%) patients underwent surgical intervention for NEC. The overall survival rate was 161/191 (84.3%). A CRP/ALB ratio of ≥ 3 on day 2 of NEC diagnosis was associated with a statistically significant higher likelihood for surgery [AUC 0.71 (95% CI 0.63-0.79); p

Matched MeSH terms: Infant; Infant Mortality/trends; Infant, Newborn; Infant, Newborn, Diseases/blood*; Infant, Newborn, Diseases/mortality; Infant, Newborn, Diseases/surgery

Fulltext Shock in the neonate

Davendralingam Sinniah, Thiruselvi Subramaniam, Myint Myint Soe-Hsiao

International e-Journal of Science, Medicine & Education, 2013;7(2):17-28.

MyJurnal

Shock is a clinical challenge to neonatal intensivists and pediatricians alike. It occurs in critically ill babies for many reasons, but the main cause is sepsis that kills more than a million newborn globally every year. This article is designed to help young doctors and trainees have a better understanding of shock in the neonatal period and its management. The paper reviews the basic pathophysiology, risk factors, clinical investigation, management, supportive care, and complications in the common types of shock seen in neonates. Treatment is governed largely by the underlying cause, with the ultimate goal of achieving adequate tissue perfusion with delivery of oxygen and substrates to the cells, and removal of toxic metabolic waste products. Intervention needs to be anticipatory and urgent to prevent progression to uncompensated and irreversible shock respectively. Early recognition and urgent effective management are crucial to successful outcomes.

Matched MeSH terms: Infant; Infant, Newborn

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