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ISH ADA-04 TRANSCRIPTOME PATHWAY ANALYSIS OF AUTONOMOUS AND PHYSIOLOGICAL ALDOSTERONE-PRODUCING HUMAN TISSUE

Zhou J, Lam B, Neogi S, Yeo G, Azizan E, Brown M

J Hypertens, 2016 Sep;34 Suppl 1 - ISH 2016 Abstract Book:e40.
PMID: 27753883

Primary aldosteronism (PA) is the most common type of secondary hypertension occurring in ∼10% of hypertensive patients. Up to 50% of PA is caused by aldosterone-producing adenomas (APA). This study is to identify the potential biological processes and canonical pathways involved with aldosterone regulation, APA formation, or APA and ZG cell functions.

Matched MeSH terms: Humans
Fulltext OPTN/SRTR 2011 Annual Data Report: international data

Kasiske BL, Skeans MA, Leighton TR, Ghimire V, Leppke SN, Israni AK

Am J Transplant, 2013 Jan;13 Suppl 1:199-225.
PMID: 23237702 DOI: 10.1111/ajt.12026

For the first time, OPTN/SRTR has undertaken to publish global transplant rates as part of its Annual Data Report. Understanding why rates vary from country to country may lead to a better understanding of how to improve access to transplant everywhere. Availability of information varies substantially from country to country, and how complete and accurate the data are is difficult to ascertain. For Canada, Malaysia, and the United Kingdom, data were supplied at SRTR request from well-known registries. For many other countries, SRTR was unable to obtain information, and data from the World Health Organization's Global Observatory on Donation and Transplantation were used. Transplant counts and rates vary substantially around the world, likely due to 1) differences in rates of end-organ diseases, 2) economic differences in the ability to provide transplants or other end-organ disease treatment, 3) cultural differences that might support or hinder organ donation and transplant, and 4) reporting differences.

Matched MeSH terms: Humans
Healthcare Policies for Stateless Populations in ASEAN Countries: A Scoping Review

Barua P, Bangpan M, Narattharaksa K, Suphanchaimat R, Chaiyakunapruk N

J Immigr Minor Health, 2020 Jun;22(3):597-620.
PMID: 31741181 DOI: 10.1007/s10903-019-00945-y

This study aimed at summarizing the existing health policies for stateless populations living in the 10 ASEAN countries: Brunei, Cambodia, Lao PDR, Indonesia, Malaysia, Myanmar, the Philippines, Singapore, Thailand, and Vietnam. We followed scoping review method recommended by Arksey and O'Malley. Our inclusion criteria were based on three concepts: populations (stateless and undocumented people), issues (healthcare policies and regulations), and settings (10 ASEAN countries). Our findings suggest that none of the ASEAN countries have explicit healthcare policies for stateless people except Thailand. We also observed that ratification of international human rights treaties relating to the right to health does not necessarily translate into the provision of healthcare policies for stateless population. Although Thailand seems like the only country among 10 ASIAN countries having health policies for stateless populations in the country, the question remains whether having a policy would lead to a proper implementation by ensuring right to health.

Matched MeSH terms: Humans
The COVID-19 pandemic: Theoretical and practical perspectives on children, women and sex trafficking

Asongu SA, Usman UM

Health Care Women Int, 2020 12 08;41(11-12):1384-1397.
PMID: 33290191 DOI: 10.1080/07399332.2020.1849219

We provide theoretical and practical perspectives on children, women, and sex trafficking during the COVID-19 pandemic. Process tracing is employed as a primary research instrument. It is an analytical technique used for either theory-building or theory-testing purposes that is employed to elucidate causation and change as well as to develop and evaluate extant theories in social sciences. We illustrate that a policy is needed that will strengthen the capacity of existing structures in the fight against the underlying trafficking so that these attendant structures are efficiently used to stop the trafficking and avoid the corresponding threats to public health safety.

Matched MeSH terms: Humans
Secondary prevention of fragility fractures in Asia Pacific: an educational initiative

Ebeling PR, Chan DC, Lau TC, Lee JK, Songpatanasilp T, Wong SH, et al.

Osteoporos Int, 2020 May;31(5):805-826.
PMID: 31788717 DOI: 10.1007/s00198-019-05197-y

The Asia -Pacific Bone Academy (APBA) Fracture Liaison Service (FLS) Focus Group educational initiative has stimulated activity across the Asia -Pacific region with the intention of supporting widespread implementation of new FLS. In 2017, the APBA FLS Focus Group developed a suite of tools to support implementation of FLS across the Asia-Pacific region as a component of a multi-faceted educational initiative. This article puts this initiative into context with a narrative review describing the burden of fragility fractures in the region, the current secondary fracture prevention care gap and a summary of emerging best practice. The results of a survey to evaluate the impact of the APBA educational initiative is presented, in addition to commentary on recent activities intended to improve the care of individuals who sustain fragility fractures across the Asia -Pacific. A FLS Toolbox for Asia-Pacific was developed which included the following sections:1. The burden of fragility fractures in the Asia-Pacific region.2. A summary of evidence for FLS in the Asia-Pacific.3. A generic, fully referenced FLS business plan template.4. Potential cost savings accrued by each country, based on a country-specific FLS Benefits Calculator.5. How to start and expand FLS programmes in the Asia-Pacific context.6. A step-by-step guide to setting up FLS in countries in the Asia-Pacific region.7. Other practical tools to support FLS establishment.8. FLS online resources and publications.The FLS Toolbox was provided as a resource to support FLS workshops immediately following the 5th Scientific Meeting of the Asian Federation of Osteoporosis Societies (AFOS) held in Kuala Lumpur in October 2017. The FLS workshops addressed three key themes:• The FLS business case.• Planning the FLS patient pathway.• The role of the FLS coordinator in fragility fracture care management.A follow-up survey of 142 FLS workshop participants was conducted in August-September 2018. The survey included questions regarding how FLS were developed, funded, the scope of service provision and the support provided by the educational initiative. Almost one-third (30.3%) of FLS workshop participants completed the survey. Survey responses were reported for those who had established a FLS at the time the survey was conducted and, separately, for those who had not established a FLS. Findings for those who had established a FLS included:• 78.3% of respondents established a multidisciplinary team to develop the business case for their FLS.• 87.0% of respondents stated that a multidisciplinary team was established to design the patient pathway for their FLS.• 26.1% of respondents stated that their FLS has sustainable funding.• The primary source of funding for FLS was from public hospitals (83.3%) as compared with private hospitals (16.7%).Most hospitals that had not established a FLS at the time the survey was conducted were either in the process of setting-up a FLS (47%) or had plans in place to establish a FLS for which approval is being sought (29%). The primary barrier to establishing a new FLS was lack of sustainable funding. The APBA FLS Focus Group educational initiative has stimulated activity across the Asia-Pacific region with the intention of supporting widespread implementation of new FLS. A second edition of the FLS Toolbox is in development which is intended to complement ongoing efforts throughout the region to expedite widespread implementation of FLS.

Matched MeSH terms: Humans
Fulltext Tumour mutation burden of non-small cell lung cancer with pre-existing ILD

Liam CK

Respirology, 2020 08;25(8):784-786.
PMID: 31805607 DOI: 10.1111/resp.13750
Matched MeSH terms: Humans
Fulltext Innovation of buying and selling process for used reference materials

Zuraini Jusoh, Nur Amirah Zainal, Nurhidayah Abu Bakar, Dina Adriana Mohd Rahmatullah, Nur Zulaikha Ab Rahman, Farah Adibah Ahmad Zaifuddin, et al.

Jurnal Inovasi Malaysia, 2020;4(1):132-149.
MyJurnal

Students need the used of reference materials because they want to save their money for daily expenses. It is also as their side income if they become as a seller. However, the available buying and selling process using Whatsapp as a medium seen inefficient because the user was faced with several problems. Among the problems were incomplete advertisements information, sale status cannot be updated automatically and the process of buying and selling takes too long. Therefore, the construction of the BOOKU webpage is recommended to solve the problems. There was a several methods used in problem selection phase such as brain storming, preliminary study of problems, verification and validation as well as T-shape Matrix. Ishikawa diagram has been used to identify the cause and effect of the problem in terms of material, process, human and environmental factors. A review from user also was carried out to obtain an endorsement of the problem in hand. Then the SWOT analysis method was used to assess the suggestion solution. After the completion construction of BOOKU webpage, a few trials were carried out to ensure the BOOKU webpage functioned properly. Again, a review from the user was carried out based on the trials results. The result showed majority of users was agreed on the BOOKU webpage as a good solution for identified problems. The BOOKU webpage can provide a completed advertisement, automatically updated the sale status and the buying and selling process has been shorten from seven days to one day. For the spin-off project, the BOOKU website is planned to be devoted to the borrowing service for used of reference materials. Meanwhile for the purpose of replicating, the BOOKU webpage can be adapted in the school level. In conclusion, the BOOKU webpage can increase the quality of available process. It also can optimize the use of manpower and time.

Matched MeSH terms: Humans
Analysis of complications following multidisciplinary functional intervention in paediatric craniomaxillofacial deformities

Hariri F, Abdullah MF, Adam KBC, Bahuri NFA, Kulasegarah J, Nathan AM, et al.

Int J Oral Maxillofac Surg, 2021 Apr;50(4):457-462.
PMID: 32891466 DOI: 10.1016/j.ijom.2020.08.002

Paediatric craniomaxillofacial (CMF) surgery requires a multidisciplinary team approach to ensure the optimal and holistic management of children with craniofacial deformities. The aim of this retrospective study was to analyse the complications following functional interventions among 34 CMF deformity patients in a single multidisciplinary craniofacial centre. Electronic data including patient demographic characteristics and clinical entry were analysed. Inclusion criteria were all paediatric patients with CMF deformities who underwent various functional interventions. A total of 64 interventions (48 intermediate and 16 definitive) were conducted. Based on the Sharma classification of complications, 20.3% were type I, 4.7% were type II, 1.6% were type III, and 4.7% were type IV . Most complications were type I, which included local infection (3.1%) and premature opening of tarsorrhaphy (3.1%). More serious complications (types III and IV) included temporary visual loss (1.6%) and intraoperative haemorrhage (1.6%). Although a low complication rate was observed in intermediate interventions, a higher complication rate was observed in more complex definitive interventions such as monobloc distraction osteogenesis. Although most complications were manageable, effective prevention remains mandatory, as serious complications may lead to permanent damage and mortality. This analysis highlights the importance of a multidisciplinary team approach to optimize the outcomes in CMF patient management.

Matched MeSH terms: Humans
Fulltext Enhancing the preparation of industrial training report through Report Repository System and Industrial Training Kit

Salliza Md Radzi, Noor Masliana Razlan, Huda Hamidon, Faizal Haini Fadzil, Izzatil Husna Arshad, Mohd Zafian Mohd Zawawi, et al.

Jurnal Inovasi Malaysia, 2019;2(2):93-109.
MyJurnal

Industrial Training Course (IMC690) is a mandatory course to be taken by seventh (7th) semester students of Information Systems Management programme (IM245). This course carries a high credit hour which weigh 12 credit hours. There are four (4) parts evaluated and the largest contributor is the industrial training report which consists of 40% marks. The problem occurs when students do not complete the report according to the date specified by the Faculty. Hence, late submission and marking of reports as well as low report scores have affected the students and lecturers. This study aims to reduce the percentage of industrial training report late submission by introducing two (2) creative innovation projects namely the Industrial Training Report Repository (ITR2) System and Industrial Training Kit (IT Kit) as the solution. Based on research findings, the percentage of late submission in the preparation of the industrial training report has successfully reduced from 60% to 0% and indirectly led to an increase in percentage of final report scores; which exceeded 30%. The results from both innovations have proven to be a comprehensive reference sources that have helped the students in producing a high quality report that complies with standards.

Matched MeSH terms: Humans
Fulltext Marks recorded in Co-curricular Registration System using QR code

Teh Faradilla Abdul Rahman, Zamri Abu Bakar

Jurnal Inovasi Malaysia, 2019;2(2):19-39.
MyJurnal

The co-curricular is important for students at The Centre of Foundation Studies, Universiti Teknologi MARA Dengkil to score. This is because it contributes 10% of the merits in the students’ applications for their degree program as set up by Bahagian Pengurusan Kemasukan Pelajar (UPU). In each new cohort, almost 5,000 students registered at this academic center. Previously, the grading process was done manually based on the number of activity coupon collected by the students in their co-curricular activity card. The use of co- curricular activity card had some challenges such as involving high cost, loss of coupons and activity cards, stolen activity cards and it was difficult for the students to monitor their achievement throughout their study. The process of recording thousands of students’ marks took place almost everyday, hence it must be improvised. To solve the problems mentioned, the CRS developers had came up with the idea of using QR code as an approach to ease and speed up the scoring process. Hence, this system helps supervisors to reduce human error and ease users (supervisors and administrators). Besides, the students could monitor their co-curricular total score from time to time to know how well they are doing so far. As a result, it has fruitfully benefited to almost 5,000 students, supervisors and administrator at the Student Affairs Division (HEP) as well as reducing the cost of buying co-curricular activity cards.

Matched MeSH terms: Humans
Rational design of built-in stannic oxide-copper manganate microrods p-n heterojunction for photoelectrochemical sensing of tetracycline

Velmurugan S, Zhi-Xiang L, C-K Yang T, Juan JC

Chemosphere, 2021 May;271:129788.
PMID: 33556631 DOI: 10.1016/j.chemosphere.2021.129788

Tetracycline (TC), a popularly found drug pollutant, can be contaminated in food and aquatic regions and causes a severe impact on human health. In this research, a visible light active p-stannic oxide/n-copper manganate (p-SnO2/n-CuMnO2) heterojunction was synthesized and has been applied for a signal on photoelectrochemical sensing of antibiotic TC. Firstly, the n-SnO2 microrods were synthesized via a simple and efficient homogeneous precipitation method and the p-CuMnO2 nanoparticles were synthesized by a facile ultrasound-assisted hydrothermal method. The SnO2/CuMnO2 microrods p-n heterojunction was prepared through a simple impregnation method and physicochemical properties of the microrods are characterized by using X-ray diffraction (XRD), Raman, Brunauer-Emmett-Teller (BET), Fourier-transform infrared (FTIR), UV-Vis diffuse reflectance spectroscopy (UVDRS), X-ray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), and Mott-Schottky analyses. The photoelectrochemical sensing performance of SnO2/CuMnO2 microrods was 2.7 times higher than that of as-synthesized pure SnO2 microrods is due to the more visible light absorption ability and p-n heterojunction (synergy). The designed SnO2/CuMnO2/ITO sensor gives photocurrent signals for the detection of TC in the range of 0.01-1000 μM with the detection limit (LOD) of 5.6 nM. The practical applicability of the sensor was monitored in cow milk and the Taipei River water sample.

Matched MeSH terms: Humans
Fulltext Variations in motility and biofilm formation of Salmonella enterica serovar Typhi

Kalai Chelvam K, Chai LC, Thong KL

Gut Pathog, 2014;6(1):2.
PMID: 24499680 DOI: 10.1186/1757-4749-6-2

Salmonella enterica serovar Typhi (S. Typhi) exhibits unique characteristics as an intracellular human pathogen. It causes both acute and chronic infection with various disease manifestations in the human host only. The principal factors underlying the unique lifestyle of motility and biofilm forming ability of S. Typhi remain largely unknown. The main objective of this study was to explore and investigate the motility and biofilm forming behaviour among S. Typhi strains of diverse background.

Matched MeSH terms: Humans
Fulltext Technologies Trend towards 5G Network for Smart Health-Care Using IoT: A Review

Ahad A, Tahir M, Aman Sheikh M, Ahmed KI, Mughees A, Numani A

Sensors (Basel), 2020 Jul 21;20(14).
PMID: 32708139 DOI: 10.3390/s20144047

Smart health-care is undergoing rapid transformation from the conventional specialist and hospital-focused style to a distributed patient-focused manner. Several technological developments have encouraged this rapid revolution of health-care vertical. Currently, 4G and other communication standards are used in health-care for smart health-care services and applications. These technologies are crucial for the evolution of future smart health-care services. With the growth in the health-care industry, several applications are expected to produce a massive amount of data in different format and size. Such immense and diverse data needs special treatment concerning the end-to-end delay, bandwidth, latency and other attributes. It is difficult for current communication technologies to fulfil the requirements of highly dynamic and time-sensitive health care applications of the future. Therefore, the 5G networks are being designed and developed to tackle the diverse communication needs of health-care applications in Internet of Things (IoT). 5G assisted smart health-care networks are an amalgamation of IoT devices that require improved network performance and enhanced cellular coverage. Current connectivity solutions for IoT face challenges, such as the support for a massive number of devices, standardisation, energy-efficiency, device density, and security. In this paper, we present a comprehensive review of 5G assisted smart health-care solutions in IoT. We present a structure for smart health-care in 5G by categorizing and classifying existing literature. We also present key requirements for successful deployment of smart health-care systems for certain scenarios in 5G. Finally, we discuss several open issues and research challenges in 5G smart health-care solutions in IoT.

Matched MeSH terms: Humans
Estimates of genetic parameters of certain characters in Hevea brasiliensis

Tan H, Mukherjee TK, Subramaniam S

Theor Appl Genet, 1975 Jan;46(4):181-90.
PMID: 24419927 DOI: 10.1007/BF00281668

Heritability estimates of five quantitative characters, namely, yield, girth, girth increment, virgin bark and renewed bark thickness, of the breeding Phase III Hevea families have been obtained by variance component analyses. In general, the combined heritability estimates for various characters were low to moderate. The heritabilities of these characters based on female variance components, however, were high, suggesting that considerable improvement of each of the characters could be achieved in properly designed experiments.Estimates of heritability for average yields (Range: 0.11-0.34) over different years showed that the first three years' yield was adequate for predicting estimates of genetic variance for the average of five years' yield.Correlation studies on yield with other characters indicated considerable influence of environment, with genetic correlations accounting for about 0.07 to 0.36 in the characters studied.Expected direct response to selection in yield and correlated response in yield to selection for girth at opening and virgin bark thickness have been calculated using three arbitrary values of selection intensity. The efficiency of the correlated response was found to be approximately half that of the direct response. However, the indirect selection for yield using virgin bark thickness appeared to be more favourable than that using the girth at opening favoured by earlier workers.

Matched MeSH terms: Humans
Estimates of general combining ability in Hevea breeding at the Rubber Research Institute of Malaysia : I. Phases II and III A

Tan H

Theor Appl Genet, 1977 Jan;50(1):29-34.
PMID: 24407495 DOI: 10.1007/BF00273794

Estimates of general combining ability of parents for yield and girth obtained separately from seedlings and their corresponding clonal families in Phases II and IIIA of the RRIM breeding programme are compared. A highly significant positive correlation (r = 0.71***) is found between GCA estimates from seedling and clonal families for yield in Phase IIIA, but not in Phase II (r = -0.03(NS)) nor for girth (r= -0.27(NS)) in Phase IIIA. The correlations for Phase II yield and Phase IIIA girth, however, improve when the GCA estimates based on small sample size or reversed rankings are excluded.When the best selections (based on present clonal and seedling information) are compared, all five of the parents top-ranking for yield are common in Phase IIIA but only two parents are common for yield and girth in Phases II and IIIA respectively. However, only one parent for yield in Phase II and two parents for girth in Phase IIIA would, if selected on clonal performance, have been omitted from the top ranking selections made by previous workers using seedling information.These findings, therefore, justify the choice of parents based on GCA estimates for yield obtained from seedling performance. Similar justification cannot be offered for girth, for which analysis is confounded by uninterpretable site and seasonal effects.

Matched MeSH terms: Humans
Field study of pedestrians' comfort temperatures under outdoor and semi-outdoor conditions in Malaysian university campuses

Othman NE, Zaki SA, Rijal HB, Ahmad NH, Razak AA

Int J Biometeorol, 2021 Apr;65(4):453-477.
PMID: 33416948 DOI: 10.1007/s00484-020-02035-3

Difficulties in controlling the effects of outdoor thermal environment on the human body are attracting considerable research attention. This study investigated the outdoor thermal comfort of urban pedestrians by assessing their perceptions of the tropical, micrometeorological, and physical conditions via a questionnaire survey. Evaluation of the outdoor thermal comfort involved pedestrians performing various physical activities (sitting, walking, and standing) in outdoor and semi-outdoor spaces where the data collection of air temperature, globe temperature, relative humidity, wind speed, solar radiation, metabolic activity, and clothing insulation data was done simultaneously. A total of 1011 participants were interviewed, and the micrometeorological data were recorded under outdoor and semi-outdoor conditions at two Malaysian university campuses. The neutral temperatures obtained which were 28.1 °C and 30.8 °C were within the biothermal acceptable ranges of 24-34 °C and 26-33 °C of the PET thermal sensation ranges for the outdoor and semi-outdoor conditions, respectively. Additionally, the participants' thermal sensation and preference votes were highly correlated with the PET and strongly related to air and mean radiant temperatures. The findings demonstrated the influence of individuals' thermal adaptation on the outdoor thermal comfort levels. This knowledge could be useful in the planning and designing of outdoor environments in hot and humid regions to create better thermal environments.

Matched MeSH terms: Humans
Fulltext Potential interactions between COVID-19 vaccines and antiepileptic drugs

Kow CS, Hasan SS

Seizure, 2021 03;86:80-81.
PMID: 33578259 DOI: 10.1016/j.seizure.2021.01.021
Matched MeSH terms: Humans
Fulltext A glance at molecular identification of bamboo (poaceae: bambusoideae)

Nabilah Mohamad Khairi, Wilson Thau Lym Yong, Julius Kulip, Kenneth Francis Rodrigues

Borneo International Journal of Biotechnology, 2020;1(1):19-33.
MyJurnal

Conservation of plant species plays a vital role in preventing the loss of valuable plant resources. The success of conservation depends on the correct identification and characterization of plant species. Bamboo is one of the most important plants with multiple uses that have contributed to the economy and socio-economy of many people in rural areas. It is under the subfamily of Bambusoideae that includes both woody and herbaceous bamboo. Conventionally, like other plants, bamboo has been classified dependently based on morphological characteristics. However, morphological identification leads to difficulties and misclassification of bamboo species due to their infrequent flowering behaviour and peculiar reproductive biology. Since then, molecular markers have been introduced to overcome the problems associated with bamboo taxonomy and phylogeny. This paper provides an overview of the diverse, predominantly molecular techniques used to assess and determine the genetic diversity of bamboo species.

Matched MeSH terms: Humans
Fulltext Methodological dilemma in qualitative research in education

ROHAIDA MOHD. SAAT, HIDAYAH MOHD FADZIL

Malaysian Journal of Qualitative Research, 2019;5(2):41-46.
MyJurnal

This paper discusses methodological dilemma that arise in qualitative research, specifically in education field. It outlines the broad principles that underpin good qualitative research and the aspects of practice that qualitative researchers should consider when designing, conducting, and disseminating their research. Two primary methodological dilemma are (i) lack of objectivity, and (ii) issue of generalizability in qualitative research. The aim of this paper is to argue the dilemmas and encourage researchers to examine the relevance of qualitative issues to their own research. These dilemmas could be taken as important consideration for others who wish to conduct qualitative research in education.

Matched MeSH terms: Humans
Fulltext Audiovestibular clinician experiences and opinions about cisplatin vestibulotoxicity

Prayuenyong P, Kasbekar AV, Hall DA, Baguley DM

Eur Arch Otorhinolaryngol, 2020 Dec;277(12):3283-3293.
PMID: 32430772 DOI: 10.1007/s00405-020-06033-4

PURPOSE: Vestibulotoxicity associated with cisplatin chemotherapy is known to exist, but the extent, severity, and impact is unclear from the literature. This study explored knowledge, experiences, and opinions of audiovestibular professionals about cisplatin vestibulotoxicity.
METHODS: An online survey was disseminated to clinicians working in the audiovestibular field.
RESULTS: Ninety-three respondents participated in the survey. Most professionals were aware of potential vestibulotoxicity associated with cisplatin chemotherapy. Thirty-three percent of the respondents reported that they had seen patients with cisplatin vestibulotoxicity. Forty percent of them were confident in making the diagnosis and in managing the patient in this situation. The prevalence and impact of vestibulotoxicity including practicality of the assessment should be considered when designing an effective vestibulotoxicity screening protocol.
CONCLUSION: This study provides a better understanding of cisplatin vestibulotoxicity from the perspectives of audiovestibular clinicians, which will underpin appropriate detection and management of the condition.

Matched MeSH terms: Humans

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