MyMedR

Selective IgA deficiency presenting with hypersplenism

Teh A, Bosco JJ

Br J Clin Pract, 1994 Sep-Oct;48(5):276-7.

A young patient presenting with splenomegaly and hypersplenism was inadvertently found to have selective IgA deficiency. There were no symptoms of immunodeficiency and the patient responded well to splenectomy, with return of blood counts to normal without adverse effects. No other cause for the hypersplenism was found. We postulate selective IgA deficiency as a cause of splenomegaly and hypersplenism.

Antigenic comparisons of hog cholera virus isolates from Europe, America and Asia using monoclonal antibodies

Edwards S, Sands JJ

DTW. Dtsch. Tierarztl. Wochenschr., 1990 Feb;97(2):79-81.

PMID: 2178905

Nineteen monoclonal antibodies (MAbs) with specificity for hog cholera virus (HCV) were prepared. They were used in an immune binding (peroxidase linked) assay to determine the reaction patterns of HCV isolates from Europe, Brazil, USA, Japan and Malaysia, as well as laboratory reference strains of the virus. A further panel of 17 MAbs raised against bovine virus diarrhoea virus (BVDV) was included in the study, together with 5 MAbs raised against a non-HCV pestivirus of porcine origin. All the MAbs were also tested against representative strains of BVDV and border disease virus. Six MAbs were HCV-specific, reacting with all isolates of HCV and none of the ruminant viruses. Among the other HCV MAbs geographical variation in reaction patterns was observed. There was evidence of antigenic distinction between recent European isolates, and archive material originally isolated more than 10 years ago.

East Asia review 1978-79. Introduction

Clinton JJ, Baker J

Stud Fam Plann, 1980 Nov;11(11):311-6.

PMID: 7456105 DOI: 10.2307/1966032

Design considerations in the estimation of intraclass correlation

Donner A, Koval JJ

Ann. Hum. Genet., 1982 07;46(3):271-7.

PMID: 7125598 DOI: 10.1111/j.1469-1809.1982.tb00718.x

The design of family studies to estimate the value of an intraclass correlation coefficient p is considered when ni individuals are to be selected from each of k families, i = 1, 2, ..., k. In particular, the accuracy of a balance design (ni = n, i = 1, 2, ..., k) for estimating p is compared with the accuracy of an unbalanced "natural" design, in which the ni are sampled at random from family size distributions that tend to occur in practice. It is found for two different estimators of p that the balanced design is usually preferable, but only to a small degree if the number of families sampled is greater than 50.

New host and locality records for Gastronyssus bakeri (Acari: Gastronyssidae), a stomach parasite of Malaysian fruit bats, with notes on immature stages

Stiller D, Sullivan JJ

J Med Entomol, 1977 Nov 25;14(2):250-2.

PMID: 606828

Magnesium sulfate for persistent pulmonary hypertension of the newborn

Ho JJ, Rasa G

Cochrane Database Syst Rev, 2007 Jul 18;2007(3):CD005588.

PMID: 17636807

BACKGROUND: Persistent pulmonary hypertension of the newborn (PPHN) occurs in approximately 1.9 per 1000 newborns and may be more frequent in developing countries. There is strong evidence for the use of inhaled nitric oxide (iNO) and extra corporeal membrane oxygenation (ECMO) in the treatment of PPHN. However, many developing countries do not have access or the technical expertise required for these expensive therapies. Magnesium sulfate is a potent vasodilator and hence has the potential to reduce the high pulmonary arterial pressures associated with PPHN. If magnesium sulfate were found to be effective in the treatment of PPHN, this could be a cost effective and potentially life-saving therapy.

OBJECTIVES: To evaluate the use of magnesium sulfate compared with placebo or standard ventilator management alone, sildenafil infusion, adenosine infusion, or inhaled nitric oxide on mortality or the use of backup iNO or ECMO in term and near-term newborns (> 34 weeks gestational age) with PPHN.

SEARCH STRATEGY: The standard search strategy of the Cochrane Neonatal Review Group (CNRG) was used. No language restrictions was applied. The Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 1, 2006) and MEDLINE (1966 to April 20, 2007) were searched for relevant randomized and quasi-randomized trials. In addition the reference lists of retrieved articles were reviewed and known experts were contacted to obtain unpublished data.

SELECTION CRITERIA: All randomised or quasi-random studies were eligible where one of the treatment groups received magnesium sulfate for PPHN.

DATA COLLECTION AND ANALYSIS: Standard methods of the Cochrane Collaboration and the CNRG were used, including independent assessment of trial quality and extraction of data by each author.

MAIN RESULTS: No eligible trials were found

AUTHORS' CONCLUSIONS: On the basis of the current lack of evidence, the use of magnesium sulphate cannot be recommended in the treatment of PPHN. Randomised controlled trials are recommended.

Isolation of chromatic and achromatic mechanisms: a new approach

Sharanjeet-Kaur, Kulikowski JJ, Carden D

Ophthalmic Physiol Opt, 1998 Jan;18(1):49-56.

PMID: 9666910

The purpose of this study was to optimise the testing paradigm for isolating the contributions of chromatic and achromatic mechanisms to the human spectral sensitivity function. Spectral sensitivity was determined for a test spot size of 1.2 deg presented with various spatial and temporal masks on a large, 10 deg background field of moderate intensity (1000 td) and colour temperature, CT = 2700 K. Sinusoidal temporal presentation (1 Hz) and a masking annulus of between 3 and 10 min of arc surrounding the test spot, was found to be most effective in separating chromatic from achromatic mechanisms. Square-wave (1 Hz) temporal presentation combined with the annulus was slightly less selective. The presence of the annulus did not affect the shape of flicker detection at 25 Hz which is a measure of the luminosity (achromatic) spectral sensitivity function.

Effects of Melatonin on Colchicine-Treated PLBs of Dendrobium sonia-28 Orchid

Lim MS, Antony JJ, Islam SM, Suhana Z, Sreeramanan S

Appl Biochem Biotechnol, 2017 Jan;181(1):15-31.

PMID: 27461541 DOI: 10.1007/s12010-016-2196-3

Dendrobium hybrid orchid is popular in orchid commercial industry due to its short life cycle and ability to produce various types of flower colours. This study was conducted to identify the morphological, biochemical and scanning electron microscopy (SEM) analysis in the Dendrobium sonia-28 orchid plants. In this study, 0.05 and 0.075 % of colchicine-treated Dendrobium sonia-28 (4-week-old culture) protocorm-like bodies (PLBs) were treated in different concentrations of melatonin (MEL) posttreatments (0, 0.05, 0.1, 0.5, 1, 5 and 10 μM). Morphological parameters such as number of shoots, growth index and number of PLBs were determined. In the 0.05 and 0.075 % of colchicine-treated PLBs which were posttreated with 0.05 μM MEL resulted in the highest value of the morphological parameters tested based on the number of shoots (84.5 and 96.67), growth index (16.94 and 12.15) and number of PLBs (126.5 and 162.33), respectively. SEM analysis of the 0.05 μM MEL posttreatment on both the colchicine-treated regenerated PLBs showed irregular cell lineages, and some damages occurred on the stomata. This condition might be due to the effect of plasmolyzing occurred in the cell causing irregular cell lineages.

Primary biliary cirrhosis and auto immune hepatitis overlap syndrome mimicking cholangiocarcinoma

Adel A, Zamri Z, Azlanuddin A, Bong JJ

Clin Ter, 2013;164(6):e493-5.

PMID: 24424229 DOI: 10.7417/CT.2013.1643

Primary Biliary Cirrhosis (PBC) and Auto Immune Hepatitis (AIH) are autoimmune diseases of the liver which highlighted with slow destructive process of intra hepatic small bile ducts. As a result of these damages cholestasis and over the time tissue damage will happen, which leads to scarring, fibrosis and finally cirrhosis. Some patients may present with clinical and biochemical features of both conditions, which is called "Overlap syndrome". Here we are reporting a case of PBC-AIH overlap syndrome that primarily diagnosed as gallbladder carcinoma and went under operation and finally histological examination revealed to be PBC.

Fulltext A report of two non-AIDS associated Kaposi's sarcoma in Malaysia

Choon SE, Khoo JJ

Med J Malaysia, 1997 Dec;52(4):437-40.

PMID: 10968124

Kaposi's sarcoma is an uncommon cutaneous neoplasm seen classically in elderly males of East European or Jewish extract. It has been known to be endemic in sub-Saharan Africa for many years. Numerous cases had been described in patients on long-term immunosuppressive therapy and in patients living with acquired immunodeficiency syndrome (AIDS). In spite of the increasing number of organ transplant recipients and people living with AIDS. Kaposi's sarcoma remains rare in Asia. We report two cases seen in Johor, Malaysia.

Fulltext MRI appearances of peritoneal mesothelioma--a case report

Hashim S, Abdullah BJJ, Jayaram G

Med J Malaysia, 1999 Sep;54(3):358-60.

PMID: 11045063

A rare case of diffuse malignant peritoneal mesothelioma in a 71 year-old Malay man with no previous history of asbestos or radiation exposure is described. The clinical manifestation was a large abdominal mass. At laparotomy he was found to be in the advanced stage of the disease. The tumour was not resectable and patient was sent home. He gradually deteriorated and died three months after diagnosis was made. The magnetic resonance imaging (MRI) features of peritoneal mesothelioma which has not been previously reported are described.

Fulltext Calcified vertical plate of the cricoid--a rare pitfall in the diagnosis of an oesophageal foreign body

Arasaratnam S, Abdullah BJJ, Fernandez V

Med J Malaysia, 1998 Sep;53(3):290-2.

PMID: 10968170

We present a case of rare pitfall in the diagnosis of an oesophageal foreign body due to the calcified vertical plate of the cricoid to highlight the need to be aware of this entity to avoid unnecessary morbidity.

Fulltext Hereditary angioedema: report of a family in Malaysia

Leong WK, Bosco JJ

Med J Malaysia, 1995 Jun;50(2):197-8.

PMID: 7565199

Adult acute lymphoblastic leukaemia at University Hospital, Malaysia

Bosco JJ, Cherian R, Pang T

Haematol Blood Transfus, 1985;29:67-9.

PMID: 3861492

Fulltext Rhinosporidiosis presenting as recurrent nasal polyps

Khoo JJ, Kumar KS

Med J Malaysia, 2003 Jun;58(2):282-5.

PMID: 14569751 MyJurnal

Rhinosporidiosis is a chronic granulomatous disease of the mucous membrane, predominantly of the nose and nasopharynx. It is uncommon in Malaysia but has been seen in immigrant workers from endemic areas like India and Sri Lanka. A case seen in Johor is reported here to highlight the need of awareness among clinicians at a time where there is increasing numbers of immigrant workers in our country. The causative organism of this disease is Rhinosporidium seeberi, which is found in stagnant waters. Sporangia and endospores of R. seeberi are seen in the granulomatous polypoidal lesions. The patients commonly present with epistaxis and nasal blockage. Complete excision is the treatment of choice for this disease. Recurrences are common despite anti-microbial treatment.

Fulltext Knowledge, attitude and practice on antenatal care among Orang Asli women in Jempol, Negeri Sembilan

Rosliza AM, Muhamad JJ

Malaysian Journal of Public Health Medicine, 2011;11(2):13-21.

MyJurnal

The maternal health status of Orang Asli women in Malaysia was noted to be lower as compared to other groups of population in the country. This study aimed to determine the level of knowledge, attitude and practice on antenatal care, which is a vital component of maternal health among the Orang Asli women in three Orang Asli villages in Jempol District, Negeri Sembilan. All women aged between 15 to 49 years old who had at least one antenatal experience were interviewed using a structured, pretested questionnaire. A total of 104 women were interviewed. Among them, 92.3% admitted attending antenatal clinic during their previous pregnancies while only 48.1% came early for their first check-up. About 70% of the women had history of home delivery and 44.2% had experienced at least one high risk pregnancy before. Study revealed that 44.2% (95% CI, 34.7 – 53.7%) of the women have good knowledge regarding antenatal care while 53.8% (95% CI, 44.3 – 63.1%) of them noted to have positive attitude regarding antenatal care. However, result showed that the level of knowledge regarding the importance of early antenatal care, screening test and complications of diabetes and hypertension in pregnancy were poor. In conclusion, the rate of home delivery and late antenatal booking was still high among the Orang Asli women and it is significantly associated with their attitude regarding antenatal care. These findings can be used to plan a customized health intervention program aiming to improve the maternal health practices and eventually improve the health status of the Orang Asli women
Study site: Orang Asli village, Jempol, Negeri Sembilan, Malaysia

Clinical stage of chronic granulocytic leukaemia and BCR breakpoint location in South-East Asian patients

Dyck JA, Bosco JJ

Br J Haematol, 1989 May;72(1):64-7.

PMID: 2736243

Forty-six Malaysian patients with chronic granulocytic leukaemia were found to be rearranged in the breakpoint cluster region (BCR) of chromosome 22, molecular evidence of Philadelphia chromosome (t9.22) translocation. Through the use of a 1.2 kb 3' BCR probe and two restriction enzyme digests, patients' breakpoints could be localized either to 5' or 3' regions of the BCR. Breakpoint site localization at the time of DNA sampling did not show any positive statistical association to clinical status defined as chronic phase, chronic phase with less than 6 months to blast crisis, accelerated phase and blast crisis. This was in contrast to earlier reports which indicated that patients with breakpoint at 3' site were at a higher biologic risk for entering blast crisis.

A STUDY ON THE NATURAL HISTORY OF IMMUNITY TO MALARIA IN PROTECTED AND UNPROTECTED POPULATIONS OF AUSTRALIAN NEW GUINEA

DESOWITZ RS, SAAVE JJ

Med J Malaysia, 1964 Sep;19:36-7.

PMID: 14240060

Studies on filariasis in Malaya: on the migration and rate of growth of Wuchereria malayi in experimentally infected cats

EDESON JF, BUCKLEY JJ

Ann Trop Med Parasitol, 1959 Apr;53(1):113-9.

PMID: 13650497

Progressive eradication of malarial disease in New Guinea. Experience in Maprik

Saave JJ, Jeffery W, Haroi M

Med J Malaya, 1966 Jun;20(4):322.

PMID: 4224341