MyMedR

A bizarre case of accessory larynx in an infant with OEIS syndrome

Wong TL, Baki MM, Ishak S, See GB

Int J Pediatr Otorhinolaryngol, 2018 Nov;114:134-137.

PMID: 30262351 DOI: 10.1016/j.ijporl.2018.08.037

We report a bizarre case of accessory larynx in an infant with OEIS syndrome (omphalocele, cloacal exstrophy, imperforated anus & spinal defects). This is the first reported case in literature of a duplicate accessory larynx which is a mirror image of the true larynx. A congenital duplication of the larynx is a rare anomaly and can present in various forms. In this case, the infant presented with recurrent lung infection and inability to wean off oxygen. Scope revealed severe laryngomalacia in addition to the accessory larynx. Hence, supraglottoplasty was done with aim to resolve the lung and airway problem.

Matched MeSH terms: Infant, Newborn

Fulltext A case of Dandy Walker cyst with porencephaly

Ramasamy SP, Chandrasekaran S, Jayakumar CR, Mallick AS

Singapore Med J, 1992 Apr;33(2):196-7.

PMID: 1621130

A 27-year-old gravida two para one mother delivered a term male baby by caesarean section. The baby was referred for enlarged head. This neonate with large head was found to have Porencephalic cyst with dilated Triventricular system. There was a posterior fossa cyst communicating with fourth ventricle. A diagnosis of Dandy Walker Cyst with Porencephaly was made. Ventriculo-Peritoneal shunt was done on the ninth day of life. The baby had an uneventful postoperative period and was subsequently discharged.

Matched MeSH terms: Infant, Newborn

A case of congenital malaria in Malaysia with IgM malaria antibodies

Thomas V, Chit CW

Trans R Soc Trop Med Hyg, 1980;74(1):73-6.

PMID: 7001686

Congenital malaria from Malaysia is reported here for the first time. It occurred in a baby boy born to a 16-year-old primigravida who contracted Plasmodium falciparum infection during pregnancy. She suffered malaria during the later stages of pregnancy and at parturition. The placenta was heavily infested with various asexual stages of P. falciparum. Gametocytes were not seen. Extensive search did not show other species. Cord blood showed very light infection with young trophozoites of P. falciparum. Serological studies using IFA technique showed specific IgG and IgM antibodies to P. falciparum in maternal cord and two early neonatal sera. These serum samples showed lower levels of IgG antibodies against P. vivax and P. malariae, but there were no specific IgM antibodies against these species. The value of specific IgM antibody in the diagnosis of congenital malaria is discussed.

Matched MeSH terms: Infant, Newborn

A case of congenital pulmonary lymphangiectasis

Liew SH

Med J Malaysia, 1974 Jun;28(4):293-5.

PMID: 4278975

Matched MeSH terms: Infant, Newborn

Fulltext A case of neonatal meningitis caused by Acinetobacter calcoaceticus var anitratus

Lim VKE, Talib S

Med J Malaysia, 1982 Mar;37(1):11-3.

PMID: 6981750

A case of neonatal meningitis caused by an unusual organism, Acinetobacter calcoaceticus var anitratus is reported. The source of the meningitis is probably a scalp abscess caused by the same organism. This patient was successfully treated with cotrimoxazole. Infections caused by Acinetobacter are rare and are briefly reviewed in this article

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/diagnosis*

A case of neonatal testicular torsion

Wong CY, Yong SC, Boo NY, Phang KS

Hosp Med, 2005 Jun;66(6):368-9.

PMID: 15974173 DOI: 10.12968/hmed.2005.66.6.18409

Matched MeSH terms: Infant, Newborn

A case of pneumoperitoneum in a new-born child

Radhamanalan D, Isaac T

Med J Malaysia, 1979 Mar;33(3):272-3.

PMID: 522735

Matched MeSH terms: Infant, Newborn

A case of situs inversus

Banu SZ

Med J Malaysia, 1977 Mar;31(3):236-40.

PMID: 904519

Matched MeSH terms: Infant, Newborn

A case of surgically resected cardiac rhabdomyoma with progressive left ventricular outflow tract obstruction

Mohammed F, Tan GC, Hor KN, Arnold M, Wong YP

Cardiovasc. Pathol., 2020 05 12;49:107226.

PMID: 32574866 DOI: 10.1016/j.carpath.2020.107226

Cardiac rhabdomyoma is the most prevalent cardiac tumors in the pediatric population, in close association with tuberous sclerosis complex. It is usually detected antenatally or postnatally by echocardiography. Clinical presentations depend greatly on the size and position of the tumor mass. Interestingly, rhabdomyoma has a propensity to regress spontaneously and is not usually operated upon, unless the patient becomes hemodynamically compromised. Herein, we report an unusual case of surgically treated cardiac rhabdomyoma in a baby boy presented at birth with a progressive enlarging intraventricular mass, complicated with left ventricular outflow tract obstruction 7 weeks later. Histopathological examination of the intracardiac mass revealed sheets of tumor cells with spider-like morphology (known as "spider cells"), confirmed the diagnosis of rhabdomyoma. Close disease monitoring of patient's hemodynamic status in a newly diagnosed cardiac rhabdomyoma is inevitable as the tumor, although rare, may progress.

Matched MeSH terms: Infant, Newborn

Fulltext A case series of fetal valproate syndrome in the Republic of Crimea

Rybalko ON, Kaladze NN, Sukhareva IA, Khoo CS

J Neurosci Rural Pract, 2019 Oct;10(4):700-702.

PMID: 31831992 DOI: 10.1055/s-0039-1700599

Valproic acid or valproate is a well-recognized potent teratogen. Antenatal exposure to this drug can cause fetal valproate syndrome (FVS), which is a constellation of distinctive dysmorphic features and congenital malformations. Despite an abundance of reports and registries about this syndrome, there is lack of information from Russia, in particular, the Republic of Crimea. We herein describe two cases of FVS from our registry.

Matched MeSH terms: Infant, Newborn

Fulltext A case series of hereditary congenital cataract

Nurul Faaiqah Jainuddin, Azlindarita Aisyah Mohd Abdullah, Visvaraja Subrayan, Norlina Ramli, Nurliza Khaliddin

Malaysian Journal of Medicine and Health Sciences, 2020;16(2):336-338.

MyJurnal

Congenital cataract is a major cause of preventable blindness in children. It can be either hereditary or non-hereditary. In this case series, we present three cases of congenital cataract with a strong family history. The grandparents
and parents of these patients had cataract diagnosed in late childhood whilst the patients in this case series were
diagnosed with congenital cataract earlier. There was no history of consanguineous marriage in any of the families.
These cases show that, in the presence of a strong family history, a child will present with congenital cataract earlier
in their life. Hence, babies from such families should be screened at birth and at regular intervals within the first
year of life to enable early diagnosis and subsequent surgical intervention to reduce the incidence and burden of
amblyopia.

Matched MeSH terms: Infant, Newborn

Fulltext A case study of distinctive phenotypes arising from emanuel syndrome in two karyotypically identical patients

Mot Yee Yik, Rabiatul Basria S.M.N. Mydin, Emmanuel Jairaj Moses, Shahrul Hafiz Mohd Zaini, Abdul Rahman Azhari, Narazah Mohd Yusoff

Malaysian Journal of Medicine and Health Sciences, 2020;16(102):78-80.

MyJurnal

Emanuel syndrome, also referred to as supernumerary der(22) or t(11;22) syndrome, is a rare genomic syndrome. Patients are normally presented with multiple congenital anomalies and severe developmental disabilities. Affected newborns usually carry a derivative chromosome 22 inherited from either parent, which stems from a balanced translocation between chromosomes 11 and 22. Unfortunately, identification of Emanuel syndrome carriers is diffi- cult as balanced translocations do not typically present symptoms. We identified two patients diagnosed as Emanuel syndrome with identical chromosomal aberration: 47,XX,+der(22)t(11;22)(q24;q12.1)mat karyotype but presenting variable phenotypic features. Emanuel syndrome patients present variable phenotypes and karyotypes have also been inconsistent albeit the existence of a derivative chromosome 22. Our data suggests that there may exist ac- companying genetic aberrations which influence the outcome of Emanuel syndrome phenotypes but it should be cautioned that more patient observations, diagnostic data and research is required before conclusions can be drawn on definitive karyotypic-phenotypic correlations.

Matched MeSH terms: Infant, Newborn

A case-control study of risk factors associated with rectal colonization of extended-spectrum beta-lactamase producing Klebsiella sp. in newborn infants

Boo NY, Ng SF, Lim VK

J Hosp Infect, 2005 Sep;61(1):68-74.

PMID: 15953660

To determine the risk factors for rectal colonization by extended-spectrum beta-lactamase (ESBL) Klebsiella sp. in 368 newborns admitted consecutively to a neonatal intensive care unit over six months, rectal swabs were cultured on admission and weekly until discharge. Eighty infants (21.7%) had ESBL Klebsiella sp. cultured from their rectal swabs. Eighty controls were selected at random from infants with negative cultures admitted within the 14-day period prior to the detection of ESBL Klebsiella sp. in the cases. Cases had significantly lower birth weight, gestational age, earlier age of admission, longer hospital stay, and higher proportions of congenital malformations, early-onset pneumonia and respiratory distress syndrome compared with controls. Significantly more cases received mechanical ventilation, nasal continuous positive airway pressure support, total parenteral nutrition, umbilical vascular catheterization, arterial line insertion, urinary bladder catheterization, and prior treatment with antibiotics. However, stepwise logistic regression analysis showed that only two independent risk factors were significantly associated with ESBL rectal colonization: duration of hospital stay [adjusted odds ratio (OR): 1.3; 95% confidence intervals (CI): 1.2, 1.4; P<0.0001) and early-onset pneumonia (adjusted OR: 8.3; 95% CI: 1.6, 43.4; P=0.01).

Matched MeSH terms: Infant, Newborn

A clinical audit on the practice of platelet transfusions at a tertiary paediatric referral centre

Jamal R, Hoe TS, Ong LC, Afifah I, Khuzaiah R, Doraisamy G

Malays J Pathol, 1998 Jun;20(1):35-40.

PMID: 10879262

Platelet transfusions are indicated in a wide variety of clinical conditions especially those with thrombocytopenia. However, without proper clinical practice guidelines, inappropriate transfusions are bound to happen. To ascertain the provision of a quality and appropriate practice of platelet transfusions, an audit study was carried out over a period of one month at the Paediatric Institute, Kuala Lumpur Hospital. A prospective audit was performed during that period whilst a retrospective collection of data was carried out for the previous month for comparison. Based on a set of criteria agreed upon by the audit committee, it was found that in 18.5% (22 of 119) of the cases, the indications for platelet transfusions were inappropriate. The audit committee concluded that there is a need for a more detailed clinical practice guideline for local use to reduce or lower the incidence of inappropriate transfusions of platelets.

Matched MeSH terms: Infant, Newborn

Fulltext A clinical tool to predict Plasmodium vivax recurrence in Malaysia

Mat Ariffin N, Islahudin F, Kumolosasi E, Makmor-Bakry M

BMC Infect Dis, 2017 12 08;17(1):759.

PMID: 29216842 DOI: 10.1186/s12879-017-2868-9

BACKGROUND: Recurrence rates of Plasmodium vivax infections differ across various geographic regions. Interestingly, South-East Asia and the Asia-Pacific region are documented to exhibit the most frequent recurrence incidences. Identifying patients at a higher risk for recurrences gives valuable information in strengthening the efforts to control P. vivax infections. The aim of the study was to develop a tool to identify P. vivax- infected patients that are at a higher risk of recurrence in Malaysia.

METHODS: Patient data was obtained retrospectively through the Ministry of Health, Malaysia, from 2011 to 2016. Patients with incomplete data were excluded. A total of 2044 clinical P. vivax malaria cases treated with primaquine were included. Data collected were patient, disease, and treatment characteristics. Two-thirds of the cases (n = 1362) were used to develop a clinical risk score, while the remaining third (n = 682) was used for validation.

RESULTS: Using multivariate analysis, age (p = 0.03), gametocyte sexual count (p = 0.04), indigenous transmission (p = 0.04), type of treatment (p = 0.12), and incomplete primaquine treatment (p = 0.14) were found to be predictors of recurrence after controlling for other confounding factors; these predictors were then used in developing the final model. The beta-coefficient values were used to develop a clinical scoring tool to predict possible recurrence. The total scores ranged between 0 and 8. A higher score indicated a higher risk for recurrence (odds ratio [OR]: 1.971; 95% confidence interval [CI]: 1.562-2.487; p ≤ 0.001). The area under the receiver operating characteristic (ROC) curve of the developed (n = 1362) and validated model (n = 682) was of good accuracy (ROC: 0.728, 95% CI: 0.670-0.785, p value

Matched MeSH terms: Infant, Newborn

A clinician looks at the placenta

Sen DK

Med J Malaysia, 1977 Sep;32(1):96-9.

PMID: 609354

Matched MeSH terms: Infant, Newborn

A comparative epidemiologic study of fractures among Indian, Malay and Swedish children

Wong PC

Med J Malaya, 1965 Dec;20(2):132-43.

PMID: 4221974

Matched MeSH terms: Infant, Newborn

A comparative study on management of intravenous lines among nurses in a neonatal intensive care unit

Faridah Ahmad Shiek, Alimatulsaadiah Abu Hassan, Zaiton Sudin, Zaitun Aris, Khoo A.S.B., Lim, N.L.

Malaysian Journal of Child Health, 1998;10(1):34-39.

MyJurnal

This research describes a comparative study using convenience sampling on management of intravenous lines in Maternity Neonatal Intensive Care Unit (MNICU), HKL. Questionnaires were answered by nurses and the techniques of anchoring, splinting and maintaining of intravenous lines by nurses in MNICU were observed by the researchers. The study showed that nurses with less than two years experience working in MNICU had significantly less knowledge and skills in the management of intravenous lines and are likely to encounter more difficulties and complications, compared to nurses with more experience.

Matched MeSH terms: Infant, Newborn

A hospital-based surveillance for Japanese encephalitis in Bali, Indonesia

Kari K, Liu W, Gautama K, Mammen MP, Clemens JD, Nisalak A, et al.

BMC Med, 2006;4:8.

PMID: 16603053

Japanese encephalitis (JE) is presumed to be endemic throughout Asia, yet only a few cases have been reported in tropical Asian countries such as Indonesia, Malaysia and the Philippines. To estimate the true disease burden due to JE in this region, we conducted a prospective, hospital-based surveillance with a catchment population of 599,120 children less than 12 years of age in Bali, Indonesia, from July 2001 through December 2003.

Matched MeSH terms: Infant, Newborn

Fulltext A laboratory study of fluoride concentration in infant formulas marketed in Malaysia and estimation of daily intake

Mohd Desa, S. N. F., Muhamad, N. A., Mohd Nor, N. A., Abdul Razak, F., Abdul Manan, N. S., Abdul Manan, N. S., et al.

International Food Research Journal, 2020;27(5):893-902.

MyJurnal

The window of maximum susceptibility for the development of dental fluorosis for anterior
teeth is during the first two to three years of life. The primary source of fluoride intake for
infants at this age is mainly from the diet including infant formula. Thus, the present work
aimed to investigate the fluoride concentration in commercially available Malaysian infant
formulas that required reconstitution before consumption. A total of 29 infant formulas available in the Malaysian market were reconstituted with deionised water, fluoridated tap water,
and filtered tap water. The fluoride concentration of the infant formulas was analysed directly
using a fluoride ion selective electrode. The daily fluoride intake estimation from the infant
formulas was calculated using the median infant body weight and recommended volumes for
formula consumption from newborn to > 12 months of age. Results showed that the fluoride
concentration of the infant formulas when reconstituted with deionised water ranged between
0.009 to 0.197 mg/L that contributed to the estimated daily fluoride intake ranging from 0.005
to 0.100 mg (total intake per day) or 0.001 to 0.025 mg/kg (total intake per body weight/day).
The fluoride concentration in the selected infant formulas was low, but after reconstitution
with fluoridated tap water, the overall fluoride concentration in infant formulas sample significantly increased (p < 0.001). Nevertheless, the estimated daily fluoride intake from infant
formulas alone did not exceed the lowest-observed-adverse-effect level (LOAEL) of fluoride
at 0.10 mg/kg/day.

Matched MeSH terms: Infant, Newborn

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