Displaying publications 21 - 40 of 105 in total

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  1. Fulltext Effects of Curcuma xanthorrhiza Extracts and Their Constituents on Phase II Drug-metabolizing Enzymes Activity
    Salleh NA, Ismail S, Ab Halim MR
    Pharmacognosy Res, 2016 Oct-Dec;8(4):309-315.
    PMID: 27695274 DOI: 10.4103/0974-8490.188873
    BACKGROUND: Curcuma xanthorrhiza is a native Indonesian plant and traditionally utilized for a range of illness including liver damage, hypertension, diabetes, and cancer.
    OBJECTIVE: The study determined the effects of C. xanthorrhiza extracts (ethanol and aqueous) and their constituents (curcumene and xanthorrhizol) on UDP-glucuronosyltransferase (UGT) and glutathione transferase (GST) activities.
    MATERIALS AND METHODS: The inhibition studies were evaluated both in rat liver microsomes and in human recombinant UGT1A1 and UGT2B7 enzymes. p-nitrophenol and beetle luciferin were used as the probe substrates for UGT assay while 1-chloro-2,4-dinitrobenzene as the probe for GST assay. The concentrations of extracts studied ranged from 0.1 to 1000 μg/mL while for constituents ranged from 0.01 to 500 μM.
    RESULTS: In rat liver microsomes, UGT activity was inhibited by the ethanol extract (IC50 =279.74 ± 16.33 μg/mL). Both UGT1A1 and UGT2B7 were inhibited by the ethanol and aqueous extracts with IC50 values ranging between 9.59-22.76 μg/mL and 110.71-526.65 μg/Ml, respectively. Rat liver GST and human GST Pi-1 were inhibited by ethanol and aqueous extracts, respectively (IC50 =255.00 ± 13.06 μg/mL and 580.80 ± 18.56 μg/mL). Xanthorrhizol was the better inhibitor of UGT1A1 (IC50 11.30 ± 0.27 μM) as compared to UGT2B7 while curcumene did not show any inhibition. For GST, both constituents did not show any inhibition.
    CONCLUSION: These findings suggest that C. xanthorrhiza have the potential to cause herb-drug interaction with drugs that are primarily metabolized by UGT and GST enzymes.
    SUMMARY: Findings from this study would suggest which of Curcuma xanthorrhiza extracts and constituents that would have potential interactions with drugs which are highly metabolized by UGT and GST enzymes. Further clinical studies can then be designed if needed to evaluate the in vivo pharmacokinetic relevance of these interactions Abbreviations Used: BSA: Bovine serum albumin, CAM: Complementary and alternative medicine, cDNA: Complementary deoxyribonucleic acid, CDNB: 1-Chloro-2,4-dinitrobenzene, CuSO4.5H2O: Copper(II) sulfate pentahydrate, CXEE: Curcuma xanthorrhiza ethanol extract, CXAE: Curcuma xanthorrhiza aqueous extract, GC-MS: Gas chromatography-mass spectroscopy, GSH: Glutathione, GST: Glutathione S-transferase, KCl: Potassium chloride, min: Minutes, MgCl2: Magnesium chloride, mg/mL: Concentration (weight of test substance in milligrams per volume of test concentration), mM: Milimolar, Na2CO3: Sodium carbonate, NaOH: Sodium hydroxide, nmol: nanomol, NSAIDs: Non-steroidal antiinflammatory drug, p-NP: para-nitrophenol, RLU: Relative light unit, SEM: Standard error of mean, UDPGA: UDP-glucuronic acid, UGT: UDP-glucuronosyltransferase.
    KEYWORDS: Curcuma xanthorrhiza; UDP-glucuronosyltransferase; glutathione transferase; xanthorrhizol
    Matched MeSH terms: Liver Diseases
  2. Massive subcapsular air collection in the liver: a rare life-threatening complication following ERCP rendezvous procedure
    Koh PS, Ho SH, Yoong BK, Abdullah BJ, Goh KL
    J Dig Dis, 2013 Jun;14(6):337-9.
    PMID: 23279747 DOI: 10.1111/1751-2980.12030
    Matched MeSH terms: Liver Diseases/etiology*
  3. A fuzzy-based texture analysis for tissue characterization of diffused liver diseases on B-scan images
    Gangeh MJ, Hanmandlu M, Bister M
    Biomed Sci Instrum, 2002;38:369-74.
    PMID: 12085634
    The specific texture on B-scan images is believed to be related to both ultrasound machine characteristics and tissue properties, i.e., the pathological states of the soft tissue. Therefore, for classification, features can be extracted with the use of image texture analysis techniques. In this paper a novel fuzzy approach for texture characterization is used for classification of normal liver and diffused liver diseases, here fatty liver, liver cirrhosis, and hepatitis are emphasized. The texture analysis techniques are diversified by the existence of several approaches. We propose fuzzy features for the analysis of the texture image. For this, a membership function is constructed to represent the effect of the neighboring pixels on the current pixel in a window. Using these membership function values, we find a feature by weighted average method for the current pixel. This is repeated for all pixels in the window treating each time one pixel as the current pixel. Using these fuzzy based features, we derive three descriptors: maximum, entropy, and energy as used in co-occurrence method, for each window.
    Matched MeSH terms: Liver Diseases/ultrasonography*
  4. Fulltext Ultrasound--a new imaging technique
    Md Alif AK
    Med J Malaysia, 1980 Jun;34(4):383-6.
    PMID: 7219268
    Matched MeSH terms: Liver Diseases/diagnosis
  5. Problems and usefulness of serum enzyme measurement in the diagnosis of diseases
    Buttery JE
    Med J Malaysia, 1974 Mar;28(3):180-4.
    PMID: 4278233
    Matched MeSH terms: Liver Diseases/enzymology
  6. Hepatic and pulmonary porocephaliasis in a Malaysian Orang Asli (aborigine)
    Prathap K, Ramachandran CP, Haug N
    Med J Malaya, 1968 Dec;23(2):92-5.
    PMID: 4240827
    Matched MeSH terms: Liver Diseases, Parasitic/epidemiology*
  7. Human Exfoliated Deciduous Teeth Stem Cells: Features and Therapeutic Effects on Neurogenerative and Hepatobiliary-pancreatic Diseases
    Wahab NWA, Guad RM, Subramaniyan V, Fareez IM, Choy KW, Bonam SR, et al.
    Curr Stem Cell Res Ther, 2021;16(5):563-576.
    PMID: 32957893 DOI: 10.2174/1574888X15999200918105623
    Stem cells can multiply into more cells with similar types in an undifferentiated form and differentiate into other types of cells. The great success and key essence of stem cell technology is the isolation of high-quality Mesenchymal Stem Cells (MSCs) with high potency, either with multipotent or pluripotent property. In this line, Stem cells from Human Exfoliated Deciduous teeth (SHEDs) are highly proliferative stem cells from dental pulp and have multipoint differentiation capacity. These cells play a pivotal role in regenerative medicine, such as cell repair associated with neurodegenerative, hepatobiliary, and pancreatic diseases. In addition, stem cell therapy has been widely used to regulate immune response and repair of tissue lesions. This overview captured the differential biological characteristics, and the potential role of stem cell technology and paid special attention to human welfare SHEDs in eliminating the above-mentioned diseases. This review provides further insights into stem cell technology by expanding the therapeutic potential of SHEDs in tissue engineering and cell organ repairs.
    Matched MeSH terms: Liver Diseases/therapy
  8. Fulltext Human pentastomiasis caused by Armillifer moniliformis in Malaysian Borneo
    Latif B, Omar E, Heo CC, Othman N, Tappe D
    Am J Trop Med Hyg, 2011 Nov;85(5):878-81.
    PMID: 22049042 DOI: 10.4269/ajtmh.2011.11-0404
    We report a case of visceral pentastomiasis caused by Armillifer moniliformis in a 70-year-old aboriginal farmer from rural Malaysian Borneo. The patient complained of upper abdominal pain, jaundice, and loss of weight. Radiological investigations and subsequent histopathological examination revealed an adenocarcinoma of the pancreas with an adjacent liver nodule containing a nymph of A. moniliformis. This report constitutes the first documented human pentastomid infection in the whole of Malaysia after nearly 40 years, and it is the third description from Malaysian Borneo. Cases of human and animal pentastomiasis in Malaysia are discussed.
    Matched MeSH terms: Liver Diseases, Parasitic/diagnosis*; Liver Diseases, Parasitic/parasitology*; Liver Diseases, Parasitic/surgery
  9. alpha1-Antitrypsin deficiency is not an important cause of childhood liver diseases in a multi-ethnic Southeast Asian population
    Lee WS, Yap SF, Looi LM
    J Paediatr Child Health, 2007 Sep;43(9):636-9.
    PMID: 17688648
    We conducted a prospective study to determine the role of alpha1-antitrypsin (alpha1AT) deficiency in the pathogenesis of neonatal cholestasis and other childhood liver diseases in a multi-ethnic Southeast Asian population.
    Matched MeSH terms: Liver Diseases/ethnology; Liver Diseases/etiology*; Liver Diseases/genetics
  10. Asian consensus on the relationship between obesity and gastrointestinal and liver diseases
    Koh JC, Loo WM, Goh KL, Sugano K, Chan WK, Chiu WY, et al.
    J Gastroenterol Hepatol, 2016 Aug;31(8):1405-13.
    PMID: 27010240 DOI: 10.1111/jgh.13385
    The incidence of obesity is increasing in Asia, with implications on gastrointestinal (GI) and liver diseases. The Gut and Obesity in Asia Workgroup comprises regional experts with the aim of studying relationship between obesity and the GI and liver diseases in Asia. Through literature review and the modified Delphi process, consensus statements examining the impact of obesity on esophageal, gastric, pancreatic, colorectal, and liver diseases, exploring relationship between gut microbiome and obesity, and assessing obesity therapies have been produced by the Gut and Obesity in Asia Workgroup. Sixteen experts participated with 9/15 statements having strong consensus (>80% agreement). The prevalence of obesity in Asia is increasing (100% percentage agreement in brackets), and this increased prevalence of obesity will result in a greater burden of obesity-related GI and liver diseases (93.8%). There was consensus that obesity increases the risk of gastric cancer (75%) and colorectal neoplasia (87.5%). Obesity was also associated with Barrett's esophagus and esophageal adenocarcinoma (66.7%) and pancreatic cancer (66.7%) in Asia. The prevalence of non-alcoholic fatty liver disease (NAFLD) in Asia is on the rise (100%), and the risk of NAFLD in Asia (100%) is increased by obesity. Obesity is a risk factor for the development of hepatocellular carcinoma (93.8%). Regarding therapy, it was agreed that bariatric surgery was an effective treatment modality for obesity (93.8%) but there was less agreement on its benefit for NAFLD (62.5%). These experts' consensus on obesity and GI diseases in Asia forms the basis for further research, and its translation into addressing this emerging issue.
    Matched MeSH terms: Liver Diseases/diagnosis; Liver Diseases/microbiology; Liver Diseases/epidemiology*
  11. Fulltext Interventions for preventing and managing advanced liver disease in cystic fibrosis
    Palaniappan SK, Than NN, Thein AW, van Mourik I
    Cochrane Database Syst Rev, 2020 03 30;3:CD012056.
    PMID: 32227478 DOI: 10.1002/14651858.CD012056.pub3
    BACKGROUND: Cystic fibrosis is an autosomal recessive inherited defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in abnormal regulation of salt and water movement across the membranes. In the liver this leads to focal biliary fibrosis resulting in progressive portal hypertension and end-stage liver disease in some individuals. This can be asymptomatic, but may lead to splenomegaly and hypersplenism, development of varices and variceal bleeding, and ascites; it has negative impact on overall nutritional status and respiratory function in this population. Prognosis is poor once significant portal hypertension is established. The role and outcome of various interventions for managing advanced liver disease (non-malignant end stage disease) in people with cystic fibrosis is currently unidentified. This is an updated version of a previously published review.

    OBJECTIVES: To review and assess the efficacy of currently available treatment options for preventing and managing advanced liver disease in children and adults with cystic fibrosis.

    SEARCH METHODS: We searched the Cochrane Cystic Fibrosis Trials Register, compiled from electronic database searches and handsearching of journals and conference abstract books. Date of last search: 19 November 2019. We also searched the reference lists of relevant articles and reviews and online trials registries. Date of last search: 01 January 2020.

    SELECTION CRITERIA: Any published and unpublished randomised controlled trials and quasi-randomised controlled trials of advanced liver disease in cystic fibrosis with cirrhosis or liver failure, portal hypertension or variceal bleeding (or both).

    DATA COLLECTION AND ANALYSIS: Authors independently examined titles and abstracts to identify potentially relevant trials, but none were eligible for inclusion in this review.

    MAIN RESULTS: A comprehensive search of the literature did not identify any published eligible randomised controlled trials.

    AUTHORS' CONCLUSIONS: In order to develop the best source of evidence, there is a need to undertake randomised controlled trials of interventions for preventing and managing advanced liver disease in adults and children with cystic fibrosis.

    Matched MeSH terms: Liver Diseases/etiology; Liver Diseases/prevention & control; Liver Diseases/therapy*
  12. Fulltext Transient abnormal myelopoiesis with life-threatening complications
    Abdul-Wahab, J., Naznin, M, Norlelawati, A.T., Amir Hamzah, A.R.
    International Medical Journal Malaysia, 2006;5(2):1-6.
    MyJurnal
    Transient abnormal myelopoiesis (TAM) occurs in approximately 10% of neonates with Down syndrome. In most cases it resolves spontaneously. Life threatening complications such as cardiopulmonary and liver diseases have been described. We present here two cases which suggest that management of TAM in selected cases will have to be more aggressive.
    Matched MeSH terms: Liver Diseases
  13. Fulltext Automatic liver segmentation on Computed Tomography using random walkers for treatment planning
    Moghbel M, Mashohor S, Mahmud R, Saripan MI
    EXCLI J, 2016;15:500-517.
    PMID: 28096782 DOI: 10.17179/excli2016-473
    Segmentation of the liver from Computed Tomography (CT) volumes plays an important role during the choice of treatment strategies for liver diseases. Despite lots of attention, liver segmentation remains a challenging task due to the lack of visible edges on most boundaries of the liver coupled with high variability of both intensity patterns and anatomical appearances with all these difficulties becoming more prominent in pathological livers. To achieve a more accurate segmentation, a random walker based framework is proposed that can segment contrast-enhanced livers CT images with great accuracy and speed. Based on the location of the right lung lobe, the liver dome is automatically detected thus eliminating the need for manual initialization. The computational requirements are further minimized utilizing rib-caged area segmentation, the liver is then extracted by utilizing random walker method. The proposed method was able to achieve one of the highest accuracies reported in the literature against a mixed healthy and pathological liver dataset compared to other segmentation methods with an overlap error of 4.47 % and dice similarity coefficient of 0.94 while it showed exceptional accuracy on segmenting the pathological livers with an overlap error of 5.95 % and dice similarity coefficient of 0.91.
    Matched MeSH terms: Liver Diseases
  14. Fulltext Hepatoprotective Effects of Morinda citrifolia Leaf Extract on Ovariectomized Rats Fed with Thermoxidized Palm Oil Diet: Evidence at Histological and Ultrastructural Level
    Chong CLG, Hussan F, Othman F
    Oxid Med Cell Longev, 2019;2019:9714302.
    PMID: 31827717 DOI: 10.1155/2019/9714302
    Morinda citrifolia (Rubiaceae) or Noni was previously reported to have leaf with broad therapeutic property whereas the fruit was rarely described as medicinal. Ironically, extensive research and review has been done on the fruit and little was known about the therapeutic activity of the leaf as a medicinal food. The aim of this study was to investigate the therapeutic effects of Morinda citrifolia (MC) ethanolic leaf extract on the hepatic structure and function in postmenopausal rats fed with thermoxidized palm oil (TPO) diet. Thirty eight female Sprague Dawley rats were divided into five groups: sham (Sham), ovariectomized (OVX), ovariectomized and treated with simvastatin 10 mg/kg (OVX+ST), ovariectomized and supplemented with low dose MC 500 mg/kg (OVX+MCLD), and ovariectomized and supplemented with high dose MC 1000 mg/kg (OVX+MCHD). All the ovariectomized groups were fed with TPO diet whereas the Sham group was fed with normal diet. Consumption of TPO diet in postmenopausal rats resulted in obesity, significantly elevated (P < 0.05) liver oxidative stress marker; malondialdehyde (MDA), diffuse microvesicular steatosis, and defective mitochondria. Treatment with MC leaf extract prevented hepatic steatosis by significantly increasing (P < 0.05) the liver antioxidant enzyme SOD and GPx, significantly increasing (P < 0.05) ALP, decreasing liver lipids infiltration, preventing mitochondrial damage, and overall maintaining the normal liver histology and ultrastructure. In conclusion, we provided detailed histological and ultrastructural evidence showing hepatoprotective effects of MC leaf extract through its antioxidant mechanism.
    Matched MeSH terms: Liver Diseases/etiology; Liver Diseases/pathology; Liver Diseases/prevention & control*
  15. Fulltext Hepatoprotective activity of dried- and fermented-processed virgin coconut oil
    Zakaria ZA, Rofiee MS, Somchit MN, Zuraini A, Sulaiman MR, Teh LK, et al.
    Evid Based Complement Alternat Med, 2011;2011:142739.
    PMID: 21318140 DOI: 10.1155/2011/142739
    The present study aims to determine the hepatoprotective effect of MARDI-produced virgin coconut oils, prepared by dried- or fermented-processed methods, using the paracetamol-induced liver damage in rats. Liver injury induced by 3 g/kg paracetamol increased the liver weight per 100 g bodyweight indicating liver damage. Histological observation also confirms liver damage indicated by the presence of inflammations and necrosis on the respective liver section. Interestingly, pretreatment of the rats with 10, but not 1 and 5, mL/kg of both VCOs significantly (P < .05) reduced the liver damage caused by the administration of paracetamol, which is further confirmed by the histological findings. In conclusion, VCO possessed hepatoprotective effect that requires further in-depth study.
    Matched MeSH terms: Liver Diseases
  16. Fulltext Intestinal Microbiota, Lipids, and the Pathogenesis of Intestinal Failure-Associated Liver Disease
    Lee WS, Sokol RJ
    J Pediatr, 2015 Sep;167(3):519-26.
    PMID: 26130113 DOI: 10.1016/j.jpeds.2015.05.048
    Matched MeSH terms: Liver Diseases/etiology*; Liver Diseases/microbiology; Liver Diseases/physiopathology
  17. Fulltext Hepatoprotective Activity of Elephantopus scaber on Alcohol-Induced Liver Damage in Mice
    Ho WY, Yeap SK, Ho CL, Abdul Rahim R, Alitheen NB
    Evid Based Complement Alternat Med, 2012;2012:417953.
    PMID: 22973401 DOI: 10.1155/2012/417953
    Elephantopus scaber has been traditionally used as liver tonic. However, the protective effect of E. scaber on ethanol-induced liver damage is still unclear. In this study, we have compared the in vivo hepatoprotective effect of E. scaber with Phyllanthus niruri on the ethanol-induced liver damage in mice. The total phenolic and total flavanoid content of E. scaber ethanol extract were determined in this study. Accelerating serum biochemical profiles (including AST, ALT, ALP, triglyceride, and total bilirubin) associated with fat drop and necrotic body in the liver section were observed in the mice treated with ethanol. Low concentration of E. scaber was able to reduce serum biochemical profiles and the fat accumulation in the liver. Furthermore, high concentration of E. scaber and positive control P. niruri were able to revert the liver damage, which is comparable to the normal control. Added to this, E. scaber did not possess any oral acute toxicity on mice. These results suggest the potential effect of this extract as a hepatoprotective agent towards-ethanol induced liver damage without any oral acute toxicity effect. These activities might be contributed, or at least in part, by its high total phenolic and flavonoid contents.
    Matched MeSH terms: Liver Diseases
  18. Endoscopic ultrasound-guided injection therapy for hepatobiliary disease
    Ponnudurai R, Sachithanandan S, George A
    J Hepatobiliary Pancreat Sci, 2011 May;18(3):311-8.
    PMID: 21468788 DOI: 10.1007/s00534-010-0354-5
    Endoscopic ultrasound (EUS)-guided injection therapy is the new frontier in the management of patients with hepatobiliary disease. Celiac plexus block/neurolysis was the first form of injection therapy and has been validated in many subsequent trials. Cyst ablation therapy, fiducial insertion, angiography, portal hypertensive therapy, endoscopic portosystemic shunt creation, portal vein embolization and injection of chemotherapeutic/biologic agents for antitumor therapy are more recent uses and will be discussed. Celiac plexus neurolysis is currently well established in providing adjunct pain control in patients with advanced malignancy. There are limited data available for its use in benign conditions. EUS-guided ablative therapy for pancreatic cysts remains an area for future research but seems to have a role for small thin-walled non-septated cysts. EUS-guided implantation of fiducials is technically feasible but its exact impact on tumor regression is unknown. Several case reports have documented EUS-guided alcohol and thrombin injection into pseudoaneurysms and cyanoacrylate and coil embolization for variceal therapy. Injection of viral vectors and immunomodulating cell cultures as antitumor therapy has been described but the evidence is still preliminary and further data are awaited.
    Matched MeSH terms: Liver Diseases/drug therapy*; Liver Diseases/ultrasonography
  19. Prealbumin rather than albumin is a more sensitive indicator of acute liver disease
    Yasmin MY, Aziz B, Nazim M, Madhavan RK
    Malays J Pathol, 1993 Dec;15(2):147-50.
    PMID: 8065177
    The changes in serum prealbumin (transthyretin) and serum albumin in acute and chronic liver diseases were investigated. Albumin has long been used as a useful indicator of liver function but serum prealbumin has recently been noted for its clinical significance in acute liver diseases. Serum prealbumin concentrations and liver function tests (albumin, bilirubin, alanine aminotransferase) were determined on blood obtained from normal donors (n = 148) and from patients suffering from liver diseases (n = 78) such as acute viral hepatitis, chronic active hepatitis, cirrhosis and hepatoma. The mean serum prealbumin concentration in normal subjects was 29.6 +/- 4.82 mg/dl while the mean serum prealbumin concentration in patients with liver disease was greatly reduced (acute viral hepatitis = 15.3 +/- 7.4mg/dl; chronic active hepatitis = 10.2 +/- 6.6mg/dl; cirrhosis = 9.9 +/- 6.4mg/dl and hepatoma = 10.7 +/- 4.2). Albumin concentrations dropped slightly (13% compared to control) in acute viral hepatitis but dropped markedly (28% compared to control) in chronic liver diseases. The study suggests that serum prealbumin concentration might be a more sensitive indicator than albumin in assessing liver dysfunction in acute liver diseases.
    Matched MeSH terms: Liver Diseases/blood; Liver Diseases/diagnosis*
  20. Fulltext Polycystic liver disease treated by fenestration and segmental liver resection
    Haron A, Hisham AN, Samad SA
    Med J Malaysia, 1994 Mar;49(1):86-9.
    PMID: 8057997
    A case of symptomatic polycystic liver disease treated by fenestration and segmental liver resection is reported. The intraoperative use of ultrasound to define the plane of liver resection is emphasised. No significant post-operative complication was encountered. The clinical presentation, management and treatment are discussed.
    Matched MeSH terms: Liver Diseases/diagnosis; Liver Diseases/surgery*
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