Displaying publications 21 - 40 of 449 in total

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  1. Facile fabrication of arecanut palm sheath based robust hydrophobic cellulose nanopapers via self-assembly of ZnO nanoflakes and its shelf-life prediction for sustainable packaging applications
    Poulose A, Mathew A, Uthaman A, Lal HM, Parameswaranpillai J, Mathiazhagan A, et al.
    Int J Biol Macromol, 2024 Jan;255:128004.
    PMID: 37979737 DOI: 10.1016/j.ijbiomac.2023.128004
    Cellulose nanofibers have been extracted from arecanut palm sheath fibers via mild oxalic acid hydrolysis coupled with steam explosion technique. Cellulose nanofibers with diameter of 20.23 nm were obtained from arecanut palm sheath fibers. A series of robust hydrophobic cellulose nanopapers were fabricated by combining the synergistic effect of surface roughness induced by the successful deposition of zinc oxide (ZnO) nanoflakes and stearic acid modification via a simple and cost-effective method. In this work, agro-waste arecanut palm sheath was employed as a novel source for the extraction of cellulose nanofibers. 2 wt% of ZnO nanoflakes and 1 M concentration of stearic acid were used to fabricate mechanically robust hydrophobic cellulose nanopapers with a water contact angle (WCA) of 134°. During the deposition of zinc oxide nanoflakes on the CNP for inducing surface roughness, a hydrogen bonding interaction is formed between the hydroxyl groups of cellulose nanofibers and the zinc oxide nanoflakes. When this surface roughened CNP was dipped in stearic acid solution. The hydroxyl groups in zinc oxide nanoflakes undergoes esterification reaction with carboxyl groups in stearic acid solution forming an insoluble stearate layer and thus inducing hydrophobicity on CNP. The fabricated hydrophobic cellulose nanopaper displayed a tensile strength of 22.4 MPa and better UV blocking ability which is highly desirable for the sustainable packaging material in the current scenario. Furthermore, the service life of the pristine and modified cellulose nanopapers was predicted using the Arrhenius equation based on the tensile properties obtained during the accelerated ageing studies. The outcome of this study would be broadening the potential applications of hydrophobic and mechanically robust cellulose nanopapers in sustainable packaging applications.
    Matched MeSH terms: Cellulose/chemistry
  2. β-cyclodextrin polymer composites for the removal of pharmaceutical substances, endocrine disruptor chemicals, and dyes from aqueous solution- A review of recent trends
    Kamaraj M, Suresh Babu P, Shyamalagowri S, Pavithra MKS, Aravind J, Kim W, et al.
    J Environ Manage, 2024 Feb;351:119830.
    PMID: 38141340 DOI: 10.1016/j.jenvman.2023.119830
    Cyclodextrin (CD) and its derivatives are receiving attention as a new-generation adsorbent for water pollution treatment due to their external hydrophilic and internal hydrophobic properties. Among types of CD, β-Cyclodextrin (βCD) has been a material of choice with a proven track record for a range of utilities in distinct domains, owing to its unique cage-like structural conformations and inclusion complex-forming ability, especially to mitigate emerging contaminants (ECs). This article outlines βCD composites in developing approaches of their melds and composites for purposes such as membranes for removal of the ECs in aqueous setups have been explored with emphasis on recent trends. Electrospinning has bestowed an entirely different viewpoint on polymeric materials, comprising βCD, in the framework of diverse functions across a multitude of niches. Besides, this article especially discusses βCD polymer composite membrane-based removal of contaminants such as pharmaceutical substances, endocrine disruptors chemicals, and dyes. Finally, in this article, the challenges and future directions of βCD-based adsorbents are discussed, which may shed light on pragmatic commercial applications of βCD polymer composite membranes.
    Matched MeSH terms: Cellulose*
  3. Oil palm frond-derived cellulose nanocrystals: Effect of pretreatment and elucidating its reinforcing potential in hydrogel beads
    Hamidon TS, Idris NN, Adnan R, Haafiz MKM, Zahari A, Hussin MH
    Int J Biol Macromol, 2024 Mar;262(Pt 2):130239.
    PMID: 38367788 DOI: 10.1016/j.ijbiomac.2024.130239
    Herein, cellulose nanocrystals were synthesized from oil palm fronds (CNC-OPF) involving two pretreatment approaches, viz. autohydrolysis and soda pulping. The pretreatments were applied individually to OPF fibers to assess their influence on CNCs' physicochemical and thermal properties. CNC-OPF samples were assessed using complementary characterization techniques, which confirmed their purity and characteristics. CP/MAS 13C NMR and TEM studies revealed that autohydrolysis pretreatment yielded CNCs with effective hemicellulose and extractives removal compared to that of soda pulping. XRD analysis demonstrated that autohydrolysis-treated CNC-OPF contained a much higher crystallinity index compared to soda pulping treatment. BET measurement disclosed a relatively higher surface area and wider pore diameter of autohydrolysis-treated CNC-OPF. Autohydrolysis-treated CNCs were applied as a reinforcement filler in alginate-based hydrogel beads for the removal of 4-chlorophenol from water, which attained a qmax of 19.168 mg g-1. BET analysis revealed the less porous nature of CNC-ALG hydrogel beads which could have contributed to hydrogel beads' relatively lower adsorption capacity. The point of zero charge of CNC-ALG hydrogel beads was 4.82, suggesting their applicability only within a short solution pH range. This study directs future studies to unveil the possibilities of functionalizing CNCs in order to enhance the adsorption performance of CNC-immobilized hydrogel beads towards 4-chlorophenol and other organic contaminants.
    Matched MeSH terms: Cellulose/chemistry
  4. Fulltext Plant- vs. Bacterial-Derived Cellulose for Wound Healing: A Review
    Naomi R, Bt Hj Idrus R, Fauzi MB
    Int J Environ Res Public Health, 2020 Sep 18;17(18).
    PMID: 32961877 DOI: 10.3390/ijerph17186803
    Cellulose is a naturally existing element in the plant's cell wall and in several bacteria. The unique characteristics of bacterial cellulose (BC), such as non-toxicity, biodegradability, hydrophilicity, and biocompatibility, together with the modifiable form of nanocellulose, or the integration with nanoparticles, such as nanosilver (AgNP), all for antibacterial effects, contributes to the extensive usage of BC in wound healing applications. Due to this, BC has gained much demand and attention for therapeutical usage over time, especially in the pharmaceutical industry when compared to plant cellulose (PC). This paper reviews the progress of related research based on in vitro, in vivo, and clinical trials, including the overall information concerning BC and PC production and its mechanisms in wound healing. The physicochemical differences between BC and PC have been clearly summarized in a comparison table. Meanwhile, the latest Food and Drug Administration (FDA) approved BC products in the biomedical field are thoroughly discussed with their applications. The paper concludes on the need for further investigations of BC in the future, in an attempt to make BC an essential wound dressing that has the ability to be marketable in the global marketplace.
    Matched MeSH terms: Cellulose*
  5. Characterisation of microcrystalline cellulose from oil palm fibres for food applications
    Xiang LY, P Mohammed MA, Samsu Baharuddin A
    Carbohydr Polym, 2016 09 05;148:11-20.
    PMID: 27185110 DOI: 10.1016/j.carbpol.2016.04.055
    Microcrystalline cellulose (MCC) extracted from empty fruit bunches (EFB), stalk and spikelet were characterised through physicochemical and microstructure analyses. Raw stalk fibres yielded the highest cellulose content (42.43%), followed by EFB (32.33%) and spikelet (18.83%). Likewise, lowest lignin and residual oil content was reported in raw stalk fibres compared to EFB and spikelet. SEM revealed significant changes on fibres' surface morphology throughout the extraction process. FTIR analysis showed that main characteristic peaks of hemicellulose and lignin was absent on the extracted MCC. The crystallinity index for MCC extracted from EFB (82.5%), stalk (82.2%) and spikelet (86.5%) was comparable to commercial MCC (81.9%). Results suggested stalk fibres is more preferable for the production of MCC compared to EFB and spikelet. Further rheological studies showed viscoelastic behaviour with no significant differences between commercial and stalk-based MCC, while modelling work showed ability to simulate complex deformation of the MCC-hydrogel/food mixture during processing/handling stage.
    Matched MeSH terms: Cellulose/ultrastructure; Cellulose/chemistry*
  6. Production of new cellulose nanomaterial from red algae marine biomass Gelidium elegans
    Chen YW, Lee HV, Juan JC, Phang SM
    Carbohydr Polym, 2016 Oct 20;151:1210-1219.
    PMID: 27474672 DOI: 10.1016/j.carbpol.2016.06.083
    Nanocellulose was successfully isolated from Gelidium elegans red algae marine biomass. The red algae fiber was treated in three stages namely alkalization, bleaching treatment and acid hydrolysis treatment. Morphological analysis was performed by field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). TEM results revealed that the isolated nanocellulose had the average diameter and length of 21.8±11.1nm and of 547.3±23.7nm, respectively. Fourier transform infrared (FTIR) spectroscopy proved that the non-cellulosic polysaccharides components were progressively removed during the chemically treatment, and the final derived materials composed of cellulose parent molecular structure. X-ray diffraction (XRD) study showed that the crystallinity of yielded product had been improved after each successive treatments subjected to the treated fiber. The prepared nano-dimensional cellulose demonstrated a network-like structure with higher crystallinity (73%) than that of untreated fiber (33%), and possessed of good thermal stability which is suitable for nanocomposite material.
    Matched MeSH terms: Cellulose/biosynthesis*; Cellulose/chemistry*
  7. Isolation and characterization of microcrystalline cellulose from roselle fibers
    Kian LK, Jawaid M, Ariffin H, Alothman OY
    Int J Biol Macromol, 2017 Oct;103:931-940.
    PMID: 28549863 DOI: 10.1016/j.ijbiomac.2017.05.135
    In this study, microcrystalline cellulose (MCC) was extracted from roselle fiber through acid hydrolysis treatment and its properties were compared with those of commercially available MCC. The physicochemical and morphological characteristics, elemental composition, size distribution, crystallinity and thermal properties of the obtained MCC were analyzed in this work. Fourier transform infrared spectroscopy (FTIR) analysis provided clear evidence that the characteristic peak of lignin was absent in the spectrum of the MCC prepared from roselle fiber. Rough surface and slight aggregation of MCC were observed by scanning electron microscopy (SEM). Energy dispersive X-ray (EDX) analysis showed that pure MCC with small quantities of residues and impurities was obtained, with a similar elemental composition to that of commercial MCC. A mean diameter of approximately 44.28μm was measured for MCC by using a particle size analyzer (PSA). X-ray diffraction (XRD) showed the crystallinity increased from 63% in roselle pulp to 78% in roselle MCC, the latter having a slightly higher crystallinity than that of commercial MCC (74%). TGA and DSC results indicated that the roselle MCC had better thermal stability than the roselle pulp, whereas it had poorer thermal stability in comparison with commercial MCC. Thus, the isolated MCC from roselle fibers will be going to use as reinforcing element in green composites and may be a precursor for future roselle derived nanocellulose, and thus a promising subject in nanocomposite research.
    Matched MeSH terms: Cellulose/isolation & purification*; Cellulose/chemistry*
  8. Kenaf bast cellulosic fibers hierarchy: a comprehensive approach from micro to nano
    Karimi S, Tahir PM, Karimi A, Dufresne A, Abdulkhani A
    Carbohydr Polym, 2014 Jan 30;101:878-85.
    PMID: 24299851 DOI: 10.1016/j.carbpol.2013.09.106
    Cellulosic fibers from kenaf bast were isolated in three distinct stages. Initially raw kenaf bast fibers were subjected to an alkali pulping process. Then pulped fibers undergone a bleaching process and finally both pulped and bleached fibers were separated into their constituent nanoscale cellulosic fibers by mechanical shearing. The influence of each treatment on the chemical composition of fibers was investigated. Moreover morphology, functional groups, crystallinity, and thermal behavior of fiber hierarchy at different stages of purification were studied using scanning and transmission electron microscopies, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA), respectively. Microscopy studies revealed that applied procedures successfully isolated nanoscale cellulosic fibers from both unbleached and bleached pulps. Chemical composition analysis and FTIR spectroscopy showed that lignin and hemicellulose were almost entirely removed by the applied treatments. XRD and TGA analyses demonstrated progressive enhancement of properties in fibers, hierarchically, in going from micro to nano scale. Interestingly no significant evolution was observed between obtained data of characterized ubnleached and bleached nanofibers.
    Matched MeSH terms: Cellulose/chemistry*
  9. Regenerated cellulose membrane as bio-template for in-situ growth of visible-light driven C-modified mesoporous titania
    Mohamed MA, W Salleh WN, Jaafar J, Mohd Hir ZA, Rosmi MS, Abd Mutalib M, et al.
    Carbohydr Polym, 2016 08 01;146:166-73.
    PMID: 27112862 DOI: 10.1016/j.carbpol.2016.03.050
    Visible light driven C-doped mesoporous TiO2 (C-MTiO2) nanorods have been successfully synthesized through green, low cost, and facile approach by sol-gel bio-templating method using regenerated cellulose membrane (RCM) as nanoreactor. In this study, RCM was also responsible to provide in-situ carbon sources for resultant C-MTiO2 nanorods in acidified sol at low temperatures. The composition, crystallinity, surface area, morphological structure, and optical properties of C-MTiO2 nanorods, respectively, had been characterized using FTIR, XRD, N2 adsorption/desorption, TEM, UV-vis-NIR, and XPS spectroscopy. The results suggested that the growth of C-MTiO2 nanorods was promoted by the strong interaction between the hydroxyl groups of RCMs and titanium ion. Optical and XPS analysis confirmed that carbon presence in TiO2 nanorods were responsible for band-gap narrowing, which improved the visible light absorption capability. Photocatalytic activity measurements exhibited the capability of C-MTiO2 nanorods in degradation of methyl orange in aqueous solution, with 96.6% degradation percentage under visible light irradiation.
    Matched MeSH terms: Cellulose/chemistry*
  10. Study on a Novel natural cellulosic fiber from Kigelia africana fruit: Characterization and analysis
    Siva R, Valarmathi TN, Palanikumar K, Samrot AV
    Carbohydr Polym, 2020 Sep 15;244:116494.
    PMID: 32536404 DOI: 10.1016/j.carbpol.2020.116494
    In recent days, there is an increasing use of green composites in composite manufacturing, where cellulosic natural fibers have been started using for this purpose. In line with this, a novel cellulose fiber was extracted from the Kigelia africana fruit and its physical, chemical and thermal properties, crystallography and surface morphology analysis were studied and reported in this investigative research paper. The physical analysis revealed the mean tensile strength as 50.31 ± 24.71 to 73.12 ± 32.48 MPa, diameter as 0.507 ± 0.162 to 0.629 ± 0.182 mm and density as 1.316 g/cm³ for the Kigelia africana fiber. The proximate chemical analysis estimated the cellulose percentage to be 61.5 % and the existence of different basic components like cellulose, hemicellulose and lignin are confirmed by Fourier transform infrared spectroscopy analysis. Thermogravimetric analysis establishes the thermal stability of the fiber as 212 ⁰C. The crystallinity index, 57.38 % of the fiber was determined by X-ray diffraction. Surface morphology by field emission scanning electron microscopy reveals the presence of protrusions in fiber which aid in the better adhesion with the matrix in composite manufacturing.
    Matched MeSH terms: Cellulose/chemistry*
  11. Bio-cellulose Production by Beijerinckia fluminensis WAUPM53 and Gluconacetobacter xylinus 0416 in Sago By-product Medium
    Voon WWY, Muhialdin BJ, Yusof NL, Rukayadi Y, Meor Hussin AS
    Appl Biochem Biotechnol, 2019 Jan;187(1):211-220.
    PMID: 29915916 DOI: 10.1007/s12010-018-2807-2
    Bio-cellulose is the microbial extracellular cellulose that is produced by growing several microorganisms on agriculture by-products, and it is used in several food applications. This study aims to utilize sago by-product, coconut water, and the standard medium Hestrin-Schramm as the carbon sources in the culture medium for bio-cellulose production. The bacteria Beijerinkia fluminensis WAUPM53 and Gluconacetobacter xylinus 0416 were selected based on their bio-cellulose production activity. The structure was determined by Fourier transform infrared spectroscopy and scanning electron microscopy, while the toxicity safety was evaluated by brine shrimp lethality test. The results of Fourier transform infrared spectroscopy showed that the bio-cellulose produced by B. fluminensis cultivated in sago by-products was of high quality. The bio-cellulose production by B. fluminensis in the sago by-product medium was slightly higher than that in the coconut water medium and was comparable with the production in the Hestrin-Schramm medium. Brine shrimp lethality test confirmed that the bio-cellulose produced by B. fluminensis in the sago by-product medium has no toxicity, which is safe for applications in the food industry. This is the first study to determine the high potential of sago by-product to be used as a new carbon source for the bio-cellulose production.
    Matched MeSH terms: Cellulose/biosynthesis*
  12. Fulltext Review of Functional Aspects of Nanocellulose-Based Pickering Emulsifier for Non-Toxic Application and Its Colloid Stabilization Mechanism
    Teo SH, Chee CY, Fahmi MZ, Wibawa Sakti SC, Lee HV
    Molecules, 2022 Oct 23;27(21).
    PMID: 36363998 DOI: 10.3390/molecules27217170
    In the past few years, the research on particle-stabilized emulsion (Pickering emulsion) has mainly focused on the usage of inorganic particles with well-defined shapes, narrow size distributions, and chemical tunability of the surfaces such as silica, alumina, and clay. However, the presence of incompatibility of some inorganic particles that are non-safe to humans and the ecosystem and their poor sustainability has led to a shift towards the development of materials of biological origin. For this reason, nano-dimensional cellulose (nanocellulose) derived from natural plants is suitable for use as a Pickering material for liquid interface stabilization for various non-toxic product formulations (e.g., the food and beverage, cosmetic, personal care, hygiene, pharmaceutical, and biomedical fields). However, the current understanding of nanocellulose-stabilized Pickering emulsion still lacks consistency in terms of the structural, self-assembly, and physio-chemical properties of nanocellulose towards the stabilization between liquid and oil interfaces. Thus, this review aims to provide a comprehensive study of the behavior of nanocellulose-based particles and their ability as a Pickering functionality to stabilize emulsion droplets. Extensive discussion on the characteristics of nanocelluloses, morphology, and preparation methods that can potentially be applied as Pickering emulsifiers in a different range of emulsions is provided. Nanocellulose's surface modification for the purpose of altering its characteristics and provoking multifunctional roles for high-grade non-toxic applications is discussed. Subsequently, the water-oil stabilization mechanism and the criteria for effective emulsion stabilization are summarized in this review. Lastly, we discuss the toxicity profile and risk assessment guidelines for the whole life cycle of nanocellulose from the fresh feedstock to the end-life of the product.
    Matched MeSH terms: Cellulose/chemistry
  13. Fulltext Enhancing in vitro ruminal digestibility of oil palm empty fruit bunch by biological pre-treatment with Ganoderma lucidum fungal culture
    Nur-Nazratul FMY, Rakib MRM, Zailan MZ, Yaakub H
    PLoS One, 2021;16(9):e0258065.
    PMID: 34591932 DOI: 10.1371/journal.pone.0258065
    The changes in lignocellulosic biomass composition and in vitro rumen digestibility of oil palm empty fruit bunch (OPEFB) after pre-treatment with the fungus Ganoderma lucidum were evaluated. The results demonstrated that the pre-treatment for 2-12 weeks has gradually degraded the OPEFB in a time-dependent manner; whereby lignin, cellulose, and hemicellulose were respectively degraded by 41.0, 20.5, and 26.7% at the end of the incubation period. The findings were corroborated using the physical examination of the OPEFB by scanning electron microscopy. Moreover, the OPEFB pre-treated for 12 weeks has shown the highest in vitro digestibility of dry (77.20%) and organic (69.78%) matter, where they were enhanced by 104.07 and 96.29%, respectively, as compared to the untreated control. The enhancement in the in vitro ruminal digestibility was negatively correlated with the lignin content in the OPEFB. Therefore, biologically delignified OPEFB with G. lucidum fungal culture pre-treatment have the potential to be utilized as one of the ingredients for the development of a novel ruminant forage.
    Matched MeSH terms: Cellulose/metabolism*
  14. Investigation of optimal conditions for production of highly crystalline nanocellulose with increased yield via novel Cr(III)-catalyzed hydrolysis: Response surface methodology
    Chen YW, Lee HV, Abd Hamid SB
    Carbohydr Polym, 2017 Dec 15;178:57-68.
    PMID: 29050615 DOI: 10.1016/j.carbpol.2017.09.029
    For the first time, a highly efficient Cr(NO3)3 catalysis system was proposed for optimization the yield and crystallinity of nanocellulose end product. A five-level three-factor central composite design coupled with response surface methodology was employed to elucidate parameters interactions between three design factors, namely reaction temperature (x1), reaction time (x2) and concentration of Cr(NO3)3 (x3) over a broad range of process conditions and determine the effect on crystallinity index and product yield. The developed models predicted the maximum nanocellulose yield of 87% at optimum process conditions of 70.6°C, 1.48h, and 0.48M Cr(NO3)3. At these conditions, the obtained nanocellulose presented high crystallinity index (75.3%), spider-web-like interconnected network morphology with the average width of 31.2±14.3nm. In addition, the yielded nanocellulose rendered a higher thermal stability than that of original cellulosic source and expected to be widely used as reinforcement agent in bio-nanocomposites materials.
    Matched MeSH terms: Cellulose/chemistry*
  15. Enhanced single cell oil production by mixed culture of Chlorella pyrenoidosa and Rhodotorula glutinis using cassava bagasse hydrolysate as carbon source
    Liu L, Chen J, Lim PE, Wei D
    Bioresour Technol, 2018 May;255:140-148.
    PMID: 29414159 DOI: 10.1016/j.biortech.2018.01.114
    The single cell oil (SCO) production by the mono and mixed culture of microalgae Chlorella pyrenoidosa and red yeast Rhodotorula glutinis was investigated using non-detoxified cassava bagasse hydrolysate (CBH) as carbon source. The results suggested that the two strains were able to tolerate and even degrade some byproducts presented in the CBH, and the mixed culture approach enhanced the degradation of certain byproducts. Biomass (20.37 ± 0.38 g/L) and lipid yield (10.42 ± 1.21 g/L) of the mixed culture achieved in the batch culture were significantly higher than that of the mono-cultures (p 
    Matched MeSH terms: Cellulose*
  16. Current advances of nanocellulose application in biomedical field
    Leong MY, Kong YL, Harun MY, Looi CY, Wong WF
    Carbohydr Res, 2023 Oct;532:108899.
    PMID: 37478689 DOI: 10.1016/j.carres.2023.108899
    Nanocellulose (NC) is a natural fiber that can be extracted in fibrils or crystals form from different natural sources, including plants, bacteria, and algae. In recent years, nanocellulose has emerged as a sustainable biomaterial for various medicinal applications including drug delivery systems, wound healing, tissue engineering, and antimicrobial treatment due to its biocompatibility, low cytotoxicity, and exceptional water holding capacity for cell immobilization. Many antimicrobial products can be produced due to the chemical functionality of nanocellulose, such disposable antibacterial smart masks for healthcare use. This article discusses comprehensively three types of nanocellulose: cellulose nanocrystals (CNC), cellulose nanofibrils (CNF), and bacterial nanocellulose (BNC) in view of their structural and functional properties, extraction methods, and the distinctive biomedical applications based on the recently published work. On top of that, the biosafety profile and the future perspectives of nanocellulose-based biomaterials have been further discussed in this review.
    Matched MeSH terms: Cellulose/chemistry
  17. Jackfruit peel cellulose nanocrystal - Alginate hydrogel for doripenem adsorption and release study
    Nyoo Putro J, Soetaredjo FE, Santoso SP, Irawaty W, Yuliana M, Wijaya CJ, et al.
    Int J Biol Macromol, 2024 Feb;257(Pt 1):128502.
    PMID: 38040139 DOI: 10.1016/j.ijbiomac.2023.128502
    As a natural raw material to replace synthetic chemicals, cellulose and its derivatives are the most popular choices in the pharmaceutical industry. For drug delivery applications, cellulose is usually used as a cellulose nanocrystal (CNC). CNC-based hydrogels are widely utilized for drug delivery because drug molecules can be encapsulated in their pore-like structures. This study aims to develop CNC hydrogels for the delivery of doripenem antibiotics. CNC was obtained from jackfruit peel extraction, and alginate was used as a network polymer to produce hydrogels. Ionotropic gelation was used in the synthesis of CNC-alginate hydrogel composites. The maximum adsorption of doripenem by CNC was 65.7 mg/g, while the maximum adsorption by CNC-alginate was 98.4 mg/g. One of the most challenging aspects of drug delivery is predicting drug release from a solid matrix using simple and complex mathematical equations. The sigmoidal equation could represent the doripenem release from CNC, while the Ritger-Peppas equation could describe the doripenem release from CNC-Alginate. The biocompatibility testing of CNC and CNC-alginate against a 7F2 cell line indicates that both materials were non-toxic.
    Matched MeSH terms: Cellulose/chemistry
  18. Electrospun microcrystalline cellulose/chitosan porous composite nanofibrous membranes modified by non-thermal plasma for gaseous formaldehyde adsorption
    Xiong J, Luo R, Jia Z, Ge S, Lam SS, Xie L, et al.
    Int J Biol Macromol, 2024 Jan;256(Pt 2):128399.
    PMID: 38007014 DOI: 10.1016/j.ijbiomac.2023.128399
    To develop a green and facile adsorbent for removing indoor polluted formaldehyde (HCHO) gas, the biomass porous nanofibrous membranes (BPNMs) derived from microcrystalline cellulose/chitosan were fabricated by electrospinning. The enhanced chemical adsorption sites with diverse oxygen (O) and nitrogen (N)-containing functional groups were introduced on the surface of BPNMs by non-thermal plasma modification under carbon dioxide (CO2) and nitrogen (N2) atmospheres. The average nanofiber diameters of nanofibrous membranes and their nanomechanical elastic modulus and hardness values decreased from 341 nm to 175-317 nm and from 2.00 GPa and 0.25 GPa to 1.70 GPa and 0.21 GPa, respectively, after plasma activation. The plasma-activated nanofibers showed superior hydrophilicity (WCA = 0°) and higher crystallinity than that of the control. The optimal HCHO adsorption capacity (134.16 mg g-1) of BPNMs was achieved under a N2 atmosphere at a plasma power of 30 W and for 3 min, which was 62.42 % higher compared with the control. Pyrrolic N, pyridinic N, CO and O-C=O were the most significant O and N-containing functional groups for the improved chemical adsorption of the BPNMs. The adsorption mechanism involved a synergistic combination of physical and chemical adsorption. This study provides a novel strategy that combines clean plasma activation with electrospinning to efficiently remove gaseous HCHO.
    Matched MeSH terms: Cellulose*
  19. Whole genome sequencing analysis of Komagataeibacter nataicola reveals its potential in food waste valorisation for cellulose production
    Nasharudin MIH, Siew SW, Ahmad HF, Mahmud N
    Mol Biol Rep, 2024 Apr 11;51(1):503.
    PMID: 38600404 DOI: 10.1007/s11033-024-09492-8
    BACKGROUND: Komagataeibacter nataicola (K. nataicola) is a gram-negative acetic acid bacterium that produces natural bacterial cellulose (BC) as a fermentation product under acidic conditions. The goal of this work was to study the complete genome of K. nataicola and gain insight into the functional genes in K. nataicola that are responsible for BC synthesis in acidic environments.

    METHODS AND RESULT: The pure culture of K. nataicola was obtained from yeast-glucose-calcium carbonate (YGC) agar, followed by genomic DNA extraction, and subjected to whole genome sequencing on a Nanopore flongle flow cell. The genome of K. nataicola consists of a 3,767,936 bp chromosome with six contigs and 4,557 protein coding sequences. The maximum likelihood phylogenetic tree and average nucleotide identity analysis confirmed that the bacterial isolate was K. nataicola. The gene annotation via RAST server discovered the presence of cellulose synthase, along with three genes associated with lactate utilization and eight genes involved in lactate fermentation that could potentially contribute to the increase in acid concentration during BC synthesis.

    CONCLUSION: A more comprehensive genome study of K. nataicola may shed light into biological pathway in BC productivity as well as benefit the analysis of metabolites generated and understanding of biological and chemical interactions in BC production later.

    Matched MeSH terms: Cellulose/metabolism
  20. Colon-specific delivery of 5-fluorouracil from zinc pectinate pellets through in situ intracapsular ethylcellulose-pectin plug formation
    Elyagoby A, Layas N, Wong TW
    J Pharm Sci, 2013 Feb;102(2):604-16.
    PMID: 23225084 DOI: 10.1002/jps.23388
    Conventional fluid-bed and immersion film coating of hydrophilic zinc pectinate pellets by hydrophobic ethylcellulose is met with fast drug release. This study explored in situ intracapsular pellet coating for colon-specific delivery of 5-fluorouracil (5-FU). The solid coating powder constituted ethylcellulose and pectin in weight ratios of 11:0 to 2:9. Its weight ratio to pellets varied between 2:3 and 3:2. Pectin was used as excipient of core pellets and coating powder in view of its potential use in colon cancer treatment. Delayed 5-FU release and core pectin dissolution were attainable when the weight ratio of solid coating powder to pellets was kept at 3:2, and weight ratio of ethylcellulose and pectin in coating powder was kept at 8:3 with particle size of ethylcellulose reduced to 22 μm. In situ intracapsular wetting of pectin coat by dissolution medium resulted in the formation of ethylcellulose plug interconnecting with pellets through the binding action of pectin. Less than 25% of drug was released at the upper gastrointestinal tract. The majority of drug was released upon prolonged dissolution and in response to colonic enzyme pectinase, which digested core pellets.
    Matched MeSH terms: Cellulose/administration & dosage; Cellulose/analogs & derivatives*; Cellulose/metabolism; Cellulose/chemistry
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