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  1. Prevalence, comorbidities and mortality of generalized pustular psoriasis: A literature review
    Prinz JC, Choon SE, Griffiths CEM, Merola JF, Morita A, Ashcroft DM, et al.
    J Eur Acad Dermatol Venereol, 2023 Feb;37(2):256-273.
    PMID: 36331364 DOI: 10.1111/jdv.18720
    Generalized pustular psoriasis (GPP) is a rare auto-inflammatory skin disease characterised by acute episodes of sterile pustule formation. Diagnosis and treatment of the disease have historically been complicated by a lack of awareness, and no consistent global definition or clinical coding standards. Now acknowledged as a distinct clinical entity with a recognised genetic component, GPP can take a serious and life-threatening course due to systemic inflammatory complications and its association with various comorbidities. As with other rare diseases, there are significant challenges to understanding the epidemiology of GPP, notably a small patient population, non-standardised study methodologies and ethnic differences in its presentation. A clearer understanding of GPP is therefore required for clinicians to better manage patients with this rare condition. In this review article, we present an overview of the available data on GPP prevalence estimates in key demographics and report the frequency of genetic mutations associated with the disease. We detail the incidence of known comorbidities and summarise the data on mortality and assigned causes of death. Lastly, we discuss the various factors that impact the collection, interpretation and comparison of these data.
  2. Fulltext Influence of Highly Stable Ni2+ Species in Ni Phyllosilicate Catalysts on Selective Hydrogenation of Furfural to Furfuryl Alcohol
    Kuhaudomlap S, Mekasuwandumrong O, Praserthdam P, Lee KM, Jones CW, Panpranot J
    ACS Omega, 2023 Jan 10;8(1):249-261.
    PMID: 36643509 DOI: 10.1021/acsomega.2c03590
    Enhancing the catalytic performance of non-noble Ni catalysts in the selective hydrogenation of furfural to furfuryl alcohol (FA) in terms of furfural conversion, selectivity, and good recyclability is challenging. Here, spherical nickel phyllosilicate catalysts (Ni_PS) with fibrous-like structures are prepared via a modified sol-gel method with Ni loadings of 2-30 wt %. Upon exposure to air, all the reduced Ni_PS catalysts exhibit more than 80% Ni0/Niphyllosilicate species on the surface, whereas a large portion of Ni oxide species (>55%) is presented on the impregnated catalyst. The Ni2+ species in nickel phyllosilicate catalysts are active and highly stable during reduction, reaction, and regeneration, yielding stable catalytic performance for multiple recycle tests in furfural hydrogenation to FA. Furfural conversion over the Ni_PS catalysts increased monotonically with increasing Ni loading without an FA selectivity drop. The presence of both metallic Ni0 and Niphyllosilicate also produces a synergistic promotional effect for FA formation.
  3. Fulltext Centering and collaborating with community knowledge systems: piloting a novel participatory modeling approach
    Shaikh Y, Jeelani M, Gibbons MC, Livingston D, Williams DR, Wijesinghe S, et al.
    Int J Equity Health, 2023 Mar 13;22(1):45.
    PMID: 36915080 DOI: 10.1186/s12939-023-01839-0
    BACKGROUND: Systems science approaches like simulation modeling can offer an opportunity for community voice to shape policies. In the episteme of many communities there are elders, leaders, and researchers who are seen as bearers of historic knowledge and can contextualize and interpret contemporary research using knowledge systems of the community. There is a need for a systematic methodology to collaborate with community Knowledge Bearers and Knowledge Interpreters. In this paper we report the results of piloting a systematic methodology for collaborating with a community Knowledge-Bearer and Knowledge-Interpreter to develop a conceptual model revealing the local-level influences and architecture of systems shaping community realities. The use case for this pilot is 'persistent poverty' in the United States, specifically within the inner-city African American community in Baltimore City.

    METHODS: This pilot of a participatory modeling approach was conducted over a span of 7 sessions and included the following steps, each with an associated script: Step 1: Knowledge-Bearer and Knowledge-Interpreter recruitment Step 2: Relationship building Step 3: Session introduction, Vignette development & enrichment Step 4: Vignette analysis & constructing architecture of systems map Step 5: Augmenting architecture of systems map RESULTS: Each step of the participatory modeling approach resulted in artifacts that were valuable for both the communities and the research effort. Vignette construction resulted in narratives representing a spectrum of lived experiences, trajectories, and outcomes within a community. The collaborative analysis of vignettes yielded the Architecture of Systemic Factors map, that revealed how factors inter-relate to form a system in which lived experience of poverty occurs. A literature search provided an opportunity for the community to contextualize existing research about them using realities of lived experience.

    CONCLUSION: This methodology showed that a community Knowledge Bearer can function as communicators and interpreters of their community's knowledge base, can develop coherent narratives of lived experiences within which research and knowledge is contextualized, and can collaboratively construct conceptual mappings necessary for simulation modeling. This participatory modeling approach showed that even if there already exists a vast body of research about a community, collaborating with community gives context to that research and brings together disparate findings within narratives of lived experience.

  4. Repurposing FDA-approved drugs as HIV-1 integrase inhibitors: an in silico investigation
    Ha CHX, Lee NK, Rahman T, Hwang SS, Yam WK, Chee XW
    J Biomol Struct Dyn, 2023 Apr;41(6):2146-2159.
    PMID: 35067186 DOI: 10.1080/07391102.2022.2028677
    The Human Immunodeficiency Virus (HIV) infection is a global pandemic that has claimed 33 million lives to-date. One of the most efficacious treatments for naïve or pretreated HIV patients is the HIV integrase strand transfer inhibitors (INSTIs). However, given that HIV treatment is life-long, the emergence of HIV strains resistant to INSTIs is an imminent challenge. In this work, we showed two best regression QSAR models that were constructed using a boosted Random Forest algorithm (r2 = 0.998, q210CV = 0.721, q2external_test = 0.754) and a boosted K* algorithm (r2 = 0.987, q210CV = 0.721, q2external_test = 0.758) to predict the pIC50 values of INSTIs. Subsequently, the regression QSAR models were deployed against the Drugbank database for drug repositioning. The top-ranked compounds were further evaluated for their target engagement activity using molecular docking studies and accelerated Molecular Dynamics simulation. Lastly, their potential as INSTIs were also evaluated from our literature search. Our study offers the first example of a large-scale regression QSAR modelling effort for discovering highly active INSTIs to combat HIV infection.Communicated by Ramaswamy H. Sarma.
  5. Fulltext A multi-resolution textural approach to diagnostic neuropathology reporting
    Fauzi MF, Gokozan HN, Elder B, Puduvalli VK, Pierson CR, Otero JJ, et al.
    J Neurooncol, 2015 Sep;124(3):393-402.
    PMID: 26255070 DOI: 10.1007/s11060-015-1872-4
    We present a computer aided diagnostic workflow focusing on two diagnostic branch points in neuropathology (intraoperative consultation and p53 status in tumor biopsy specimens) by means of texture analysis via discrete wavelet frames decomposition. For intraoperative consultation, our methodology is capable of classifying glioblastoma versus metastatic cancer by extracting textural features from the non-nuclei region of cytologic preparations based on the imaging characteristics of glial processes, which appear as anisotropic thin linear structures. For metastasis, these are homogeneous in appearance, thus suitable and extractable texture features distinguish the two tissue types. Experiments on 53 images (29 glioblastomas and 24 metastases) resulted in average accuracy as high as 89.7 % for glioblastoma, 87.5 % for metastasis and 88.7 % overall. For p53 interpretation, we detect and classify p53 status by classifying staining intensity into strong, moderate, weak and negative sub-classes. We achieved this by developing a novel adaptive thresholding for detection, a two-step rule based on weighted color and intensity for the classification of positively and negatively stained nuclei, followed by texture classification to classify the positively stained nuclei into the strong, moderate and weak intensity sub-classes. Our detection method is able to correctly locate and distinguish the four types of cells, at 85 % average precision and 88 % average sensitivity rate. These classification methods on the other hand recorded 81 % accuracy in classifying the positive and negative cells, and 60 % accuracy in further classifying the positive cells into the three intensity groups, which is comparable with neuropathologists' markings.
  6. Fulltext Low Evidence for Tinnitus Risk Factors: A Systematic Review and Meta-analysis
    Biswas R, Genitsaridi E, Trpchevska N, Lugo A, Schlee W, Cederroth CR, et al.
    J Assoc Res Otolaryngol, 2023 Feb;24(1):81-94.
    PMID: 36380120 DOI: 10.1007/s10162-022-00874-y
    AIMS/HYPOTHESIS: Identifying risk factors for tinnitus could facilitate not only the recommendations for prevention measures, but also identifying potential pathways for new interventions. This study reports the first comprehensive systematic review of analytical observational studies able to provide information about causality (i.e., case-control and cohort designs).

    METHODS: A literature search of four electronic databases identified epidemiological studies published on tinnitus and different exposures. Independent raters screened all studies, extracted data, and evaluated study quality using the Newcastle-Ottawa Scale. Reported relative risks (RR), hazard ratios (HR), odds ratios (OR), and prevalence ratios (PR) with 95% confidence intervals (CI) were used to compute crude estimates of RR for tinnitus risk factors.

    RESULTS: From 2389 records identified, a total of 374 articles were read as full text (24 reviews, 301 cross-sectional studies, 42 cohort studies, and 7 case-control studies). However, from 49 case-control and cohort studies, only 25 adequately reported risk ratios. Using the findings from these studies, positive causal associations were found for various hearing-related factors (i.e., unspecified hearing loss, sensorineural hearing loss, occupational noise exposure, ototoxic platinum therapy, and otitis media). Evidence was also found for a number of non-otological risk factors including temporo-mandibular joint disorder, depression, chronic obstructive pulmonary disease, and hyperlipidemia. Negative associations indicating preventative effects were found for diabetes and high alcohol consumption. No associations were found for low alcohol consumption, body mass index, head injury, heart failure, hypertension, leisure noise exposure, migraine, rheumatoid arthritis, sex, smoking, stroke, and whiplash. However, with the exception of unspecified hearing loss, these findings resulted from pooling no more than 4 studies, illustrating that the vast majority of the associations still remain inconclusive.

    CONCLUSIONS: These systematic review and meta-analysis confirm a number of otological and non-otological risk factors for tinnitus. By highlighting major gaps in knowledge, our synthesis can help provide direction for future research that will shed light on the pathophysiology, improve management strategies, and inform more effective preventions.

  7. Fulltext Determination of Median Lethal Concentration (LC50) for Endosulfan, Heptachlor and Dieldrin Pesticides to African Catfish, Clarias gariepinus and Their Impact on Its Behavioral Patterns and Histopathological Responses
    Islam MA, Amin SMN, Brown CL, Juraimi AS, Uddin MK, Arshad A
    Toxics, 2021 Dec 08;9(12).
    PMID: 34941774 DOI: 10.3390/toxics9120340
    Pesticides such as endosulfan, heptachlor and dieldrin persist in aquatic environments as a result of their resistance to biodegradation. However, there is no adequate information about the toxicity of endosulfan, heptachlor and dieldrin to the aquatic organism, African catfish (Clarias gariepinus)-a high valued widely distributed commercially interesting species. The current experiment was performed with the aim to determine the median lethal concentration (LC50) of endosulfan, heptachlor and dieldrin to African catfish (Clarias gariepinus); their behavioral abnormalities and histopathological alterations in several vital organs. A total of 324 juvenile fish were exposed for 96 h to six concentrations of endosulfan and dieldrin at 0, 0.001, 0.002, 0.004, 0.008 and 0.016 ppm, and to heptachlor at concentrations of 0, 0.02, 0.04, 0.08, 0.16 and 0.32 ppm for dose-response tests. The study demonstrated that the species is highly susceptible to those contaminants showing a number of behavioral abnormalities and histopathological changes in gill, liver and muscle. The 96-h LC50 value of endosulfan, dieldrin and heptachlor for the African catfish was found as 0.004 (0.001-0.01) mg/L, 0.006 mg/L and 0.056 (0.006-0.144) mg/L, respectively. Abnormal behaviors such as erratic jerky swimming, frequent surfacing movement with gulping of air, secretion of mucus on the body and gills were observed in response to the increasing exposure concentrations. Histopathological alterations of liver, gill and muscle tissues were demonstrated as vacuolization in hepatocytes, congestion of red blood cells (RBCs) in hepatic portal vein; deformed secondary lamellae and disintegrated myotomes with disintegrated epidermis, respectively. These findings are important to monitor and responsibly manage pesticide use in and around C. gariepinus aquacultural areas.
  8. Fulltext Forest contraction in north equatorial Southeast Asia during the Last Glacial Period
    Wurster CM, Bird MI, Bull ID, Creed F, Bryant C, Dungait JA, et al.
    Proc Natl Acad Sci U S A, 2010 Aug 31;107(35):15508-11.
    PMID: 20660748 DOI: 10.1073/pnas.1005507107
    Today, insular Southeast Asia is important for both its remarkably rich biodiversity and globally significant roles in atmospheric and oceanic circulation. Despite the fundamental importance of environmental history for diversity and conservation, there is little primary evidence concerning the nature of vegetation in north equatorial Southeast Asia during the Last Glacial Period (LGP). As a result, even the general distribution of vegetation during the Last Glacial Maximum is debated. Here we show, using the stable carbon isotope composition of ancient cave guano profiles, that there was a substantial forest contraction during the LGP on both peninsular Malaysia and Palawan, while rainforest was maintained in northern Borneo. These results directly support rainforest "refugia" hypotheses and provide evidence that environmental barriers likely reduced genetic mixing between Borneo and Sumatra flora and fauna. Moreover, it sheds light on possible early human dispersal events.
  9. Antimicrobial quaternary ammonium silane K21 promotes wound healing
    Rongo C, Prusty B, Baban B, Daood U, Ilyas MS, Kimmerling K
    J Wound Care, 2024 Mar 01;33(Sup3):S11-S12.
    PMID: 38457304 DOI: 10.12968/jowc.2024.33.Sup3.S11a
  10. Fulltext Reliability, interrelationships, and minimal detectable changes of strength and power metrics among well-trained rugby sevens players
    Washif JA, Hébert-Losier K, Gill N, Zainuddin M, Nasruddin NS, Zakaria AZ, et al.
    Biol Sport, 2024 Jul;41(3):231-241.
    PMID: 38952920 DOI: 10.5114/biolsport.2024.133000
    Despite the importance of strength and power in rugby skills and match outcomes, there exists a noticeable gap in the measurement consistency and estimation of a true change of typical assessments designed to assess these qualities. To address this gap, we investigated the between-session reliability, interrelationships, and minimal detectable changes (MDC) of commonly used strength and power measures in team sports. Sixteen national-level rugby 7 s players were tested on two occasions, one week apart. Both the best and average (of 2-3 trials) peak force, peak power, height, distance, and/or strength indices during countermovement jump (CMJ), drop jump (DJ), isometric mid-thigh pull (IMTP), plyometric push-up (PPU), and standing long jump (SLJ) were obtained. Furthermore, one-repetition maximum (1RM) strength for bench press and back squat, reactive strength index, and dynamic strength index were also determined. Reliability was assessed using intraclass correlation coefficients (ICC) and coefficients of variation (CV), and used for MDC calculations, and interrelationships between variables were determined using correlation coefficients. Reliability was excellent for bench press, back squat, and SLJ (ICCs > 0.91); high to excellent for IMTP peak force, all CMJ, and DJ (except best DJ height and contact time), and PPU peak force parameters (ICCs > 0.78), with < 10% CVs (except PPU peak power). MDCs were generally smaller for average than best values. Large to very large relationships (r = 0.60 to 0.85) were observed between bench press, back squat, and IMTP with selected parameters of CMJ and PPU (p < 0.05), but not in DJ and SLJ. In conclusion, selected measures of strength and power displayed high to excellent reproducibility, with average values (rather than best) offering more stable assessments, and "smaller" MDCs. Based upon the relationships, it can be inferred that maximising strength would likely contribute to enhanced explosive performance.
  11. Fulltext In Silico and In Vitro Analysis of Bacoside A Aglycones and Its Derivatives as the Constituents Responsible for the Cognitive Effects of Bacopa monnieri
    Ramasamy S, Chin SP, Sukumaran SD, Buckle MJ, Kiew LV, Chung LY
    PLoS One, 2015;10(5):e0126565.
    PMID: 25965066 DOI: 10.1371/journal.pone.0126565
    Bacopa monnieri has been used in Ayurvedic medicine to improve memory and cognition. The active constituent responsible for its pharmacological effects is bacoside A, a mixture of dammarane-type triterpenoid saponins containing sugar chains linked to a steroid aglycone skeleton. Triterpenoid saponins have been reported to be transformed in vivo to metabolites that give better biological activity and pharmacokinetic characteristics. Thus, the activities of the parent compounds (bacosides), aglycones (jujubogenin and pseudojujubogenin) and their derivatives (ebelin lactone and bacogenin A1) were compared using a combination of in silico and in vitro screening methods. The compounds were docked into 5-HT1A, 5-HT2A, D1, D2, M1 receptors and acetylcholinesterase (AChE) using AutoDock and their central nervous system (CNS) drug-like properties were determined using Discovery Studio molecular properties and ADMET descriptors. The compounds were screened in vitro using radioligand receptor binding and AChE inhibition assays. In silico studies showed that the parent bacosides were not able to dock into the chosen CNS targets and had poor molecular properties as a CNS drug. In contrast, the aglycones and their derivatives showed better binding affinity and good CNS drug-like properties, were well absorbed through the intestines and had good blood brain barrier (BBB) penetration. Among the compounds tested in vitro, ebelin lactone showed binding affinity towards M1 (Ki = 0.45 μM) and 5-HT2A (4.21 μM) receptors. Bacoside A and bacopaside X (9.06 μM) showed binding affinity towards the D1 receptor. None of the compounds showed any inhibitory activity against AChE. Since the stimulation of M1 and 5-HT2A receptors has been implicated in memory and cognition and ebelin lactone was shown to have the strongest binding energy, highest BBB penetration and binding affinity towards M1 and 5-HT2A receptors, we suggest that B. monnieri constituents may be transformed in vivo to the active form before exerting their pharmacological activity.
  12. Navigating through 65 years of insights: lessons learned on functional abdominal pain in children
    Rajindrajith S, Boey CC, Devanarayana NM, Niriella MA, Thapar N, Benninga MA
    Eur J Pediatr, 2024 Jul 08.
    PMID: 38972964 DOI: 10.1007/s00431-024-05667-4
    In 1958, Apley and Naish authored a groundbreaking paper in Archives of Disease in Childhood, elucidating the epidemiology and risk factors of recurrent abdominal pain in children-a subject that had confounded clinicians of their time. Surprisingly, even after 65 years, there are several unanswered questions regarding the etiology, pathophysiology, and management of pediatric abdominal pain. Contrary to the prevailing notion that children naturally outgrow functional abdominal pain, compelling evidence suggests it's possible these children develop a number of clinically significant psychological issues that could profoundly impact their quality of life and, consequently, future health and educational outcomes. In this light, we aimed to comprehensively review the current literature to update the knowledge of practicing clinicians on functional abdominal pain, summarizing the evidence from the last 65 years.Conclusion: The enduring unanswered questions surrounding childhood abdominal pain continue to challenge clinicians, resulting in unnecessary investigations, thereby contributing to substantial healthcare expenditures. It is also evident that children with long-standing symptoms would progress to adulthood with the potential to develop irritable bowel syndrome and many psychological disturbances. Several key interventions using pharmacological agents, such as amitriptyline, showed that some of these drugs are no more effective than the placebo in clinical trials. Several research during the recent past suggest that psychological interventions such as gut-directed hypnotherapy alleviate symptoms and ensure better prognosis in the long run. Therefore, clinicians and researchers must join hands to explore the pathophysiological mechanisms underpinning functional abdominal pain and novel therapeutic strategies to ensure the well-being of these children. What is Known: • Functional abdominal pain disorders are common among children, with a worldwide prevalence of 13.5% of children suffering from at least one of these disorders • These disorders contribute to a significant reduction in the quality of life of affected children and their families and lead to an array of psychological problems What is New: • The biological basis of functional abdominal pain is becoming more explicit, including complex interactions between altered microbiome, deranged motility, and psychological dysfunction with gut-brain interactions • Novel approaches giving minimal emphasis on pharmacological interventions and exploring psychological interventions are showing promising results.
  13. Fulltext Code-mixing unveiled: Enhancing the hate speech detection in Arabic dialect tweets using machine learning models
    Alhazmi A, Mahmud R, Idris N, Mohamed Abo ME, Eke CI
    PLoS One, 2024;19(7):e0305657.
    PMID: 39018339 DOI: 10.1371/journal.pone.0305657
    Technological developments over the past few decades have changed the way people communicate, with platforms like social media and blogs becoming vital channels for international conversation. Even though hate speech is vigorously suppressed on social media, it is still a concern that needs to be constantly recognized and observed. The Arabic language poses particular difficulties in the detection of hate speech, despite the considerable efforts made in this area for English-language social media content. Arabic calls for particular consideration when it comes to hate speech detection because of its many dialects and linguistic nuances. Another degree of complication is added by the widespread practice of "code-mixing," in which users merge various languages smoothly. Recognizing this research vacuum, the study aims to close it by examining how well machine learning models containing variation features can detect hate speech, especially when it comes to Arabic tweets featuring code-mixing. Therefore, the objective of this study is to assess and compare the effectiveness of different features and machine learning models for hate speech detection on Arabic hate speech and code-mixing hate speech datasets. To achieve the objectives, the methodology used includes data collection, data pre-processing, feature extraction, the construction of classification models, and the evaluation of the constructed classification models. The findings from the analysis revealed that the TF-IDF feature, when employed with the SGD model, attained the highest accuracy, reaching 98.21%. Subsequently, these results were contrasted with outcomes from three existing studies, and the proposed method outperformed them, underscoring the significance of the proposed method. Consequently, our study carries practical implications and serves as a foundational exploration in the realm of automated hate speech detection in text.
  14. Fulltext Combined benefits of fermented washed rice water and NPK mineral fertilizer on plant growth and soil fertility over three field planting cycles
    Nabayi A, Teh CBS, Tan AKZ, Tan NP, Beke D
    Heliyon, 2023 Sep;9(9):e20213.
    PMID: 37809856 DOI: 10.1016/j.heliyon.2023.e20213
    Washed rice water (WRW) is the leftover water after washing rice grains and is usually discarded. However, WRW contains nutrients leached from rice, making it a potential plant fertilizer. Reusing WRW promotes better water governance, particularly in the face of increased freshwater needs due to population expansion and climate change. Recent experiments in rain shelters have demonstrated the advantages of using WRW as fertilizer. Building on this, our study assessed WRW's efficacy in an open field against NPK fertilizer, both individually and in combination. The treatments were: R3 (3-day fermented WRW), N1 (full recommended NPK rate), N0.5R3 (half NPK rate and R3), and CON (tap water only). These treatments were tested over three consecutive planting cycles of choy sum (Brassica chinensis var. parachinensis) vegetable. At the end of each planting cycle, measurements were taken for the plant's growth, nutrient content and uptake, as well as various soil chemical properties and bacterial population. Plants were watered daily with 5 mm WRW (R3 and N0.5R3) or tap water (N1 and CON). N0.5R3 showed the best results in terms of plant growth, nutrient content, uptake, and soil nutrient levels. N0.5R3 supplied the most nutrients, especially N, P, and K. Increased plant growth also led to increased plant uptake of nutrients, including micronutrients. Macronutrients had a greater impact on plant biomass than micronutrients, as R3 and N1 had similar results. R3 soils had higher bacterial populations but were more acidic than N1 soils. The negative effect of NPK on bacteria was partially offset by combining NPK with WRW as N0.5R3. No carryover effects were observed, likely because of the high nutrient leaching from heavy rains. These findings confirm WRW's is an effective fertilizer in open fields, but measures like surface mulching are crucial to minimize nutrient leaching prior to its use.
  15. Fulltext The Noise Exposure Structured Interview (NESI): An Instrument for the Comprehensive Estimation of Lifetime Noise Exposure
    Guest H, Dewey RS, Plack CJ, Couth S, Prendergast G, Bakay W, et al.
    Trends Hear, 2018;22:2331216518803213.
    PMID: 30295145 DOI: 10.1177/2331216518803213
    Lifetime noise exposure is generally quantified by self-report. The accuracy of retrospective self-report is limited by respondent recall but is also bound to be influenced by reporting procedures. Such procedures are of variable quality in current measures of lifetime noise exposure, and off-the-shelf instruments are not readily available. The Noise Exposure Structured Interview (NESI) represents an attempt to draw together some of the stronger elements of existing procedures and to provide solutions to their outstanding limitations. Reporting is not restricted to prespecified exposure activities and instead encompasses all activities that the respondent has experienced as noisy (defined based on sound level estimated from vocal effort). Changing exposure habits over time are reported by dividing the lifespan into discrete periods in which exposure habits were approximately stable, with life milestones used to aid recall. Exposure duration, sound level, and use of hearing protection are reported for each life period separately. Simple-to-follow methods are provided for the estimation of free-field sound level, the sound level emitted by personal listening devices, and the attenuation provided by hearing protective equipment. An energy-based means of combining the resulting data is supplied, along with a primarily energy-based method for incorporating firearm-noise exposure. Finally, the NESI acknowledges the need of some users to tailor the procedures; this flexibility is afforded, and reasonable modifications are described. Competency needs of new users are addressed through detailed interview instructions (including troubleshooting tips) and a demonstration video. Limited evaluation data are available, and future efforts at evaluation are proposed.
  16. Operational nuclear research reactors in the Asia-Pacific with potential for medical radionuclide production
    Tan HY, Wong YH, Kasbollah A, Md Shah MN, Perkins AC, Yeong CH
    Nucl Med Commun, 2023 Apr 01;44(4):227-243.
    PMID: 36808108 DOI: 10.1097/MNM.0000000000001665
    Personalised cancer treatment is of growing importance and can be achieved via targeted radionuclide therapy. Radionuclides with theranostic properties are proving to be clinically effective and are widely used because diagnostic imaging and therapy can be accomplished using a single formulation that avoids additional procedures and unnecessary radiation burden to the patient. For diagnostic imaging, single photon emission computed tomography (SPECT) or positron emission tomography (PET) is used to obtain functional information noninvasively by detecting the gamma (γ) rays emitted from the radionuclide. For therapeutics, high linear energy transfer (LET) radiations such as alpha (α), beta (β - ) or Auger electrons are used to kill cancerous cells in close proximity, whereas sparing the normal tissues surrounding the malignant tumour cells. One of the most important factors that lead to the sustainable development of nuclear medicine is the availability of functional radiopharmaceuticals. Nuclear research reactors play a vital role in the production of medical radionuclides for incorporation into clinical radiopharmaceuticals. The disruption of medical radionuclide supplies in recent years has highlighted the importance of ongoing research reactor operation. This article reviews the current status of operational nuclear research reactors in the Asia-Pacific region that have the potential for medical radionuclide production. It also discusses the different types of nuclear research reactors, their operating power, and the effects of thermal neutron flux in producing desirable radionuclides with high specific activity for clinical applications.
  17. Fulltext Recent advances in the understanding of Xanthomonas citri ssp. citri pathogenesis and citrus canker disease management
    Ference CM, Gochez AM, Behlau F, Wang N, Graham JH, Jones JB
    Mol Plant Pathol, 2018 Jun;19(6):1302-1318.
    PMID: 29105297 DOI: 10.1111/mpp.12638
    Taxonomic status: Bacteria; Phylum Proteobacteria; Class Gammaproteobacteria; Order Xanthomonadales; Family Xanthomonadaceae; Genus Xanthomonas; Species Xanthomonas citri ssp. citri (Xcc). Host range: Compatible hosts vary in their susceptibility to citrus canker (CC), with grapefruit, lime and lemon being the most susceptible, sweet orange being moderately susceptible, and kumquat and calamondin being amongst the least susceptible. Microbiological properties: Xcc is a rod-shaped (1.5-2.0 × 0.5-0.75 µm), Gram-negative, aerobic bacterium with a single polar flagellum. The bacterium forms yellow colonies on culture media as a result of the production of xanthomonadin. Distribution: Present in South America, the British Virgin Islands, Africa, the Middle East, India, Asia and the South Pacific islands. Localized incidence in the USA, Argentina, Brazil, Bolivia, Uruguay, Senegal, Mali, Burkina Faso, Tanzania, Iran, Saudi Arabia, Yemen and Bangladesh. Widespread throughout Paraguay, Comoros, China, Japan, Malaysia and Vietnam. Eradicated from South Africa, Australia and New Zealand. Absent from Europe.
  18. Fulltext Comparative mitogenomics of the Decapoda reveals evolutionary heterogeneity in architecture and composition
    Tan MH, Gan HM, Lee YP, Bracken-Grissom H, Chan TY, Miller AD, et al.
    Sci Rep, 2019 Jul 24;9(1):10756.
    PMID: 31341205 DOI: 10.1038/s41598-019-47145-0
    The emergence of cost-effective and rapid sequencing approaches has resulted in an exponential rise in the number of mitogenomes on public databases in recent years, providing greater opportunity for undertaking large-scale comparative genomic and systematic research. Nonetheless, current datasets predominately come from small and disconnected studies on a limited number of related species, introducing sampling biases and impeding research of broad taxonomic relevance. This study contributes 21 crustacean mitogenomes from several under-represented decapod infraorders including Polychelida and Stenopodidea, which are used in combination with 225 mitogenomes available on NCBI to investigate decapod mitogenome diversity and phylogeny. An overview of mitochondrial gene orders (MGOs) reveals a high level of genomic variability within the Decapoda, with a large number of MGOs deviating from the ancestral arthropod ground pattern and unevenly distributed among infraorders. Despite the substantial morphological and ecological variation among decapods, there was limited evidence for correlations between gene rearrangement events and species ecology or lineage specific nucleotide substitution rates. Within a phylogenetic context, predicted scenarios of rearrangements show some MGOs to be informative synapomorphies for some taxonomic groups providing strong independent support for phylogenetic relationships. Additional comparisons for a range of mitogenomic features including nucleotide composition, strand asymmetry, unassigned regions and codon usage indicate several clade-specific trends that are of evolutionary and ecological interest.
  19. Fulltext Coming of age, becoming obese: a cross-sectional analysis of obesity among adolescents and young adults in Malaysia
    Pell C, Allotey P, Evans N, Hardon A, Imelda JD, Soyiri I, et al.
    BMC Public Health, 2016 10 13;16(1):1082.
    PMID: 27737680
    BACKGROUND: Malaysians have become increasingly obese over recent years. The transition from adolescence to early adulthood is recognized as critical for the development of eating and activity habits. However, little obesity-related research focuses on this life stage. Drawing on data from a health and demographic surveillance site in Malaysia, this article describes obesity and overweight amongst adolescents and young adults in a multi-ethnic population.

    METHODS: Data were collected at the South East Asia Community Observatory (SEACO) in Segamat District, Johor. In this dynamic cohort of approximately 40,000 people, 5,475 were aged 16-35 in 2013-2014. The population consists of Malay, Chinese, Indian and Indigenous (Orang Asli) families in proportions that reflect the national ethnic diversity. Data were collected through health profiles (Body Mass Index [BMI] measurements in homes) and self-report questionnaires.

    RESULTS: Age and ethnicity were associated with overweight (BMI 25.0-29.9Kg/m2) and obesity (BMI ≥ 30Kg/m2). The prevalence of overweight was 12.8 % at ages 16-20 and 28.4 % at ages 31-35; obesity was 7.9 % and 20.9 % at the same age groups. The main ethnic groups also showed varied patterns of obesity and overweight at the different age groups with Chinese at lowest and Orang Asli at highest risk. Level of education, employment status, physical activity and frequency of eating out were poorly predictive of overweight and obesity.

    CONCLUSION: The pattern of overweight and obesity in the 16-35 age group further highlights this as a significant period for changes in health-related behaviours. Further longitudinal research is however needed to confirm the observed pattern and investigate causal factors.
  20. Fulltext High time for an intervention accelerator to prevent abuse of older people
    Mikton C, Beaulieu M, Burnes D, Choo WY, Herbst JH, Pillemer K, et al.
    Nat Aging, 2022 Nov;2(11):973-975.
    PMID: 37118090 DOI: 10.1038/s43587-022-00301-0
    Currently, there are no evidence-based interventions to prevent and respond to abuse of older people. We propose to create, within the Decade of Healthy Ageing 2021–2030, an intervention accelerator to speed up the development of effective interventions for abuse of older people in community and institutional settings within low-, middle- and high-income countries.
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