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Fulltext Sustainable risk management practice in the organization: a Malaysian case study

Zainuddin SA, Abdullah B, Nasir NAM, Abdullah T, Nawi NC, Patwary AK, et al.

Environ Sci Pollut Res Int, 2023 Feb;30(9):24708-24717.
PMID: 36344894 DOI: 10.1007/s11356-022-23897-7

Businesses are becoming more conscious of operational risk management practices due to the COVID-19 pandemic. However, some firms practice risk management without fully comprehending how it might help them and their needs. As a result, companies that practice risk management without realizing it are being controlled by the discipline itself. The goal of this study is to look into the epistemic process of risk management practice in the workplace. This phenomenological study interviewed 39 risk management officers, executives, and employees. Data are thematically analyzed. This study discovered five epistemic processes of risk mapping using Foucault's governmentality paradigm. This phenomenological study, interestingly, revealed the black box of risk management practices, as well as the behavior of risk management officers, executives, and risk owners who preferred to monitor the compliance aspects of risk management practices rather than comprehend the capabilities of risk management that could be used within their strategic planning process. Unaware of this black box, organizational actors were blanketed by the organization's culture of fear, which created the impression that the authority was always watching every word said and every action taken. Practically, this study contributes an improved understanding of the real function of risk management that helps them justify the practice and reduce unnecessary fear. The paper concludes with limitations and research recommendations.

Matched MeSH terms: Humans
Fulltext Exploring the perceptions of Malaysian Gen Z towards the impact of COVID-19 on sustainable development

Homer ST, Khor KS

Environ Sci Pollut Res Int, 2022 Dec;29(57):85700-85716.
PMID: 34826070 DOI: 10.1007/s11356-021-17763-1

COVID-19 has affected the pursuit of sustainable development in multifaceted ways; this study investigates Malaysian Gen Z perceptions of the COVID-19 pandemics' disruptions to sustainable development. The exploratory research began with brainstorming from Malaysian Gen Z individuals with the following excerpt, 'The COVID-19 pandemic has disrupted the world and led to unprecedented change. How do you believe this has impacted either positively or negatively, the global pursuit of sustainable development?' Ninety-eight unique statements were generated with subsequent participants sorting these statements into thematic groups before rating each of them on impact and duration. Subsequently, multi-dimensional scaling and cluster analysis was performed with eight-cluster solution being proposed. This study suggests that the pandemic has contributed both positively and negatively to sustainable development, while also highlighting the duration of these impacts. This community-based participatory research provides a guide for policy to mitigate negative impacts whilst also attempting to fully realise the positive impacts in response to managing the unprecedented effects of the pandemic.

Matched MeSH terms: Humans
Fulltext Disease Progression of WHIM Syndrome in an International Cohort of 66 Pediatric and Adult Patients

Geier CB, Ellison M, Cruz R, Pawar S, Leiss-Piller A, Zmajkovicova K, et al.

J Clin Immunol, 2022 Nov;42(8):1748-1765.
PMID: 35947323 DOI: 10.1007/s10875-022-01312-7

Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome (WS) is a combined immunodeficiency caused by gain-of-function mutations in the C-X-C chemokine receptor type 4 (CXCR4) gene. We characterize a unique international cohort of 66 patients, including 57 (86%) cases previously unreported, with variable clinical phenotypes. Of 17 distinct CXCR4 genetic variants within our cohort, 11 were novel pathogenic variants affecting 15 individuals (23%). All variants affect the same CXCR4 region and impair CXCR4 internalization resulting in hyperactive signaling. The median age of diagnosis in our cohort (5.5 years) indicates WHIM syndrome can commonly present in childhood, although some patients are not diagnosed until adulthood. The prevalence and mean age of recognition and/or onset of clinical manifestations within our cohort were infections 88%/1.6 years, neutropenia 98%/3.8 years, lymphopenia 88%/5.0 years, and warts 40%/12.1 years. However, we report greater prevalence and variety of autoimmune complications of WHIM syndrome (21.2%) than reported previously. Patients with versus without family history of WHIM syndrome were diagnosed earlier (22%, average age 1.3 years versus 78%, average age 5 years, respectively). Patients with a family history of WHIM syndrome also received earlier treatment, experienced less hospitalization, and had less end-organ damage. This observation reinforces previous reports that early treatment for WHIM syndrome improves outcomes. Only one patient died; death was attributed to complications of hematopoietic stem cell transplantation. The variable expressivity of WHIM syndrome in pediatric patients delays their diagnosis and therapy. Early-onset bacterial infections with severe neutropenia and/or lymphopenia should prompt genetic testing for WHIM syndrome, even in the absence of warts.

Matched MeSH terms: Humans
A survey of COVID-19 vaccine acceptance across 23 countries in 2022

Lazarus JV, Wyka K, White TM, Picchio CA, Gostin LO, Larson HJ, et al.

Nat Med, 2023 Feb;29(2):366-375.
PMID: 36624316 DOI: 10.1038/s41591-022-02185-4

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continued to mutate and spread in 2022 despite the introduction of safe, effective vaccines and medications. Vaccine hesitancy remains substantial, fueled in part by misinformation. Our third study of Coronavirus Disease 2019 (COVID-19) vaccine hesitancy among 23,000 respondents in 23 countries (Brazil, Canada, China, Ecuador, France, Germany, Ghana, India, Italy, Kenya, Mexico, Nigeria, Peru, Poland, Russia, Singapore, South Africa, South Korea, Spain, Sweden, Turkey, the United Kingdom and the United States), surveyed from 29 June to 10 July 2022, found willingness to accept vaccination at 79.1%, up 5.2% from June 2021. Hesitancy increased in eight countries, however, ranging from 1.0% (United Kingdom) to 21.1% (South Africa). Almost one in eight (12.1%) vaccinated respondents are hesitant about booster doses. Overall support for vaccinating children under 18 years of age increased slightly but declined among parents who were personally hesitant. Almost two in five (38.6%) respondents reported paying less attention to new COVID-19 information than previously, and support for vaccination mandates decreased. Almost a quarter (24%) of those who became ill reported taking medications to combat COVID-19 symptoms. Vaccination remains a cornerstone of the COVID-19 pandemic response, but broad public support remains elusive. These data can be used by health system decisionmakers, practitioners, advocates and researchers to address COVID-19 vaccine hesitancy more effectively.

Matched MeSH terms: Humans
Fulltext Bilateral isolated mylohyoid groove fracture progressing as submandibular abscess: an usual fracture pattern of mandible

Rajaran JR, Nazimi AJ

BMJ Case Rep, 2021 Mar 17;14(3).
PMID: 33731407 DOI: 10.1136/bcr-2020-239542

The mylohyoid ridges or lines are pairs of anatomical bony structures located on the internal or lingual surface of mandible. They are the origin for the mylohyoid muscle. These bony structures are distinct in the mandibular molar region, well protected and gradually become undiscernible towards anterior mandible. Bilateral, isolated fracture of the mylohyoid ridges without concomitant mandibular fracture is rare and, to the best of the authors knowledge, was never previously described. This case report describes an isolated bilateral mylohyoid groove fracture, where one side of a necrotic bone fragment at the fracture site progress to became a nidus of infection, which later caused submandibular space abscess requiring emergency surgical intervention. Diagnosis, possible theory to explain the occurrence of isolated mylohyoid groove fracture and management of these condition are explained in this report.

Matched MeSH terms: Humans
Visible-light-driven photocatalytic dual-layer hollow fibre membrane ameliorates the changes of bisphenol A exposure in gastrointestinal tract

Kamaludin R, Othman MHD, Kadir SHSA, Khan J, Ismail AF, Rahman MA, et al.

Environ Sci Pollut Res Int, 2023 Jan;30(1):259-273.
PMID: 35902521 DOI: 10.1007/s11356-022-22121-w

Various treatments of choice are available to overcome contamination of bisphenol A (BPA) in the environment including membrane technologies; however, the treatment still releases contaminants that threaten the human being. Therefore, the present study is conducted to investigate the degradation of BPA by recently developed visible-light-driven photocatalytic nitrogen-doping titanium dioxide (N-doped TiO2) dual-layer hollow fibre (DLHF) membrane and its efficiency in reducing the level of BPA in contaminated water. Fabricated with suitable polymer/photocatalyst (15/7.5 wt.%) via co-extrusion spinning method, the DLHF was characterized morphologically, evaluated for BPA degradation by using submerged photocatalytic membrane reactor under visible light irradiations followed by the investigation of intermediates formed. BPA exposure effects were accessed by immunohistochemistry staining of gastrointestinal sample obtained from animal model. BPA has been successfully degraded up to 72.5% with 2 intermediate products, B1 and B2, being identified followed by total degradation of BPA. BPA exposure leads to the high-intensity IHC staining of Claudin family which indicated the disruption of small intestinal barrier (SIB) integrity. Low IHC staining intensity of Claudin family in treated BPA group demonstrated that reducing the level of BPA by N-doped TiO2 DLHF is capable of protecting the important component of SIB. Altogether, the fabricated photocatalytic DLHF membrane is expected to have an outstanding potential in removing BPA and its health effect for household water treatment to fulfil the public focus on the safety of their household water and their need to consume clean water.

Matched MeSH terms: Humans
An eco-environmental efficiency analysis of Malaysia sewage treatment plants: an incorporated window-based data envelopment analysis and ordinary least square regression

Fallahiarezoudar E, Ahmadipourroudposht M, Yakideh K, Ngadiman NA

Environ Sci Pollut Res Int, 2022 May;29(25):38285-38302.
PMID: 35075563 DOI: 10.1007/s11356-022-18742-w

Most human activities that use water produced sewage. As urbanization grows, the overall demand for water grows. Correspondingly, the amount of produced sewage and pollution-induced water shortage is continuously increasing worldwide. Ensuring there are sufficient and safe water supplies for everyone is becoming increasingly challenging. Sewage treatment is an essential prerequisite for water reclamation and reuse. Sewage treatment plants' (STPs) performance in terms of economic and environmental perspective is known as a critical indicator for this purpose. Here, the window-based data envelopment analysis model was applied to dynamically assess the relative annual efficiency of STPs under different window widths. A total of five STPs across Malaysia were analyzed during 2015-2019. The labor cost, utility cost, operation cost, chemical consumption cost, and removal rate of pollution, as well as greenhouse gases' (GHGs) emissions, all were integrated to interpret the eco-environmental efficiency. Moreover, the ordinary least square as a supplementary method was used to regress the efficiency drivers. The results indicated the particular window width significantly affects the average of overall efficiencies; however, it shows no influence on the ranking of STP efficiency. The labor cost was determined as the most influential parameter, involving almost 40% of the total cost incurred. Hence, higher efficiency was observed with the larger-scale plants. Meanwhile, the statistical regression analysis illustrates the significance of plant scale, inflow cBOD concentrations, and inflow total phosphorus concentrations at [Formula: see text] on the performance. Lastly, some applicable techniques were suggested in terms of GHG emission mitigation.

Matched MeSH terms: Humans
The global research trend on microbially induced carbonate precipitation during 2001-2021: a bibliometric review

Omoregie AI, Muda K, Ojuri OO, Hong CY, Pauzi FM, Ali NSBA

Environ Sci Pollut Res Int, 2022 Dec;29(60):89899-89922.
PMID: 36369439 DOI: 10.1007/s11356-022-24046-w

Microbially induced carbonate precipitation (MICP) is a remarkable method that creates sustainable cementitious binding material for use in geotechnical/structural engineering and environmental engineering. This is due to the increasing demand for alternative environmentally friendly technologies and materials that result in minimal or zero carbon footprint. In contrast to the previously published literature, through bibliometric analysis, this review paper focuses on the current prospects and future research trends of MICP technology via the Scopus database and VOSviewer analysis. The objective of the study was to determine the annual publications and citations trend, most contributing countries, the leading journals, prolific authors, productive institutions, funding sponsors, trending author keywords, and research directions of MICP. There were a total of 1058 articles published from 2001 to 2021 on MICP. The result demonstrated that the volume of publications is increasing. China, Construction and Building Materials, Satoru Kawasaki, Nanyang Technological University, and the National Natural Science Foundation of China are the leading country, journal, author, institution, and funding sponsor in terms of total publications. Through the co-occurrence analysis of the author keywords, MICP was revealed to be the most frequently used author keyword with 121 occurrences, a total link strength of 213, and 152 links to other author keywords. Furthermore, co-occurrence analysis of text data revealed that researchers are concentrating on four important research areas: precipitation, MICP, compressive strength, and biomineralization. This review can provide information to researchers that can lead to novel ideas and research collaboration or engagement on MICP technology.

Matched MeSH terms: Humans
Fulltext Fresh evidence on connectedness between prominent markets during COVID-19 pandemic

Younis I, Hkiri B, Shah WU, Qureshi F, Ilyas M, Longsheng C

Environ Sci Pollut Res Int, 2023 Feb;30(9):22430-22457.
PMID: 36287363 DOI: 10.1007/s11356-022-23408-8

Various empirical studies have examined the nexus between financial markets, but this study focused on the comovement among prominent markets. Our study examines the interrelationship among main financial markets, i.e., stock, oil, and commodity during the recent pandemic. The interconnections among the selected markets are investigated using a battery of wavelet coherence tools and the Granger causality test. From the wavelet coherence analysis, our findings indicate strong co-movements among the VIX, oil volatility, and commodity prices during pandemic and localized in all scales and over the sample period. The dependency strength among the considered economies is noted to increase in pandemic, which implies increased short- and long-term benefits for the investors. Moreover, Our result exhibits a feedback causality between OVIX and crude oil, VIX and S&P 500, and gasoline and VIX. Interestingly, a unidirectional causality exists between VIX and crude oil, S&P 500 and crude oil, Brent and crude oil, gasoline, crude oil, and VIX and OVIX. We advocate that the findings will be helpful for portfolio managers, investors, and officials around the world.

Matched MeSH terms: Humans
Economic and environmental life cycle perspectives on two engineered wood products: comparison of LVL and GLT construction materials

Balasbaneh AT, Sher W, Yeoh D, Yasin MN

Environ Sci Pollut Res Int, 2023 Feb;30(10):26964-26981.
PMID: 36374387 DOI: 10.1007/s11356-022-24079-1

The embodied carbon of building materials and the energy consumed during construction have a significant impact on the environmental credentials of buildings. The structural systems of a building present opportunities to reduce environmental emissions and energy. In this regard, mass timber materials have considerable potential as sustainable materials over other alternatives such as steel and concrete. The aim of this investigation was to compare the environment impact, energy consumption, and life cycle cost (LCC) of different wood-based materials in identical single-story residential buildings. The materials compared are laminated veneer lumber (LVL) and glued laminated timber (GLT). GLT has less global warming potential (GWP), ozone layer depletion (OLD), and land use (LU), respectively, by 29%, 37%, and 35% than LVL. Conversely, LVL generally has lower terrestrial acidification potential (TAP), human toxicity potential (HTP), and fossil depletion potential (FDP), respectively, by 30%, 17%, and 27%. The comparative outcomes revealed that using LVL reduces embodied energy by 41%. To identify which of these materials is the best alternative, various environmental categories, embodied energy, and cost criteria require further analysis. Therefore, the multi-criteria decision-making (MCDM) method has been applied to enable robust decision-making. The outcome showed that LVL manufacturing using softwood presents the most sustainable choice. These research findings contribute to the body of knowledge about the use of mass timber in construction.

Matched MeSH terms: Humans
Fulltext Targeting natural products against SARS-CoV-2

Al-Harrasi A, Behl T, Upadhyay T, Chigurupati S, Bhatt S, Sehgal A, et al.

Environ Sci Pollut Res Int, 2022 Jun;29(28):42404-42432.
PMID: 35362883 DOI: 10.1007/s11356-022-19770-2

The human coronavirus disease (COVID-19) pandemic is caused by a novel coronavirus; the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). Natural products, secondary metabolites show positive leads with antiviral and immunotherapy treatments using genomic studies in silico docking. In addition, it includes the action of a mechanism targeting the SARS-CoV-2. In this literature, we aimed to evaluate the antiviral movement of the NT-VRL-1 unique terpene definition to Human coronavirus (HCoV-229E). The effects of 19 hydrolysable tannins on the SARS-CoV-2 were therefore theoretically reviewed and analyzed utilising the molecular operating surroundings for their C-Like protease 3CLpro catalytic dyad residues Angiotensin converting enzyme-2 (MOE 09). Pedunculagin, tercatan, and castalin were detected as interacting strongly with SARS-receptor Cov-2's binding site and catalytic dyad (Cys145 and His41). SARS-CoV-2 methods of subunit S1 (ACE2) inhibit the interaction of the receiver with the s-protein once a drug molecule is coupled to the s-protein and prevent it from infecting the target cells in alkaloids. Our review strongly demonstrates the evidence that natural compounds and their derivatives can be used against the human coronavirus and serves as an area of research for future perspective.

Matched MeSH terms: Humans
Fulltext Resolving sex and gender bias in COVID-19 vaccines R&D and beyond

Vijayasingham L, Heidari S, Munro J, Omer S, MacDonald N

Hum Vaccin Immunother, 2022 Dec 31;18(1):2035142.
PMID: 35143380 DOI: 10.1080/21645515.2022.2035142

The influence of sex and gender in immune response and vaccine outcomes is established in many disease areas, including in COVID-19. Yet, there are notable gaps in the consideration of sex and gender in the analysis and reporting of COVID-19 vaccines clinical trial data. The push for stronger sex and gender integration in vaccines science should be championed by all researchers and stakeholders across the R&D and access ecosystem - not just gender experts. This requires joint action on the tactical framing of customized value propositions (based on stakeholder motivations), the stronger enforcement of existing regulation, tools, and commitments, and aligning the overall agenda to parallel calls on intersectionality, equity diversity and inclusion.

Matched MeSH terms: Humans
ISOLATION AND CHARACTERIZATION OF BACTERIOPHAGE WITH LYTIC ACTIVITY AGAINST CARBAPENEM RESISTANCE STRAIN OF KLEBSIELLA PNEUMONIA

Baqer AA, Nor NSM, Alagely HS, Musa M, Adnan NA

Pol Merkur Lekarski, 2023;51(1):35-41.
PMID: 36960898 DOI: 10.36740/Merkur202301105

OBJECTIVE: Aim: Klebsiella pneumonia has emerged as an increasingly important cause of community-acquired nosocomial infections and many of these strains are highly virulent and exhibit a strong propensity to spread. Infections cause by K. pneumonia produces carbapen¬emase (KPC) enzyme and can be difficult to treat since only a few antibiotics are effective against them. Bacteriophage targeting this strain can be an alternative treatment. Characterisation of bacteriophage is utmost important in assisting the application of bacteriophage in phage therapy.
PATIENTS AND METHODS: Materials and methods: In the present study, the lytic bacteriophage, k3w7, isolated by the host Klebsiella pneumoniae kP2 was characterised using transmission electron microscope (TEM), plaque assay, and restriction digestive enzyme to investigate mor¬phology, host spectrum, bacteriophage life cycle and stability accordingly.
RESULTS: Results and conclusions: As shown by TEM, k3w7 was observed to have the characteristic of icosahedral heads 100 nm and contractile sheaths 120 nm suggesting it belongs to the family of myoviridae.The Investigation has done on the phage growth cycle showed a short latent period of 20 min and a burst size of approximately 220 plaque forming units per infected cell. Stability test showed the phage was stable over a wide range of pH and temperatures. According to restriction analysis, k3w7 had 50 -kb double-stranded DNA genome as well as the heterogeneous nature of genetic material. These findings suggest that K3W7 has a potential use in therapy against infections caused by K. pneumonia produces carbapenemase.

Matched MeSH terms: Humans
Multilevel Pharmacological Effects of Antipsychotics in Potential Glioblastoma Treatment

Awuah WA, Kalmanovich J, Mehta A, Huang H, Abdul-Rahman T, Cheng Ng J, et al.

Curr Top Med Chem, 2023;23(5):389-402.
PMID: 36593538 DOI: 10.2174/1568026623666230102095836

Glioblastoma Multiforme (GBM) is a debilitating type of brain cancer with a high mortality rate. Despite current treatment options such as surgery, radiotherapy, and the use of temozolomide and bevacizumab, it is considered incurable. Various methods, such as drug repositioning, have been used to increase the number of available treatments. Drug repositioning is the use of FDA-approved drugs to treat other diseases. This is possible because the drugs used for this purpose have polypharmacological effects. This means that these medications can bind to multiple targets, resulting in multiple mechanisms of action. Antipsychotics are one type of drug used to treat GBM. Antipsychotics are a broad class of drugs that can be further subdivided into typical and atypical classes. Typical antipsychotics include chlorpromazine, trifluoperazine, and pimozide. This class of antipsychotics was developed early on and primarily works on dopamine D2 receptors, though it can also work on others. Olanzapine and Quetiapine are examples of atypical antipsychotics, a category that was created later. These medications have a high affinity for serotonin receptors such as 5- HT2, but they can also act on dopamine and H1 receptors. Antipsychotic medications, in the case of GBM, also have other effects that can affect multiple pathways due to their polypharmacological effects. These include NF-B suppression, cyclin deregulation, and -catenin phosphorylation, among others. This review will delve deeper into the polypharmacological, the multiple effects of antipsychotics in the treatment of GBM, and an outlook for the field's future progression.

Matched MeSH terms: Humans
Fulltext A high-quality chromosome-level genome assembly of rohu carp, Labeo rohita, and its utilization in SNP-based exploration of gene flow and sex determination

Arick MA, Grover CE, Hsu CY, Magbanua Z, Pechanova O, Miller ER, et al.

G3 (Bethesda), 2023 Mar 09;13(3).
PMID: 36639248 DOI: 10.1093/g3journal/jkad009

Labeo rohita (rohu) is a carp important to aquaculture in South Asia, with a production volume close to Atlantic salmon. While genetic improvements to rohu are ongoing, the genomic methods commonly used in other aquaculture improvement programs have historically been precluded in rohu, partially due to the lack of a high-quality reference genome. Here we present a high-quality de novo genome produced using a combination of next-generation sequencing technologies, resulting in a 946 Mb genome consisting of 25 chromosomes and 2,844 unplaced scaffolds. Notably, while approximately half the size of the existing genome sequence, our genome represents 97.9% of the genome size newly estimated here using flow cytometry. Sequencing from 120 individuals was used in conjunction with this genome to predict the population structure, diversity, and divergence in three major rivers (Jamuna, Padma, and Halda), in addition to infer a likely sex determination mechism in rohu. These results demonstrate the utility of the new rohu genome in modernizing some aspects of rohu genetic improvement programs.

Matched MeSH terms: Humans
A walk of corporate sustainability towards sustainable development: a bibliometric analysis of literature from 2005 to 2021

Jan AA, Lai FW, Siddique J, Zahid M, Ali SEA

Environ Sci Pollut Res Int, 2023 Mar;30(13):36521-36532.
PMID: 36547839 DOI: 10.1007/s11356-022-24842-4

Recent years have seen a burgeoning interest in the involvement of corporate sustainability (CS) in sustainable development (SD), yet both concepts are fewer and newer in the academic field. This study aims to present a thorough bibliometric analysis that provides fresh new insights on the subject. Using VOSviewer software, this study analyzed and visualized 1214 documents for the period 2005-2021 in the Web of Science (WoS) database. The findings of the study indicate that the co-theme CS and SD are lasting but thriving research subjects. The findings also revealed that authors from the USA published the highest number of articles followed by the UK, Spain, Italy, and Germany. The co-authorship network showed strong links between these countries. Three main clusters are identified based on research titles frequently co-cited and have significant co-citation connections. In general, this study provides valuable insight into the current status and future trends for research on SDGs. The outcome of the study could be useful to policymakers, regulators, sustainability practitioners, and researchers in understanding the key research areas, influential authors, institutions, and countries actively involved in the field. Considering the involvement of corporate sustainability in sustainable development is a useful and informative endeavor for all community actors. To the best of the authors' knowledge, this is the first comprehensive study that presents the holistic picture of CS and SD-related research to identify the knowledge map between the two subjects.

Matched MeSH terms: Humans
Viral modulation of lipid rafts and their potential as putative antiviral targets

Gee YJ, Sea YL, Lal SK

Rev Med Virol, 2023 Mar;33(2):e2413.
PMID: 36504273 DOI: 10.1002/rmv.2413

Lipid rafts are ubiquitous in cells. They are identified as cholesterol and glycosphingolipid enriched microdomains on cellular membranes. They serve as platforms for cellular communications by functioning in signal transduction and membrane trafficking. Such structural organisation fulfils cellular needs for normal function, but at the same time increases vulnerability of cells to pathogen invasion. Viruses rely heavily on lipid rafts in basically every stage of the viral life cycle for successful infection. Various mechanisms of lipid rafts modification exploited by diverse viruses for attachment, internalisation, membrane fusion, genome replication, assembly and release have been brought to light. This review focuses on virus-raft interactions and how a wide range of viruses manipulate lipid rafts at distinct stages of infection. The importance of virus-raft interactions in viral infections has inspired researchers to discover and develop antivirals that target this interaction, such as statins, methyl-β-cyclodextrin, viperin, 25-hydroxycholesterol and even anti-malarial drugs. The therapeutic modulations of lipid rafts as potential antiviral intervention from in vitro and in vivo evidence are discussed herein.

Matched MeSH terms: Humans
Fulltext Blended learning in physical education: A systematic review

Wang C, Omar Dev RD, Soh KG, Mohd Nasirudddin NJ, Yuan Y, Ji X

Front Public Health, 2023;11:1073423.
PMID: 36969628 DOI: 10.3389/fpubh.2023.1073423

This review aims to provide a detailed overview of the current status and development trends of blended learning in physical education by reviewing journal articles from the Web of Science (WOS) database. Several dimensions of blended learning were observed, including research trends, participants, online learning tools, theoretical frameworks, evaluation methods, application domains, Research Topics, and challenges. Following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), a total of 22 journal articles were included in the current review. The findings of this review reveal that the number of blended learning articles in physical education has increased since 2018, proving that the incorporation of online learning tools into physical education courses has grown in popularity. From the reviewed journal articles, most attention is given to undergraduates, emphasizing that attention in the future should be placed on K-12 students, teachers, and educational institutions. The theoretical framework applied by journal articles is also limited to a few articles and the assessment method is relatively homogeneous, consisting mostly of questionnaires. This review also discovers the trends in blended learning in physical education as most of the studies focus on the topic centered on dynamic physical education. In terms of Research Topics, most journal articles focus on perceptions, learning outcomes, satisfaction, and motivation, which are preliminary aspects of blended learning research. Although the benefits of blended learning are evident, this review identifies five challenges of blended learning: instructional design challenges, technological literacy and competency challenges, self-regulation challenges, alienation and isolation challenges, and belief challenges. Finally, a number of recommendations for future research are presented.

Matched MeSH terms: Humans
Reducing environmental pollution by organisational citizenship behaviour in hospitality industry: the role of green employee involvement, performance management and dynamic capability

Patwary AK, Sharif A, Aziz RC, Hassan MGB, Najmi A, Rahman MK

Environ Sci Pollut Res Int, 2023 Mar;30(13):37105-37117.
PMID: 36567391 DOI: 10.1007/s11356-022-24710-1

Being a prominent tourist destination, the hotel industry's demand in Malaysia has been increasing day by day. There is still a shortage of studies focusing on how hotels can make environmental management routine work, take environmental laws seriously and be more responsive to the environment. This study focused on the connections between green employee involvement, green performance management and green dynamic capability in implementing environmental law in the hospitality industry. The study also evaluates the mediating role of implementing environmental law between green employee involvement, green performance management, green dynamic capability and organisational citizenship behaviour to reduce pollution. This study employed a quantitative approach to test the hypotheses and a convenient sampling method to collect the data from hotel employees. Out of 600 distributed questionnaires, useable responses were 253 to proceed with data analysis. Data were analysed through structural equation modelling (SEM) using the Smart-PLS and SPSS. The relationship between green employee involvement, green performance management, green dynamic capability and implementation of environmental laws was discovered and considered unique in the hotel industry in Malaysia. The study further established the mediating role of environmental law between independent and dependent variables.

Matched MeSH terms: Humans
Badminton-related eye injuries: a systematic review

Hoskin AK, Watson S, Kamalden TA

Inj Prev, 2023 Apr;29(2):116-120.
PMID: 36564168 DOI: 10.1136/ip-2022-044564

OBJECTIVES: To report the nature of badminton-related eye injuries in the published literature.
METHODS: A review of the literature with key word and MeSH terms: 'Eye injury', 'Ocular trauma', 'Badminton' 'Shuttlecock' using CENTRAL, MEDLINE, EMBASE and Informit Health Collection databases. Papers were reviewed to assess the circumstances of the injury, patient demographics and clinical data.
RESULTS: 19 studies from 1974 to 2020 from 12 countries reported 378 monocular badminton-related eye injuries from 378 patients with a male-to-female ratio of 2.5:1. A closed globe injury was sustained in 97% of eyes and a shuttlecock responsible for 85% of injuries. Doubles play, the shuttlecock and a lack of eye protection were associated with eye injury.
CONCLUSION: Vision impairment was associated with the majority of badminton-related eye injuries, and doubles play, the shuttlecock and a lack of eye protection were risk factors.

Matched MeSH terms: Humans

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