Displaying publications 41 - 60 of 5427 in total

Abstract:
Sort:
  1. Fulltext Hematological and serum biochemical parameters of rescued Sunda pangolins (Manis javanica) in Singapore
    Ahmad AA, Samsuddin S, Oh SJWY, Martinez-Perez P, Rasedee A
    J Vet Med Sci, 2018 Dec 11;80(12):1867-1874.
    PMID: 30333379 DOI: 10.1292/jvms.17-0585
    The Sunda pangolin (Manis javanica) population in Southeast Asia faces threats such as poaching and deforestation. Health assessments of rescued individuals including physical examination and blood work are crucial for clinicians to determine the health status of these animals. The establishments of reference intervals of hematology and serum biochemistry are important for identifying clinical abnormalities. The objectives of our study were to establish blood reference intervals for Sunda pangolins, to determine if there are age and sex related differences in hematology and serum biochemistry, and to compare our results with those of a previous study on confiscated Sunda pangolins in Thailand. Fifty-eight Sunda pangolins were rescued between January 2011 and December 2015. The hematology and serum biochemistry results of 51 clinically normal Sunda pangolins were selected for the establishment of the blood reference intervals. No sex related differences were noted in this study. Age-related differences were observed, in which adult Sunda pangolins had a significantly higher mean corpuscular volume than juveniles, and juvenile Sunda pangolins had significantly higher red blood cell counts and hemoglobin levels than those of the adults (P<0.05). Age-related differences were also noted in several serum biochemistry parameters: alkaline phosphatase (ALP) was significantly higher in juveniles, and total protein was significantly higher in adult Sunda pangolins. Compared to a previous study the white blood cell counts, neutrophil counts, and ALP were higher, and the lymphocyte counts were lower in the present study.
    Matched MeSH terms: Aging/blood; Animals, Wild/blood; Xenarthra/blood*
  2. Fulltext Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) Activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian Individuals
    Yusof F, Mehde AA, Mehdi WA, Raus RA, Ghazali H, Rahman AA
    Biomed Environ Sci, 2015 Sep;28(9):660-5.
    PMID: 26464253 DOI: 10.3967/bes2015.092
    OBJECTIVE: Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this study was to examine a possible relationship between DNase I/II activity and E3 SUMO-protein ligase NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for evaluating kidney damage.
    METHODS: Sixty nephrolithiasis patients and 50 control patients were enrolled in a case-control study. Their blood urea, creatinine, protein levels and DNase I/II activity levels were measured by spectrometry. Serum NSMCE2 levels were measured by ELISA. Blood was collected from patients of the government health clinics in Kuantan-Pahang and fulfilled the inclusion criteria.
    RESULTS: The result indicated that mean levels of sera NSMCE2 have a significantly increase (P<0.01) in patients compared to control group. Compared with control subjects, activities and specific activities of serum DNase I and II were significantly elevated in nephrolithiasis patients (P$lt;0.01).
    CONCLUSION: This study suggests that an increase in serum concentrations of DNase I/II and E3 SUMO-protein ligase NSE2 level can be used as indicators for the diagnosis of kidney injury in patients with nephrolithiasis.
    Matched MeSH terms: Blood Proteins/analysis; Creatinine/blood; Deoxyribonuclease I/blood*; Endodeoxyribonucleases/blood*; Ligases/blood*; Urea/blood; Nephrolithiasis/blood
  3. Partition of potassium and calcium stored in blood
    Lee TS
    Journal of the Malaya Branch of the British Medical Association, 1940;4:295-303.
    The rates of rise of the plasma potassium concentrations are not affected by the nature ot the preservative solutions although the solutions influence in a marked degree the rates of haemolysis. The rise in the plasma potassium luvel exhibits two phases. It rises very rapidly for the first ten days of storage, increasing to 12 times the initial concentration in that brief period, after which the change is by comparison much slower. Variation in storage temperature has a greater effect relatively on the increase in the extra-cellular potassium concentration than daily shaking. The plasma calcium level falls by about 25 per cent of the original quantity and then begins to rise when the blood starts to haemolyse. It is suggested that it is the ionised calcium that is affected in this phenomenon. Storage at 38 degree Celcius hastens this fall and rise and so also does the effect of daily shaking.
    Matched MeSH terms: Blood
  4. Serum protein in beri-beri
    Rosedale JL
    Malayan Medical Journal, 1929;4:152.
    Matched MeSH terms: Blood Proteins
  5. Aspects of obstetrical defibrination in West Malaysia
    White JC, Chan LK, Lau KS, Sen DK
    J Trop Med Hyg, 1976 Jun;79(6):132-6.
    PMID: 1084931
    Five patients illustrate various aspects of obstetrical defibrination in West Malaysia, resulting from exaggeration of changes in fibrinolytic-coagulation equilibrium that occur at delivery. Hypofibrinogenaemia and fibrinolysis may occur in association or either feature predominate. These patients are from a population in which a variety of genetic and environmental factors may interact, e.g. abnormal haemoglobins, cold agglutinins, viral and other infections, introducing additional complications.
    Matched MeSH terms: Abortion, Spontaneous/blood; Abruptio Placentae/blood; Afibrinogenemia/blood*; Postpartum Hemorrhage/blood; Hepatitis B/blood; Pregnancy Complications, Hematologic/blood*; Thalassemia/blood; Thrombocytopenia/blood
  6. Diseases associated with extreme elevation of ESR
    Zulkifli A, Ng WH, Chelvam P, Pillay RP
    Med J Malaysia, 1979 Sep;34(1):55-6.
    PMID: 317347
    Matched MeSH terms: Blood Sedimentation*; Gastrointestinal Diseases/blood; Hematologic Diseases/blood; Infection/blood; Kidney Diseases/blood; Neoplasms/blood; Rheumatic Diseases/blood
  7. Hyperferritinaemia: An Iron Sword of Autoimmunity
    Giemza-Stokłosa J, Islam MA, Kotyla PJ
    Curr Pharm Des, 2019;25(27):2909-2918.
    PMID: 31686632 DOI: 10.2174/1381612825666190709202804
    BACKGROUND: Ferritin is a molecule that plays many roles being the storage for iron, signalling molecule, and modulator of the immune response.

    METHODS: Different electronic databases were searched in a non-systematic way to find out the literature of interest.

    RESULTS: The level of ferritin rises in many inflammatory conditions including autoimmune disorders. However, in four inflammatory diseases (i.e., adult-onset Still's diseases, macrophage activation syndrome, catastrophic antiphospholipid syndrome, and sepsis), high levels of ferritin are observed suggesting it as a remarkable biomarker and pathological involvement in these diseases. Acting as an acute phase reactant, ferritin is also involved in the cytokine-associated modulator of the immune response as well as a regulator of cytokine synthesis and release which are responsible for the inflammatory storm.

    CONCLUSION: This review article presents updated information on the role of ferritin in inflammatory and autoimmune diseases with an emphasis on hyperferritinaemic syndrome.

    Matched MeSH terms: Ferritins/blood*; Iron/blood*; Biomarkers/blood; Still's Disease, Adult-Onset/blood; Antiphospholipid Syndrome/blood; Sepsis/blood; Iron Metabolism Disorders/blood*; Macrophage Activation Syndrome/blood
  8. Stored blood. A summary of the behaviour of normal blood stored outside the body, the sources of supply, and the methods for its preservation
    Macgregor RGS
    Journal of the Malaya Branch of British Medical Association, 1939;3:119-27.
    Matched MeSH terms: Blood
  9. Fulltext High sPLA2-IIA level is associated with eicosanoid metabolism in patients with bacterial sepsis syndrome
    Ahmad NS, Tan TL, Arifin KT, Ngah WZW, Yusof YAM
    PLoS One, 2020;15(3):e0230285.
    PMID: 32160261 DOI: 10.1371/journal.pone.0230285
    The aim of this study was to determine the association between secretory phospholipase A2 group IIA (sPLA2-IIA) and eicosanoid pathway metabolites in patients with bacterial sepsis syndrome (BSS). Levels of sPLA2-IIA, eicosanoids prostaglandin (PG)E2, PGD synthase were quantified in the sera from patients confirmed to have bacterial sepsis (BS; N = 45), bacterial severe sepsis/septic shock (BSS/SS; N = 35) and healthy subjects (N = 45). Cyclooxygenase (COX)-1 and COX-2 activities were analyzed from cell lysate. Serum levels of sPLA2-IIA, PGE2, and PGDS increased significantly in patients with BS and BSS/SS compared to healthy subjects (p<0.05). COX-2 activity was significantly increased in patients with BS compared to healthy subjects (p<0.05), but not COX-1 activity. Binary logistic regression analysis showed that sPLA2-IIA and PGE2 were independent factors predicting BSS severity. In conclusion, high level of sPLA2-IIA is associated with eicosanoid metabolism in patients with BSS.
    Matched MeSH terms: Dinoprostone/blood*; Biomarkers/blood; Bacteremia/blood*; Intramolecular Oxidoreductases/blood; Cyclooxygenase 1/blood; Cyclooxygenase 2/blood; Group II Phospholipases A2/blood*; Lipocalins/blood
  10. Transfusion practice blind spot in para-Bombay: A case report
    Abdullah MR, Faizli AA, Noordin SS, Lee CJ, Ahmad NH
    Transfus Apher Sci, 2021 Jun;60(3):103076.
    PMID: 33574008 DOI: 10.1016/j.transci.2021.103076
    H-deficient phenotype individuals with absent or weak anti-H activity may remain undetected on standard routine blood grouping. We report a case of a 59-year-old-man presented with symptomatic anaemia secondary to upper gastrointestinal bleed with haemoglobin level of 68 g/L who required two units of packed red blood cells. He was previously grouped as O Rh D positive and had a history of uneventful multiple blood transfusions. His latest pre-transfusion investigations showed ABO discrepancy between forward and reverse blood grouping, pan-agglutination in both antibody screening and identification with negative direct Coombs test and autocontrol. Further testing including anti-H lectin test and saliva secretor study confirmed that the patient blood group was para-Bombay B RhD positive. This case highlights that the para-Bombay phenotype can be mistakenly labelled as "O" if further investigations are not performed.
    Matched MeSH terms: ABO Blood-Group System/genetics*; Blood Transfusion/methods*
  11. Home blood pressure-centered approach - from digital health to medical practice: HOPE Asia Network consensus statement 2023
    Kario K, Tomitani N, Wang TD, Park S, Li Y, Shin J, et al.
    Hypertens Res, 2023 Dec;46(12):2561-2574.
    PMID: 37605071 DOI: 10.1038/s41440-023-01397-6
    Recent innovations in digital technology have enabled the simultaneous accumulation, and the linking and analysis of time-series big data relating to several factors that influence blood pressure (BP), including biological indicators, physical activity, and environmental information. Various approaches can be used to monitor BP: in the office/clinic; at home; 24-h ambulatory recording; or with wearable and cuffless devices. Of these, home BP monitoring is a reliable and convenient method, and is recommended for hypertension management by current national and international guidelines. This recommendation is based on evidence showing that home BP is an important predictor of cardiovascular, cerebrovascular and kidney disease in patients with hypertension. In addition, lifetime personalized health record (PHR)-based home BP with telemonitoring combined with co-interventions has been shown to lower BP more effectively than the traditional approach based on office BP. Thus, home BP represents a key metric for personalized anticipation medicine, from digital healthcare to digital medicine. This paper summarizes the latest evidence on home BP monitoring and proposes a Hypertension Cardiovascular Outcome Prevention and Evidence in Asia (HOPE Asia) Network consensus on a home BP-centered approach to the management of hypertension.
    Matched MeSH terms: Blood Pressure; Blood Pressure Determination/methods; Blood Pressure Monitoring, Ambulatory
  12. Fulltext Neurodegenerative diseases and blood pressure variability: A comprehensive review from HOPE Asia
    Turana Y, Shen R, Nathaniel M, Chia YC, Li Y, Kario K
    J Clin Hypertens (Greenwich), 2022 Sep;24(9):1204-1217.
    PMID: 36196471 DOI: 10.1111/jch.14559
    Asia has an enormous number of older people and is the primary contributor to the rise in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. The therapy of many neurodegenerative diseases has not yet progressed to the point where it is possible to alter the course of the disease. Mid-life hypertension is an important predictor of later-life cognitive impairment and brain neurodegenerative conditions. These findings highlight the pivotal role of preventing and managing hypertension as a risk factor for neurodegenerative disease. Autonomic dysfunction, neuropsychiatric and sleep disturbances can arise in neurodegenerative diseases, resulting in blood pressure variability (BPV). The BPV itself can worsen the progression of the disease. In older people with neurodegenerative disease and hypertension, it is critical to consider 24-h blood pressure monitoring and personalized blood pressure therapy.
    Matched MeSH terms: Blood Pressure/physiology; Blood Pressure Determination/methods
  13. Fulltext Target blood pressure and control status in Asia
    Chia YC, Kario K, Turana Y, Nailes J, Tay JC, Siddique S, et al.
    J Clin Hypertens (Greenwich), 2020 Mar;22(3):344-350.
    PMID: 31742891 DOI: 10.1111/jch.13714
    It is widely accepted that hypertension constitutes a significant cardiovascular risk factor and that treating high blood pressure (BP) effectively reduces cardiovascular risk. An important issue in Asia is not just the high prevalence of hypertension, particularly in some countries, but also the low level of awareness and treatment rates in many regions. The 2017 update of the American College of Cardiology/American Heart Association hypertension guidelines raised the question about which BP threshold should be used to diagnose and treat hypertension. Although there is a theoretical rationale for a stricter BP criterion in Asia given the ethnic-specific features of hypertension in the region, the majority of countries in Asia have retained a diagnostic BP threshold of ≥140/90 mm Hg. Although lowering thresholds might make theoretical sense, this would increase the prevalence of hypertension and also markedly reduce BP control rates. In addition, there are currently no data from robust randomized clinical trials of the benefits of the lower targets in preventing cardiovascular disease and reducing cardiovascular risk, particularly in high-risk patients and especially for Asian populations. There is also no defined home BP treatment target level for an office BP treatment target of 130/80 mm Hg. However, in this regard, in the interim, lifestyle modifications, including reducing body weight and salt intake, should form an important part of hypertension management strategies in Asia, while studies on treating at lower BP threshold level in Asians and getting to lower BP targets will be helpful to inform and optimize the management of hypertension in the region.
    Matched MeSH terms: Blood Pressure; Blood Pressure Determination; Blood Pressure Monitoring, Ambulatory*
  14. Fulltext Recent Advances in Non-Invasive Blood Pressure Monitoring and Prediction Using a Machine Learning Approach
    Ismail SNA, Nayan NA, Jaafar R, May Z
    Sensors (Basel), 2022 Aug 18;22(16).
    PMID: 36015956 DOI: 10.3390/s22166195
    Blood pressure (BP) monitoring can be performed either invasively via arterial catheterization or non-invasively through a cuff sphygmomanometer. However, for conscious individuals, traditional cuff-based BP monitoring devices are often uncomfortable, intermittent, and impractical for frequent measurements. Continuous and non-invasive BP (NIBP) monitoring is currently gaining attention in the human health monitoring area due to its promising potentials in assessing the health status of an individual, enabled by machine learning (ML), for various purposes such as early prediction of disease and intervention treatment. This review presents the development of a non-invasive BP measuring tool called sphygmomanometer in brief, summarizes state-of-the-art NIBP sensors, and identifies extended works on continuous NIBP monitoring using commercial devices. Moreover, the NIBP predictive techniques including pulse arrival time, pulse transit time, pulse wave velocity, and ML are elaborated on the basis of bio-signals acquisition from these sensors. Additionally, the different BP values (systolic BP, diastolic BP, mean arterial pressure) of the various ML models adopted in several reported studies are compared in terms of the international validation standards developed by the Advancement of Medical Instrumentation (AAMI) and the British Hypertension Society (BHS) for clinically-approved BP monitors. Finally, several challenges and possible solutions for the implementation and realization of continuous NIBP technology are addressed.
    Matched MeSH terms: Blood Pressure/physiology; Blood Pressure Determination*
  15. Plasma renin and aldosterone in thyroid diseases
    Asmah BJ, Wan Nazaimoon WM, Norazmi K, Tan TT, Khalid BA
    Horm. Metab. Res., 1997 Nov;29(11):580-3.
    PMID: 9479560 DOI: 10.1055/s-2007-979105
    The effect of thyroid hormones on the renin-angiotensin-aldosterone system has not been fully resolved. Highly specific immunoassays for measurement of renin, aldosterone, free T4 (fT4), free T3 (fT3) and ultrasensitive TSH enables a direct and more accurate measurement of these hormones. We investigated the relationship between plasma renin, aldosterone and thyroid hormones in the basal state and after intravenous frusemide. This is a cross-sectional study involving 37 patients with thyrotoxicosis, 42 rendered euthyroid with normal fT4, fT3 and TSH levels, 17 with euthyroid levels of fT4 and fT3 but suppressed TSH, and 11 with hypothyroidism. Basal plasma renin was significantly higher in thyrotoxicosis (63.4 +/- 9.8 microU/ml, mean +/- SEM) compared to euthyroid (32.7 +/- 4.4 microU/ml) and hypothyroid (26.7 +/- 9.8 microU/ml). Basal plasma renin for euthyroid with suppressed TSH (41.0 +/- 7.4 microU/ml) was significantly higher than hypothyroid (p = 0.02). Basal plasma aldosterones were not significantly different except for suppressed TSH (157.7 +/- 13 pg/ml), which was higher than normal (109.9 +/- 10.4 pg/ml; p = 0.04). Following frusemide, plasma renin and aldosterone were significantly increased in all groups. Plasma renin was highly correlated to fT3 (r = 0.405, p < 0.001), total T3 (r = 0.359, p < 0.001), fT4 (r = 0.331, p < 0.001) and TSH (r = 0.300, p < 0.001) in the basal state, but less to total T4 (r = 0.248, p < 0.01). Plasma renin correlated poorly to serum aldosterone (r = 0.212, p < 0.03). This study clearly showed that regulation of renin was mainly influenced by fT3, and that aldosterone response to frusemide was blunted in thyrotoxicosis despite normal electrolytes.
    Matched MeSH terms: Aldosterone/blood*; Hypothyroidism/blood; Potassium/blood; Renin/blood*; Sodium/blood; Thyroid Diseases/blood*; Thyrotoxicosis/blood; Thyrotropin/blood; Thyroxine/blood; Triiodothyronine/blood
  16. Fulltext Serum thyroid stimulating hormone (TSH) in malnutrition: preliminary results
    Osman A, Khalid BA, Tan TT, Wan Nazaimoon WM, Wu LL, Ng ML
    Singapore Med J, 1993 Jun;34(3):225-8.
    PMID: 8266178
    This is a report of a cross sectional study involving 3 groups of children, moderately malnourished (BMI < 15), mildly malnourished (BMI 15-18) and well nourished (BMI > 18) to determine the differences in hormonal and biochemical parameters between the groups. The children were of age range from 7-17 years old. The children were from the same area with exposure to the same food, drinking water and environment. There were significant differences in the nutritional indices between the three groups. No differences were observed in levels of triiodothyronine (T3), thyroxine (T4) and T3:T4 ratio. Significant difference however was found in the TSH levels using highly sensitive IRMA TSH assays. Moderately malnourished children had higher TSH levels (p < 0.05) compared to mildly malnourished and well-nourished children. No difference was found between the mildly malnourished and well-nourished groups. There were no significant differences in serum cortisols done at similar times, fasting growth hormone and calcium. Serum alanine transminase (ALT) however was higher in moderately malnourished than in well-nourished children. Thus using highly sensitive IRMA TSH assays, we were able to detect differences in TSH levels even though T3, T4 and T3:T4 ratio, cortisol, growth hormone and calcium were normal, implying in moderately malnourished children, a higher TSH drive to maintain euthyroid state.
    Matched MeSH terms: Alanine Transaminase/blood; Blood Glucose/analysis; Calcium/blood; Hydrocortisone/blood; Nutrition Disorders/blood*; Growth Hormone/blood; Thyrotropin/blood*; Thyroxine/blood; Triiodothyronine/blood
  17. Fulltext Trends of platelet inhibition in different clopidogrel pretreatment patterns in malaysian patients undergoing elective percutaneous coronary intervention
    Tiong WN, Mejin M, Fong AY, Wee CC, Lai LY, Hwang SS, et al.
    Med J Malaysia, 2013 Aug;68(4):326-31.
    PMID: 24145261 MyJurnal
    Matched MeSH terms: Blood Platelets*
  18. Endocrine hypertension--current understanding and comprehensive management review
    Sukor N
    Eur J Intern Med, 2011 Oct;22(5):433-40.
    PMID: 21925049 DOI: 10.1016/j.ejim.2011.05.004
    Hypertension is a very common disease, leading to significant morbidity with reduction in quality of life. In addition to being a major cause of morbidity and mortality, hypertension places a heavy burden on health care systems, families, and society as a whole. In patients with hypertension, the ability to identify a contributing or secondary cause that is potentially curable or amenable to specific forms of management is of great importance. Endocrine hypertension has emerged as one of the common forms of secondary hypertension. Primary aldosteronism, pheochromocytoma and Cushing's syndrome are among the common causes of endocrine hypertension. The application of new clinical, biochemical, and radiologic approaches has significantly advanced our understanding of the pathophysiology and clinical spectrum of these diseases and improved the management strategies of these challenging conditions.
    Matched MeSH terms: Blood Pressure/physiology*
  19. Role of blood bag temperature indicators in maintaining patent temperature of the returned unused blood bags in blood bank
    Nurasyikin Y, Leong CF, Fadhlullah TM, Hafiz WM, Nadiah Z, Atieqah AN, et al.
    Clin Ter, 2011;162(1):19-22.
    PMID: 21448541
    The main objective of the present study was to evaluate the temperature chain of red blood cells (RBC) returned unused blood bags using blood temperature indicator and ascertain the factors like transportation time, type, size of coolant box and number of bags per box.
    Matched MeSH terms: Blood Banks/methods*; Blood Banks/standards; Blood Physiological Phenomena; Blood Preservation/instrumentation; Blood Preservation/methods*; Blood Preservation/standards
  20. Fulltext Umbilical cord blood transplant--will it change the medical scenario in Malaysia?
    Ariffin N
    Med J Malaysia, 2009 Jun;64(2):103-4.
    PMID: 20058565
    Umbilical Cord Blood Transplant (UCBT) is a type of allogenic haematopoetic stem cell transplant. Stem cell transplantation as a mode of treatment of diseases was first successfully done by the pioneering work of a Nobel Prize Winner in Physiology or Medicine, E. Donnall Thomas in 1957. Throughout the past 50 years, numerous other researchers have improved the techniques of this previously highly risky procedure. Among the notable landmark in haematopoetic stem cell transplant include: advancement in immunogenetics of HLA, better immunosuppressive preparative regimen, improved control of infections, appearance of donor registries throughout the world and successful transplantation stories using haematopoetic stem cells from peripheral blood and the cord blood. These developments lead to a change in terminology from marrow transplantation to haematopoetic stem cell transplantation .
    Matched MeSH terms: Cord Blood Stem Cell Transplantation*
Related Terms
Filters
Contact Us

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links