Displaying publications 41 - 60 of 142 in total

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  1. Fulltext Demographic determinants and outcome of in vitro fertilization (IVF) services in Saudi Arabia
    Almaslami F, Aljunid SM, Ghailan K
    J Int Med Res, 2018 Apr;46(4):1537-1544.
    PMID: 29350090 DOI: 10.1177/0300060517749329
    Objectives To assess the demographic characteristics and outcomes of couples undergoing in vitro fertilisation (IVF) treatment at a private hospital in Al Qassim district, Saudi Arabia. Methods For this retrospective study, information was extracted from the hospital electronic database and IVF unit medical records. Results 2259 couples underwent 2703 IVF/ICSI cycles during 2014 to 2016. The utilization rate was approximately 1000 cycle per million of inhabitants. Mean ages ± standard deviation (SD) for women and men were 32.9 ± 5.7 and 39.2 ± 7.4 years, respectively. More couples were diagnosed with secondary infertility (55.2%) than primary infertility (44.8%). Male factor was the commonest single indication for IVF (36.2%). Mean ± SD infertility duration was 4.70 ± 4.03 years. Overall, 949 couples had a successful pregnancy. Age-specific pregnancy rates (PR) were highest for women <35 years (39.8%) and lowest for women >40 years (11.6%). Male age and infertility duration had no effect on PR but sperm source (fresh vs. frozen) and female age had significant impacts. However, fresh sperm was used in 90.6% cycles whereas frozen sperm was used in 9.4% cycles. Conclusions IVF treatment outcomes in the Al Qassim district are within the boundaries of average international success rates. Infertile couples seeking IVF services should be counselled with regard to important prognostic factors.
    Matched MeSH terms: Infertility, Male/therapy
  2. Mating compatibility and competitiveness of transgenic and wild type Aedes aegypti (L.) under contained semi-field conditions
    Lee HL, Vasan S, Ahmad NW, Idris I, Hanum N, Selvi S, et al.
    Transgenic Res, 2013 Feb;22(1):47-57.
    PMID: 22700207 DOI: 10.1007/s11248-012-9625-z
    We conducted the world's first experiments under semi-field conditions (ACL-2 field house) to assess the mating competitiveness of genetically sterile RIDL male mosquitoes (513A strain). The field house is a state-of-the-art, fully-contained trial facility, simulating the living space for a household of 2-4 people in Peninsular Malaysia. Ten genetically sterile RIDL male A. aegypti mosquitoes competed with ten wild type males inside this field house to mate with ten wild type females. Hatched larvae from mated females were screened under a fluorescent microscope for genetic markers to determine if they were fathered by RIDL male or wild type male, and all results were cross-checked by PCR. Two such experiments were conducted, each repeated sufficient number of times. All strains were on a Malaysian lab strain background for the first experiment, while the RIDL males alone were on a recently-colonised Mexican strain background for the second experiment. A total of 52 % of the matings were with RIDL males in the first experiment, while 45 % of the matings were with RIDL (Mexican) males in the second experiment. Statistically, this is not significantly different from 50 % of the matings expected to take place with RIDL males if the latter were as competitive as that of the wild type males. This shows that A. aegypti RIDL-513A has excellent mating competitiveness under semi-field conditions, verifying earlier trends obtained in small lab cages. We also observed high mating compatibility between recently-colonised Mexican RIDL males and lab-reared Malaysian wild type females.
    Matched MeSH terms: Infertility, Male/genetics*
  3. Endometriosis and social class
    Arumugam K, Templeton AA
    Med J Aust, 1990 Nov 05;153(9):567.
    PMID: 2233493
    Matched MeSH terms: Infertility, Female/complications
  4. Elucidating the chrononutrition patterns and sleep quality among subfertile patients with different vitamin D levels
    Maluin SM, Juliana N, Aris S, Lokman N, Roslan AN, Yusof J, et al.
    Sci Rep, 2025 Mar 05;15(1):7719.
    PMID: 40044749 DOI: 10.1038/s41598-025-92628-y
    Subfertility affects about 10-15% of Malaysians, characterized by difficulty conceiving after 12 months of unprotected intercourse. Emerging research suggests that vitamin D deficiency, influenced by dietary intake and sleep patterns, may contribute to fertility. This study examines the relationship between chrononutrition patterns, sleep quality and vitamin D deficiency in subfertile patients. A cross-sectional study was conducted at two hospitals in Selangor, Malaysia, involving 140 subfertile individuals who fit the inclusion and exclusion criteria. Data were collected through self-administered questionnaires, including food frequency questionnaires (FFQ), the Chrononutrition Profile Questionnaire (CPQ), and the Pittsburgh Sleep Quality Index (PSQI). Serum vitamin D levels were measured through 25-hydroxyvitamin D blood test. Statistical analyses were performed using SPSS version 29. Results revealed a significant difference in mean serum vitamin D levels between male and female participants (p < 0.001), with 76.7% of the females being vitamin D deficient. Most parameters were not significant in males compared to females. Notably, a negative correlation was found between vitamin D levels and both energy and fat intake in females (p < 0.05). Female gender was identified as a significant determinant of vitamin D deficiency (OR 5.186, p < 0.001), while poor evening eating habits were strongly associated with deficiency (AOR 10.553, p < 0.05). These findings highlight the importance of gender and dietary patterns in vitamin D deficiency among subfertile patients. Hence, there is a need for targeted nutritional and lifestyle interventions.
    Matched MeSH terms: Infertility/blood
  5. Association of azoospermia factor region deletions in infertile male subjects among Malaysians
    Hussein AA, Vasudevan R, Patimah I, Prashant N, Nora FA
    Andrologia, 2015 Mar;47(2):168-77.
    PMID: 24528375 DOI: 10.1111/and.12240
    Azoospermia factor region (AZF) deletions (AZFa, AZFb, AZFc and AZFd) in the Y chromosome were analysed in male infertility subjects in various populations with conflicting results. This study comprised of 54 infertile males and 63 fertile controls, and the frequency of AZFa, AZFb, AZFc and AZFd deletions were determined using conventional polymerase chain reaction (PCR) as well as real-time PCR-high resolution melting analysis-based methods. The results of this study showed that, three of 54 cases (5.55%) had AZF (a, b and c) deletions (two had AZFc and one had AZFa deletions). Four cases were found to have AZFd deletions (7.4%) with two of them being associated with AZFc deletions (P = 0.028). The frequency of AZF (a, b and c) deletions in Malaysian infertile male subjects was found to be comparable with other populations. AZFd deletions were found to be significant (P < 0.05) in male infertility and it may be associated with other types of AZF deletions.
    Matched MeSH terms: Infertility, Male/ethnology*; Infertility, Male/genetics*; Infertility, Male/epidemiology
  6. Does SARS-CoV-2 infection cause sperm DNA fragmentation? Possible link with oxidative stress
    Sengupta P, Dutta S
    Eur J Contracept Reprod Health Care, 2020 Oct;25(5):405-406.
    PMID: 32643968 DOI: 10.1080/13625187.2020.1787376
    Matched MeSH terms: Infertility, Male/diagnosis; Infertility, Male/etiology; Infertility, Male/virology
  7. Orlistat attenuates obesity-induced decline in steroidogenesis and spermatogenesis by up-regulating steroidogenic genes
    Suleiman JB, Nna VU, Othman ZA, Zakaria Z, Bakar ABA, Mohamed M
    Andrology, 2020 09;8(5):1471-1485.
    PMID: 32438512 DOI: 10.1111/andr.12824
    BACKGROUND: Steroidogenesis decline is reported to be one of the mechanisms associated with obesity-induced male factor subfertility/infertility.

    OBJECTIVES: We explored the possible preventive/therapeutic effects of orlistat (a medication prescribed for weight loss) on obesity-induced steroidogenesis and spermatogenesis decline.

    MATERIALS AND METHODS: Twenty-four adult male Sprague Dawley rats weighing 250-300 g were randomized into four groups (n = 6/group), namely; normal control, high-fat diet, high-fat diet plus orlistat preventive group and high-fat diet plus orlistat treatment group. Orlistat (10 mg/kg/b.w./d suspended in distilled water) was either concurrently administered with high-fat diet for 12 weeks (high-fat diet plus orlistat preventive group) or administered from week 7-12 post- high-fat diet feeding (high-fat diet plus orlistat treatment group). Thereafter, serum, testes and epididymis were collected for analyses.

    RESULTS: Obesity increased serum leptin and decreased adiponectin levels, decreased serum and intra-testicular levels of follicle stimulating hormone, luteinising hormone and testosterone, sperm count, motility, viability, normal morphology and epididymal antioxidants, but increased epididymal malondialdehyde level and sperm nDNA fragmentation. Testicular mRNA transcript levels of androgen receptor, luteinizing hormone receptor, steroidogenic acute regulatory protein, cytochrome P450 enzyme (CYP11A1), 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase were significantly decreased in the testes of the high-fat diet group. Further, the levels of steroidogenic acute regulatory protein protein and enzymatic activities of CYP11A1, 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase were also significantly decreased in the testes of the high-fat diet group. Treatment with orlistat significantly decreased leptin and increased adiponectin levels, improved sperm parameters, decreased sperm DNA fragmentation, increased the levels of steroidogenic hormones, proteins and associated genes in high-fat diet-induced obese male rats, with the preventive group (high-fat diet plus orlistat preventive group) having better results relative to the treatment group (high-fat diet plus orlistat treatment group).

    DISCUSSION AND CONCLUSION: Orlistat attenuated impaired spermatogenesis and steroidogenesis decline by up-regulating steroidogenic genes. This may not be unconnected to its significant effect in lowering serum leptin levels, since the hormone is known to dampen fertility potential. Therefore, orlistat may improve fertility potential in overweight/obese men.

    Matched MeSH terms: Infertility, Male/etiology; Infertility, Male/genetics; Infertility, Male/metabolism*
  8. Orlistat reverses intratesticular lactate transport decline and infertility in male obese rats
    Suleiman JB, Nna VU, Zakaria Z, Othman ZA, Bakar ABA, Usman UZ, et al.
    Reproduction, 2020 12;160(6):863-872.
    PMID: 33112813 DOI: 10.1530/REP-20-0381
    Obesity and its accompanying complications predispose to abnormal testicular glucose metabolism, penile erectile dysfunction and subfertility. This study examined the potentials of orlistat in attenuating erectile dysfunction and fertility decline in high-fat diet (HFD)-induced obesity in male rats. Eighteen adult male Sprague-Dawley rats whose weights were between 250 and 300 g were divided into three groups (n = 6/group) namely: normal control (NC), HFD and HFD + orlistat (10 mg/kg body weight/day co-administered for 12 weeks) (HFD+O). During the 11th and 12th week, mating behaviour and fertility parameters were evaluated, and parameters of glucose metabolism were assessed at the end of the 12th week. Orlistat increased testicular mRNA levels of glucose transporters (Glut1 and Glut3), monocarboxylate transporters (Mct2 and Mct4) and lactate dehydrogenase type C (Ldhc), decreased intratesticular lactate and glucose levels, and LDH activity in obese rats. Furthermore, orlistat increased superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR) activities, and total antioxidant capacity (TAC), but decreased malondialdehyde level in the penis of obese rats. Similarly, orlistat improved penile cGMP level, sexual behaviour and fertility outcome in obese rats. Penile cGMP level correlated positively with total mounts and intromissions but correlated negatively with mount/intromission ratio. Orlistat improves fertility potential in obese state by targeting testicular lactate metabolism, penile oxidative stress and sexual behaviour in rats. Therefore, orlistat shows a promising protective effect and may preserve the fertility potential of obese men.
    Matched MeSH terms: Infertility, Male/etiology; Infertility, Male/pathology; Infertility, Male/prevention & control*
  9. Fulltext Concurrent validity of the depression and anxiety components in the Bahasa Malaysia version of the Depression Anxiety and Stress Scales (DASS).
    Ramli Musa, Kartini Abdullah, Roszaman Ramli, Rosnani Sarkarsi
    ASEAN Journal of Psychiatry, 2011;12(1):66-70.
    MyJurnal
    Objectives: The Bahasa Malaysia (BM) version of Depression Anxiety Stress Scales 21-item (DASS-21) has been widely used ever since the establishment of its validity. To consolidate the evidence of the BM DASS-21 validity by examining its concurrent validity.
    Methods: The BM DASS was administered together with the Hospital Anxiety and Depressive Scale (HADS) to a total of 246 patients at International Islamic University Malaysia (IIUM) Infertility Centre.
    Results: The anxiety domain of BM DASS-21 had good correlation with anxiety domain in HADS (0.61) but for DASS depressive domain, it had modest correlation with its respective domain in HADS (0.49).
    Conclusions: The results of this study further ensconced the evidence that the BM DASS-21 had relatively satisfactory psychometric properties for clinical subjects in Malaysia.
    Matched MeSH terms: Infertility
  10. Fulltext Congenital bilateral aplasia of vas deferens (CBAVD): a reminder to clinicians
    Koh, P.S., Shanggar, K., Razack, A.H., Lee, G.
    JUMMEC, 2008;11(2):89-90.
    MyJurnal
    Male factor infertility which accounts for 30-50% of infertility is a major problem faced by married couples. Congenital absence of the vas deferens, though uncommon, remains the most common abnormality seen in extratesticular ductal and ejaculatory system, accounting for 1-2% of male infertility. It may be unilateral or bilateral. Association with renal abnormality has also been reported with congenital absence of vas deferens (1). The patients are asymptomatic and the congenital abnormality is usually detected when investigation for infertility is carried out. We present a case of an unusual presentation of congenital bilateral absence of vas deferens (CBAVD).
    Matched MeSH terms: Infertility, Male
  11. Hysterosalpingogram in the diagnosis of tuboperitoneal abnormalities in female infertility: Experience at the General Hospital, Kota Bharu
    Sathyamoorthy P, Abdul Rahman MA
    Family Physician, 1994;6:9-11.
    Matched MeSH terms: Infertility
  12. Fulltext Electrophoretic Techniques for the Detection of Human Microsatellite D19S884
    Mansor F, Zamri L, Hamzah SS
    Malays J Med Sci, 2015 Mar-Apr;22(2):18-24.
    PMID: 26023291 MyJurnal
    The detection and analysis of microsatellites is very important for the mapping of genetic diseases because they are commonly used as genetic markers. Microsatellite marker D19S884 has been associated with polycystic ovary syndrome (PCOS), the most common reproductive endocrine disease of women in their childbearing years. It is responsible for an estimated 70% of cases of anovulatory infertility. In this work, we detected microsatellites in DNA extracted from the blood of PCOS patients.
    Matched MeSH terms: Infertility, Female
  13. Spermatogonial Stem Cells Protein Identification in In Vitro Culture from Non-Obstructive Azoospermia Patient
    Abdul Wahab AY, Md Isa ML, Ramli R
    Malays J Med Sci, 2016 May;23(3):40-8.
    PMID: 27418868
    Spermatogonial stem cells (SSCs) are classifiedas a unique adult stem cells that have capability to propagate, differentiate, and transmit genetic information to the next generation. Studies on human SSCs may help resolve male infertility problems, especially in azoospermia patients. Therefore, this study aims to propagate SSCs in-vitro with a presence of growth factor and detect SSC-specific protein cell surface markers.
    Matched MeSH terms: Infertility, Male
  14. Differential proteomic profiling of spermatozoal proteins of infertile men with unilateral or bilateral varicocele
    Agarwal A, Sharma R, Durairajanayagam D, Cui Z, Ayaz A, Gupta S, et al.
    Urology, 2015 Mar;85(3):580-8.
    PMID: 25733269 DOI: 10.1016/j.urology.2014.11.030
    To compare the sperm protein profile between infertile men with unilateral varicocele and infertile men with bilateral varicocele.
    Matched MeSH terms: Infertility, Male/etiology; Infertility, Male/metabolism*
  15. Pyruvate reduces in vitro the embryotoxic effect of peritoneal fluid from infertile women with endometriosis
    Noordin L, San GT, Singh HJ, Othman MS, Hafizah W
    Eur J Obstet Gynecol Reprod Biol, 2008 Jan;136(1):67-73.
    PMID: 18079036
    To ascertain the embryotoxicity of peritoneal fluid from infertile women with endometriosis (PF-E), on mouse embryos in culture and to examine the effect of pyruvate in the culture medium on PF-E induced embryotoxicity.
    Matched MeSH terms: Infertility, Female/etiology; Infertility, Female/physiopathology*
  16. The impact of endometrioma on IVF/ICSI outcomes: a systematic review and meta-analysis
    Hamdan M, Dunselman G, Li TC, Cheong Y
    Hum. Reprod. Update, 2015 Nov-Dec;21(6):809-25.
    PMID: 26168799 DOI: 10.1093/humupd/dmv035
    Endometriosis is a disease known to be detrimental to fertility. Women with endometriosis, and the presence of endometrioma, may require artificial reproductive techniques (ART) to achieve a pregnancy. The specific impact of endometrioma alone and the impact of surgical intervention for endometrioma on the reproductive outcome of women undergoing IVF/ICSI are areas that require further clarification. The objectives of this review were as follows: (i) to determine the impact of endometrioma on IVF/ICSI outcomes, (ii) to determine the impact of surgery for endometrioma on IVF/ICSI outcome and (iii) to determine the effect of different surgical techniques on IVF/ICSI outcomes.
    Matched MeSH terms: Infertility, Female/complications; Infertility, Female/therapy*
  17. Endometriosis and infertility: raised iron concentration in the peritoneal fluid and its effect on the acrosome reaction
    Arumugam K
    Hum Reprod, 1994 Jun;9(6):1153-7.
    PMID: 7962392
    Endometriosis and infertility are commonly associated. This study investigated the role of accelerated lipid peroxidation of spermatozoa by the peritoneal fluid of patients with endometriosis as a cause for this association. It proposes that the increased iron concentration present in the fluid of these patients acts as a catalyst for the process. Peritoneal fluid from 25 patients with endometriosis and 25 matched controls was obtained at laparoscopy. Spermatozoa were incubated in the fluid from both groups and the subsequent acrosome reaction rates analysed. The relationship between these results and iron concentration in the fluid was examined. A significant decrease in the acrosome reaction rate was seen in the endometriotic group (P = 0.034). Overall, a decrease in the acrosome reaction rate was associated with an increased iron concentration in the fluid (18 of the 25 pairs). In mild disease, (six of 11 pairs), the relationship was not as marked as that in severe disease (12 of 14 pairs). These results suggest that the peritoneal fluid in patients with endometriosis has a detrimental action on the acrosome reaction of spermatozoa in vitro.
    Matched MeSH terms: Infertility, Female/complications; Infertility, Female/metabolism*
  18. Varicocele among infertile men in Qatar
    ElBardisi H, Arafa M, Rengan AK, Durairajanayagam D, AlSaid SS, Khalafalla K, et al.
    Andrologia, 2017 May;49(4).
    PMID: 27401026 DOI: 10.1111/and.12637
    Objective of this retrospective study was to assess the presence and clinical grade of varicocele among Qatari and non-Qatari men evaluated for infertility. Diagnosis of varicocele was performed clinically and confirmed via colour Doppler ultrasonography. A total of 455 infertile male patients (mean age 36.3 ± 7.6 years) were divided into either Qatari (n = 91, mean age 37.3 ± 9.1 years) or non-Qatari (n = 364, mean age 36.0 ± 7.1 years) groups. Among all patients, 43.1% (n = 196) were confirmed to have varicocele, of which 40 were Qatari and 156 non-Qatari. Among all patients, 171 (37.6%) presented with left-sided varicocele and 25 (5.5%) with bilateral varicocele. Of the 196 patients with varicocele, grade I was given to 40 (20.4%), grade II to 68 (34.7%) and grade III to 88 (44.9%). Grade II and III varicocele were seen significantly more frequently than grade I among all patients and non-Qatari patients (p 
    Matched MeSH terms: Infertility, Male/diagnosis; Infertility, Male/epidemiology*
  19. Fulltext Salpingitis isthmica nodosa: review of four cases from the General Hospital, Kota Bharu
    Sathyamoorthy P
    Singapore Med J, 1994 Feb;35(1):65-6.
    PMID: 8009284
    Four cases of salpingitis isthmica nodosa diagnosed from a total of 82 hysterosalpingograms, over a period of three years at the General Hospital, Kota Bharu, were reviewed. The diagnosis was made based on the radiographic appearance of globules of contrast medium in the periluminal tissues which were in continuity with the lumen of the fallopian tubes. Three of these patients had ectopic pregnancy. Diagnosis of salpingitis isthmica nodosa which is readily demonstrated by hysterosalpingogram, is extremely important because of its impact on ectopic pregnancy rates. Hysterosalpingography is indicated following ectopic pregnancy to show whether there is diverticulosis of the contralateral tube. By such knowledge, optimal treatment can be offered to patients wishing to attempt further conception. As the disease is relatively localised it is amenable to resection with reimplantation of the distal portion of the tube.
    Matched MeSH terms: Infertility, Female/radiography; Infertility, Female/surgery
  20. Fulltext Mammalian sperm fertility related proteins
    Ashrafzadeh A, Karsani SA, Nathan S
    Int J Med Sci, 2013;10(12):1649-57.
    PMID: 24151436 DOI: 10.7150/ijms.6395
    Infertility is an important aspect of human and animal reproduction and still presents with much etiological ambiguity. As fifty percent of infertility is related to the male partner, molecular investigations on sperm and seminal plasma can lead to new knowledge on male infertility. Several comparisons between fertile and infertile human and other species sperm proteome have shown the existence of potential fertility markers. These proteins have been categorized into energy related, structural and other functional proteins which play a major role in sperm motility, capacitation and sperm-oocyte binding. The data from these studies show the impact of sperm proteome studies on identifying different valuable markers for fertility screening. In this article, we review recent development in unraveling sperm fertility related proteins.
    Matched MeSH terms: Infertility, Male/genetics*; Infertility, Male/metabolism
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