MyMedR

Fulltext An Asian validation of the TIMI risk score for ST-segment elevation myocardial infarction

Selvarajah S, Fong AY, Selvaraj G, Haniff J, Uiterwaal CS, Bots ML

PLoS One, 2012;7(7):e40249.

PMID: 22815733 DOI: 10.1371/journal.pone.0040249

Risk stratification in ST-elevation myocardial infarction (STEMI) is important, such that the most resource intensive strategy is used to achieve the greatest clinical benefit. This is essential in developing countries with wide variation in health care facilities, scarce resources and increasing burden of cardiovascular diseases. This study sought to validate the Thrombolysis In Myocardial Infarction (TIMI) risk score for STEMI in a multi-ethnic developing country.

Matched MeSH terms: Myocardial Infarction/diagnosis; Myocardial Infarction/mortality; Myocardial Infarction/epidemiology*; Myocardial Infarction/physiopathology*

Fulltext Re-examining the effect of door-to-balloon delay on STEMI outcomes in the context of unmeasured confounders: a retrospective cohort study

Foo CY, Andrianopoulos N, Brennan A, Ajani A, Reid CM, Duffy SJ, et al.

Sci Rep, 2019 12 27;9(1):19978.

PMID: 31882674 DOI: 10.1038/s41598-019-56353-7

Literature studying the door-to-balloon time-outcome relation in coronary intervention is limited by the potential of residual biases from unobserved confounders. This study re-examines the time-outcome relation with further consideration of the unobserved factors and reports the population average effect. Adults with ST-elevation myocardial infarction admitted to one of the six registry participating hospitals in Australia were included in this study. The exposure variable was patient-level door-to-balloon time. Primary outcomes assessed included in-hospital and 30 days mortality. 4343 patients fulfilled the study criteria. 38.0% (1651) experienced a door-to-balloon delay of >90 minutes. The absolute risk differences for in-hospital and 30-day deaths between the two exposure subgroups with balanced covariates were 2.81 (95% CI 1.04, 4.58) and 3.37 (95% CI 1.49, 5.26) per 100 population. When unmeasured factors were taken into consideration, the risk difference were 20.7 (95% CI -2.6, 44.0) and 22.6 (95% CI -1.7, 47.0) per 100 population. Despite further adjustment of the observed and unobserved factors, this study suggests a directionally consistent linkage between longer door-to-balloon delay and higher risk of adverse outcomes at the population level. Greater uncertainties were observed when unmeasured factors were taken into consideration.

Matched MeSH terms: ST Elevation Myocardial Infarction/diagnosis; ST Elevation Myocardial Infarction/mortality; ST Elevation Myocardial Infarction/epidemiology*; ST Elevation Myocardial Infarction/therapy*

Molecular Understanding of the Cardiomodulation in Myocardial Infarction and the Mechanism of Vitamin E Protections

Zarkasi KA, Jen-Kit T, Jubri Z

Mini Rev Med Chem, 2019;19(17):1407-1426.

PMID: 30706809 DOI: 10.2174/1389557519666190130164334

Myocardial infarction is a major cause of deaths globally. Modulation of several molecular mechanisms occurs during the initial stages of myocardial ischemia prior to permanent cardiac tissue damage, which involves both pathogenic as well as survival pathways in the cardiomyocyte. Currently, there is increasing evidence regarding the cardioprotective role of vitamin E in alleviating the disease. This fat-soluble vitamin does not only act as a powerful antioxidant; but it also has the ability to regulate several intracellular signalling pathways including HIF-1, PPAR-γ, Nrf-2, and NF-κB that influence the expression of a number of genes and their protein products. Essentially, it inhibits the molecular progression of tissue damage and preserves myocardial tissue viability. This review aims to summarize the molecular understanding of the cardiomodulation in myocardial infarction as well as the mechanism of vitamin E protection.

Matched MeSH terms: Myocardial Infarction/drug therapy*; Myocardial Infarction/genetics; Myocardial Infarction/metabolism; Myocardial Infarction/pathology

Life after myocardial infarction from the perspective of Muslim patients and carers in Malaysia

Sukeri S, Mirzaei M, Leeder SR

Int J Cardiol, 2013 Oct;168(4):4512-3.

PMID: 23886534 DOI: 10.1016/j.ijcard.2013.06.112

Matched MeSH terms: Myocardial Infarction*

Fulltext Myocardial infarction induced by appetite suppressants in Malaysia

Azarisman SM, Magdi YA, Noorfaizan S, Oteh M

N Engl J Med, 2007 Nov 1;357(18):1873-4.

PMID: 17978302 DOI: 10.1056/NEJMc070990

Matched MeSH terms: Myocardial Infarction/chemically induced*

Stem cells and injectable hydrogels: Synergistic therapeutics in myocardial repair

Sepantafar M, Maheronnaghsh R, Mohammadi H, Rajabi-Zeleti S, Annabi N, Aghdami N, et al.

Biotechnol Adv, 2016 Jul-Aug;34(4):362-379.

PMID: 26976812 DOI: 10.1016/j.biotechadv.2016.03.003

One of the major problems in the treatment of cardiovascular diseases is the inability of myocardium to self-regenerate. Current therapies are unable to restore the heart's function after myocardial infarction. Myocardial tissue engineering is potentially a key approach to regenerate damaged heart muscle. Myocardial patches are applied surgically, whereas injectable hydrogels provide effective minimally invasive approaches to recover functional myocardium. These hydrogels are easily administered and can be either cell free or loaded with bioactive agents and/or cardiac stem cells, which may apply paracrine effects. The aim of this review is to investigate the advantages and disadvantages of injectable stem cell-laden hydrogels and highlight their potential applications for myocardium repair.

Matched MeSH terms: Myocardial Infarction/therapy*

Further elucidation on "Hybrid ABSORB bioresorbable vascular scaffold and drug eluting stent or hybrid BVS-DES percutaneous coronary intervention: Method and rationale for hybrid overlapping PCI"

Yew KL

Int J Cardiol, 2015 Jul 15;191:170-1.

PMID: 25965626 DOI: 10.1016/j.ijcard.2015.05.018

Matched MeSH terms: Myocardial Infarction/surgery*

Fulltext Myocardial infarct imaging using 99m technetium pyrophosphate and 99mtechnetium methylene diphosphonate: a clinical evaluation

Paramsothy M, Singham KT

Med J Malaysia, 1980 Mar;34(3):289-300.

PMID: 7412670

Radioisotope detection and localisation of myocardial infarction is discussed. Its clinical value and pitfalls are also discussed. The clinical application of this safe, simple, sensitive, repeatable, reproducible and non-invasive method in Malaysian patients performed during the period October 1978 to April 1979 at the University Hospital is reviewed. The main value of 99mTc labelled phosphate scan is in the demonstration and localisation of recent myocardial infarctions in patients where the electrocardiogram or serum enzymes changes are unhelpful.

Matched MeSH terms: Myocardial Infarction/radionuclide imaging*

Fulltext Sexual morbidity after myocardial infarction

Chin CN, Quek DKL, Ong SBL

Med J Malaysia, 1991 Mar;46(1):35-40.

PMID: 1836036

Sixty five patients were interviewed on an average of 42 months after a myocardial infarction. Using a semi structured interview, they were systematically questioned on their usual sexual activity just before their infarction and at the time of follow up. All were married men with a mean age of 54.4 years and had resumed a normal active life. Forty six (70%) reported a decrease in frequency of sexual intercourse (mean 6.9 times/month before infarction and 0.8 times/month at time of interview, p less than 0.01). The majority had difficulty in discussing sex with their doctors because of impaired doctor-patient communication, cultural factors and lack of privacy. Discussion concerning sex should be initiated as soon as the patient is stable and pertinent advice is the key to better sexual adjustment after myocardial infarction.

Matched MeSH terms: Myocardial Infarction/complications*

Fulltext Myocardial infarction, circadian rhythm and delay in hospital admission

Quek DK, Ong SB, Lim LY

Med J Malaysia, 1989 Mar;44(1):14-22.

PMID: 2626108

Circadian variations have been observed in the onset of acute coronary syndromes including acute myocardial infarction. We studied 422 acute myocardial infarction patients who presented to the coronary care unit of General Hospital Kuala Lumpur. Of the 318 (75.4%) patients whose data was complete, a circadian rhythm with bimodal peak was demonstrated. The second quarter of the day i.e. 6.00 a.m. to 12 noon was shown to have a significantly increased frequency of onset of acute myocardial infarction (p less than 0.05). Time delay in presenting to the hospital was also determined. This showed that 56.8% of acute myocardial infarction patients presented early, within four hours of the onset of symptoms. By six hours, more than 71% had sought hospital care. This early presentation to the hospital may offer a realistic opportunity for optimal thrombolytic therapy should this treatment modality be offered as routine to infarct patients.

Matched MeSH terms: Myocardial Infarction/physiopathology*

Concurrent stroke and ST-elevation myocardial infarction: Is it a contraindication for intravenous tenecteplase?

Wan Asyraf WZ, Elengoe S, Che Hassan HH, Abu Bakar A, Remli R

Med J Malaysia, 2020 03;75(2):169-170.

PMID: 32281601

Acute ischemic stroke (AIS) and acute ST-elevation myocardial infarction (STEMI) are leading causes of mortality worldwide. Concurrent AIS presentation with STEMI is rare and potentially fatal. Most importantly to date many centres in Malaysia are still not aware on how to treat this condition. We report a case of AIS, which was treated with intravenous tenecteplase (TNK) according to ischemic stroke dosage and lead to improvement of neurological deficit.

Matched MeSH terms: ST Elevation Myocardial Infarction/drug therapy*

Fulltext Public Awareness of and Action towards Heart Attack Symptoms: An Exploratory Study

Abdo Ahmed AA, Mohammed Al-Shami A, Jamshed S, Fata Nahas AR, Mohamed Ibrahim MI

Int J Environ Res Public Health, 2020 12 02;17(23).

PMID: 33276636 DOI: 10.3390/ijerph17238982

BACKGROUND: Cardiovascular disease (CVD) is still the leading cause of mortality worldwide, and Malaysia is not an exception in this regard. The current research is an attempt to explore symptom awareness of and necessary actions in response to heart attack (HA) among lay public.

METHODS: This is a cross-sectional study design, and a survey was conducted from May to July 2018 among general public in Kuantan, Pahang state, Malaysia.

RESULTS: A total of 393 respondents recruited. Slightly more than one-fourth of the respondents (26.35%) were aware of HA symptoms like pain and/or discomfort in the jaw, neck, or back, while 71.65% showed awareness only of chest pain or discomfort as symptoms. Only 35.6% reported to call an ambulance if they experience someone suffering from HA symptoms, while 82% recognized ≥1 symptom, and only 11.5% recognized all five HA symptoms. Very few respondents, i.e., 1.3% reported awareness about correct recognition of all five HA symptoms. Respondents who had diabetes and hypercholesteremia were more likely to recognize all five HA symptoms. For those who had excellent awareness of all five HA symptoms, the odds ratio (OR) were significantly higher among single respondents (OR 0.023; 95% CI 0.001-0.594), Malay (OR 0.376; 95% CI 0.193-0.733), and those who received information associated with HA (OR 7.540; 95% CI 2.037-27.914). However, those who were aware that HA requires quick treatment had significantly low odds ratio (OR 0.176; 95% CI 0.044-0.710).

CONCLUSIONS: The awareness of and action towards the signs and symptoms of HA among the public were poor.

Matched MeSH terms: Myocardial Infarction*

Concomitant measurements of serum annexin A5 levels and hematological indices as markers in recent and old myocardial infarction with low ejection fraction: A preliminary study

Alhusseiny AH, Al-Nimer MS, Mohammad FI, Ali Jadoo SA

Int J Cardiol, 2016 Nov 15;223:514-518.

PMID: 27552568 DOI: 10.1016/j.ijcard.2016.08.244

Serum annexin A5 (anxA5) level is significantly increased in patients with acute coronary syndrome. Hematological indices are significantly increased in patients with ischemic heart disease. This study aimed to demonstrate the changes in the distribution of blood cells and the levels of anxA5 in patients presented with significant low ejection fraction ST-elevation acute myocardial infarction (STEMI) in comparison with corresponding patients with ischemic heart disease.

Matched MeSH terms: Anterior Wall Myocardial Infarction; ST Elevation Myocardial Infarction

Progression in sensing cardiac troponin biomarker charge transductions on semiconducting nanomaterials

Fathil MF, Md Arshad MK, Ruslinda AR, Nuzaihan M N M, Gopinath SC, Adzhri R, et al.

Anal Chim Acta, 2016 Sep 07;935:30-43.

PMID: 27543013 DOI: 10.1016/j.aca.2016.06.012

A real-time ability to interpret the interaction between targeted biomolecules and the surface of semiconductors (metal transducers) into readable electrical signals, without biomolecular modification involving fluorescence dyes, redox enzymes, and radioactive labels, created by label-free biosensors has been extensively researched. Field-effect transistor (FET)- and capacitor-based biosensors are among the diverse electrical charge biosensing architectures that have drawn much attention for having charge transduction; thus, enabling the early and rapid diagnosis of the appropriate cardiac biomarkers at lower concentrations. These semiconducting material-based transducers are very suitable to be integrated with portable electronic devices for future online collection, transmission, reception, analysis, and reporting. This overview elucidates and clarifies two major electrical label-free systems (FET- and capacitor-based biosensors) with cardiac troponin (cTn) biomarker-mediated charge transduction for acute myocardial infarction (AMI) diagnosis. Advances in these systems are highlighted by their progression in bridging the laboratory and industry; the foremost technologies have made the transition from benchtop to bedside and beyond.

Matched MeSH terms: Myocardial Infarction/diagnosis*

Cardiac arrhythmias in acute myocardial infarction

Ng WH, Goh TH, Ishak E, Ahmad Z

Med J Malaysia, 1979 Dec;34(2):131-5.

PMID: 548713

Matched MeSH terms: Myocardial Infarction/diagnosis*

ST. segment displacement in myocardial infarction

Fah NT

Med J Malaysia, 1977 Jun;31(4):309-15.

PMID: 927238

Matched MeSH terms: Myocardial Infarction/diagnosis*

Fulltext Using neural networks and just nine patient-reportable factors of screen for AMI

Bulgiba AM, Fisher MH

Health Informatics J, 2006 Sep;12(3):213-25.

PMID: 17023409 DOI: 10.1177/1460458206066665

The study investigated the effect of different input selections on the performance of artificial neural networks in screening for acute myocardial infarction (AMI) in Malaysian patients complaining of chest pain. We used hospital data to create neural networks with four input selections and used these to diagnose AMI. A 10-fold cross-validation and committee approach was used. All the neural networks using various input selections outperformed a multiple logistic regression model, although the difference was not statistically significant. The neural networks achieved an area under the ROC curve of 0.792 using nine inputs, whereas multiple logistic regression achieved 0.739 using 64 inputs. Sensitivity levels of over 90 per cent were achieved using low output threshold levels. Specificity levels of over 90 per cent were achieved using threshold levels of 0.4-0.5. Thus neural networks can perform as well as multiple logistic regression models even when using far fewer inputs.

Matched MeSH terms: Myocardial Infarction/diagnosis*

Acute myocardial infarction in an adolescent

Muthupalaniappen L, Menon RK, Das S

Saudi Med J, 2012 Feb;33(2):197-200.

PMID: 22327763

Myocardial infarction (MI) is known to be common in adults. Interestingly, we report a case of a 15-year-old boy who presented with typical chest pain secondary to myocardial infarct attributable to a combination of familial hyperlipidemia and possible episode of Kawasaki disease in the past. The patient failed treatment and follow-up care, and died 2 years later. Although rare, this case demonstrates that MI should be considered as a diagnosis in adolescents presenting with typical chest pain as early detection, and management is vital for survival.

Matched MeSH terms: Myocardial Infarction/etiology*

Fulltext Health utilities in Chinese patients with coronary heart disease and impaired glucose tolerance (ACE): A longitudinal analysis of a randomized, double-blind, placebo-controlled trial

Leal J, Becker F, Lim LL, Holman RR, Gray AM

J Diabetes, 2022 Jul;14(7):455-464.

PMID: 35876124 DOI: 10.1111/1753-0407.13294

BACKGROUND: We estimate health-related quality of life and the impact of four cardiovascular events (myocardial infarction [MI], stroke, congestive heart failure, angina) and gastrointestinal events in 6522 Chinese patients with coronary heart disease (CHD) and impaired glucose tolerance (IGT) participating in the Acarbose Cardiovascular Evaluation (ACE) trial.

METHODS: Health-related quality of life was captured using the EuroQol-5 Dimension-3 Level (EQ-5D-3L), with data collected at baseline and throughout the trial. Multilevel mixed-effects linear regression with random effects estimated health-related quality of life over time, capturing variation between hospital sites and individuals, and a fixed-effects linear model estimated the impact of cardiovascular and gastrointestinal events.

RESULTS: Patients were followed for a median of 5 years (interquartile range 3.4-6.0). The average baseline EQ-5D score of 0.930 (SD 0.104) remained relatively unchanged over the trial period with no evidence of statistically significant differences in EQ-5D score between randomized treatment groups. The largest decrement in the year of an event was estimated for stroke (-0.107, P

Matched MeSH terms: Myocardial Infarction*

Fulltext Utility of alpha-blockade in a hypotensive pheochromocytoma patient with myocardial infarction

Wahab NA, Zainudin S, AbAziz A, Kamaruddin NA

Med Princ Pract, 2015;24(1):96-8.

PMID: 25428406 DOI: 10.1159/000369021

OBJECTIVE: The aim of this case study is to emphasize the importance of α-blockade in managing a rare complication of an untreated pheochromocytoma.

CLINICAL PRESENTATION AND INTERVENTION: A 41-year-old man with previous bilateral pheochromocytoma presented with chest pain. He was suffering from cardiac failure and persistent hypotension requiring an inotrope. Cardiac markers, an electrocardiogram and an echocardiogram confirmed acute myocardial infarct with poor ejection fraction and global hypokinesia. An (18)F-fluorodeoxyglucose PET/CT scan showed progressive left suprarenal and organ of Zuckerkandl pheochromocytomas. Blood pressure stabilisation proved challenging but was achieved by titrating an incremental dose of α-blocker against a tapering inotropic dose.

CONCLUSION: This case showed the efficacy of an α-blocker despite persistent hypotension in a patient with pheochromocytoma-induced cardiomyopathy.

Matched MeSH terms: Myocardial Infarction/complications; Myocardial Infarction/diagnosis; Myocardial Infarction/drug therapy*

Displaying publications 41 - 60 of 262 in total