Displaying publications 41 - 60 of 616 in total

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  1. Fulltext Receiver-Based Ad Hoc On Demand Multipath Routing Protocol for Mobile Ad Hoc Networks
    Al-Nahari A, Mohamad MM
    PLoS One, 2016;11(6):e0156670.
    PMID: 27258013 DOI: 10.1371/journal.pone.0156670
    Decreasing the route rediscovery time process in reactive routing protocols is challenging in mobile ad hoc networks. Links between nodes are continuously established and broken because of the characteristics of the network. Finding multiple routes to increase the reliability is also important but requires a fast update, especially in high traffic load and high mobility where paths can be broken as well. The sender node keeps re-establishing path discovery to find new paths, which makes for long time delay. In this paper we propose an improved multipath routing protocol, called Receiver-based ad hoc on demand multipath routing protocol (RB-AOMDV), which takes advantage of the reliability of the state of the art ad hoc on demand multipath distance vector (AOMDV) protocol with less re-established discovery time. The receiver node assumes the role of discovering paths when finding data packets that have not been received after a period of time. Simulation results show the delay and delivery ratio performances are improved compared with AOMDV.
    Matched MeSH terms: Computer Simulation*
  2. Fulltext A Biogeography-Based Optimization Algorithm Hybridized with Tabu Search for the Quadratic Assignment Problem
    Lim WL, Wibowo A, Desa MI, Haron H
    Comput Intell Neurosci, 2016;2016:5803893.
    PMID: 26819585 DOI: 10.1155/2016/5803893
    The quadratic assignment problem (QAP) is an NP-hard combinatorial optimization problem with a wide variety of applications. Biogeography-based optimization (BBO), a relatively new optimization technique based on the biogeography concept, uses the idea of migration strategy of species to derive algorithm for solving optimization problems. It has been shown that BBO provides performance on a par with other optimization methods. A classical BBO algorithm employs the mutation operator as its diversification strategy. However, this process will often ruin the quality of solutions in QAP. In this paper, we propose a hybrid technique to overcome the weakness of classical BBO algorithm to solve QAP, by replacing the mutation operator with a tabu search procedure. Our experiments using the benchmark instances from QAPLIB show that the proposed hybrid method is able to find good solutions for them within reasonable computational times. Out of 61 benchmark instances tested, the proposed method is able to obtain the best known solutions for 57 of them.
    Matched MeSH terms: Computer Simulation*
  3. Fulltext A newton cooperative genetic algorithm method for in silico optimization of metabolic pathway production
    Ismail MA, Deris S, Mohamad MS, Abdullah A
    PLoS One, 2015;10(5):e0126199.
    PMID: 25961295 DOI: 10.1371/journal.pone.0126199
    This paper presents an in silico optimization method of metabolic pathway production. The metabolic pathway can be represented by a mathematical model known as the generalized mass action model, which leads to a complex nonlinear equations system. The optimization process becomes difficult when steady state and the constraints of the components in the metabolic pathway are involved. To deal with this situation, this paper presents an in silico optimization method, namely the Newton Cooperative Genetic Algorithm (NCGA). The NCGA used Newton method in dealing with the metabolic pathway, and then integrated genetic algorithm and cooperative co-evolutionary algorithm. The proposed method was experimentally applied on the benchmark metabolic pathways, and the results showed that the NCGA achieved better results compared to the existing methods.
    Matched MeSH terms: Computer Simulation*
  4. A review of fluid-structure interaction simulation for patients with sleep related breathing disorders with obstructive sleep
    Faizal WM, Ghazali NNN, Badruddin IA, Zainon MZ, Yazid AA, Ali MAB, et al.
    Comput Methods Programs Biomed, 2019 Oct;180:105036.
    PMID: 31430594 DOI: 10.1016/j.cmpb.2019.105036
    Obstructive sleep apnea is one of the most common breathing disorders. Undiagnosed sleep apnea is a hidden health crisis to the patient and it could raise the risk of heart diseases, high blood pressure, depression and diabetes. The throat muscle (i.e., tongue and soft palate) relax narrows the airway and causes the blockage of the airway in breathing. To understand this phenomenon computational fluid dynamics method has emerged as a handy tool to conduct the modeling and analysis of airflow characteristics. The comprehensive fluid-structure interaction method provides the realistic visualization of the airflow and interaction with the throat muscle. Thus, this paper reviews the scientific work related to the fluid-structure interaction (FSI) for the evaluation of obstructive sleep apnea, using computational techniques. In total 102 articles were analyzed, each article was evaluated based on the elements related with fluid-structure interaction of sleep apnea via computational techniques. In this review, the significance of FSI for the evaluation of obstructive sleep apnea has been critically examined. Then the flow properties, boundary conditions and validation of the model are given due consideration to present a broad perspective of CFD being applied to study sleep apnea. Finally, the challenges of FSI simulation methods are also highlighted in this article.
    Matched MeSH terms: Computer Simulation*
  5. The effects of electrical and thermal boundary condition on the simulation of radiofrequency ablation of liver cancer for tumours located near to the liver boundary
    Ooi EH, Lee KW, Yap S, Khattab MA, Liao IY, Ooi ET, et al.
    Comput Biol Med, 2019 03;106:12-23.
    PMID: 30665137 DOI: 10.1016/j.compbiomed.2019.01.003
    Effects of different boundary conditions prescribed across the boundaries of radiofrequency ablation (RFA) models of liver cancer are investigated for the case where the tumour is at the liver boundary. Ground and Robin-type conditions (electrical field) and body temperature and thermal insulation (thermal field) conditions are examined. 3D models of the human liver based on publicly-available CT images of the liver are developed. An artificial tumour is placed inside the liver at the boundary. Simulations are carried out using the finite element method. The numerical results indicated that different electrical and thermal boundary conditions led to different predictions of the electrical potential, temperature and thermal coagulation distributions. Ground and body temperature conditions presented an unnatural physical conditions around the ablation site, which results in more intense Joule heating and excessive heat loss from the tissue. This led to thermal damage volumes that are smaller than the cases when the Robin type or the thermal insulation conditions are prescribed. The present study suggests that RFA simulations in the future must take into consideration the choice of the type of electrical and thermal boundary conditions to be prescribed in the case where the tumour is located near to the liver boundary.
    Matched MeSH terms: Computer Simulation*
  6. Fulltext Prediction of remaining useful life (RUL) of Komatsu excavator under reliability analysis in the Weibull-frailty model
    Ghomghaleh A, Khaloukakaie R, Ataei M, Barabadi A, Nouri Qarahasanlou A, Rahmani O, et al.
    PLoS One, 2020;15(7):e0236128.
    PMID: 32667940 DOI: 10.1371/journal.pone.0236128
    It is an essential task to estimate the remaining useful life (RUL) of machinery in the mining sector aimed at ensuring the production and the customer's satisfaction. In this study, a conceptual framework was used to determine the RUL under the reliability analysis in a frailty model. The proposed framework was implemented on a Komatsu PC-1250 excavator from the Sungun copper mine. Also, the Weibull-frailty model was selected to describe the failure behavior and compare it with the classical-exponential model. The frailty model was also used to evaluate the impact of unobserved environmental conditions on the RUL values. Both applied models were fitted to the obtained data from 80 operational hours of the Komatsu PC-1250 excavator. Plotting the results from the reliability analysis of two models demonstrated that the mine system with the frailty model performs better than the classical model before reaching the reliability of 80%. Besides, the frailty model shows a coherent with the operational time of the excavator, while the classical model demonstrates a sinusoid variation. The obtained results may be used for the development of maintenance, preventive repairs planning, and the spare parts replacement intervals.
    Matched MeSH terms: Computer Simulation*
  7. In vitro and in silico anticancer evaluation of a medicinal mushroom, Ganoderma neo-japonicum Imazeki, against human colonic carcinoma cells
    Lau MF, Chua KH, Sabaratnam V, Kuppusamy UR
    Biotechnol Appl Biochem, 2021 Aug;68(4):902-917.
    PMID: 32856730 DOI: 10.1002/bab.2013
    Ganoderma neo-japonicum is a well-known medicinal mushroom in Asian countries. However, scientific validations on its curative activities are confined to cirrhosis and diabetes. In this study, the anticancer properties of G. neo-japonicum were evaluated using cellular and computational models. The ethanolic extract (EtOH) with a promising inhibitory effect was fractionated into four different fractions: hexane (Hex), chloroform (Chl), butanol (Btn), and aqueous (Aq). The active fractions were then subjected to cell apoptosis assessment and phytochemical profiling. Molecular docking was conducted to elucidate the affinity of selected constituents towards antiapoptotic Bcl-2 protein. The butanol fraction showed the highest antioxidant activities as well as total phenolic content. Both hexane and chloroform fractions exerted a potent cytotoxic effect on colonic carcinoma cells through the induction of apoptosis. Phytochemical analysis revealed that the chloroform fraction is terpenoid enriched whereas the hexane fraction comprises predominantly sterol constituents. Stellasterol and 1,25-dihydroxyvitamin D3 3-glycoside were demonstrated to have a high affinity towards Bcl-2 protein. Overall, G. neo-japonicum can be considered as a compelling therapeutic candidate for cancer treatment.
    Matched MeSH terms: Computer Simulation*
  8. Shape-shifting thermal coagulation zone during saline-infused radiofrequency ablation: A computational study on the effects of different infusion location
    Kho ASK, Foo JJ, Ooi ET, Ooi EH
    Comput Methods Programs Biomed, 2020 Feb;184:105289.
    PMID: 31891903 DOI: 10.1016/j.cmpb.2019.105289
    BACKGROUND AND OBJECTIVE: The majority of the studies on radiofrequency ablation (RFA) have focused on enlarging the size of the coagulation zone. An aspect that is crucial but often overlooked is the shape of the coagulation zone. The shape is crucial because the majority of tumours are irregularly-shaped. In this paper, the ability to manipulate the shape of the coagulation zone following saline-infused RFA by altering the location of saline infusion is explored.

    METHODS: A 3D model of the liver tissue was developed. Saline infusion was described using the dual porosity model, while RFA was described using the electrostatic and bioheat transfer equations. Three infusion locations were investigated, namely at the proximal end, the middle and the distal end of the electrode. Investigations were carried out numerically using the finite element method.

    RESULTS: Results indicated that greater thermal coagulation was found in the region of tissue occupied by the saline bolus. Infusion at the middle of the electrode led to the largest coagulation volume followed by infusion at the proximal and distal ends. It was also found that the ability to delay roll-off, as commonly associated with saline-infused RFA, was true only for the case when infusion is carried out at the middle. When infused at the proximal and distal ends, the occurrence of roll-off was advanced. This may be due to the rapid and more intense heating experienced by the tissue when infusion is carried out at the electrode ends where Joule heating is dominant.

    CONCLUSION: Altering the location of saline infusion can influence the shape of the coagulation zone following saline-infused RFA. The ability to 'shift' the coagulation zone to a desired location opens up great opportunities for the development of more precise saline-infused RFA treatment that targets specific regions within the tissue.

    Matched MeSH terms: Computer Simulation*
  9. Analytical and computational sliding wear prediction in a novel knee implant: a case study
    Hussin MS, Fernandez J, Ramezani M, Kumar P, Kelly PA
    Comput Methods Biomech Biomed Engin, 2020 Mar;23(4):143-154.
    PMID: 31928215 DOI: 10.1080/10255842.2019.1709118
    Osteoarthritis (OA) is a commonly occurring cartilage degenerative disease. The end stage treatment is Total Knee Arthroplasty (TKA), which can be costly in terms of initial surgery, but also in terms of revision knee arthroplasty, which is quite often required. A novel conceptual knee implant has been proposed to function as a reducer of stress across the joint surface, to extend the period of time before TKA becomes necessary. The objective of this paper is to develop a computational model which can be used to assess the wear arising at the implant articulating surfaces. Experimental wear coefficients were determined from physical testing, the results of which were verified using a semi-analytical model. Experimental results were incorporated into an anatomically correct computational model of the knee and implant. The wear-rate predicted for the implant was 27.74 mm3 per million cycles (MC) and the wear depth predicted was 1.085 mm/MC. Whereas the wear-rate is comparable to that seen in conventional knee implants, the wear depth is significantly higher than for conventional knee prostheses, and indicates that, in order to be viable, wear-rates should be reduced in some way, perhaps by using low-wear polymers.
    Matched MeSH terms: Computer Simulation*
  10. Fulltext Forecasting shear stress parameters in rectangular channels using new soft computing methods
    Sheikh Khozani Z, Sheikhi S, Mohtar WHMW, Mosavi A
    PLoS One, 2020;15(4):e0229731.
    PMID: 32271780 DOI: 10.1371/journal.pone.0229731
    Shear stress comprises basic information for predicting the average depth velocity and discharge in channels. With knowledge of the percentage of shear force carried by walls (%SFw) it is possible to more accurately estimate shear stress values. The %SFw, non-dimension wall shear stress ([Formula: see text]) and non-dimension bed shear stress ([Formula: see text]) in smooth rectangular channels were predicted by a three methods, the Bayesian Regularized Neural Network (BRNN), the Radial Basis Function (RBF), and the Modified Structure-Radial Basis Function (MS-RBF). For this aim, eight data series of research experimental results in smooth rectangular channels were used. The results of the new method of MS-RBF were compared with those of a simple RBF and BRNN methods and the best model was selected for modeling each predicted parameters. The MS-RBF model with RMSE of 3.073, 0.0366 and 0.0354 for %SFw, [Formula: see text] and [Formula: see text] respectively, demonstrated better performance than those of the RBF and BRNN models. The results of MS-RBF model were compared with three other proposed equations by researchers for trapezoidal channels and rectangular ducts. The results showed that the MS-RBF model performance in estimating %SFw, [Formula: see text] and [Formula: see text] is superior than those of presented equations by researchers.
    Matched MeSH terms: Computer Simulation*
  11. Fulltext CFD study on NACA 4415 airfoil implementing spherical and sinusoidal Tubercle Leading Edge
    Aftab SMA, Ahmad KA
    PLoS One, 2017;12(8):e0183456.
    PMID: 28850622 DOI: 10.1371/journal.pone.0183456
    The Humpback whale tubercles have been studied for more than a decade. Tubercle Leading Edge (TLE) effectively reduces the separation bubble size and helps in delaying stall. They are very effective in case of low Reynolds number flows. The current Computational Fluid Dynamics (CFD) study is on NACA 4415 airfoil, at a Reynolds number 120,000. Two TLE shapes are tested on NACA 4415 airfoil. The tubercle designs implemented on the airfoil are sinusoidal and spherical. A parametric study is also carried out considering three amplitudes (0.025c, 0.05c and 0.075c), the wavelength (0.25c) is fixed. Structured mesh is utilized to generate grid and Transition SST turbulence model is used to capture the flow physics. Results clearly show spherical tubercles outperform sinusoidal tubercles. Furthermore experimental study considering spherical TLE is carried out at Reynolds number 200,000. The experimental results show that spherical TLE improve performance compared to clean airfoil.
    Matched MeSH terms: Computer Simulation*
  12. Fulltext In-silico identification of deleterious non-synonymous SNPs of TBX1 gene: Functional and structural impact towards 22q11.2DS
    Almakhari M, Chen Y, Kong AS, Moradigaravand D, Lai KS, Lim SE, et al.
    PLoS One, 2024;19(6):e0298092.
    PMID: 38905172 DOI: 10.1371/journal.pone.0298092
    The TBX1 gene plays a critical role in the development of 22q11.2 deletion syndrome (22q11.2DS), a complex genetic disorder associated with various phenotypic manifestations. In this study, we performed in-silico analysis to identify potentially deleterious non-synonymous single nucleotide polymorphisms (nsSNPs) within the TBX1 gene and evaluate their functional and structural impact on 22q11.2DS. A comprehensive analysis pipeline involving multiple computational tools was employed to predict the pathogenicity of nsSNPs. This study assessed protein stability and explored potential alterations in protein-protein interactions. The results revealed the rs751339103(C>A), rs780800634(G>A), rs1936727304(T>C), rs1223320618(G>A), rs1248532217(T>C), rs1294927055 (C>T), rs1331240435 (A>G, rs1601289406 (A>C), rs1936726164 (G>A), and rs911796187(G>A) with a high-risk potential for affecting protein function and stability. These nsSNPs were further analyzed for their impact on post-translational modifications and structural characteristics, indicating their potential disruption of molecular pathways associated with TBX1 and its interacting partners. These findings provide a foundation for further experimental studies and elucidation of potential therapeutic targets and personalized treatment approaches for individuals affected by 22q11.2DS.
    Matched MeSH terms: Computer Simulation*
  13. Fulltext Computational fluid dynamics modelling of microfluidic channel for dielectrophoretic BioMEMS application
    Low WS, Kadri NA, Abas WA
    ScientificWorldJournal, 2014;2014:961301.
    PMID: 25136701 DOI: 10.1155/2014/961301
    We propose a strategy for optimizing distribution of flow in a typical benchtop microfluidic chamber for dielectrophoretic application. It is aimed at encouraging uniform flow velocity along the whole analysis chamber in order to ensure DEP force is evenly applied to biological particle. Via the study, we have come up with a constructive strategy in improving the design of microfluidic channel which will greatly facilitate the use of DEP system in laboratory and primarily focus on the relationship between architecture and cell distribution, by resorting to the tubular structure of blood vessels. The design was validated by hydrodynamic flow simulation using COMSOL Multiphysics v4.2a software. Simulations show that the presence of 2-level bifurcation has developed portioning of volumetric flow which produced uniform flow across the channel. However, further bifurcation will reduce the volumetric flow rate, thus causing undesirable deposition of cell suspension around the chamber. Finally, an improvement of microfluidic design with rounded corner is proposed to encourage a uniform cell adhesion within the channel.
    Matched MeSH terms: Computer Simulation
  14. Fulltext An Aligned-Gap and Centered-Gap Rectangular Multiple Split Ring Resonator for dielectric sensing applications
    Rusni IM, Ismail A, Alhawari AR, Hamidon MN, Yusof NA
    Sensors (Basel), 2014 Jul 21;14(7):13134-48.
    PMID: 25051036 DOI: 10.3390/s140713134
    This paper presents the design and development of a planar Aligned-Gap and Centered-Gap Rectangular Multiple Split Ring Resonator (SRR) for microwave sensors that operates at a resonance frequency around 5 GHz. The sensor consists of a microstrip transmission line loaded with two elements of rectangular SRR on both sides. The proposed metamaterial sensors were designed and fabricated on Rogers RT5880 substrate having dielectric constant of 2.2 and thickness of 0.787 mm. The final dimension of the proposed sensor was measured at 35 × 14 mm2. Measured results show good agreement with simulated ones as well as exhibiting high Q-factor for use in sensing application. A remarkably shift of resonance frequency is observed upon introduction of several sample with different dielectric value.
    Matched MeSH terms: Computer Simulation
  15. Fulltext Experimental investigation of a wing-in-ground effect craft
    Tofa MM, Maimun A, Ahmed YM, Jamei S, Priyanto A, Rahimuddin
    ScientificWorldJournal, 2014;2014:489308.
    PMID: 24701170 DOI: 10.1155/2014/489308
    The aerodynamic characteristics of the wing-in-ground effect (WIG) craft model that has a noble configuration of a compound wing was experimentally investigated and Universiti Teknologi Malaysia (UTM) wind tunnel with and without endplates. Lift and drag forces, pitching moment coefficients, and the centre of pressure were measured with respect to the ground clearance and the wing angle of attack. The ground effect and the existence of the endplates increase the wing lift-to-drag ratio at low ground clearance. The results of this research work show new proposed design of the WIG craft with compound wing and endplates, which can clearly increase the aerodynamic efficiency without compromising the longitudinal stability. The use of WIG craft is representing an ambitious technology that will help in reducing time, effort, and money of the conventional marine transportation in the future.
    Matched MeSH terms: Computer Simulation
  16. Fulltext Comparison of newtonian and special-relativistic trajectories with the general-relativistic trajectory for a low-speed weak-gravity system
    Liang SN, Lan BL
    PLoS One, 2012;7(4):e34720.
    PMID: 22536328 DOI: 10.1371/journal.pone.0034720
    We show, contrary to expectation, that the trajectory predicted by general-relativistic mechanics for a low-speed weak-gravity system is not always well-approximated by the trajectories predicted by special-relativistic and newtonian mechanics for the same parameters and initial conditions. If the system is dissipative, the breakdown of agreement occurs for chaotic trajectories only. If the system is non-dissipative, the breakdown of agreement occurs for chaotic trajectories and non-chaotic trajectories. The agreement breaks down slowly for non-chaotic trajectories but rapidly for chaotic trajectories. When the predictions are different, general-relativistic mechanics must therefore be used, instead of special-relativistic mechanics (newtonian mechanics), to correctly study the dynamics of a weak-gravity system (a low-speed weak-gravity system).
    Matched MeSH terms: Computer Simulation
  17. Inverse frequency weighting of fragments for similarity-based virtual screening
    Arif SM, Holliday JD, Willett P
    J Chem Inf Model, 2010 Aug 23;50(8):1340-9.
    PMID: 20672867 DOI: 10.1021/ci1001235
    This paper discusses the weighting of two-dimensional fingerprints for similarity-based virtual screening, specifically the use of weights that assign greatest importance to the substructural fragments that occur least frequently in the database that is being screened. Virtual screening experiments using the MDL Drug Data Report and World of Molecular Bioactivity databases show that the use of such inverse frequency weighting schemes can result, in some circumstances, in marked increases in screening effectiveness when compared with the use of conventional, unweighted fingerprints. Analysis of the characteristics of the various schemes demonstrates that such weights are best used to weight the fingerprint of the reference structure in a similarity search, with the database structures' fingerprints unweighted. However, the increases in performance resulting from such weights are only observed with structurally homogeneous sets of active molecules; when the actives are diverse, the best results are obtained using conventional, unweighted fingerprints for both the reference structure and the database structures.
    Matched MeSH terms: Computer Simulation
  18. Static watson-crick linear grammars and its computational power
    Aqilahfarhana Abdul Rahman, Wan Heng Fong, Nor Haniza Sarmin, Sherzod Turaev, Nurul Liyana Mohamad Zulkufli
    MATEMATIKA, 2019;35(3):283-296.
    MyJurnal
    DNA computing, or more generally, molecular computing, is a recent development on computations using biological molecules, instead of the traditional silicon-chips. Some computational models which are based on different operations of DNA molecules have been developed by using the concept of formal language theory. The operations of DNA molecules inspire various types of formal language tools which include sticker systems, grammars and automata. Recently, the grammar counterparts of Watson-Crick automata known as Watson-Crick grammars which consist of regular, linear and context-free grammars, are defined as grammar models that generate double-stranded strings using the important feature of Watson-Crick complementarity rule. In this research, a new variant of static Watson-Crick linear grammar is introduced as an extension of static Watson-Crick regular grammar. A static Watson-Crick linear grammar is a grammar counterpart of sticker system that generates the double-stranded strings and uses rule as in linear grammar. The main result of the paper is to determine some computational properties of static Watson-Crick linear grammars. Next, the hierarchy between static Watson-Crick languages, Watson-Crick languages, Chomsky languages and families of languages generated by sticker systems are presented.
    Matched MeSH terms: Computer Simulation
  19. Fulltext Computational fluid dynamics modelling of human upper airway: A review
    Faizal WM, Ghazali NNN, Khor CY, Badruddin IA, Zainon MZ, Yazid AA, et al.
    Comput Methods Programs Biomed, 2020 Nov;196:105627.
    PMID: 32629222 DOI: 10.1016/j.cmpb.2020.105627
    BACKGROUND AND OBJECTIVE: Human upper airway (HUA) has been widely investigated by many researchers covering various aspects, such as the effects of geometrical parameters on the pressure, velocity and airflow characteristics. Clinically significant obstruction can develop anywhere throughout the upper airway, leading to asphyxia and death; this is where recognition and treatment are essential and lifesaving. The availability of advanced computer, either hardware or software, and rapid development in numerical method have encouraged researchers to simulate the airflow characteristics and properties of HUA by using various patient conditions at different ranges of geometry and operating conditions. Computational fluid dynamics (CFD) has emerged as an efficient alternative tool to understand the airflow of HUA and in preparing patients to undergo surgery. The main objective of this article is to review the literature that deals with the CFD approach and modeling in analyzing HUA.

    METHODS: This review article discusses the experimental and computational methods in the study of HUA. The discussion includes computational fluid dynamics approach and steps involved in the modeling used to investigate the flow characteristics of HUA. From inception to May 2020, databases of PubMed, Embase, Scopus, the Cochrane Library, BioMed Central, and Web of Science have been utilized to conduct a thorough investigation of the literature. There had been no language restrictions in publication and study design of the database searches. A total of 117 articles relevant to the topic under investigation were thoroughly and critically reviewed to give a clear information about the subject. The article summarizes the review in the form of method of studying the HUA, CFD approach in HUA, and the application of CFD for predicting HUA obstacle, including the type of CFD commercial software are used in this research area.

    RESULTS: This review found that the human upper airway was well studied through the application of computational fluid dynamics, which had considerably enhanced the understanding of flow in HUA. In addition, it assisted in making strategic and reasonable decision regarding the adoption of treatment methods in clinical settings. The literature suggests that most studies were related to HUA simulation that considerably focused on the aspects of fluid dynamics. However, there is a literature gap in obtaining information on the effects of fluid-structure interaction (FSI). The application of FSI in HUA is still limited in the literature; as such, this could be a potential area for future researchers. Furthermore, majority of researchers present the findings of their work through the mechanism of airflow, such as that of velocity, pressure, and shear stress. This includes the use of Navier-Stokes equation via CFD to help visualize the actual mechanism of the airflow. The above-mentioned technique expresses the turbulent kinetic energy (TKE) in its result to demonstrate the real mechanism of the airflow. Apart from that, key result such as wall shear stress (WSS) can be revealed via turbulent kinetic energy (TKE) and turbulent energy dissipation (TED), where it can be suggestive of wall injury and collapsibility tissue to the HUA.

    Matched MeSH terms: Computer Simulation
  20. Aerosol deposition and airflow dynamics in healthy and asthmatic human airways during inhalation
    Chen WH, Chang CM, Mutuku JK, Lam SS, Lee WJ
    J Hazard Mater, 2021 08 15;416:125856.
    PMID: 34492805 DOI: 10.1016/j.jhazmat.2021.125856
    Inhalation of aerosols such as pharmaceutical aerosols or virus aerosol uptake is of great concern to the human population. To elucidate the underlying aerosol dynamics, the deposition fractions (DFs) of aerosols in healthy and asthmatic human airways of generations 13-15 are predicted. The Navier-stokes equations governing the gaseous phase and the discrete phase model for particles' motion are solved using numerical methods. The main forces responsible for deposition are inertial impaction forces and complex secondary flow velocities. The curvatures and sinusoidal folds in the asthmatic geometry lead to the formation of complex secondary flows and hence higher DFs. The intensities of complex secondary flows are strongest at the generations affected by asthma. The DF in the healthy airways is 0%, and it ranges from 1.69% to 52.93% in the asthmatic ones. From this study, the effects of the pharmaceutical aerosol particle diameters in the treatment of asthma patients can be established, which is conducive to inhibiting the inflammation of asthma airways. Furthermore, with the recent development of COVID-19 which causes pneumonia, the predicted physics and effective simulation methods of bioaerosols delivery to asthma patients are vital to prevent the exacerbation of the chronic ailment and the epidemic.
    Matched MeSH terms: Computer Simulation
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