Gestational Diabetes Mellitus (GDM) is associated with pregnancy complications, however its mechanism has not been fully understood. The aim of this study was to investigate the single nucleotide polymorphism (SNP) for identifying candidate genes involve in risk factors and complications of GDM. A total of 174 pregnant women with GDM and 114 healthy pregnant women were genotyped with 384 SNPs from 236 genes. The SNPs identified were rs10946398 (CDKAL1) in GDM risk factors; rs328 (LPL) and rs1042778 (OXTR) in complications of caesarean section; rs5404 (SLC2A2), rs5400 (SLC2A2) and rs13306465 (IRS1) for neonatal intensive care admission. Whereby SNPs rs12255372, rs7901695 and rs7903146 from TCF7L2 gene had six times higher risk (OR, 6.40-6.53) for T2DM at postpartum. In conclusion, although the above SNPs were identified with GDM risk factors and complications among pregnant Malaysian women with GDM, a larger study is needed to ascertain this candidate genes actual association.
INTRODUCTION The continuous monitoring of smoking prevalence and its associated factors is an integral part of anti-smoking programmes and valuable for the evaluation of the effectiveness of anti-smoking measures and policies. This study aimed at determining prevalence of smoking and identifying socio-demographic factors associated with smoking among adults in Malaysia aged 15 years and over.
METHODS This is a cross-sectional study with a representative sample of 21 445 adults in Malaysia, aged 15 years and over, selected via a stratified, two-stage proportionate-to-size sampling method. Data were obtained from face-to-face interviews by trained research assistants, using a standard validated questionnaire. Multivariable logistic regression was performed to determine socio-demographic factors associated with smoking among Malaysians.
RESULTS The overall prevalence of smoking was 22.8% (95% CI: 21.9–23.8%), with males having a significantly higher prevalence compared to females (43.0%, 95% CI: 41.1–44.6 vs 1.4%, 95% CI: 1.1–1.7). The highest smoking prevalence was observed among other ethnicities (35.7%), those aged 25–44 years (59.3%), and low educational attainment (25.2%). Males, those with lower educational attainment and Malays were significantly associated with smoking.
CONCLUSIONS The prevalence of smoking among Malaysians, aged 15 years and over, remains high despite the implementation of several anti-smoking measures over the past decades. Specially tailored anti-smoking policies or measures, particularly targeting males, the Malays, younger adults and those with lower educational attainment, are greatly warranted to reduce the prevalence of smoking in Malaysia.
Study name: National Health and Morbidity Survey (NHMS-2015)
The objective of the present study is to examine the sociodemographic determinants of amount of smoking knowledge in Malaysia. Data are obtained from the Global Adult Tobacco Survey (GATS). The GATS uses a multistage stratified sampling. A total of 4,153 respondents are used for analyses. The effects of sociodemographic factors on smoking knowledge are examined using a negative binomial regression. Age, wealth index, education, ethnicity, house locality, and smoking behavior are significantly associated with smoking knowledge. In particular, there are negative relationships between smoking knowledge and higher wealth index, less-educated individuals, Chinese, rural dwellers, and smokers. The present study concludes that sociodemographic factors play an important role in determining smoking knowledge. Hence, as an intervention measure directed toward improving the knowledge of smoking among Malaysian population, effective policies should pay special attention to individuals who are likely to have poor information on smoking.
Study name: Global Adults Tobacco Survey (GATS-2011)
There is some evidence stated that mood states might influence cognitive functioning, such as episodic memory, working memory and creative problem solving. This study was conducted to evaluate the relationship between mood states and cognitive functioning among older adults with Mild Cognitive Impairment (MCI). This study involved 12 male and 37 female subjects from Klang Valley aged 60 year old and above. MCI was defined based on criteria proposed by Peterson. Cognitive functions of the subjects were accessed using Mini Mental State Examination (MMSE), Rey Auditory Verbal Learning Test (RAVLT), Digit Span, Digit Symbol Substituition Test (DSST) and Visual Reproduction; while mood states including tension, depression, anger, vigour, esteem related affect, fatigue and confusion were accessed using Profile of Mood States (POMS) questionnaire. Total positive subscales score, total negative subscales score and total mood disturbance (TMD) were also calculated. There were significant positive correlations between tension (r = 0.325, p = 0.30), vigour (r = 0.235, p = 0.036), esteem related affect (r = 0.316, p = 0.034) and total positive subscales score (r = 0.307, p = 0.040) with verbal episodic memory as measured using RAVLT fifth trial. In addition, positive correlations were also observed between vigour (r = 0.228, p = 0.035) and total positive subscales score (r = 0.237, p = 0.025) with DSST. After adjusted for confounding factors, subjects who scored higher in esteem related affect (Adjusted OR = 0.390, 95% CI [0.069-0.711], p = 0.019) and tension (Adjusted OR = 0.253, 95% CI [0.075-0.431], p = 0.007) had better verbal episodic memory. Subjects who have higher total positive subscales score were also had faster processing speed (OR = 0.856, 95% CI [0.099-1.614], p = 0.028). However after adjusted for confounding factors, the relationship was not significant (Adjusted OR = 0.383, 95% CI [-0.247-1.013], p = 2.226). Older adults with MCI who had a more positive mood tend to have a better short-term verbal memory and faster processing speed.
Aris T, Abd Ghani AA, Mohd Yusoff MF, Robert TG, Tee GH, Mohd Hasri NH, et al.
ISBN: 978-983-2387-30-5
Citation: Aris T, Abd Ghani AA, Mohd Yusoff MF, Robert TG, Tee GH, Mohd Hasri NH, et al. Tobacco & E-cigarette Survey Among Malaysian Adolescent (TECMA) 2016. Kuala Lumpur: Institute for Public Health, National Institutes of Health, Ministry of Health Malaysia; 2016
This study investigates bullying and victimisation in juvenile rehabilitation institutions in Malaysia, where research on this phenomenon has been particularly limited. It examines the prevalence of bullying and victimisation in these settings and investigates the role of personal characteristics and aspects of institutional environments, and explores how these factors relate to bullying behaviour. The study comprised a survey completed by 289 male and female young people, aged 12 to 21 years old, in 8 juvenile rehabilitation institutions, using the scale version of Direct and Indirect Prisoner Behaviour Checklist (DIPC-SCALEDr) and the Measuring the Quality of Prison Life (MQPL) instruments. The findings showed that 95 percent of young people reported at least one behaviour indicative of bullying others, and 99 percent reported at least one behaviour indicative of victimisation in a month. Seven predictors were found to underpin bullying behaviour, including three personal characteristics (i.e. time spent in the institution, experiences of punishment inside the institution, and gang membership) and four institutional dimensions (i.e respect; bureaucratic legitimacy; fairness; and family contact). To conclude, bullying behaviour seemed to be normalized in juvenile rehabilitation institutions. As the heart of institution, staff members play an important role to control bullying behaviour amongst young people. The importance of these findings for bullying prevention strategies and directions for future research are discussed.
The prevalence of Autism Spectrum Disorder (ASD) cases has been increasing worldwide. There are countless aspects of challenges faced by parents to bring up children with ASD. Parents of children with ASD are often reported to have higher stress in parenting compared to parents with normal children or children with other disabilities such as Down syndrome. Therefore, this study explored the challenges faced by mothers of children with ASD. Mothers whom were selected are the primary guardians and spend a lot of time nurturing these children. This qualitative study involved in-depth interviews with five (5) informants in Selangor. The thematic analysis identified the challenges faced by the mothers of children with ASD, which are the aspects of behavioral, financial and community acceptance. The findings showed that mothers to children with ASD encountered numerous complicated challenges which require the support of all parties to address those challenges. High support and compassionate understanding are really needed from the spouse, normal children, local communities, and government to alleviate their difficulties. Thus, the findings of this study hopefully will help various parties to understand the challenges faced by the mothers of children with ASD. It can also be the guiding principle in designing supportive programs and interventions for children with ASD as well as their parents.
The first time report on the feeding ecology and food preference of mangrove horseshoe crab Carcinoscorpius rotundicauda (Latreille 1802) at their nesting grounds along the Pahang coast is given. Monthly sampling was carried out between March 2010 and February 2011 covering both monsoonal (March to October) and non-monsoonal (November to February) seasons. Major macrobenthic gut contents (bivalves, gastropods, crustaceans, polychaetes and miscellaneous food items including plant materials) were identified using microscopic examination. An electivity index (E1) was calculated for the frequent food items observed in the gut region of C. rotundicauda during monsoon and non-monsoon seasons. The EI was negative for crustaceans and positive for all the other food items including bivalves, gastropods, polychaetes and miscellaneous food items (which include insects, amphipods, Isopods, larval and juvenile stages of fishes, foraminifera and other Annelid worms). It is interesting to note that C. rotundicauda prefered less number of bivalves than polychaetes during non monsoon seasons but it was the reverse during monsoonal period. Male crabs intensely preyed on gastropods and female prefers polychaete worms during the peak mating/nesting season (June - August 2010). Seasonal variations in food composition showed that mollusks formed the main item especially gastropods. Unidentified organic matters in the gut content analysis of C. rotundicauda showed high preference towards plant materials. Gastro Somatic Index (GaSI) analysis showed that the feeding intensity of male crabs was higher during non-monsoon period while it was higher during monsoonal period in female crabs. In conclusion, the feeding ecology of mangrove horseshoe crabs were more similar to its closer and distant conspecifics. However, it was postulated that the higher preference of polychaete worms by the female C. rotundicauda during the peak mating season indicated its role in regulating the nesting behaviour.
A cross sectional study was conducted to determine the prevalence of Sarcopenia and its association with health profiles and oxidative stress among multiethnic older adults in an urban area of Malaysia. Sarcopenia was assessed using Bioimpedance analysis (BIA) and the associations between demography, socioeconomic status, lifestyle practices, health risk factors and blood profile were examined on 388 apparently healthy subjects aged 60 years and above. Prevalence of sarcopenia was 89.0% in men and 40.3% in women with the overall prevalence of 59.8%. It was found that prevalence of severe sarcopenia was 13.9% and sarcopenia obese was 23.5%. Binary logistic regression showed that there was no predictor found in men or women. However, a decline in muscle mass was observed in sarcopenic as compared with normal subjects. Sarcopenia is prevalent and there is a need to implement interventional strategies to prevent sarcopenia and its associated comorbidities.
Introduction. Male-to-female transgender individuals are known as mak nyahs in Malaysia. Akin to many other countries, mak nyahs face discriminations in securing proper employment, thus many end up in sex trade, exposing them to HIV-related high risk behaviours. This paper aims to investigate the knowledge, attitude, and risk behaviours in HIV/AIDS among mak nyahs in Malaysia. Method. Validated questionnaires in local language were used. Knowledge, attitude, and HIV-related risk behaviours were measured. With respondent-driven sampling method, 54 subjects participated in the survey. IBM SPSS was used for data analysis. Results. Majority of the subjects reported to have HIV-related sexual risk, although only a quarter were sex workers. Misconceptions still remained among the subjects. Inconsistent condom use was common. Adequate knowledge did result in better attitude towards HIV/AIDS. However, multiple regression analysis showed that subjects with higher knowledge in HIV/AIDS tend to have higher sexual risks (β = 0.320, p = 0.030). Conclusion. Educating the transgender community about HIV/AIDS does not seem to adequately reduce the HIV-related sexual risks. Other approaches, i.e. socio-cultural values and religious practices may be effective to instil higher levels of awareness and self-responsibility in this community to eliminate HIVrelated high risk behaviours.
Happiness is the natural goal of life for every human being. Every indivdual is trying to find happiness because it describes a good life. Therefore, this study aims to examine an influence on happiness, which is optimistic, using a positive psychological strength,. Social support is utilized as an external quality as it supports the optimistic influence towards happiness. The study was conducted on 436 adolescents in higher education, aged between 18 and 25 years old. The quantitative study uses a set of questionnaires to obtain the data, Extended Life Orientation Test for optimistic measurements, Inventory of Socially Supportive Behavior Short Form measures social support, and Oxford Happiness Questionnaire measures adolescents happiness. Descriptively, adolescents in higher education showed high optimism (Min = 3.77, SP = .62), while moderate social support for the three forms of support, namely guidance support (Min = 3.07, SP = .81), emotional support (Min = 3.17, SP = .99) and tangible support (Min = 2.82, SP = .95). Adolescents in higher education reported having a moderate level of happiness (Min = 3.39, S.P = .92). The findings show that guidance and emotion support mediating the influence of optimistic towards happiness among adolescents in higher education. Tangible support does not play any role. The implication of the study is to adolescents that even the positive attitudes of optimistic can enhance their happiness, but the guidance and emotional support from significant people can further reinforce those influences.
Study site: Universiti Malaysia Sabah (UMS)
The end stage renal disease (ESRD) patients requires hemodialysis to survive. Efficacy of the treatment is determined by evaluation of minimal dialysis dose (Kt/V) which is 1.2. A cross sectional study was conducted among patients that undergo hemodialysis in a dialysis centre in Kuala Lumpur, Malaysia. The objectives of the study were to determine the association between dialysis dose and demographic factors and assessed the association between biochemical blood parameter and the demographic factors. The biochemical blood parameters were serum albumin, creatinine, cholesterol and hemoglobin. Result showed that all Indians and 54% of Chinese patients achieved the required dialysis dose. However only 29% of Malay patients attained the effective dialysis dose. More women patients accomplished the dialysis dose of at least 1.2 compared to men patients with odd ratio of 11.24. All the biochemical blood parameters were independent of the demographic factors. However, the cholesterol level was associated significantly with gender (p<0.05). In conclusion, the study found the biochemical blood parameter and dialysis dose were not influenced by the demographic factors.
This study evaluated four different doses of Strobilanthes crispa juice (700, 2100, 3500 and 4900 mg kg-1 of body weight) administered orally to normal female and male Sprague dawley rats on possible changes in various physical, behaviour, morphology and biochemical parameter. The rats were treated with a single dose of juice and observed for 14 days. No significant toxicity was observed with respect to clinical parameters and organ morphology. In addition, no significant changes were observed in the level of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase,
creatinine and albumin. The S. crispa juice was found to be safe at the maximum dose used in this study (4900 mg kg-1 of body weight).
Bullous impetigo is a highly contagious skin infection commonly affecting children due to epidermolytic toxins of bacteria Staphylococcus sp. This presentation described a case of a 3 year-old Indian girl with bullous lesion around the peri-oral region. The lesion was initially thought to be of viral origin and was treated symptomatically. However, the lesion progressed without any resolution with more vesicles at distant sites. The patient was also having fever and refused any oral intake. At this point, a probable diagnosis of bacterial skin infection was considered and the patient was admitted. Intra-venous fluid was administered to rehydrate the patient and she was treated with topical antibiotic and antipyretic. The lesion resolved within 14 days without scarring. As dental practitioners, we should be aware of bacterial infection around the peri-oral region and consider it as part of a differential diagnosis so that an appropriate treatment can be given.
Recent studies suggested that exposure to household smoking (HHS) could be a modifiable risk factor for caries development among children. Majority of the studies were cross sectional in nature. Therefore, a case-control study was designed to test the hypothesis that HHS is a risk factor to caries experience in permanent teeth. Calculation of sample size was based on the ratio of 1 case to 4 controls. Case was defined as a child aged 13-14 years old with caries in at least one second permanent molar and control was defined as a child from the same age and school with no caries second permanent molars. Matching was done for gender and ethnicity. School dental records provided information on oral health status and oral hygiene status. Information on HHS, socio-economic status, child’s smoking status and child’s oral health practices were obtained from a self- administered questionnaire, completed by the children and their parents. The result showed that 55.9% of the case group was exposed to HHS, as compared to 44.1% among the control group. In the final multiple logistic regression model after controlling for important risk factors for caries, children with caries were almost twice as likely to have been exposed to HHS for more than 10 years as compared to children with no caries, (Adjusted OR=1.90 and 95% CI=1.35, 2.60). In addition, children who only received dental care from the school dental service had reduced risk of having dental caries by more than one third (36%) as compared with those who received dental care from school dental service (SDS) as well as had additional dental problem solving visit outside SDS (Adjusted OR=0.64 and 95% CI=0.50, 0.90). It is concluded that exposure to HHS for a long duration (> than 10 years) increase the risk to have caries experience in permanent teeth of children.
Study site: 12 secondary schools, Kelang District, Selangor, Malaysia
Prevalence of dermatomycoses varies from one centre to another due to many factors. Knowledge of local prevalence is useful to aid clinical diagnosis and treatment. Due to lack of data in Malaysia, this study aimed to look at the causes of dermatomycoses in Kuala Lumpur, Malaysia. Dermatological specimens including skin scrapings, hair and nail clippings were collected carefully from clinically suspected cases of dermatomycoses between 2008 and 2010. All cultures of skin, hair and nails that yielded positive fungal growth were included. Any fungal growth outside the streaking area, duplicate and incomplete data were excluded from the study. Three-hundred-fifty-eight patients were included. Male patients were slightly more than females with a ratio of 1.2:1. The median age was 53 years old with interquartile range of 38-64 years. More than half (53.6%) belonged to 20-60 years age group. Rates of culture isolation were 89.0% for nails, 56.2% for hair and 55.6% for skin. Five-hundred-twenty-two fungi were isolated from 358 clinical specimens. Non-dermatophyte moulds (NDMs) represented the largest group (50.5%; mainly Aspergillus species 18.7%), followed by yeasts (41.6%; mainly Candida species 26.8%) and dermatophytes (7.9%; mainly Trichophyton species 7.7%). In conclusion, NDMs and yeasts were more commonly isolated than dermatophytes from dermatological specimens in this centre. Current treatment regime that focuses on dermatophytes may be ineffective to treat dermatomycoses caused by NDMs or yeasts. Antifungal susceptibility study may be needed to guide therapy in recalcitrant cases.
There is ample research on aggression amongst children and adolescents that highlights several antecedents of aggression. While researchers have remarked on the relationship between parenting styles and aggression in children, there are few studies that integrate and systemize the available studies on parenting styles and aggression. The present review is an attempt to fill this gap. For this review, relevant studies were first searched, then coded and classified. As a result of thorough review, 34 relevant studies were identified. The review shows that parenting styles have a direct impact on aggression in children. Authoritative parenting styles play a positive role in psychological behavior in children while authoritarian and permissive parenting styles result in aggressive and negative behaviors in children. The current study also suggests that there is room to conduct studies on this topic in developing countries. Future research should be undertaken in developing and under-developed countries and should focus on mixed modes of research and examine the direct influence of parenting styles on aggressive behavior in children in different cultural contexts.
Job satisfaction is significantly related to overall attitudes towards life or life satisfaction. For most people, work is a central life activity. Full time employees spent substantial amount of time at work. Middle-aged women are working longer hours and spending less time with their families, which has led to family crisis, burn out, and depression. Thus, this study helps to determine the relationship between social support and family attachment on life satisfaction among middle-aged career women in Kelantan. It will also analyse the mediating role of job satisfaction. This study is a quantitative study, which was conducted in Kelantan. It involves 438 middle-aged career women in Kelantan. Social support, family attachment and job satisfaction were found to positively relate to life satisfaction. Moreover, job satisfaction was proven as the mediator in the relationship between social support and life satisfaction. This result indicates that life satisfaction of middle-aged career women rely significantly on job satisfaction. Job satisfaction can intervene the direction and the level of life satisfaction of middle-aged career women. This finding could be used as an input for any intervention programs and policies to uplift the well- being and quality of life of middle-aged women.
In the era of globalization, role in work and role in the family has experienced significant change especially for working parents. The equilibrium claim in both roles such as the role of the job and the role of the family is strongly emphasized in ensuring that working parents can manage their life and perform well. The aim of this study was to identify the influence of work-family conflicts such as timebased conflicts, strain-based conflicts and behavior-based conflicts towards life satisfaction among working parents. A total of 378 respondents in this study consisted of mothers and fathers working in the Public Department around Kota Kinabalu, Sabah. Respondents were selected using the purposive sampling method where the researcher had determined the characteristics of respondents such as the status of the respondent should be married (living with spouse) and at least have one child. The WorkFamily Conflict Scale (WFCS) and Satisfaction With Life Scale (SWLS) questionnaire were used to see the influence of work-family conflicts towards life satisfaction especially among working parents. The findings were analyzed using the Statistical Package for Social Sciences (SPSS) version 23.0. Simple Linear Regression Analysis was used in this study. The findings show that there are negative and significant influences in time-based conflicts, strain-based conflicts and behavior-based conflicts towards life satisfaction among working parents. The implications and recommendations of the study were also discussed.
Spectra data from two instruments (UV-Vis/NIR and FT-NIR) consisting of three and one detectors, respectively, were employed in order to discriminate the geographical origin of milk as a way to detect adulteration. Initially, principal component analysis (PCA) was used to see if clusters of milk from different origins are formed. Separation between samples of different origins were not observed with PCA, hence, feed-forward multi-layer perceptron artificial neural network (MLP-ANN) models were designed. ANN models were developed by changing the number of input variables and the best models were chosen based on high values of generalized R-square and entropy R-square, as well as small values of root mean square error (RMSE), mean absolute deviation (Mean Abs. Dev), and -loglikelihood while considering 100% classification rate. Based on the results, whether the spectra data was collected from a single or three detector instrument the same clustering was observed based on geographical origin.