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  1. Risk factors associated with adverse drug reactions in hospitalised children: international multicentre study
    Rashed AN, Wong IC, Cranswick N, Tomlin S, Rascher W, Neubert A
    Eur J Clin Pharmacol, 2012 May;68(5):801-10.
    PMID: 22166934 DOI: 10.1007/s00228-011-1183-4
    BACKGROUND: Understanding the epidemiology and risk factors of adverse drug reactions (ADRs) is important in order to develop appropriate prevention strategies. This study aimed to identify risk factors associated with ADRs in hospitalised children and recommend strategies to minimise ADRs.

    METHODS: A prospective multicentre cohort study was conducted on paediatric general medical wards in five European and non-European hospitals. ADRs were identified by intensive chart review. Multivariable logistic regression was used to investigate risk factors associated with ADRs. For the risk factor analysis, prescribed drugs were divided into high-risk and low-risk drug groups. Analgesics, anti-epileptics, antibacterials and antimycotics for systemic use, corticosteroids for systemic use and immunosuppressant agents were considered as high-risk groups whereas the remaining drug classes were defined as low-risk drug groups.

    RESULTS: A total of 1,253 paediatric patients were identified [Australia (n = 145), Germany (n = 372), Hong Kong (n = 138), Malaysia (n = 291), UK (n = 307)]. A total of 328 ADRs were observed in 16.7% of patients (186/1,115). Use of five or more low-risk drugs per patient or three or more high-risk drugs was a strong predictor for ADRs (OR 4.7, 95% CI 2.4-9.3; OR 6.5, 95% CI 2.7-16.0 respectively; p < 0.001). Older children were more likely to experience ADRs; gender was not significantly associated.

    CONCLUSION: To reduce the risk of ADRs in children, clinicians and pharmacists should aim to minimise polypharmacy and be aware of higher ADR risks associated with some drug groups.

    Matched MeSH terms: Adolescent; Adolescent Development*
  2. Fulltext The Impact of Emotional Solidarity on Residents' Attitude and Tourism Development
    Hasani A, Moghavvemi S, Hamzah A
    PLoS One, 2016;11(6):e0157624.
    PMID: 27341569 DOI: 10.1371/journal.pone.0157624
    In many countries, especially one such as Malaysia, tourism has become a key factor in economic development, and the industry heavily relies on feedback from local residents. It is essential to observe and examine the perceptions of residents towards tourists and tourism development for better planning in realizing successful and sustainable tourism development. Therefore, this research measured the relationship between residents' welcoming nature, emotional closeness, and sympathetic understanding (emotional solidarity) towards tourists and their respective attitudes towards supporting tourism development. To test the proposed research model, we collected data using a questionnaire survey from 333 residents in rural areas in Malaysia. We used the structural equation modelling technique (Amos) to evaluate the research model, and the results revealed that the residents' willingness (welcoming nature) to accept tourists is the strongest factor that effects the residents' attitudes towards supporting tourism development. However, there was no significant relationship between residents' emotional closeness and their sympathetic understanding towards tourists with their attitude and support towards tourism development. Welcoming nature, emotional closeness, and sympathetic understanding are able to predict 48% of residents' attitudes towards tourism development and 62% of their support towards tourism development.
    Matched MeSH terms: Adolescent
  3. Fulltext A comparison of 1995 WHO classification with 2003 ISN/RPS classification of lupus nephritis: a single centre observation
    Chow TK, Looi LM, Cheah PL
    Malays J Pathol, 2015 Dec;37(3):239-46.
    PMID: 26712669
    BACKGROUND: In the past, lupus nephritis was histologically classified according to the 1995 WHO Classification. With the introduction of the 2003 ISN/RPS Classification, many nephropathology services converted to this new classification. This study was undertaken to compare both classification systems in a single centre practice.
    METHODS: 103 consecutive adequate renal biopsies initially reported as lupus nephritis in the Department of Pathology, Faculty of Medicine, University of Malaya were reassessed using the criteria of both the 1995 WHO Classification and the 2003 ISN/ RPS Classification.
    RESULTS: The relative prevalence for each class using the WHO Classification were: Class I (1%), Class II (8.7%), Class III (6.8%), Class IV (60.2%), Class V (20.4%), Class VI (2.9%) while the prevalence using the 2003 ISN/RPS Classification were: Class I (1%), Class II (8.7%), Class III (6.8%), Class IV (61.2%), Class V (21.3%), Class VI (1%). Both classifications were essentially comparable with regards to Classes I, II and III. The differences in Classes IV, V and VI were significant in potential to alter patient management. The identification of segmental lesions (Class IV-S) over and above a global nephritis (Class IV-G) deserves more focused clinicopathological studies to gauge whether these groups have different clinical manifestations and outcomes. With regards Class V, the ISN/RPS system, by requiring that all mixed classes be stipulated in the diagnostic line, minimizes the chances of patients missing out on additional treatment. The ISN/ RPS system has stricter criteria for Class VI, which again minimizes patients missing out on therapy. On the whole, the ISN/RPS system is more user-friendly as criteria are more clearly defined which translates to more benefits to patient care.
    Study site: Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Matched MeSH terms: Adolescent
  4. Fulltext The Link between Knowledge, Attitudes and Practices in Relation to Atmospheric Haze Pollution in Peninsular Malaysia
    De Pretto L, Acreman S, Ashfold MJ, Mohankumar SK, Campos-Arceiz A
    PLoS One, 2015;10(12):e0143655.
    PMID: 26646896 DOI: 10.1371/journal.pone.0143655
    Transboundary haze episodes caused by seasonal forest fires have become a recurrent phenomenon in Southeast Asia, with serious environmental, economic, and public health implications. Here we present a cross-sectional survey conducted among people in Kuala Lumpur and surrounds to assess the links between knowledge, attitudes, and practices in relation to the transboundary haze episodes. Of 305 respondents, 125 were amateur athletes participating in a duathlon event and the remainder were surveyed in an inner-city shopping mall. Across the whole sample, people who possessed more factual information about the haze phenomenon showed significantly higher levels of concern. Duathletes were more knowledgeable than non-duathletes and also more concerned about the negative effects of haze, especially on health. For all people who regularly practice outdoor sports (including people interviewed at the shopping mall), higher levels of knowledge and concerned attitudes translated into a greater likelihood of engaging in protective practices, such as cancelling their outdoor training sessions, while those with greater knowledge were more likely to check the relevant air pollution index on a daily basis. Our results indicate that the provision of accurate and timely information about air quality to residents will translate into beneficial practices, at least among particularly exposed individuals, such as amateur athletes who regularly practice outdoor sports.
    Matched MeSH terms: Adolescent
  5. How Easy is it to Read the Minds of People with Autism Spectrum Disorder?
    Sheppard E, Pillai D, Wong GT, Ropar D, Mitchell P
    J Autism Dev Disord, 2016 Apr;46(4):1247-54.
    PMID: 26603886 DOI: 10.1007/s10803-015-2662-8
    How well can neurotypical adults' interpret mental states in people with ASD? 'Targets' (ASD and neurotypical) reactions to four events were video-recorded then shown to neurotypical participants whose task was to identify which event the target had experienced. In study 1 participants were more successful for neurotypical than ASD targets. In study 2, participants rated ASD targets equally expressive as neurotypical targets for three of the events, while in study 3 participants gave different verbal descriptions of the reactions of ASD and neurotypical targets. It thus seems people with ASD react differently but not less expressively to events. Because neurotypicals are ineffective in interpreting the behaviour of those with ASD, this could contribute to the social difficulties in ASD.
    Matched MeSH terms: Adolescent
  6. Aggregated effects of combining daily milk consumption and aerobic exercise on short-term memory and sustained attention among female students
    Leong IT, Moghadam S, Hashim HA
    Percept Mot Skills, 2015 Feb;120(1):57-66.
    PMID: 25621523 DOI: 10.2466/22.06.PMS.120v11x3
    Regular aerobic exercise and milk consumption have been found to have positive effects on certain cognitive functions such as short-term memory and sustained attention. However, aggregated effects of combining these modalities have not been explored. This study examined the combined effects of milk supplementation and aerobic exercise on the short-term memory and sustained attention of female students aged 16 yr. (N = 81). The intervention involved serving of 250 ml of regular milk during school days and/or a 1-hr. aerobic exercise period twice per week for 6 weeks. The Digit Span Test and Digit Vigilance Test were used to measure short-term memory and sustained attention, respectively. The combination group (milk and exercise) and exercise group performed significantly better than did the milk and control groups in terms of short-term memory. No significant interaction or group differences were found for sustained attention. The results suggest benefits of regular exercise for students' short-term memory.
    Matched MeSH terms: Adolescent
  7. Fulltext Leprosy in Sarawak, Borneo: a 5 year review from 2008 to 2012
    Ling HN
    Lepr Rev, 2014 Dec;85(4):332-5.
    PMID: 25675658
    Matched MeSH terms: Adolescent
  8. Influencing preferences for different types of causal explanation of complex events
    Klein G, Rasmussen L, Lin MH, Hoffman RR, Case J
    Hum Factors, 2014 Dec;56(8):1380-400.
    PMID: 25509820
    We examined preferences for different forms of causal explanations for indeterminate situations. Background: Klein and Hoffman distinguished several forms of causal explanations for indeterminate, complex situations: single-cause explanations, lists of causes, and explanations that interrelate several causes. What governs our preferences for single-cause (simple) versus multiple- cause (complex) explanations?
    Matched MeSH terms: Adolescent
  9. Fulltext Rhinolith: An important cause of foul-smelling nasal discharge
    Yaroko A, Mohamad I, Hashim H
    Malays Fam Physician, 2014;9(1):30-2.
    PMID: 25606296 MyJurnal
    Rhinoliths result from neglected nasal foreign bodies that gradually increase in size. They are usually discovered incidentally during routine ENT examination or due to the associated symptoms such as nasal obstruction or persistent foul-smelling unilateral nasal discharge. A case of a 14-year-old girl was reported with a year history of the symptom. The foul-smelling nasal discharge noted by her mother was not the main concern to them. She was referred by her primary care physician as she complained of impacted ear wax. However, rhinolith was incidentally found upon routine clinical examination in the ENT clinic and was removed uneventfully.
    Matched MeSH terms: Adolescent
  10. Suicide among the youth in Malaysia: What do we know?
    Bahar N, Ismail WS, Hussain N, Haniff J, Bujang MA, Hamid AM, et al.
    Asia Pac Psychiatry, 2015 Jun;7(2):223-9.
    PMID: 25367507 DOI: 10.1111/appy.12162
    This article aims to study the pattern of youth suicide cases in Malaysia, following which preventive actions can then be planned and practiced to reduce these suicide cases.
    Matched MeSH terms: Adolescent
  11. Fulltext Completed suicides and self-harm in Malaysia: a systematic review
    Armitage CJ, Panagioti M, Abdul Rahim W, Rowe R, O'Connor RC
    Gen Hosp Psychiatry, 2015 Mar-Apr;37(2):153-65.
    PMID: 25636361 DOI: 10.1016/j.genhosppsych.2014.12.002
    Most of the research into suicide and self-harm has been conducted in the United States and Europe, yet the volume of research does not reflect the distribution of suicide globally, with Asia accounting for up to 60% of all suicides. The present study systematically reviews the literature to assess the prevalence and correlates of suicidal acts in Malaysia in Southeast Asia.
    Matched MeSH terms: Adolescent
  12. Fulltext Multivariate analysis of factors affecting presence and/or agenesis of third molar tooth
    Alam MK, Hamza MA, Khafiz MA, Rahman SA, Shaari R, Hassan A
    PLoS One, 2014;9(6):e101157.
    PMID: 24967595 DOI: 10.1371/journal.pone.0101157
    To investigate the presence and/or agenesis of third molar (M3) tooth germs in orthodontics patients in Malaysian Malay and Chinese population and evaluate the relationship between presence and/or agenesis of M3 with different skeletal malocclusion patterns and sagittal maxillomandibular jaw dimensions. Pretreatment records of 300 orthodontic patients (140 males and 160 females, 219 Malaysian Malay and 81 Chinese, average age was 16.27±4.59) were used. Third-molar agenesis was calculated with respect to race, genders, number of missing teeth, jaws, skeletal malocclusion patterns and sagittal maxillomandibular jaw dimensions. The Pearson chi-square test and ANOVA was performed to determine potential differences. Associations between various factors and M3 presence/agenesis groups were assessed using logistic regression analysis. The percentages of subjects with 1 or more M3 agenesis were 30%, 33% and 31% in the Malaysian Malay, Chinese and total population, respectively. Overall prevalence of M3 agenesis in male and female was equal (P>0.05). The frequency of the agenesis of M3s is greater in maxilla as well in the right side (P>0.05). The prevalence of M3 agenesis in those with a Class III and Class II malocclusion was relatively higher in Malaysian Malay and Malaysian Chinese population respectively. Using stepwise regression analyses, significant associations were found between Mx (P<0.05) and ANB (P<0.05) and M3 agenesis. This multivariate analysis suggested that Mx and ANB were significantly correlated with the M3 presence/agenesis.
    Matched MeSH terms: Adolescent
  13. Sodium valproate-aggravated psoriasiform eruption
    Kwan Z, Che Ismail RB, Wong SM, Tan LL, Robinson S, Lim KS
    Int J Dermatol, 2014 Oct;53(10):e477-9.
    PMID: 25209632 DOI: 10.1111/ijd.12579
    Matched MeSH terms: Adolescent
  14. Prevalence and patterns of tooth agenesis among Malay children
    Mani SA, Mohsin WS, John J
    Southeast Asian J. Trop. Med. Public Health, 2014 Mar;45(2):490-8.
    PMID: 24968691
    Tooth agenesis in Malay children, hitherto unreported, was assessed retrospectively from orthopantomograms of 834 healthy children aged 12-16 years who attended the Dental Clinic of Universiti Sains Malaysia. All teeth, including third molars, were assessed for agenesis. On an average, 2.3 teeth were missing per child. Missing third molars were found in 25.7% of children with one or two third molars found to be missing in 18.3% of children. Three point two percent of children had missing teeth other than third molars. After third molars, the upper lateral incisors were found to be the most common missing tooth (1.7%), followed by upper and lower second premolars (1.5%). Eight missing upper canines were also seen (1%). Bilateral agenesis was more common than unilateral agenesis. There were no significant differences between males and females. There was a significant difference between missing teeth between the maxilla and the mandible and right and left side, with more missing teeth in the maxilla and on the right side. The odds of any 3rd molar missing were increased 3.3 times when there was any other missing tooth. In conclusion, the prevalence of tooth agenesis among the studied population was within the normal range, but less than some Asian countries. Unlike other Asian countries, the upper lateral incisor was the most common missing tooth. The prevalence of maxillary canine agenesis was higher than most previous reports. Missing teeth were associated with missing third molars, which is likely due to a genetic abnormality.
    Matched MeSH terms: Adolescent
  15. Global School-based Student Health Survey, Malaysia
    Low WY, Binns C
    Asia Pac J Public Health, 2014 Sep;26(5 Suppl):7S-8S.
    PMID: 25143527 DOI: 10.1177/1010539514545287
    Matched MeSH terms: Adolescent
  16. General Theory versus ENA Theory: Comparing Their Predictive Accuracy and Scope
    Ellis L, Hoskin A, Hartley R, Walsh A, Widmayer A, Ratnasingam M
    Int J Offender Ther Comp Criminol, 2015 Dec;59(13):1429-58.
    PMID: 25063685 DOI: 10.1177/0306624X14543263
    General theory attributes criminal behavior primarily to low self-control, whereas evolutionary neuroandrogenic (ENA) theory envisions criminality as being a crude form of status-striving promoted by high brain exposure to androgens. General theory predicts that self-control will be negatively correlated with risk-taking, while ENA theory implies that these two variables should actually be positively correlated. According to ENA theory, traits such as pain tolerance and muscularity will be positively associated with risk-taking and criminality while general theory makes no predictions concerning these relationships. Data from Malaysia and the United States are used to test 10 hypotheses derived from one or both of these theories. As predicted by both theories, risk-taking was positively correlated with criminality in both countries. However, contrary to general theory and consistent with ENA theory, the correlation between self-control and risk-taking was positive in both countries. General theory's prediction of an inverse correlation between low self-control and criminality was largely supported by the U.S. data but only weakly supported by the Malaysian data. ENA theory's predictions of positive correlations between pain tolerance, muscularity, and offending were largely confirmed. For the 10 hypotheses tested, ENA theory surpassed general theory in predictive scope and accuracy.
    Matched MeSH terms: Adolescent
  17. Methodology of the National School-based Health Survey in Malaysia, 2012
    Yusoff F, Saari R, Naidu BM, Ahmad NA, Omar A, Aris T
    Asia Pac J Public Health, 2014 Sep;26(5 Suppl):9S-17S.
    PMID: 25038193 DOI: 10.1177/1010539514542424
    The National School-Based Health Survey 2012 was a nationwide school health survey of students in Standard 4 to Form 5 (10-17 years of age), who were schooling in government schools in Malaysia during the period of data collection. The survey comprised 3 subsurveys: the Global School Health Survey (GSHS), the Mental Health Survey, and the National School-Based Nutrition Survey. The aim of the survey was to provide data on the health status of adolescents in Malaysia toward strengthening the adolescent health program in the country. The design of the survey was created to fulfill the requirements of the 3 subsurveys. A 2-stage stratified sampling method was adopted in the sampling. The methods for data collection were via questionnaire and physical examination. The National School-Based Health Survey 2012 adopted an appropriate methodology for a school-based survey to ensure valid and reliable findings.
    Study name: Global School-Based Student Health Survey (GSHS)
    Matched MeSH terms: Adolescent
  18. Fulltext Family context and Khat chewing among adult Yemeni women: a cross-sectional study
    Al-Abed AA, Sutan R, Al-Dubai SA, Aljunid SM
    Biomed Res Int, 2014;2014:505474.
    PMID: 24982886 DOI: 10.1155/2014/505474
    Khat chewing is associated with unfavourable health outcomes and family dysfunction. Few studies have addressed the factors associated with khat chewing among Yemeni women. However, the family and husband effects on chewing khat by women have not been addressed. This study aimed to determine the prevalence of khat chewing among Yemeni women and its associated factors, particularly husbands and family factors. A cross-sectional study was conducted among 692 adult Yemeni women in the city of Sana'a in Yemen using structured "face to face" interviews. Mean (±SD) age of women was 27.3 years (±6.10). The prevalence of chewing khat by women was 29.6%. Factors associated with chewing khat among women were chewing khat by husbands (OR = 1.8; 95% CI: 1.26, 2.53), being married (OR = 2.0; 95% CI: 1.20, 3.37), frequent family social gatherings (OR = 1.5; 95% CI: 1.06, 2.10), high family income (OR = 1.57; 95% CI: 1.12, 2.21), larger house (OR = 1.63; 95% CI: 1.16, 2.31), and age of women (OR = 0.64; 95% CI: 0.44, 0.92). It is concluded that khat chewing by women in this study was significantly associated with family factors and with khat chewing by their husbands. Urgent action is needed to control khat chewing particularly among women.
    Matched MeSH terms: Adolescent
  19. Is the food environment surrounding schools associated with the diet quality of adolescents in Otago, New Zealand?
    Clark EM, Quigg R, Wong JE, Richards R, Black KE, Skidmore PM
    Health Place, 2014 Nov;30:78-85.
    PMID: 25218636 DOI: 10.1016/j.healthplace.2014.08.008
    Using a sample of adolescents from schools in Otago, New Zealand, associations between food outlets around schools and dietary quality were investigated. Food outlet environment data were derived using GIS data. Multivariate regression analysis results showed that outlet density, in an 800m buffer around schools, of cafes and restaurants, supermarkets and takeaways was associated with higher Diet Quality Index scores in boys, and distance to nearest outlet for convenience stores, cafes and restaurants and supermarkets with lower scores for girls. Effect sizes were small, suggesting that the food environment around schools plays a minor role in adolescent diet quality.
    Matched MeSH terms: Adolescent
  20. Stress Symptoms Among Adolescent: A Study from Islamic Perspective
    Sham FM
    J Relig Health, 2015 Aug;54(4):1278-85.
    PMID: 24807209 DOI: 10.1007/s10943-014-9866-7
    Rapid social changes in current times which can be quite abrupt present a challenge to adolescent life. Adolescents who are unable to adapt themselves experience stress which may affect their health. Psychological issues of adolescents require attention because the long-term consequence is worse than the short-term effects, namely, there will be a group of people within society who live under stress. Stressed people show symptoms such as being aggressive, prone to rebel, uncontrollable anger, depression, mental disorders and health problems. Early recognition of adolescent stress symptoms is vital. Pursuant to this, a study is conducted among adolescents in Kajang, Selangor, Malaysia for the purpose of determining whether they experience stress or otherwise, based on stress symptoms in terms of psychology, physiology and social behaviour. An analysis is conducted on 403 respondents who comprise of male and female adolescents aged 16-17 years. The required data are gathered through questionnaire and structured interview. Analysis is based on descriptive statistical method and is explained in a table in terms of frequency, percentage and mode. Research results show that adolescents do experience stress and that the majority of them exhibit psychological stress symptoms.
    Matched MeSH terms: Adolescent
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