Displaying publications 81 - 100 of 216 in total

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  1. Plagiarism in publications using the unpublished raw data of archived research
    Yahaghi J, Beddu SB, Muda ZC
    Sci Eng Ethics, 2017 04;23(2):635-636.
    PMID: 27432400 DOI: 10.1007/s11948-016-9807-9
    It is obligatory to educate student researchers before they start their work by teaching them about the various types of plagiarism and how to avoid them. It is also vital that research supervisors take into account the sources of data that are explored in their students' manuscripts. This article tries to draw the reader's attention to the importance of avoiding all types of plagiarism in their research.
    Matched MeSH terms: Research Personnel/ethics
  2. Religious Commitment and its Relation to Happiness among Muslim Students: The Educational Level as Moderator
    Achour M, Mohd Nor MR, Amel B, Bin Seman HM, MohdYusoff MYZ
    J Relig Health, 2017 Oct;56(5):1870-1889.
    PMID: 28160189 DOI: 10.1007/s10943-017-0361-9
    This study examines the relationship between religiosity and level of happiness in an Islamic context among Muslim students studying at Malaysian universities. The determinants of happiness included in this research are positive attitudes, self-esteem, and other-esteem. Religiosity has long been considered as the main determinant in increasing happiness, and educational level strengthens its relationship. For this purpose, the researchers sampled 230 Muslim students aged 17-40 years studying at Malaysian universities in Kuala Lumpur, Malaysia. The study found a positive and significant correlation between religious commitment and level of happiness. Religious commitment also shows positive and significant correlations with positive attitudes, self-esteem, and other-esteem. The study also concludes that educational attainment moderates the relationship between religious commitment and happiness. Thus, religious commitment plays a very important role in increasing levels of happiness.
    Matched MeSH terms: Research Personnel
  3. Fulltext Medical ethics: what you should know
    Mohd Rizal Abdul Manaf
    Int J Public Health Res, 2012;2(1):129-136.
    MyJurnal
    Introduction Medical ethics is a system of moral principles that apply values and judgments to the practice of medicine. As a scholarly discipline, medical ethics encompasses its practical application in clinical settings as well as work on its history, philosophy, theology, and sociology. The medical profession has long subscribed to a body of ethical statements developed primarily for the benefit of the patient. A physician must recognize responsibility to patients first and foremost, as well as to society, to other health professionals, and to self. This paper presents some information regarding medical ethics, including the values and principles of ethical conduct. Later the requirements of consent form is presented to guide the researchers before conducting a study.
    Matched MeSH terms: Research Personnel
  4. Fulltext A review of potentialities and challenges of integrating remote sensing and GIS with socioeconomic data
    Noor Shaila Sarmin, Mohd Hasmadi Ismail
    The Pertanika Journal of Scholarly Research Reviews, 2016;2(1):129-141.
    MyJurnal
    The aim of this paper is to review the potentialities and major methodological challenges
    of integrating remote sensing (RS) and geographic information system (GIS) with socioeconomic data
    from published articles or book chapters. RS and GIS combined with social science (SS)(termed as
    geoinformation technology) serve many applications for sustainable management and monitoring of
    the environment. This combined approach gives more accurate results than the single one. It makes
    information available about the trend and pattern of land use and land cover change (LUCC) with
    socioeconomic variables like population, demographic or income. This combined study which links
    RS and GIS with socioeconomic data can also be used successfully for monitoring transmission rate
    of disease and mapping or preparing vulnerability index. For impact assessment and modelling, this
    combined technology provides better results than the single one. There are some methodological
    problems for the researchers to link completely two different disciplines as the object of study and
    observational unit is completely different. However, this interdisciplinary study is gaining popularity
    day by day to researchers from different disciplines as well as decision makers.
    Matched MeSH terms: Research Personnel
  5. Tilt table practice improved ventilation in a patient with prolonged artificial ventilation support in intensive care unit
    Hashim AM, Joseph LH, Embong J, Kasim Z, Mohan V
    Iran J Med Sci, 2012 Mar;37(1):54-7.
    PMID: 23115431
    Patients who are on prolonged ventilator support in critical care unit present wide variety of complications, which range from reduction in oxygen uptake to various musculoskeletal impairments. Early mobilization and rehabilitation are encouraged to manage these complications effectively. Use of tilt table to motivate early mobilization in the intensive care unit for ventilator practices is not a usual practice. However, this new technique has attracted involvements of clinicians and therapists for its therapeutic benefits to the patient. Herein we describe a case of a seventy eight-year-old male patient who suffered Motor car accident, and was on ventilator support in intensive care unit for more than one month. He underwent treatment using a tilt table protocol with other routine treatment, which benefited him based on clinical as well as physiological variables. For practitioners in intensive care units, this report may offer perceptivity into the alternate practice of early mobilization using tilt table, and for investigators it may promote interest for further studies.
    Matched MeSH terms: Research Personnel
  6. Fulltext Survey on the effects of athletes involvement in the Malaysian Matriculation Co-Curriculum Carnival (KAKOM) on the academic achievement in the Labuan Matriculation College
    Mahamad Yusof Abdul Rani, Asrul Kamarulzaman, Mohammad Redzuan Omar
    Jurnal Sains Sukan & Pendidikan Jasmani, 2016;5(2):44-52.
    MyJurnal
    Journal of Sports Science and Physical Education 5(2): 44-52, 2016 - The aim of this study is
    to identify the differences in academic achievement between athletes involved in Karnival
    Kokurikulum Sukan antara Kolej Matrikulasi (KAKOM) and non-athletes in Labuan
    Matriculation College. Overall 200 respondents selected athletes are students from KAKOM
    athletes (n=100) and non-athlete students (n=100) in Semester 1, 2015/2016. The survey
    design and purposely sampling technique was used for data collection. The respondents are
    comprised of students majoring in Accounting, One Year Program (PST) Module 1, PST
    Module 2 and PST Module 3. Descriptive statistic was used to obtain frequency and
    percentage for each of the variables and to determine the level of academic achievement
    (CGPA) of athletes and non-athletes. Inferential statistic was used to compare the mean
    scores achieved by cumulative grade point average (CGPA) between KAKOM athletes and
    non-athletes based on t-test. T test was also used to identify the differences in academic
    performance of athletes and non-athletes based on gender. The findings of this study showed
    no significant differences in terms of academic achievement among student who are athletes
    and non-athletes. Similarly, the findings of the performance of athletes and non-athletes
    based on gender showed no significant differences. From the results of this study, it shows
    that there are no differences in academic achievement between students who involved in
    KAKOM sports and those who dont involved. The researcher suggests that students should
    be active in sports and recreational activities during college because it will be beneficial for
    health and indirectly develop their soft skills. The study found that sports factor is not the
    cause for deterioration in academic achievement but there are other factors that affect
    academic performance which needs further study focusing more on students who are failing
    academically.
    Matched MeSH terms: Research Personnel
  7. C-Abl Inhibition; A Novel Therapeutic Target for Parkinson's Disease
    Abushouk AI, Negida A, Elshenawy RA, Zein H, Hammad AM, Menshawy A, et al.
    CNS Neurol Disord Drug Targets, 2018 Apr 26;17(1):14-21.
    PMID: 28571531 DOI: 10.2174/1871527316666170602101538
    Parkinson's disease (PD) is the most prevalent movement disorder in the world. The major pathological hallmarks of PD are death of dopaminergic neurons and the formation of Lewy bodies. At the moment, there is no cure for PD; current treatments are symptomatic. Investigators are searching for neuroprotective agents and disease modifying strategies to slow the progress of neurodegeneration. However, due to lack of data about the main pathological sequence of PD, many drug targets failed to provide neuroprotective effects in human trials. Recent evidence suggests the involvement of C-Abelson (c-Abl) tyrosine kinase enzyme in the pathogenesis of PD. Through parkin inactivation, alpha synuclein aggregation, and impaired autophagy of toxic elements. Experimental studies showed that (1) c-Abl activation is involved in neurodegeneration and (2) c-Abl inhibition shows neuroprotective effects and prevents dopaminergic neuronal' death. Current evidence from experimental studies and the first in-human trial shows that c-Abl inhibition holds the promise for neuroprotection against PD and therefore, justifies the movement towards larger clinical trials. In this review article, we discussed the role of c-Abl in PD pathogenesis and the findings of preclinical experiments and the first in-human trial. In addition, based on lessons from the last decade and current preclinical evidence, we provide recommendations for future research in this area.
    Matched MeSH terms: Research Personnel
  8. Fulltext A goal programming model for portfolio optimisation problem in fuzzy environment
    Mokhtar, M., Shuib, A., Mohamad, D.
    Pertanika Journal of Science & Technology, 2017;25(2):593-606.
    MyJurnal
    Portfolio optimisation is one of the most crucial issues in investment decision-making and has received considerable attention from researchers and practitioners. Traditionally, the portfolio optimisation models are formulated based on the assumption that investors have complete information on the distribution of random returns. However, in real life case, this is not possible since decisions have to be made under uncertainty. This paper deals with a fuzzy portfolio optimisation problem in which returns and turnover rates of securities are represented by fuzzy variables. A goal programming model is proposed to optimise three objectives: maximisation of portfolio return, maximisation of liquidity and minimisation of the portfolio risk. The cardinality constraints, floor and ceiling constraints are also taken into consideration. Finally, a numerical experiment using real data is conducted to demonstrate the applicability of the model.
    Matched MeSH terms: Research Personnel
  9. Fulltext Improving perioperative pain management: a preintervention and postintervention study in 7 developing countries
    Zaslansky R, Chapman CR, Baumbach P, Bytyqi A, Castro Lopes JM, Chetty S, et al.
    Pain Rep, 2019 01 25;4(1):e705.
    PMID: 30801045 DOI: 10.1097/PR9.0000000000000705
    Introduction: The burden of untreated postoperative pain is high.

    Objective: This study assessed feasibility of using quality improvement (QI) tools to improve management of perioperative pain in hospitals in multiple developing countries.

    Methods: The International Pain Registry and Developing Countries working groups, from the International Association for the Study of Pain (IASP), sponsored the project and PAIN OUT, a QI and research network, coordinated it, and provided the research tools. The IASP published a call about the project on its website. Principal investigators (PIs) were responsible for implementing a preintervention and postintervention study in 1 to 2 surgical wards in their hospitals, and they were free to choose the QI intervention. Trained surveyors used standardized and validated web-based tools for collecting findings about perioperative pain management and patient reported outcomes (PROs). Four processes and PROs, independent of surgery type, assessed effectiveness of the interventions.

    Results: Forty-three providers responded to the call; 13 applications were selected; and PIs from 8 hospitals, in 14 wards, in 7 countries, completed the study. Interventions focused on teaching providers about pain management. Processes improved in 35% and PROs in 37.5% of wards.

    Conclusions: The project proved useful on multiple levels. It offered PIs a framework and tools to perform QI work and findings to present to colleagues and administration. Management practices and PROs improved on some wards. Interpretation of change proved complex, site-dependent, and related to multiple factors. PAIN OUT gained experience coordinating a multicentre, international QI project. The IASP promoted research, education, and QI work.

    Matched MeSH terms: Research Personnel
  10. Development of Welding Fumes Health Index (WFHI) for Welding Workplace's Safety and Health Assessment
    Hariri A, Paiman NA, Leman AM, Md Yusof MZ
    Iran J Public Health, 2014 Aug;43(8):1045-59.
    PMID: 25927034
    This study aimed to develop an index that can rank welding workplace that associate well with possible health risk of welders.
    Matched MeSH terms: Research Personnel
  11. Fulltext Prevalence of Stress and Coping Mechanism among Staff Nurses in the Intensive Care unit
    Lexshimi RG, Raja, Saadiah Tahir, Santhna, L.P., Md Nizam, J.
    Medicine & Health, 2007;2(2):146-153.
    MyJurnal
    The working environment of intensive care unit (ICU) nurses is a constant source of stress. Researchers have described ICU as a stressful environment because of the complex nature of patients’ health problems requiring an extensive use of very sophisticated technology. This study aimed to identify the prevalence of stress among staff nurses working in ICU, Hospital Universiti Kebangsaan Malaysia (HUKM), factors influencing stress and to explore the symptoms of stress experienced. This descriptive study was conducted on 67 staff nurses working in ICU, HUKM. Data was collected using self-administered questionnaires. The questionnaires included sections on socio-demographic data, factors influencing stress and symptoms of stress experienced. Data was analyzed using frequency and percentage. The Chi square test was used to examine the relationship between socio-demographic data and factors influencing stress. Findings indicated that stress symptoms were experienced by 100 per cent (n =67) of staff nurses Knowledge, working experience, critically ill patients, and environmental factors were one of  the many  factors contributing to the stress experienced by the ICU nurses in HUKM. Nurses working in ICU, HUKM are found to have a high level of stress. Recommendations like encouraging ICU nurses to take up post basic ICU courses and increasing the nurses quota can reduce the prevalence of stress among ICU nurses. Hospital management has an important role to play in reducing the stress levels of nurses working  in  ICU as stress has an effect on job performance and quality of nursing care.
    Matched MeSH terms: Research Personnel
  12. Failure analysis of composite laminate based on experiment-simulation integration
    Jamaluddin Mahmud, Ahmad Kamil Hussain, Norzihan Rahimi, Mastura Abdul Rahim
    CREAM : Current Research in Malaysia (Penyelidikan Terkini di Malaysia), 2013;2(2):7-22.
    MyJurnal
    The finite element method is gaining acceptance in predicting mechanical response of various loading configurations and material orientations for failure analysis of composite laminates. Both fabrication of laminate samples and experimental procedures are often expensive and time consuming, and hence impractical, especially during the initial design stage. Finite element analyses require minimal amounts of input data, and the resulting stress and strain distributions can be determined throughout each individual ply. Using ANSYSTM, a commercially available finite element package, failure loads were predicted by simulating a uniaxial tensile loading on HTS40/977-2 Carbon/Epoxy composite with [+/-4512s lamination scheme. Two built-in failure theories in ANSYSTM features, viz., Maximum Stress and Tsai-Wu were applied in the simulation. The stress-strain and load-extension curves for both actual testing and FEA were then compared and the results are in good agreement. This paper is intended for researchers who have used or are considering using ANSYSTM for the prediction of failure in composite materials.
    Matched MeSH terms: Research Personnel
  13. Fulltext Lane detection using a stereo vision camera
    M. Farihin Talib, Anuar, A.A., Mohd Fauzi Othman, Masoud Samadi
    Journal of Advanced Research in Applied Sciences and Engineering Technology, 2016;5(2):55-61.
    MyJurnal
    Nowadays, intelligent vehicles have received a considerable attention among the
    researchers to reduce the number of collisions and road accidents. One of the
    challenging tasks for these vehicles is road lane detection or road boundaries
    detection. In this research, a lane detection algorithm was developed to detect the
    right and left lane markers on the road by using two cameras which act as a stereo
    vision for the system. It is based on edge detection by using Canny Edge Detection to
    reduce unnecessary data on the images and to perform features recognition for the
    lane. After the features has been extracted, the algorithm is followed by Hough
    Transform method to generate the detected lines on the image obtained from the
    stereo vision camera. The algorithm has to work in different environment to be used
    in real world applications. The stereo vision algorithm is implemented to generate
    disparity map of area. This helps to gain more information on environment, such as the
    estimated distance of the lines, the distance of the vehicle to the turns. The experiment
    result shows the detection of right and left lane on the road with disparity map to
    determine an estimate of the distance of detected lanes from the stereo vision camera.
    Matched MeSH terms: Research Personnel
  14. Fulltext Flat plate solar collectors and applications: a review
    Bande, Y. M., Mariah, N. A.
    Pertanika Journal of Science & Technology, 2014;22(2):365-385.
    MyJurnal
    In this study, various methods and applications of flat plate solar collectors are discussed and pictorial representations are presented. Low temperature applications of flat plate collectors are identified in solar cooking, solar water heating, space and air heating, industrial heating plants and in agricultural produce drying processes. Basic equations, as presented by many researchers in the performances of flat plate collectors, are also presented. The review discusses the analysis of losses from flat plate collectors towards obtaining the overall heat loss coefficient which indicate the performance of flat plate collectors.
    Matched MeSH terms: Research Personnel
  15. Fulltext The acceptability among health researchers and clinicians of social media to translate research evidence to clinical practice: mixed-methods survey and interview study
    Tunnecliff J, Ilic D, Morgan P, Keating J, Gaida JE, Clearihan L, et al.
    J Med Internet Res, 2015;17(5):e119.
    PMID: 25995192 DOI: 10.2196/jmir.4347
    BACKGROUND: Establishing and promoting connections between health researchers and health professional clinicians may help translate research evidence to clinical practice. Social media may have the capacity to enhance these connections.
    OBJECTIVE: The aim of this study was to explore health researchers' and clinicians' current use of social media and their beliefs and attitudes towards the use of social media for communicating research evidence.
    METHODS: This study used a mixed-methods approach to obtain qualitative and quantitative data. Participation was open to health researchers and clinicians. Data regarding demographic details, current use of social media, and beliefs and attitudes towards the use of social media for professional purposes were obtained through an anonymous Web-based survey. The survey was distributed via email to research centers, educational and clinical institutions, and health professional associations in Australia, India, and Malaysia. Consenting participants were stratified by country and role and selected at random for semistructured telephone interviews to explore themes arising from the survey.
    RESULTS: A total of 856 participants completed the questionnaire with 125 participants declining to participate, resulting in a response rate of 87.3%. 69 interviews were conducted with participants from Australia, India, and Malaysia. Social media was used for recreation by 89.2% (749/840) of participants and for professional purposes by 80.0% (682/852) of participants. Significant associations were found between frequency of professional social media use and age, gender, country of residence, and graduate status. Over a quarter (26.9%, 229/852) of participants used social media for obtaining research evidence, and 15.0% (128/852) of participants used social media for disseminating research evidence. Most participants (95.9%, 810/845) felt there was a role for social media in disseminating or obtaining research evidence. Over half of the participants (449/842, 53.3%) felt they had a need for training in the use of social media for professional development. A key barrier to the professional use of social media was concerns regarding trustworthiness of information.
    CONCLUSIONS: A large majority of health researchers and clinicians use social media in recreational and professional contexts. Social media is less frequently used for communication of research evidence. Training in the use of social media for professional development and methods to improve the trustworthiness of information obtained via social media may enhance the utility of social media for communicating research evidence. Future studies should investigate the efficacy of social media in translating research evidence to clinical practice.
    KEYWORDS: communication; eLearning; evidence-based medicine; social media
    Matched MeSH terms: Research Personnel*
  16. Fulltext Mentorship in the research setting
    Mak, Joon-Wah
    International e-Journal of Science, Medicine & Education, 2012;6(1):11-14.
    MyJurnal
    The research mentorship programme is unique in that it is a planned journey undertaken by the mentor and mentee, preferably with well-defined milestones along the journey. During the journey, familiar landmarks will be pointed out by the mentor. In path-finding situations the experience and wisdom of the mentor and the critical appraisal of both mentor and mentee will contribute to learning from the encounter. In most mentor-mentee partnerships, a formal acceptance to the relationship, well-defined landmarks measuring progress in the journey, regular appraisal of the skills developed and acquired, and phased, judicious modification in the individual roles of that relationship will be required. Although there is no consensus on the elements of mentorship, there are some strategies which can contribute to the success of the relationship. Critical success factors include convergence of the research area within the broad expertise of the research mentor. The research mentor should have a proven research track record and is committed to serve in that official capacity. The research mentoring process is dynamic and characteristics of both mentor and mentee contribute to the robustness of that relationship. The mentee would have identified some attributes of the mentor that are desirable and is willing to work hard to achieve, build on, and improve upon. In the research setting endpoint measurements of success will be based on recognition of the research standing of the mentee, measurable outcomes such as number of papers in top tier journals, citation indices, etc. consultancies attracted as well as invitations to deliver plenaries in scientific conferences, patents filed and research findings translated and applied, and other measures of research productivity. In the pursuit of research excellence the mentee would have imbibed values of professionalism and ethics in research and would have constantly kept in mind that to be successful, the mentee would be able to excel beyond his mentor and that the next generation of researchers will seek mentorship from him.
    Matched MeSH terms: Research Personnel
  17. Fulltext Conducting research that is both ethical and responsive to the health needs of a developing country
    Mak JW
    International e-Journal of Science, Medicine & Education, 2014;8(1):19-23.
    MyJurnal
    There is no substantial difference in conducting research that is both ethical and responsive to the health needs in developing and developed nations. Differences are in financial constraints, technological expertise in identification and addressing needs, and in the perception of equal partnership of all stakeholders. There will be differences in emphasis of research but this is slowly blurred due to globalisation. Public health emergencies in developing countries need timely and effective global collaborative research to implement control strategies. Research needs should be based on predictive models with learning from past emergencies, technological advances, strategic critical appraisal of local and global health information, and dialogue with all stakeholders. Adequate funding will be challenging and resources from national, international and aid
    foundations will be needed. Issues associated with such funding include deployment of international rapid response teams, collaborating researchers, transfer of technology, and intellectual property ownership. While all types of research ranging from basic, applied, clinical
    studies, meta-analysis, and translational research are relevant, the relative importance and specific allocation of resources to these may differ. Is the choice related to responsiveness or based on researchers’ perception of their contributions to evidence-based practice and research? Ethical issues relating to vulnerable groups, risk distribution, quality issues, research integrity and oversight are just as important. Internationally funded
    research including clinical trials must be sensitive to such issues to avoid allegations of exploitation. Thus the potential of utilisation and buy-in of research findings and recommendations must be considered.
    Matched MeSH terms: Research Personnel
  18. Fulltext Web-based decision support system for paddy planting management
    Norasma, C.Y.N., Shariff, A.R.M., Jahanshiri, E., Amin, M.S.M., Khairunniza-Bejo, S., Mahmud, A.R.
    Pertanika Journal of Science & Technology, 2013;21(2):343-364.
    MyJurnal
    Precision farming offers numerous benefits and advantages to the farming community for farm productivity improvement. Previous research has led to the development of the offline-based recision Farmer©. Our current research extends further the previous work by developing a Web Paddy GIS©. The need for this arises due to limitations of Precision Farmer© such as portability, offline system accessibility and affordability by the end users, who include semi-literate farmers. This new system has been developed to function on Windows and Linux platforms. A user satisfaction assessment was conducted on website acceptability, and performance testing was made. This study demonstrates that Web Paddy GIS© can successfully run on both platforms. However, the Linux platform has proven to be superior to Windows, based on factors such as CPU usage, speed and user satisfaction. This paper presents a novel management tool of Web-based precision farming for the semi-literate paddy farming community of a developing country. The development of the Web Paddy GIS© is very useful for paddy farmers, farm managers, decision makers and researchers.
    Matched MeSH terms: Research Personnel
  19. Fulltext Routing Protocols for Underwater Wireless Sensor Networks: Taxonomy, Research Challenges, Routing Strategies and Future Directions
    Khan A, Ali I, Ghani A, Khan N, Alsaqer M, Rahman AU, et al.
    Sensors (Basel), 2018 May 18;18(5).
    PMID: 29783686 DOI: 10.3390/s18051619
    Recent research in underwater wireless sensor networks (UWSNs) has gained the attention of researchers in academia and industry for a number of applications. They include disaster and earthquake prediction, water quality and environment monitoring, leakage and mine detection, military surveillance and underwater navigation. However, the aquatic medium is associated with a number of limitations and challenges: long multipath delay, high interference and noise, harsh environment, low bandwidth and limited battery life of the sensor nodes. These challenges demand research techniques and strategies to be overcome in an efficient and effective fashion. The design of routing protocols for UWSNs is one of the promising solutions to cope with these challenges. This paper presents a survey of the routing protocols for UWSNs. For the ease of description, the addressed routing protocols are classified into two groups: localization-based and localization-free protocols. These groups are further subdivided according to the problems they address or the major parameters they consider during routing. Unlike the existing surveys, this survey considers only the latest and state-of-the-art routing protocols. In addition, every protocol is described in terms of its routing strategy and the problem it addresses and solves. The merit(s) of each protocol is (are) highlighted along with the cost. A description of the protocols in this fashion has a number of advantages for researchers, as compared to the existing surveys. Firstly, the description of the routing strategy of each protocol makes its routing operation easily understandable. Secondly, the demerit(s) of a protocol provides (provide) insight into overcoming its flaw(s) in future investigation. This, in turn, leads to the foundation of new protocols that are more intelligent, robust and efficient with respect to the desired parameters. Thirdly, a protocol can be selected for the appropriate application based on its described merit(s). Finally, open challenges and research directions are presented for future investigation.
    Matched MeSH terms: Research Personnel
  20. Low-factor consumption for major surgery in haemophilia B with long-acting recombinant glycoPEGylated factor IX
    Escobar MA, Tehranchi R, Karim FA, Caliskan U, Chowdary P, Colberg T, et al.
    Haemophilia, 2017 Jan;23(1):67-76.
    PMID: 27480487 DOI: 10.1111/hae.13041
    INTRODUCTION: Surgery in patients with haemophilia B carries a high risk of excessive bleeding and requires adequate haemostatic control until wound healing. Nonacog beta pegol, a long-acting recombinant glycoPEGylated factor IX (FIX), was used in the perioperative management of patients undergoing major surgery.
    AIM: To evaluate the efficacy and safety of nonacog beta pegol in patients with haemophilia B who undergo major surgery.
    METHODS: This was an open-label, multicentre, non-controlled surgery trial aimed at assessing peri- and postoperative efficacy and safety of nonacog beta pegol in 13 previously treated patients with haemophilia B. All patients received a preoperative nonacog beta pegol bolus injection of 80 IU kg-1 . Postoperatively, the patients received fixed nonacog beta pegol doses of 40 IU kg-1 , repeated at the investigator's discretion. Safety assessments included monitoring of immunogenicity and adverse events.
    RESULTS: Intraoperative haemostatic effect was rated 'excellent' or 'good' in all 13 cases. Apart from the preoperative injection, none of the patients needed additional doses of nonacog beta pegol on the day of surgery. The median number of postoperative doses of nonacog beta pegol was 2.0 from days 1 to 6 and 1.5 from days 7 to 13. No unexpected intra- or postoperative complications were observed including deaths or thromboembolic events. No patients developed inhibitors.
    CONCLUSIONS: These results indicated that nonacog beta pegol was safe and effective in the perioperative setting, allowing major surgical interventions in patients with haemophilia B with minimal peri- and postoperative concentrate consumption and infrequent injections as reported with standard FIX products.
    KEYWORDS: Phase III; factor IX; haemophilia B; long-acting recombinant factor IX; nonacog beta pegol; surgery
    Matched MeSH terms: Research Personnel
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