MyMedR

Ong HC

Family Practitioner, 1977;2:25-28.

Matched MeSH terms: Pregnancy

Fulltext Chickenpox - a personal cross-cultural experience

Teng CL

Family Physician, 1996;9(3):23-24.

This article chronicles the popular health beliefs of the Malays and Chinese regarding chickenpox, as seen through the eyes of a doctor. The interplay of several factors, namely, a marriage of two major cultures, chickenpox in pregnancy, concurrence of two major festivals make this a unique study in medical socio-anthropology.

Matched MeSH terms: Pregnancy

Maternal obesity and pregnancy outcome

Begum KS, Sachchithanantham K, De Somsubhra S

Clin Exp Obstet Gynecol, 2011;38(1):14-20.

PMID: 21485717

The increasing prevalence of maternal obesity worldwide provides a major challenge to obstetric practice from preconception to postpartum. Maternal obesity can result in unfavorable outcomes for the woman and fetus. Maternal risks during pregnancy include gestational diabetes and chronic hypertension leading to preeclampsia. The fetus is at risk for stillbirth and congenital anomalies. Intrapartum care, normal and operative deliveries, anesthetic and operative interventions in the obese demand extra care. Obesity in pregnancy can also affect health later in life for both mother and child. For women, these risks include heart disease and hypertension. Children have a risk of future obesity and heart disease. Women and their offspring are at increased risk for diabetes. Obstetrician-gynecologists should be well informed to prevent and treat this epidemic. Interventions directed at weight loss and prevention of excessive weight gain during pregnancy must begin in the preconception period.

Matched MeSH terms: Pregnancy; Pregnancy Complications/etiology*; Pregnancy Outcome

Twin pregnancy -- a study of the local pattern

Teoh SK, Wong WP

Med J Malaysia, 1977 Sep;32(1):90-5.

PMID: 609353

Matched MeSH terms: Pregnancy; Pregnancy Complications; Pregnancy, Multiple*

Fulltext Gene expression in obstetric antiphospholipid syndrome: a systematic review

Muhammad Aliff M, Muhammad Shazwan S, Nur Fariha MM, Hayati AR, Nur Syahrina AR, Maizatul Azma M, et al.

Malays J Pathol, 2016 Dec;38(3):285-294.

PMID: 28028299 MyJurnal

BACKGROUND: Antiphospholipid syndrome (APS) is a multisystem disease that may present as venous or arterial thrombosis and/or pregnancy complications with the presence of antiphospholipid antibodies. Until today, heterogeneity of pathogenic mechanism fits well with various clinical manifestations. Moreover, previous studies have indicated that genes are differentially expressed between normal and in the disease state. Hence, this study systematically searched the literature on human gene expression that was differentially expressed in Obstetric APS.

METHODOLOGY: Electronic search was performed until 31st March 2015 through PubMed and Embase databases; where the following Medical Subject Heading (MeSH) terms were used and they had been specified as the primary focus of the articles; gene, antiphospholipid, obstetric, and pregnancy in the title or abstract. From 502 studies retrieved from the search, only original publications that had performed gene expression analyses of human placental tissue that reported on differentially expressed gene in pregnancies with Obstetric APS were included. Two reviewers independently scrutinized the titles and the abstracts before examining the eligibility of studies that met the inclusion criteria. For each study; diagnostic criteria for APS, method for analysis, and the gene signature were extracted independently by two reviewers. The genes listed were further analysed with the DAVID and the KEGG pathways.

RESULTS: Three eligible gene expression studies involving obstetric APS, comprising the datasets on gene expression, were identified. All three studies showed a reduction in transcript expression on PRL, STAT5, TF, DAF, ABCA1, and HBEGF in Obstetric APS. The high enrichment score for functionality in DAVID had been positive regulation of cell proliferation. Meanwhile, pertaining to the KEGG pathway, two pathways were associated with some of the listed genes, which were ErBb signalling pathway and JAK-STAT signalling pathway.

CONCLUSION: Ultimately, studies on a genetic level have the potential to provide new insights into the regulation and to widen the basis for identification of changes in the mechanism of Obstetric APS.

Matched MeSH terms: Pregnancy; Pregnancy Complications/genetics*; Pregnancy Complications/immunology*

Leptospirosis in pregnancy: A lesson in subtlety

Rahimi R, Omar E, Tuan Soh TS, Mohd Nawi SFA, Md Noor S

Malays J Pathol, 2018 Aug;40(2):169-173.

PMID: 30173235 MyJurnal

INTRODUCTION: Leptospirosis is a zoonotic disease caused by spirochaete of the genus Leptospira. Human infection occurs after exposure to water or soil contaminated by urine from an infected animal. Most patients manifest as self-limited systemic illness. However 10% of patients manifest as severe disease associated with high fatality. The disease affects mostly men, cases involving pregnant women are uncommon. We presented a case of leptospirosis in a pregnant woman leading to mortality of both mother and foetus.

CASE REPORT: A 28-year-old woman at 18 weeks of gestation, had shortness of breath and collapsed. She was brought unconscious to the emergency department and died shortly after arrival. A week prior to this, she had presented to the same hospital with pain on both thighs. Examination of the patient and ultrasound of the foetus revealed normal findings. Post mortem examination revealed hepatosplenomegaly and congested lungs; no jaundice, meningeal inflammation or cardiac abnormalities was evident. Histopathology examination of the lungs revealed pulmonary haemorrhages and oedema. Multiple infarcts were seen in the spleen and the kidneys showed foci of acute tubular necrosis. Laboratory investigations revealed Leptospira IgM antibody and PCR for leptospira were positive. This case illustrates the subtleness of clinical presentation of leptospirosis. The diagnosis was obscure even at post-mortem and was only suspected following histopathological examination, leading to further investigations.

CONCLUSION: Leptospirosis may have a subtle presentation and a high index of suspicion for this infection is required for early identification of the disease.

Matched MeSH terms: Pregnancy; Pregnancy Complications, Infectious/diagnosis*; Pregnancy Complications, Infectious/pathology*

Diabetes mellitus complicating pregnancy - an approach to its investigation and management

Ong HC

Family Practitioner, 1981;4:17-21.

Matched MeSH terms: Pregnancy

Gynaecological emergencies masquerading as ruptured ectopic pregnancy

Sivalingam N, Thavarasah AS

Family Practitioner, 1988;11:65-67.

Matched MeSH terms: Pregnancy

Peripartum cardiomyopathy: an overview

Wan Azman WA, Haizal HK

JUMMEC, 2005;8:18-22.

Peripartum cardiomyopathy (PPCM) is a life-threatening cardiomyopathy of an unknown cause that occurs in the peripartum period in previously healthy women and this article discusses the challenges that lie in diagnosing and managing this rare yet lethal disease. KEYWORDS: Peripartum, cardiomyopathy, pregnancy, cardiac failure

Matched MeSH terms: Pregnancy

Fulltext Gestational trophoblastic disease in a 54-year old woman--a case report

Tharmaseelan NK

Singapore Med J, 1990 Dec;31(6):627-8.

PMID: 2177919

A rare case of gestational trophoblastic disease (GTD) in a 54-year old Malay woman is described. A total abdominal hysterectomy with bilateral salphingo-oopherectomy was done. She was given methotrexate therapy as she had persistent high levels of serum B hCG.

Matched MeSH terms: Pregnancy

Navigating an unexpected diagnosis - experience of a tertiary referral centre with two cases of intraplacental choriocarcinoma

Lim CCW, Punjabi LS, Bhatia A, Ng QJ, Jevon GP, Aggarwal IM

Malays J Pathol, 2024 Apr;46(1):91-94.

PMID: 38682848

Intraplacental choriocarcinoma is a rare tumour, with approximately 62 reported cases. It may manifest as a spectrum of disease ranging from an incidental lesion diagnosed on routine placental examination to disseminated maternal and/or neonatal disease. In this case series, we presented two rare cases of intraplacental choriocarcinoma with extremely varied clinical presentations. The extremely varied clinical presentations of both patients described in the case series complicated the process of arriving at the diagnosis. In both cases, subsequent investigations showed no maternal or neonatal metastasis, and maternal serum beta-hCG levels downtrended with conservative management. We aim to highlight the importance of performing a detailed physical examination and evaluation of the patient and multidisciplinary management with oncology opinion. A detailed examination of the placenta should also be considered when faced with obstetric complications so that early diagnosis and the required management can be executed in a prompt fashion.

Matched MeSH terms: Pregnancy; Pregnancy Complications, Neoplastic/diagnosis; Pregnancy Complications, Neoplastic/pathology

Dengue infections and pregnancy: caution in interpreting high rates of premature deliveries and maternal mortality

Seneviratne SL, Perera J, Wijeyaratne C

Southeast Asian J Trop Med Public Health, 2007 Jan;38(1):195-6.

PMID: 17539267

Matched MeSH terms: Pregnancy; Pregnancy Complications, Infectious/mortality; Pregnancy Complications, Infectious/epidemiology*

Global prevalence of urinary tract infection in pregnant mothers: a systematic review and meta-analysis

Salari N, Khoshbakht Y, Hemmati M, Khodayari Y, Khaleghi AA, Jafari F, et al.

Public Health, 2023 Nov;224:58-65.

PMID: 37734277 DOI: 10.1016/j.puhe.2023.08.016

OBJECTIVE: Urinary tract infection (UTI) is a prevalent infection during pregnancy that can lead to complications for both the mother and the foetus. The objective of this systematic review and meta-analysis is to determine the global prevalence of UTIs (both symptomatic and asymptomatic) during pregnancy, based on previous studies in this area. Furthermore, this study aims to identify any factors that contribute to heterogeneity in the prevalence of UTIs during pregnancy.

STUDY DESIGN: Systematic review and meta-analysis.

METHODS: This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines on August 8, 2022. To conduct the systematic review and meta-analysis, a search was performed using the keywords "urinary tract system", "UTI", "pregnancy", and "gestation" was performed in several databases, including Web of Science (WoS), PubMed, Scopus, ScienceDirect, Embase, and Google Scholar, without a time limit until September 18, 2022. The analysis was performed using a random-effects model, and the heterogeneity of the studies was assessed using the I2 index. The Comprehensive Meta-Analysis software (Version 2) was used for data analysis.

RESULTS: The systematic review and meta-analysis of 27 studies, which included a total of 30,641 pregnant women, showed an overall prevalence of UTI (both symptomatic and asymptomatic) to be 23.9% (95% confidence interval: 16.2-33.8). Meta-regression analysis was conducted to examine the impact of two factors, namely study sample size and study year, on the heterogeneity of the meta-analysis. The results revealed that an increase in sample size, and the study year was associated with a decrease in the prevalence of UTI in pregnant women (P

Matched MeSH terms: Pregnancy

Social drug use in the parturient: implications for the management of obstetrical anaesthesia

Kuczkowski KM

Med J Malaysia, 2003 Mar;58(1):147-54; quiz 155.

PMID: 14556345

Maternal use of social drugs in pregnancy continues to increase--worldwide. Although a great deal has been learned regarding the implications of illicit drug abuse in pregnancy (cocaine, amphetamines, hallucinogens), the use of social drug in pregnancy has received far less attention. This article reviews the consequences of the social drug use in pregnancy including ethanol, tobacco and caffeine and offers recommendation for anaesthetic management of these potentially complicated pregnancies.

Matched MeSH terms: Pregnancy

Fulltext Blood lead levels of pregnant women from the Klang Valley

Hisham HJ, Chuah SY, Syarif HL, Nik Nasri I, Fairulnizam MN

Med J Malaysia, 1998 Mar;53(1):76-81.

PMID: 10968142

A study was conducted to compare the blood lead levels of 97 pregnant women warded at the Kuala Lumpur Hospital, according to their ethnicity, residence and place of work. The lead content of venous blood samples was determined with a graphic furnace atomic absorption spectrometer. Blood lead levels of Klang Valley women seem to have decreased from 17.3 micrograms/dl in 1982 to 7.71 micrograms/dl in the present study most probably attributed to the phasing out of leaded gasoline. This level is below the 10 micrograms/dl recommended by the United States Environmental Protection Agency for the public, even though 27.8% of them still have blood lead levels that are equal to or in excess of 10 micrograms/dl. The study shows that certain segments of the population such as Indians (geometric mean = 9.35 micrograms/dl) and housewives (geometric mean = 9.55 micrograms/dl) may still experience blood lead levels that are slightly elevated than the rest of the population.

Matched MeSH terms: Pregnancy/blood*

Fulltext Combined pregnancy--a case report

Kumarasamy S, Arumugam K

Med J Malaysia, 1991 Sep;46(3):252-4.

PMID: 1839921

A case of combined intra- and extra-uterine pregnancy is reported. Awareness of this condition, a high index of suspicion, the proper interpretation of physical signs and ultrasound findings together with early resort to laparoscopy resulted in a favourable outcome.

Matched MeSH terms: Pregnancy*

Fulltext Iron stores in pregnancy

George E, Adeeb N, Ahmad J

Med J Malaysia, 1980 Dec;35(2):129-30.

PMID: 7266404

Serum ferritin concentration has been measured in pregnant women at their first antenatal visit. Results were analysed according to trimesters. With progression of the pregnancy there is a fall in serum ferritin concentrations. Haemoglobin and red cell indices cannot be used to predict iron status supplemental iron therapy raised the serum ferritin levels.

Matched MeSH terms: Pregnancy*

Fulltext Laparoscopic Wedge Resection in a Late Second Trimester Cornual Pregnancy

Safiee AI, Ghazali WAHW

Gynecol Minim Invasive Ther, 2021 01 30;10(1):47-49.

PMID: 33747774 DOI: 10.4103/GMIT.GMIT_22_19

Cornual pregnancy happens when implantation occurs in the cavity of a rudimentary horn of the uterus, which may or may not be communicating with the uterine cavity. The diagnosis of cornual pregnancy remains challenging, and rupture of a cornual pregnancy usually causes massive bleeding. Early diagnosis and treatment, therefore, are very crucial and key to prevent mortality. Historically, the management of cornual pregnancies included wedge resection through open surgery or even hysterectomy. In this case report, we would like to highlight a case of late second trimester cornual pregnancy, at 19-week and 3-day gestation, which was managed laparoscopically.

Matched MeSH terms: Pregnancy; Pregnancy, Cornual

Fulltext Placenta increta presenting with threatened miscarriage during the first trimester in rhesus-negative mother: a case report

Nik-Ahmad-Zuky NL, Seoparjoo A, Husna EIE

J Med Case Rep, 2021 Sep 08;15(1):448.

PMID: 34493340 DOI: 10.1186/s13256-021-03030-x

BACKGROUND: Placenta accreta is known to be associated with significant maternal morbidity and mortality-primarily due to intractable bleeding during abortion or delivery at any level of gestation. The complications could be reduced if placenta accreta is suspected in a patient with a history of previous cesarean delivery and the gestational sac/placenta is located at the lower part of the uterus. Then, a proper management plan can be instituted, and complications can be reduced. The diagnosis of placenta accreta in the first trimester of pregnancy is considered uncommon.

CASE PRESENTATION: A 34-year-old Malay, gravida 4, para 3, rhesus-negative woman was referred from a private hospital at 13 weeks owing to accreta suspicion for further management. She has a history of three previous lower-segment cesarean sections. She also had per vaginal bleeding in the early first trimester, which is considered to indicate threatened miscarriage. Transabdominal ultrasound revealed features consistent with placenta accreta spectrum. She was counseled for open laparotomy and hysterectomy because of potential major complication if she continued with the pregnancy. Histopathological examination revealed placenta increta.

CONCLUSION: A high index of suspicion of placenta previa accreta must be in practice in a patient with a history of previous cesarean deliveries and low-lying placenta upon ultrasound examination during early gestation.

Matched MeSH terms: Pregnancy; Pregnancy Trimester, First

Serum protein changes during early pregnancy in Malayan women

Chandrasekharan N

Med J Malaya, 1968 Sep;23(1):47-50.

PMID: 4237556

Matched MeSH terms: Pregnancy*

Displaying publications 101 - 120 of 2446 in total