Displaying publications 1381 - 1400 of 5470 in total

Abstract:
Sort:
  1. Dietary phytochemicals that influence gut microbiota: Roles and actions as anti-Alzheimer agents
    Wang Y, Lim YY, He Z, Wong WT, Lai WF
    Crit Rev Food Sci Nutr, 2021 Feb 09.
    PMID: 33559482 DOI: 10.1080/10408398.2021.1882381
    The last decide has witnessed a growing research interest in the role of dietary phytochemicals in influencing the gut microbiota. On the other hand, recent evidence reveals that dietary phytochemicals exhibit properties of preventing and tackling symptoms of Alzheimer's disease, which is a neurodegenerative disease that has also been linked with the status of the gut microbiota over the last decade. Till now, little serious discussions, however, have been made to link recent understanding of Alzheimer's disease, dietary phytochemicals and the gut microbiota together and to review the roles played by phytochemicals in gut dysbiosis induced pathologies of Alzheimer's disease. Deciphering these connections can provide insights into the development and future use of dietary phytochemicals as anti-Alzheimer drug candidates. This review aims at presenting latest evidence in the modulating role of phytochemicals in the gut microbiota and its relevance to Alzheimer's disease and summarizing the mechanisms behind the modulative activities. Limitations of current research in this field and potential directions will also be discussed for future research on dietary phytochemicals as anti-Alzheimer agents.
    Matched MeSH terms: Alzheimer Disease
  2. Fulltext Sane and safe: Forced social distancing to prevent human-to-human transmission of COVID-19
    Jahan F
    Malays Fam Physician, 2021 Mar 25;16(1):15-17.
    PMID: 33948138 DOI: 10.51866/rv0001
    The current outbreak of COVID-19, originating from the city of Wuhan in China and ultimately involving over 200 countries, is now a global concern. Evidence indicates that COVID-19 spread to humans from wild animals, causing severe respiratory tract infections in humans; the typical symptoms of COVID include cough, high-grade fever, sore throat, and difficulty in breathing. The infection spreads from human to human via droplets. Therefore, social or physical distancing can reduce spread within communities. Asymptomatic spread can also occur during family gatherings or in the workplace; thus, we must enforce physical distancing as much as possible to reduce the spread of cases.
    Matched MeSH terms: Disease Outbreaks
  3. Fulltext Occurrence of Recurrent Aphthous Stomatitis (RAS) as a Rare Oral Manifestation in a Patient with Gilbert's Syndrome
    Heboyan A, Avetisyan A, Skallevold HE, Rokaya D, Marla V, Vardanyan A
    Case Rep Dent, 2021;2021:6648729.
    PMID: 33953989 DOI: 10.1155/2021/6648729
    Recurrent aphthous stomatitis is an ulcerative disease of the oral cavity and can occur in isolation or as a manifestation of many systemic diseases. It is a quite common entity and may hence often be overlooked as an isolated lesion. Gilbert's syndrome is a genetic disorder where a deficiency of an enzyme associated with the conjugation of bilirubin results in unconjugated hyperbilirubinemia. The disease is generally asymptomatic and is aggravated by certain trigger factors. No associated oral manifestations are known. In this case report, we discuss the concomitant presence of recurrent aphthous stomatitis in a patient of Gilbert's syndrome. The presence of such recurrent stomatitis may represent as an oral manifestation of Gilbert's syndrome. Early identification of these entities may improve the overall quality of life of the patient.
    Matched MeSH terms: Gilbert Disease
  4. Hemophilia treatment in developing countries: products and protocols
    Srivastava A, You SK, Ayob Y, Chuansumrit A, de Bosch N, Perez Bianco R, et al.
    Semin Thromb Hemost, 2005 Nov;31(5):495-500.
    PMID: 16276456
    The most important aspect of management of hemophilia is to provide adequate replacement of safe clotting factor concentrates to prevent or treat bleeding episodes. There has been considerable progress in many countries in the developing world with regard to this aspect of care. However, very little data are available in the literature on the types of products being used for factor replacement and the doses being administered for control or treatment of bleeding in different countries. These data are important to document because only then can data from different centers be compared. This article provides data from seven countries: Korea, Malaysia, Thailand, Venezuela, Argentina, Iran, and India. It shows that there is wide variability not only in the types of products used (plasma to recombinant factor concentrates) but also in the doses administered (minimal to very high) for similar indications. Prospective documentation of data on musculoskeletal outcome at these centers and correlation with dose of factor replacement could help identify different models of care. Comparing such data and collating the experience in different countries could be useful for optimizing care and establishing cost-effective models. The combined experience in the developing world in providing hemophilia services should be used to define standards of care that are practical and to set achievable goals.
    Matched MeSH terms: Disease Management
  5. Fulltext Capsule endoscopy in inflammatory bowel disease: when and how
    Hilmi I, Kobayashi T
    Intest Res, 2020 Jul;18(3):265-274.
    PMID: 32623876 DOI: 10.5217/ir.2019.09165
    Capsule endoscopy (CE) is emerging as an important investigation in inflammatory bowel disease (IBD); common types include the standard small bowel CE and colon CE. More recently, the pan-enteric CE was developed to assess the large and small bowel in patients with Crohn's disease (CD). Emerging indications include noninvasive assessment for mucosal healing (both in the small bowel and the colon) and detection of postoperative recurrence in patients with CD. Given the increasing adoption, several CE scoring systems have been specifically developed for IBD. The greatest concern with performing CE, particularly in CD, is capsule retention, but this can be overcome by performing cross-sectional imaging such as magnetic resonance enterography and using patency capsules before performing the procedure. The development of software for automated detection of mucosal abnormalities typically seen in IBD may further increase its adoption.
    Matched MeSH terms: Crohn Disease
  6. Fulltext Circulating vaccine-derived poliovirus: a menace to the end game of polio eradication
    Ming LC, Hussain Z, Yeoh SF, Koh D, Lee KS
    Global Health, 2020 07 16;16(1):63.
    PMID: 32677974 DOI: 10.1186/s12992-020-00594-z
    The World Health Organisation Western Pacific Region countries were declared free of polio in 2000 until a polio outbreak involving 305 cases occurred in Indonesia in 2006. It was not until 2014 that the World Health Organisation South East Asia region was officially declared polio-free again. However, in February 2019, the Global Polio Eradication Initiative announced a new circulating vaccine-derived poliovirus outbreak in the Papua province of Indonesia. To make matter worse, the outbreak responses were tardy and led to transmission among migrating communities to other cities. The pressing regional issues of polio outbreak caused by circulating vaccine-derived poliovirus and use of oral polio vaccine have not been well presented. Our letter highlighted the suboptimal outbreak responses as well as the necessity of cross-border vaccination to curb continued poliovirus transmission.
    Matched MeSH terms: Disease Outbreaks
  7. Fulltext Prurigo Nodularis and Hodgkin’s Lymphoma: A Rare Association
    Go, Zher Lin, Low, Qin Jian, Nurul Aisyah Abd Rahman, Ng, Ling Fong, Faizah Ahmad, Lau, Ngee Siang
    Borneo Journal of Medical Sciences, 2019;13(3):59-63.
    MyJurnal
    Prurigo nodularis (PN) is an uncommon skin condition known to be associated with underlying systemic diseases. This case report is about PN secondary to underlying Hodgkin’s lymphoma. A 30-year-old man presented with this skin condition three months before lymphadenopathy and systemic symptoms due to lymphoma. He had made multiple visits to general practitioners for the disturbing rash, given multiple courses of topical treatment without relief. His PN showed marked improvement after initiation of chemotherapy. This case reminds that an unexplained skin condition should prompt clinicians for investigating for an underlying systemic disease. This case, to our knowledge, is the first Hodgkin’s lymphoma-associated prurigo nodularis reported in Malaysia.
    Matched MeSH terms: Hodgkin Disease
  8. Fulltext Unravelling the myths of R0 in controlling the dynamics of COVID-19 outbreak: A modelling perspective
    Mohd MH, Sulayman F
    Chaos Solitons Fractals, 2020 Sep;138:109943.
    PMID: 32834577 DOI: 10.1016/j.chaos.2020.109943
    COVID-19 is an emerging and rapidly evolving pandemic around the world, which causes severe acute respiratory syndrome and results in substantial morbidity and mortality. To examine the transmission dynamics of COVID-19, we investigate the spread of this pandemic using Malaysia as a case study and scrutinise its interactions with some exogenous factors such as limited medical resources and false detection problems. To do this, we employ a simple epidemiological model and analyse this system using modelling and dynamical systems techniques. We discover some contrasting findings with respect to the observations of basic reproduction number: while it is observed that R0 seems to provide a good description of transmission dynamics in simple outbreak scenarios, this quantity might mislead the assessment on the severity of pandemic when certain complexities such as limited medical resources and false detection problems are incorporated into the model. In particular, we observe the possibility of a COVID-19 outbreak through bistable behaviour, even when the basic reproduction number is less than unity. Based on these findings, we caution policy makers not to make their decisions solely based on the guidance of the basic reproduction number only, which clearly could cause trouble.
    Matched MeSH terms: Disease Outbreaks
  9. Fulltext Acute pancreatitis with electrocardiographic changes mimicking acute coronary syndrome: a diagnostic conundrum
    Shamala N., Faizal, A.H.
    Medicine & Health, 2018;13(2):195-201.
    MyJurnal
    Electrocardiographic abnormalities can be associated with acute pancreatitis. However, data regarding the actual causative factor still remains elusive. Many previous cases were reported on non-specific ST and T wave abnormalities concurrent with acute pancreatitis but rarely with an increasing trend of cardiac markers. We describe the case of a 70-year-old female who presented with one such conundrum. Our patient had typical presentation of acute pancreatitis but had dynamic ECG changes with markedly increased cardiac markers. Subsequently after initiation of treatment for acute pancreatitis and observation for the course of several days, the ECG returned to the baseline as pre admission. This substantiates the fact that acute pancreatitis can mimic both biochemical and electrical manifestation of an acute coronary syndrome. Thus, Emergency Physicians should consider acute pancreatitis as a possible diagnosis in patients who present with abnormal electrocardiograms.
    Matched MeSH terms: Acute Disease
  10. Fulltext Data on biology and demographic parameters of the Aedes albopictus from dengue outbreaks in Klang Valley, Malaysia
    Dom NC, Alhothily IA, Camalxaman SN, Ismail SNS
    Data Brief, 2020 Aug;31:105882.
    PMID: 32642511 DOI: 10.1016/j.dib.2020.105882
    In this article, data on the demographic parameters of the Aedes albopictus were collected from those areas in Shah Alam, Malaysia that had experienced a dengue outbreak. The surveys were conducted from March to December 2017. The eggs of the Ae. albopictus were collected using ovitraps, and were analysed based on the demographic parameters in a controlled environment in an insectarium. The data were comprised of four types of biological information on the life demographic parameters of the Ae. albopictus that were monitored based on specific localities. The data were inferred information regarding egg productivity (n), egg development (%), immature development (days), and survivorship (days).
    Matched MeSH terms: Disease Outbreaks
  11. Decreasing major surgical rates for Crohn's disease in an emerging economy over two decades: Is it due to biologic therapy?
    Chuah KH, Raja Ali RA, Hilmi IN
    Indian J Gastroenterol, 2020 06;39(3):261-267.
    PMID: 32613522 DOI: 10.1007/s12664-020-01044-9
    BACKGROUND: Alteration in the natural history of Crohn's disease (CD) since the advent of biologic therapy remains to be proven. Our aim was to look at the intestinal surgical rates and the association with biologic therapy over the last two decades.

    METHODS: This was a retrospective study in which all CD patients seen in two tertiary referral hospitals in Malaysia were recruited. Patients were stratified into two cohorts; cohort 1 was patients diagnosed from year 1991 to 2000 and cohort 2 was patients diagnosed from year 2001 to 2010. These time cohorts were selected based on initial availability of biologic agents in Malaysia in year 2000. Details of demography, disease location, medications and cumulative surgical rates over 7 years were recorded.

    RESULTS: A total of 207 patients were recruited: 70 from cohort 1 and 137 from cohort 2. Differences seen in terms of disease location, phenotype, and use of immunomodulatory therapy between the two cohorts were not significant. Patients who were ever exposed to biologics were significantly different between the two cohorts, approximately two times higher at 35.8% (n = 49) in cohort 2, and 18.6% (n = 13) in cohort 1, p = 0.011. There was a significant reduction in the 7-year cumulative intestinal surgical rates between cohort 1 and cohort 2, from 21.4% (n = 15) to 10.2% (n = 14), p = 0.028. However, there was no statistically significant difference in biologic exposure between those who underwent surgery and those who did not.

    CONCLUSIONS: There has been a significant reduction in intestinal surgical rates for Crohn's disease over the last two decades but does not appear to be associated with the increased use of biologics.

    Matched MeSH terms: Crohn Disease/drug therapy; Crohn Disease/epidemiology; Crohn Disease/surgery*
  12. Fulltext Investigation of a Dengue Outbreak in Ibu Pejabat Kontigen (IPK) Kota Kinabalu, Sabah, 2017
    Lim, Carol Kai Joo
    Borneo Journal of Medical Sciences, 2018;12(101):41-42.
    MyJurnal
    Dengue is a viral infection caused by four types of viruses (DENV-1, DENV- 2, DENV-3, DENV-4) and transmitted through the bite of infected Aedes aegypti and Aedes albopictus female mosquitoes that feed both indoors and outdoors during the daytime (from dawn to dusk). These mosquitoes thrive in areas with standing water, including puddles, water tanks, containers and old tyres. There were a total of 35 dengue outbreaks under PKK KK with four active outbreaks in the year 2017. One uncontrolled outbreak occurred at Ibu Pejabat Kontigen (IPK) Kota Kinabalu from 16 November 2017 to 21 December 2017.
    Matched MeSH terms: Disease Outbreaks
  13. Nipah virus: an emergent paramyxovirus causing severe encephalitis in humans
    Bellini WJ, Harcourt BH, Bowden N, Rota PA
    J Neurovirol, 2005 Oct;11(5):481-7.
    PMID: 16287690
    Nipah virus is a recently emergent paramyxovirus that is capable of causing severe disease in both humans and animals. The first outbreak of Nipah virus occurred in Malaysia and Singapore in 1999 and, more recently, outbreaks were detected in Bangladesh. In humans, Nipah virus causes febrile encephalitis with respiratory syndrome that has a high mortality rate. The reservoir for Nipah virus is believed to be fruit bats, and humans are infected by contact with infected bats or by contact with an intermediate animal host such as pigs. Person to person spread of the virus has also been described. Nipah virus retains many of the genetic and biologic properties found in other paramyxoviruses, though it also has several unique characteristics. However, the virologic characteristics that allow the virus to cause severe disease over a broad host range, and the epidemiologic, environmental and virologic features that favor transmission to humans are unknown. This review summarizes what is known about the virology, epidemiology, pathology, diagnosis and control of this novel pathogen.
    Matched MeSH terms: Disease Reservoirs/veterinary; Disease Reservoirs/virology; Disease Vectors
  14. Mycotoxins in Food and Feed: Present Status and Future Concerns
    Bhat R, Rai RV, Karim AA
    Compr Rev Food Sci Food Saf, 2010 Jan;9(1):57-81.
    PMID: 33467806 DOI: 10.1111/j.1541-4337.2009.00094.x
      Disease outbreaks due to the consumption of contaminated food and feedstuff are a recurring problem worldwide. The major factor contributing to contamination are microorganisms, especially fungi, which produce low-molecular-weight compounds as secondary metabolites, with confirmed toxic properties referred to as mycotoxins. Several mycotoxins reported to date are cosmopolitan in distribution and incur severe health-associated risks (including cancer and neurological disorders). Hence, creating awareness among consumers, as well as developing new methods for detection and inactivation is of great importance for food safety. In this review, the focus is on the occurrence of various types of mycotoxins in food and feed associated with risks to humans and livestock, as well as legislation put forth by various authorities, and on presently practiced detoxification methods. Brief descriptions on recent developments in mycotoxin detection methodology are also inlcuded. This review is meant to be informative not only for health-conscious consumers but also for experts in the field to pave the way for future research to fill the existing gaps in our knowledge with regard to mycotoxins and food safety.
    Matched MeSH terms: Disease Outbreaks
  15. Phosphatidylethanolamine N-methyltransferase gene rs7946 polymorphism plays a role in risk of nonalcoholic fatty liver disease: evidence from meta-analysis
    Tan HL, Mohamed R, Mohamed Z, Zain SM
    Pharmacogenet Genomics, 2016 Feb;26(2):88-95.
    PMID: 26636496 DOI: 10.1097/FPC.0000000000000193
    Phosphatidylethanolamine N-methyltransferase (PEMT) governs the secretion of hepatic triglycerides in the form of very low-density lipoprotein and has been implicated in nonalcoholic fatty liver disease (NAFLD). Studies on the role of the PEMT rs7946 polymorphism as a genetic modifier of NAFLD have reported inconsistent results. This meta-analysis was carried out to evaluate and summarize the association of PEMT rs7946 with susceptibility to NAFLD.
    Matched MeSH terms: Non-alcoholic Fatty Liver Disease
  16. Establishment of Asia-Pacific Network for Enterovirus Surveillance
    Chiu ML, Luo ST, Chen YY, Chung WY, Duong V, Dussart P, et al.
    Vaccine, 2020 01 03;38(1):1-9.
    PMID: 31679864 DOI: 10.1016/j.vaccine.2019.09.111
    Enteroviruses (EV), the major pathogens of hand, foot, and mouth disease (HFMD) and herpangina, affect millions of children each year. Most human enteroviruses cause self-limited infections except polioviruses, enterovirus A71 (EV-A71), enterovirus D68 (EV-D68), and several echoviruses (Echo) and coxsackieviruses (CV). Especially, EV-A71 has repeatedly caused large-scale outbreaks in the Asia-Pacific region since 1997. Some Asian countries have experienced cyclical outbreaks of severe EV-A71 infections and initiated development of EV-A71 vaccines. Five EV-A71 vaccine candidates have been clinically evaluated and three of them were approved for marketing in China. However, none of the China-approved products seek marketing approval in other countries. This situation supports a role for collaboration among Asian countries to facilitate clinical trials and licensure of EV-A71 vaccines. Additionally, enterovirus D68 outbreaks have been reported in the US and Taiwan currently and caused severe complications and deaths. Hence, an Asia-Pacific Network for Enterovirus Surveillance (APNES) has been established to estimate disease burden, understand virus evolution, and facilitate vaccine development through harmonizing laboratory diagnosis and data collection. Founded in 2017, the APNES is comprised of internationally recognized experts in the field of enterovirus in Asian countries working to raise awareness of this potentially fatal and debilitating disease. This article demonstrated the summaries of the first expert meeting, 2017 International Workshop on Enterovirus Surveillance and Vaccine Development, held by APNES in Taipei, Taiwan, March 2017.
    Matched MeSH terms: Hand, Foot and Mouth Disease/diagnosis; Hand, Foot and Mouth Disease/epidemiology*; Hand, Foot and Mouth Disease/prevention & control
  17. Synergistic effects of intracoronary infusion of autologous bone marrow-derived mesenchymal stem cells and revascularization procedure on improvement of cardiac function in patients with severe ischemic cardiomyopathy
    Chin SP, Maskon O, Tan CS, Anderson JE, Wong CY, Hassan HHC, et al.
    Stem Cell Investig, 2021;8:2.
    PMID: 33575315 DOI: 10.21037/sci-2020-026
    Background: Ischemic cardiomyopathy (ICM) is a leading cause of cardiovascular mortality worldwide. It is defined as abnormal enlargement of the left ventricular (LV) cavity with poor LV function due to coronary artery disease. Currently available established treatments are palliative whereby blood supply is recovered to ischemic regions but fails to regenerate heart tissues. Mesenchymal stem cells (MSCs) offer a promising treatment for ICM given their regenerative and multipotent characteristics. This study aims to investigate the effect of MSCs infusion with concurrent revascularization in patients with severe ICM compared to receiving only revascularization procedure or MSCs infusion.

    Methods: Twenty-seven patients with history of anterior myocardial infarction (MI) and baseline left ventricular ejection fraction (LVEF) of less than 35% were recruited into this study. Patients who are eligible for revascularization were grouped into group A (MSCs infusion with concurrent revascularization) or group B (revascularization only) while patients who were not eligible for revascularization were allocated in group C to receive intracoronary MSCs infusion. LV function was measured using echocardiography.

    Results: Patients who received MSCs infusion (either with or without revascularization) demonstrated significant LVEF improvements at 3, 6 and 12 months post-infusion when compared to baseline LVEF within its own group. When comparing the groups, the magnitude of change in LVEF from baseline for third visits i.e., 12 months post-infusion was significant for patients who received MSCs infusion plus concurrent revascularization in comparison to patients who only had the revascularization procedure.

    Conclusions: MSCs infusion significantly improves LV function in ICM patients. MSCs infusion plus concurrent revascularization procedure worked synergistically to improve cardiac function in patients with severe ICM.

    Matched MeSH terms: Coronary Artery Disease
  18. Fulltext Rapid progression of type 2 diabetes and related complications in children and young people-A literature review
    Barrett T, Jalaludin MY, Turan S, Hafez M, Shehadeh N, Novo Nordisk Pediatric Type 2 Diabetes Global Expert Panel
    Pediatr Diabetes, 2020 03;21(2):158-172.
    PMID: 31804738 DOI: 10.1111/pedi.12953
    Type 2 diabetes (T2D) is suggested to progress faster in children and young people vs type 1 diabetes (T1D) in the same age group and T2D in adults. We reviewed the evidence base for this. A literature search was performed of PubMed-indexed publications between 2000 and 2018, for the terms "pediatric" and "T2D." Results were combined and filtered for those relating to "progression." Searches of abstract books from Latin American and Asian congresses were performed to include these populations. Pediatric populations were defined as <25 completed years of age. Of the articles and congress abstracts found, 30 were deemed relevant. Dividing the studies into categories based on how T2D progresses, we found the following: (a) yearly beta-cell function deterioration was shown to be 20% to 35% in children with T2D compared with 7% to 11% in adults with T2D, despite similar disease durations; (b) retinopathy progression was likely dependent on diabetes duration rather than diabetes type; however, nephropathy, neuropathy and probably hypertension progressed faster in youth-onset T2D vs T1D. Nephropathy progression was similar to adults with T2D, allowing for disease duration. Youth with T2D had a worse cardiovascular (CV) risk profile than youth with T1D, and a faster progression to CV death. (c) Progression to treatment failure was faster in youth-onset T2D vs adult-onset T2D. Substantial evidence exists for faster progression of T2D in pediatric patients vs T1D or adult-onset T2D. New treatments targeting the pathology are needed urgently to address this issue.
    Matched MeSH terms: Disease Progression
  19. Fulltext A mini-review on the effects of COVID-19 on younger individuals
    Manivannan M, Jogalekar MP, Kavitha MS, Maran BAV, Gangadaran P
    Exp Biol Med (Maywood), 2021 02;246(3):293-297.
    PMID: 33210552 DOI: 10.1177/1535370220975118
    Coronavirus disease 2019 (COVID-19) pandemic has uprooted our lives like never before since its onset in the late December 2019. The world has seen mounting infections and deaths over the past few months despite the unprecedented measures countries are implementing, such as lockdowns, social distancing, mask-wearing, and banning gatherings in large groups. Interestingly, young individuals seem less likely to be impacted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19. While the rate of transmission, symptom presentation, and fatality is lower in children than people from other age groups, they have been disproportionately affected by strict lockdown measures needed to curb viral spread. In this review, we describe the association between patient age and COVID-19, epidemiology of SARS-CoV-2 infection in children, psychological effects associated with lockdowns and school closures, and possible mechanisms underlying lower transmission rate of COVID-19 in children.
    Matched MeSH terms: Communicable Disease Control
  20. Fulltext Draft Genome Sequence of a Vibrio parahaemolyticus Strain, KS17.S5-1, with Multiple Antibiotic Resistance Genes, Which Causes Acute Hepatopancreatic Necrosis Disease in Penaeus monodon in the West Coast of Peninsular Malaysia
    Devadas S, Bhassu S, Christie Soo TC, Mohamed Iqbal SN, Yusoff FM, Shariff M
    Microbiol Resour Announc, 2018 Jul;7(2).
    PMID: 30533806 DOI: 10.1128/MRA.00829-18
    We report the first draft genome sequence of a Vibrio parahaemolyticus strain (VpAHPND), which causes acute hepatopancreatic necrosis disease (AHPND) in Penaeus monodon. The strain has a pVA1-like plasmid carrying pirAvp and pirBvp genes. Whole-genome comparisons revealed >98% similarity to VpAHPND isolates from Thailand, Mexico, and Vietnam.
    Matched MeSH terms: Acute Disease
Related Terms
Filters
Contact Us

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links