MyMedR

Suprasellar lymphoma masquerading as tuberculosis of the central nervous system

Dang YL, Hor JY, Chia YK, Lim TT, Eow GB

Acta Neurol Belg, 2014 Sep;114(3):239-41.

PMID: 23757110 DOI: 10.1007/s13760-013-0217-3

Matched MeSH terms: Lymphoma/pathology; Lymphoma/physiopathology*; Central Nervous System Neoplasms/pathology; Central Nervous System Neoplasms/physiopathology*; Tuberculosis, Central Nervous System/physiopathology*

Fingerprint changes and verification failure among patients with hand dermatitis

Lee CK, Chang CC, Johar A, Puwira O, Roshidah B

JAMA Dermatol, 2013 Mar;149(3):295-9.

PMID: 23682364

To determine the prevalence of fingerprint verification failure and to define and quantify the fingerprint changes associated with fingerprint verification failure.

Matched MeSH terms: Eczema/pathology*; Hand Dermatoses/pathology*

Dysregulation of miR-31 and miR-375 expression is associated with clinical outcomes in oral carcinoma

Siow MY, Ng LP, Vincent-Chong VK, Jamaludin M, Abraham MT, Abdul Rahman ZA, et al.

Oral Dis, 2014 May;20(4):345-51.

PMID: 23651447 DOI: 10.1111/odi.12118

To identify differentially expressed miRNA between oral squamous cell carcinoma (OSCC) and non-cancer (NC) and to associate these with clinico-pathological parameters.

Matched MeSH terms: Carcinoma, Squamous Cell/pathology; Mouth Neoplasms/pathology

Fulltext Detection of epidermal growth factor receptor mutations in formalin fixed paraffin embedded biopsies in Malaysian non-small cell lung cancer patients

Shi Yeen TN, Pathmanathan R, Shiran MS, Ahmad Zaid FA, Cheah YK

J Biomed Sci, 2013 Apr 16;20:22.

PMID: 23590575 DOI: 10.1186/1423-0127-20-22

BACKGROUND: Somatic mutations of the epidermal growth factor receptor (EGFR) are reportedly associated with various responses in non-small cell lung cancer (NSCLC) patients receiving the anti-EGFR agents. Detection of the mutation therefore plays an important role in therapeutic decision making. The aim of this study was to detect EGFR mutations in formalin fixed paraffin embedded (FFPE) samples using both Scorpion ARMS and high resolution melt (HRM) assay, and to compare the sensitivity of these methods.

RESULTS: All of the mutations were found in adenocarcinoma, except one that was in squamous cell carcinoma. The mutation rate was 45.7% (221/484). Complex mutations were also observed, wherein 8 tumours carried 2 mutations and 1 tumour carried 3 mutations.

CONCLUSIONS: Both methods detected EGFR mutations in FFPE samples. HRM assays gave more EGFR positive results compared to Scorpion ARMS.

Matched MeSH terms: Carcinoma, Non-Small-Cell Lung/pathology; Lung Neoplasms/pathology

Prevalence, mean intensity and site preference of Caligus rotundigenitalis Yü, 1933 (Copepoda: Caligidae) on cage cultured crimson snapper (Lutjanus erythropterus Bloch, 1790) from Bukit Tambun, Penang, Malaysia

Leaw YY, Faizah S, Anil C, Kua BC

Vet Parasitol, 2012 Jul 6;187(3-4):505-10.

PMID: 22425490 DOI: 10.1016/j.vetpar.2012.02.003

Snapper had been cultured in Malaysia since 1980 due to the fry availability and the high demand. However, details on the caligids infestation were not properly documented. This study was carried out to determine the prevalence, mean intensity and site preference of Caligus rotundigenitalis (Caligidae, Siphonostomatoida) a parasitic copepod on cage cultured crimson snapper, Lutjanus erythropterus from Bukit Tambun, Penang, Malaysia. A total of 70 specimens of cultured snapper were examined based on different infestation sites such as head, body as well as operculum. The specimens were separated into three groups according to the size of the fish. C. rotundigenitalis was found to be the only species infesting L. erythropterus with the prevalence and the mean intensity of 81.4% and 5.6±4.4, respectively. There was a significant difference between the prevalence of site infestation of the body and inner operculum sites. The prevalence of C. rotundigenitalis was highest on inner operculum of the fish followed by the body and head. However, there was no significant difference in the distribution of C. rotundigenitalis over the different infestation sites derived from the three groups. The information obtained from this study can be used for more effective control measures of ectoparasitic copepod infestation in floating cages.

Matched MeSH terms: Fish Diseases/pathology; Parasitic Diseases, Animal/pathology

Acute flaccid paralysis with chronic cough

Chai CH, Yuki N, Nor HM, Goh KJ, Shahrizaila N

Pract Neurol, 2012 Oct;12(5):328-31.

PMID: 22976064 DOI: 10.1136/practneurol-2011-000205

Matched MeSH terms: Cauda Equina/pathology; Spinal Cord/pathology

Fulltext Cholesterol granuloma in a post-mastoidectomy for cholesteatoma

Mohd Khairi MD, Ramiza Ramza R

Med J Malaysia, 2012 Apr;67(2):217-8.

PMID: 22822649 MyJurnal

Cholesterol granuloma is a histological term used to describe the foreign body reaction towards cholesterol crystals causing granuloma. We report a case of cholesterol granuloma in a patient who presented with a mass in her ear after 6 years of mastoidectomy. The diagnosis has been confirmed by MRI and postoperative findings. The difference between cholesterol granuloma and the other entities especially cholesteatoma and meningoencephalic herniation must be made in view of its implications and surgical management of each lesion.

Matched MeSH terms: Cholesteatoma/pathology; Mastoid/pathology

Stomal recurrence after total laryngectomy: a 10-year review in Universiti Kebangsaan Malaysia Medical Center

bte Abdul Rashid NH, Yunus MR, bte Baki MM, bte Ami M, Athar PP

J Pak Med Assoc, 2012 May;62(5):466-9.

PMID: 22755311

To determine the frequency of stomal recurrence in patients following total laryngectomy in our center and to compare the frequency of previously reported risk factors such as preoperative tracheostomy, subglottic invasion and the level of lymph node metastases, with the rest of the world.

Matched MeSH terms: Laryngeal Neoplasms/pathology*; Surgical Stomas/pathology*

Fulltext Review of stem cell deregulation and breast cancer: an emerging hypothesis

Kumar DH, Kutty MK

Indian J Pathol Microbiol, 2012 Apr-Jun;55(2):147-53.

PMID: 22771633 DOI: 10.4103/0377-4929.97842

Cancer is fundamentally a cellular genetic disease capable of transferring the "disease" to the next generation of mutated cells. Similar proliferative and information transferring capacity exists in the stem cells of various organ systems in the human body. Understanding the bio-mechanism of stem cell metabolism and its regulation by signaling molecules and extracellular micro-environment is an important step toward successful prevention and treatment of cancer. According to the cancer stem cell hypothesis, both hereditary and sporadic cancers can arise from deregulation of these cancer stem cells (CSCs), triggered by genetic and environmental factors. It is shown that deregulation of normal self-renewal pathways in undifferentiated breast stem cells or progenitor cells had altered mammary system or progenitor cells, resulting in abnormally differentiated cells in human and rodent breast cancer cell lines. Breakthroughs in molecular pathways have important therapeutic implications. Hence, significant stress is laid on targeting signaling molecules and their micromilieu in breast cancer therapy.

Matched MeSH terms: Breast Neoplasms/pathology*; Breast Neoplasms/physiopathology*; Neoplastic Stem Cells/pathology*

Fulltext Cholangiocarcinoma: a 10-year experience of a single tertiary centre in the multi ethnicity-Malaysia

Yusoff AR, Siti ZM, Muzammil ARM, Yoong BK, Vijeyasingam R

Med J Malaysia, 2012 Feb;67(1):45-51.

PMID: 22582548 MyJurnal

Cholangiocarcinoma (CCA) is a rare biliary tract epithelial malignancy. We described the clinical features of CCA patients in our institution. A 10-year retrospective study of patients with cholangiocarcinoma in University Malaya Medical Centre was conducted. Clinical data and outcomes in relation to the three anatomical groups of CCA were collected and analysed. Of the 69 patients that were included 55% were male. Mean age was 61 years. Twelve (17%) had intrahepatic, 38 (55%) perihilar and 19 (28%) distal tumour. Mean age (p=0.043), median duration of symptoms (p=0.011), jaundice (p<0.001), total bilirubin level (p=0.003), INR (p=0.005) and mean tumour size (p=0.048) were significantly related to the site of tumour. Only 12 patients had curative resection with seven R0 resections. Cholangiocarcinoma is increasingly diagnosed in our population. Despite that, the diagnosis is still often late. Age, jaundice and tumour size may predict anatomical location of CCA.

Matched MeSH terms: Bile Duct Neoplasms/pathology; Cholangiocarcinoma/pathology

Fulltext Tay-Sach disease with "cherry-red spot"--first reported case in Malaysia

Chan LY, Balasubramaniam S, Sunder R, Jamalia R, Karunakar TV, Alagaratnam J

Med J Malaysia, 2011 Dec;66(5):497-8.

PMID: 22390110

We present a rare case of Tay-Sachs disease with retinal 'cherry-red spots' in a 19-month-old Malay child. Molecular genetic studies confirmed the diagnosis. The case highlights that 'cherry-red spot' is a useful clinical clue in Tay-Sachs disease and several other lysosomal storage disorders. It serves as an ideal illustration of the eye as a window to inborn error of metabolism.

Matched MeSH terms: Retinal Diseases/pathology*; Tay-Sachs Disease/pathology*

Fulltext Pharmacological mechanisms underlying gastroprotective activities of the fractions obtained from Polygonum minus in Sprague Dawley rats

Qader SW, Abdulla MA, Chua LS, Sirat HM, Hamdan S

Int J Mol Sci, 2012;13(2):1481-96.

PMID: 22408403 DOI: 10.3390/ijms13021481

The leaves of Polygonum minus were fractionated using an eluting solvent to evaluate the pharmacological mechanisms underlying the anti-ulcerogenic activity of P. minus. Different P. minus fractions were obtained and evaluated for their ulcer preventing capabilities using the ethanol induction method. In this study, Sprague Dawley rats weighing 150-200 g were used. Different parameters were estimated to identify the active fraction underlying the mechanism of the gastroprotective action of P. minus: the gastric mucus barrier, as well as superoxide dismutase, total hexosamine, and prostaglandin synthesis. Amongst the five fractions from the ethanolic extract of P. minus, the ethyl acetate:methanol 1:1 v/v fraction (F2) significantly (p < 0.005) exhibited better inhibition of ulcer lesions in a dose-dependent manner. In addition, rats pre-treated with F2 showed a significant elevation in superoxide dismutase (SOD), hexosamine and PGE2 levels in the stomach wall mucosa in a dose-dependent matter. Based on these results, the ethyl acetate:methanol 1:1 v/v fraction was considered to be the best fraction for mucous protection in the ethanol induction model. The mechanisms underlying this protection were attributed to the synthesis of antioxidants and PGE2.

Matched MeSH terms: Gastric Mucosa/pathology; Peptic Ulcer/pathology

Multiple symmetrical lipomatosis: case report and literature review

Sia KJ, Tang IP, Tan TY

J Laryngol Otol, 2012 Jul;126(7):756-8.

PMID: 22583757 DOI: 10.1017/S0022215112000709

To discuss the pathophysiology and various treatment methods of multiple symmetrical lipomatosis.

Matched MeSH terms: Lipomatosis, Multiple Symmetrical/pathology; Neck/pathology*

Detection of human filarial parasite Brugia malayi in dogs by histochemical staining and molecular techniques

Ambily VR, Pillai UN, Arun R, Pramod S, Jayakumar KM

Vet Parasitol, 2011 Sep 27;181(2-4):210-4.

PMID: 21620569 DOI: 10.1016/j.vetpar.2011.04.041

Human filariasis caused by Brugia malayi is still a public health problem in many countries of Asia including India, Indonesia, Malaysia and Thailand. The World Health Organization (WHO) has targeted to eliminate filariasis by the year 2020 by Mass annual single dose Diethylcarbamazine Administration (MDA). Results of the MDA programme after the first phase was less satisfactory than expected. Malayan filariasis caused by B. malayi is endemic in the south of Thailand where domestic cat serves as the major reservoir host. There is no report about the occurrence of B. malayi in dogs. The present work was carried out to find out the incidence of microfilariasis in dogs and also to detect the presence of human filarial infection in dogs, if any. One hundred dogs above 6 months of age presented to the veterinary college Hospital, Mannuthy, Kerala, with clinical signs suggestive of microfilariasis - fever, anorexia, conjunctivitis, limb and scrotal oedema - were screened for microfilariae by wet film examination. Positive cases were subjected to Giemsa staining, histochemical staining and molecular techniques. Results of the study showed that 80% of dogs had microfilariasis; out of which 20% had sheathed microfilaria. Giemsa and histochemical staining character, PCR and sequencing confirmed it as B. malayi. High prevalence of B. malayi in dogs in this study emphasized the possible role of dogs in transmission of human filariasis.

Matched MeSH terms: Dog Diseases/pathology; Filariasis/pathology

Molecular diagnosis using multi drug delivery network and stability

Jalil MA, Innate K, Suwanpayak N, Yupapin PP, Ali J

Artif Cells Blood Substit Immobil Biotechnol, 2011 Dec;39(6):357-65.

PMID: 21999106 DOI: 10.3109/10731199.2011.618134

By using a pair of tweezers to generate the intense optical vortices within the PANDA ring resonator, the required molecules (drug volumes) can be trapped and moved dynamically within the molecular bus networks, in which the required diagnosis or drug delivery targets can be performed within the network. The advantage of the proposed system is that the proposed diagnostic method can perform within the tiny system (thin film device or circuit), which can be available for a human embedded device for diagnostic use. The channel spacing of the trapped volumes (molecules) within the bus molecular networks can be provided.

Matched MeSH terms: Pathology, Molecular/instrumentation; Pathology, Molecular/methods*

Fulltext Harmonic scalpel for a bloodless partial glossectomy: a case report

Irfan M, Aliyu YA, Baharudin A, Shahid H

Med J Malaysia, 2011 Jun;66(2):148-9.

PMID: 22106699

Tongue surgery is almost always complicated by intraoperative bleeding. Its rich blood supply especially from the lingual vessels makes the operative field bloody. Electrocautery has been widely used to replace cold scissors in order to achieve better hemostasis. The use of ultrasonic harmonic scalpel for glossectomy is still new in this country. We report a case of partial glossectomy using the harmonic scalpel in a patient who had a squamous cell carcinoma of the lateral border of the tongue.

Matched MeSH terms: Carcinoma, Squamous Cell/pathology; Tongue Neoplasms/pathology

Fulltext Arteriovenous malformation of the stomach: a rare cause of upper gastrointestinal bleeding

Latar NH, Phang KS, Yaakub JA, Muhammad R

Med J Malaysia, 2011 Jun;66(2):142-3.

PMID: 22106696 MyJurnal

Haemorrhage arising from gastric arteriovenous malformation (AVM) is rare and normally occurs in the elderly. Bleeding gastric AVM presenting in the younger age group is even rarer. We report a case of a 14 year old boy who presented with recurrent episodes of haematemesis. He subsequently underwent a proximal gastrectomy and the histological examination confirmed a gastric AVM. After reviewing the literature we believe this is the youngest ever reported case of bleeding gastric AVM reported in English literature.

Matched MeSH terms: Gastrointestinal Hemorrhage/pathology; Stomach/pathology*

Fulltext Endoscopic treatment of glottic stenosis secondary to caustic injury with silastic keel placement: a case report

Balachandran R, Rahmat O

Med J Malaysia, 2011 Jun;66(2):152-3.

PMID: 22106701

The use of an endoscopic approach for the division of glottic webs or stenosis has been reported in the literature and has been mainly confined to the anterior commisure. We report a rare case of caustic injury to the upper aerodigestive tract that resulted in extensive web formation along the membranous vocal cord which was successfully treated with endoscopic lysis of the adhesions and the use of a silastic sheet keel as a stent.

Matched MeSH terms: Burns, Inhalation/pathology; Laryngostenosis/pathology

Neuroendocrine tumor in choledochal cyst--case report and review of literature

Dahiya D, Raman K, Singh H

Pol Przegl Chir, 2011 Nov;83(11):627-9.

PMID: 22246096 DOI: 10.2478/v10035-011-0099-0

The report presents a rare case of carcinoid tumor in a 17 year female who presented with epigastric pain of one week duration. She was diagnosed to have type I choledochal cyst on abdominal ultrasound and MRI. She underwent total excision of choledochal cyst with roux-en-Y hepaticojejunostomy. Histopathological examination revealed a neuroendocrine tumor within choledochal cyst which was immunoreactive for Chromogranin A. Patient is well at 6 months of follow up. These tumors are characteristically slow-growing, therefore awareness of its presence preoperatively can facilitate optimal management by performing surgical resection with negative margins which offers the best chance of long-term survival.

Matched MeSH terms: Choledochal Cyst/pathology; Neuroendocrine Tumors/pathology

Fulltext Disseminated cutaneous sporotrichosis in an immunocompetent individual

Yap FB

Int J Infect Dis, 2011 Oct;15(10):e727-9.

PMID: 21719337 DOI: 10.1016/j.ijid.2011.05.005

Sporotrichosis is a subacute or chronic fungal infection caused by the ubiquitous fungus Sporothrix schenckii. Disseminated cutaneous sporotrichosis is an uncommon entity and is usually present in the immunosuppressed. Here, a case of disseminated cutaneous sporotrichosis in an immunocompetent patient is reported. This 70-year-old healthy woman presented with multiple painful ulcerated nodules on her face and upper and lower extremities of 6-month duration, associated with low-grade fever, night sweats, loss of appetite, and loss of weight. Histopathological examination of the skin biopsy revealed epidermal hyperplasia and granulomatous inflammation in the dermis, with budding yeast. Fungal culture identified S. schenckii. She had total resolution of the lesions after 2 weeks of intravenous amphotericin B and 8 months of oral itraconazole. All investigations for underlying immunosuppression and internal organ involvement were negative. This case reiterates that disseminated cutaneous sporotrichosis, although common in the immunosuppressed, can also be seen in immunocompetent patients.

Matched MeSH terms: Skin/pathology; Sporotrichosis/pathology

Displaying publications 1621 - 1640 of 5120 in total