MyMedR

Ossified lumbar pseudomeningocele: imaging findings

Al-Edrus SA, Mohamed Mukari SA, Ganesan D, Ramli N

Spine J, 2011 Aug;11(8):796-7.

PMID: 21724472 DOI: 10.1016/j.spinee.2011.05.013

Matched MeSH terms: Meningocele/pathology*; Ossification, Heterotopic/pathology*

Fulltext Selective cytotoxicity of goniothalamin against hepatoblastoma HepG2 cells

Al-Qubaisi M, Rozita R, Yeap SK, Omar AR, Ali AM, Alitheen NB

Molecules, 2011 Apr 06;16(4):2944-59.

PMID: 21471934 DOI: 10.3390/molecules16042944

Liver cancer has become one of the major types of cancer with high mortality and liver cancer is not responsive to the current cytotoxic agents used in chemotherapy. The purpose of this study was to examine the in vitro cytotoxicity of goniothalamin on human hepatoblastoma HepG2 cells and normal liver Chang cells. The cytotoxicity of goniothalamin against HepG2 and liver Chang cell was tested using MTT cell viability assay, LDH leakage assay, cell cycle flow cytometry PI analysis, BrdU proliferation ELISA assay and trypan blue dye exclusion assay. Goniothalamin selectively inhibited HepG2 cells [IC₅₀ = 4.6 (±0.23) µM in the MTT assay; IC₅₀ = 5.20 (±0.01) µM for LDH assay at 72 hours], with less sensitivity in Chang cells [IC₅₀ = 35.0 (±0.09) µM for MTT assay; IC₅₀ = 32.5 (±0.04) µM for LDH assay at 72 hours]. In the trypan blue dye exclusion assay, the Viability Indexes were 52 ± 1.73% for HepG2 cells and 62 ± 4.36% for Chang cells at IC₅₀ after 72 hours. Cytotoxicity of goniothalamin was related to inhibition of DNA synthesis, as revealed by the reduction of BrdU incorporation. At 72 hours, the lowest concentration of goniothalamin (2.3 µL) retained 97.6% of normal liver Chang cells proliferation while it reduced HepG2 cell proliferation to 19.8% as compared to control. Besides, goniothalamin caused accumulation of hypodiploid apoptosis and different degree of G2/M arrested as shown in cell cycle analysis by flow cytometry. Goniothalamin selectively killed liver cancer cell through suppression of proliferation and induction of apoptosis. These results suggest that goniothalamin shows potential cytotoxicity against hepatoblastoma HepG2 cells.

Matched MeSH terms: Liver Neoplasms/pathology*; Hepatoblastoma/pathology*

Fulltext Pattern and clinical characteristics of patients with nail psoriasis in Sarawak General Hospital, Malaysia

Yap FB, Pubalan M

Indian J Dermatol Venereol Leprol, 2010 Nov-Dec;76(6):703-4.

PMID: 21079320 DOI: 10.4103/0378-6323.72447

Study site: Skin Clinic, Sarawak General Hospital, Malaysia

Matched MeSH terms: Nail Diseases/pathology*; Psoriasis/pathology*

Oral cancer survival among Malay patients in Hospital Universiti Sains Malaysia, Kelantan

Razak AA, Saddki N, Naing NN, Abdullah N

Asian Pac J Cancer Prev, 2010;11(1):187-91.

PMID: 20593955

AIMS: This study was performed to determine oral cancer survival among Malay patients in Hospital Universiti Sains Malaysia (HUSM), Kelantan.

METHODS: The medical records of 118 Malay patients with oral cancer admitted in HUSM from 1st January 1986 to 31st December 2005 were reviewed. Data collected include socio-demographic background, high-risk habits practiced, clinical and histological characteristics, and treatment profile of the patients. Survival status and duration were determined by active validation until 31st December 2006. Data entry and analysis were accomplished using SPSS version 12.0. The Kaplan-Meier method was used to perform survival estimates while the log-rank test and the Cox proportional hazards regression model were employed to perform univariate analysis and multivariable analysis of the variables, respectively.

RESULTS: The overall five-year survival rate of Malay patients with oral cancer was 18.0%, with a median survival time of 9 months. Significant factors that influenced survival of the patients were age, sex, tumour site, TNM stage, histological type, and treatment received.

CONCLUSION: Survival of oral cancer patients in HUSM was very low. Being elderly, male, presenting with an advanced stage at diagnosis, and not having treatment all contributed to poor survival.

Matched MeSH terms: Carcinoma, Squamous Cell/pathology; Mouth Neoplasms/pathology

Wavelet energy-guided level set-based active contour: a segmentation method to segment highly similar regions

Achuthan A, Rajeswari M, Ramachandram D, Aziz ME, Shuaib IL

Comput Biol Med, 2010 Jul;40(7):608-20.

PMID: 20541182 DOI: 10.1016/j.compbiomed.2010.04.005

This paper introduces an approach to perform segmentation of regions in computed tomography (CT) images that exhibit intra-region intensity variations and at the same time have similar intensity distributions with surrounding/adjacent regions. In this work, we adapt a feature computed from wavelet transform called wavelet energy to represent the region information. The wavelet energy is embedded into a level set model to formulate the segmentation model called wavelet energy-guided level set-based active contour (WELSAC). The WELSAC model is evaluated using several synthetic and CT images focusing on tumour cases, which contain regions demonstrating the characteristics of intra-region intensity variations and having high similarity in intensity distributions with the adjacent regions. The obtained results show that the proposed WELSAC model is able to segment regions of interest in close correspondence with the manual delineation provided by the medical experts and to provide a solution for tumour detection.

Matched MeSH terms: Urinary Bladder Neoplasms/pathology; Thyroid Neoplasms/pathology

Ageing modifies the fibre angle and biomechanical function of the lumbar extensor muscles

Singh DK, Bailey M, Lee RY

Clin Biomech (Bristol, Avon), 2011 Jul;26(6):543-7.

PMID: 21392870 DOI: 10.1016/j.clinbiomech.2011.02.002

Ageing is associated with geometrical changes in muscle fascicles that may lead to deteriorations in physical functions. The purpose of this study was to study the effects of ageing on fibre orientation and strength of the lumbar extensor muscles.

Matched MeSH terms: Lumbar Vertebrae/pathology*; Muscle, Skeletal/pathology*

Fulltext Optic nerve involvement as a first manifestation of acute lymphoblastic leukaemia after remission

Peyman M, Hieng TL, Subrayan V

BMJ Case Rep, 2011;2011.

PMID: 22698906 DOI: 10.1136/bcr.11.2010.3517

Matched MeSH terms: Optic Nerve Diseases/pathology; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology

Fulltext A retrospective clinicopathological study of 59 osteogenic sarcoma of jaw bone archived in a stomatology unit

Ajura AJ, Lau SH

Malays J Pathol, 2010 Jun;32(1):27-34.

PMID: 20614723 MyJurnal

To determine the clinicopathological features of osteogenic sarcomas of the mandible and maxilla.

Matched MeSH terms: Jaw Neoplasms/pathology*; Osteosarcoma/pathology*

Analysis of foveal avascular zone in colour fundus images for grading of diabetic retinopathy severity

Ahmad Fadzil M, Ngah NF, George TM, Izhar LI, Nugroho H, Adi Nugroho H

Annu Int Conf IEEE Eng Med Biol Soc, 2010;2010:5632-5.

PMID: 21097305 DOI: 10.1109/IEMBS.2010.5628041

Diabetic retinopathy (DR) is a sight threatening complication due to diabetes mellitus that affects the retina. At present, the classification of DR is based on the International Clinical Diabetic Retinopathy Disease Severity. In this paper, FAZ enlargement with DR progression is investigated to enable a new and an effective grading protocol DR severity in an observational clinical study. The performance of a computerised DR monitoring and grading system that digitally analyses colour fundus image to measure the enlargement of FAZ and grade DR is evaluated. The range of FAZ area is optimised to accurately determine DR severity stage and progression stages using a Gaussian Bayes classifier. The system achieves high accuracies of above 96%, sensitivities higher than 88% and specificities higher than 96%, in grading of DR severity. In particular, high sensitivity (100%), specificity (>98%) and accuracy (99%) values are obtained for No DR (normal) and Severe NPDR/PDR stages. The system performance indicates that the DR system is suitable for early detection of DR and for effective treatment of severe cases.

Matched MeSH terms: Capillaries/pathology; Diabetic Retinopathy/pathology*

Cardiac metastasis: a rare involvement of primitive neuroectodermal tumour of the lung

Ngow HA, Wan Khairina WM

Pathol Oncol Res, 2011 Sep;17(3):771-4.

PMID: 21213128 DOI: 10.1007/s12253-010-9328-9

A 15 year-old adolescent was referred with 2 month history of worsening of breathlessness and haemoptysis. He also reported constitutional symptoms of fever, poor appetite and weight loss. The chest roentgenogram showed a massive right pleural effusion with apparent cardiomegaly. The cardiac silhouette over the right heart border was obliterated and the mediastinum was widened. Computed tomogram of the thorax showed a bulky heterogeneous mass in the right lung with extension to the heart. Subsequent CT guided lung biopsy revealed Primitive Neuroectodermal tumour (PNET). Here, we illustrate the clinical course of an aggressive pulmonary PNET with lethal cardiac metastasis.

Matched MeSH terms: Lung Neoplasms/pathology*; Neuroectodermal Tumors, Primitive/pathology*

Fulltext Which is the best method of sterilization of tumour bone for reimplantation? A biomechanical and histopathological study

Singh VA, Nagalingam J, Saad M, Pailoor J

Biomed Eng Online, 2010;9:48.

PMID: 20831801 DOI: 10.1186/1475-925X-9-48

Sterilization and re-usage of tumour bone for reconstruction after tumour resection is now gaining popularity in the East. This recycle tumour bone needs to be sterilized in order to eradicate the tumour cells before re-implantation for limb salvage procedures. The effect of some of these treatments on the integrity and sterility of the bone after treatment has been published but there has yet been a direct comparison between the various methods of sterilization to determine the one method that gives the best tumour kill without compromising the bone's structural integrity.

Matched MeSH terms: Bone and Bones/pathology*; Bone Neoplasms/pathology

Determination of foveal avascular zone in diabetic retinopathy digital fundus images

Ahmad Fadzil MH, Izhar LI, Nugroho HA

Comput Biol Med, 2010 Jul;40(7):657-64.

PMID: 20573343 DOI: 10.1016/j.compbiomed.2010.05.004

Monitoring FAZ area enlargement enables physicians to monitor progression of the DR. At present, it is difficult to discern the FAZ area and to measure its enlargement in an objective manner using digital fundus images. A semi-automated approach for determination of FAZ using color images has been developed. Here, a binary map of retinal blood vessels is computer generated from the digital fundus image to determine vessel ends and pathologies surrounding FAZ for area analysis. The proposed method is found to achieve accuracies from 66.67% to 98.69% compared to accuracies of 18.13-95.07% obtained by manual segmentation of FAZ regions from digital fundus images.

Matched MeSH terms: Diabetic Retinopathy/pathology; Fovea Centralis/pathology*

Fulltext Solitary fibrous tumour of the pleura presenting with refractory non-insulin mediated hypoglycaemia (the Doege-Potter syndrome)

Lee CE, Zanariah H, Masni M, Pau KK

Med J Malaysia, 2010 Mar;65(1):72-4.

PMID: 21265256 MyJurnal

We report a case of a 61 year-old man who presented with refractory non-insulin mediated hypoglycaemia. A chest radiograph showed a right lung opacity, which was confirmed as a large intra-thoracic mass by computed tomography (CT) of the thorax. CT-guided biopsy with histological examination revealed features of a solitary fibrous tumour of low malignant potential. We discuss the association of solitary fibrous tumour of the pleura (SFTP) with hypoglycaemia, and the management of such rare tumours.

Matched MeSH terms: Pleural Neoplasms/pathology; Solitary Fibrous Tumors/pathology

Predicted cervical canal enlargement and effective cord decompression following expansive laminoplasty using cervical magnetic resonance imaging

Yusof MI, Hassan E, Abdullah S

Surg Radiol Anat, 2011 Mar;33(2):109-15.

PMID: 20658232 DOI: 10.1007/s00276-010-0704-7

Posterior translation of the spinal cord occurs passively following laminoplasty with the presence lordotic spine and availability of a space for the spinal cord to shift. This study is to predict the distance of posterior spinal cord migration after expansive laminoplasty at different cervical levels based on measurement of posterior translation of the spinal cord in normal cervical morphometry.

Matched MeSH terms: Cervical Vertebrae/pathology*; Spinal Cord/pathology*

Fulltext Association of Ki67 with raised transaminases in hepatocellular carcinoma

Cheah PL, Looi LM, Nazarina AR, Mun KS, Goh KL

Malays J Pathol, 2008 Dec;30(2):103-7.

PMID: 19291919 MyJurnal

Transaminase enzymes, alanine (ALT) and aspartate transaminase (AST), have been reported to be raised and implicated to have prognostic value in hepatocellular carcinoma (HCC). Ki67, a marker of cellular proliferative activity, has also been noted to be increased in HCC. A study was conducted at the Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur to determine the possible association of proliferative activity, as determined by Ki67, with the transaminase enzymes. 31 cases of histologically diagnosed HCC who underwent tumour resection were retrieved from departmental archives. The patients' ages ranged between 40 to 79 years with a mean of 58.3 years. There was a male preponderance with M:F = 2.9:1. Ethnic Chinese formed 83.9% of the cases. 4 microm sections, cut from the formalin-fixed, paraffin-embedded tumour tissue block of each case, were immunohistochemically stained with Ki67 (DAKO monoclonal MIB-1) using the commercial DakoCytomation EnVision+System-HRP kit. The latest ALT and AST levels, assayed within 7 days prior to tumour resection, were retrieved from the patients' case records. 24 (77.4%) HCC demonstrated elevation of either ALT and/or AST. 27 (87.1%) HCC were immunopositive for Ki67. Ki67 immunoexpression was significantly correlated with raised transaminases (p<0.05). Hypothetically, the mechanism by which this phenomenon may occur may simply be release of transaminases due to destruction of hepatocytes by the cancer. Thus rising levels of the transaminases could signal a more rapid growth of the tumour and these routinely performed tests can be of prognostic value in management of HCC patients.

Matched MeSH terms: Carcinoma, Hepatocellular/pathology; Liver Neoplasms/pathology

Fulltext Disseminated histoplasmosis presenting with chronic ulcerative tongue lesions in a patient with diabetes

Hasmoni MH, Shah AS, Ayoub S, Hin LS, Abd Rashid MA

BMJ Case Rep, 2010;2010.

PMID: 22791841 DOI: 10.1136/bcr.06.2010.3120

Matched MeSH terms: Tongue Diseases/pathology; Ulcer/pathology

Percutaneous, non-operative radio frequency ablation for haemostasis of ruptured hepatocellular carcinoma

Manikam J, Mahadeva S, Goh KL, Abdullah BJ

Hepatogastroenterology, 2009 Jan-Feb;56(89):227-30.

PMID: 19453063

Spontaneous rupture and hemorrhage is a devastating complication of hepatocellular carcinoma (HCC). Results from current therapeutic modalities remain varied. Recent development of percutaneous radiofrequency ablation (RFA) in the management of this condition has shown promise. We describe 2 cases of ruptured HCC in which nonoperative, percutaneous radio frequency ablation (RFA) was successful in achieving hemostasis. The advantageous of RFA over other interventional techniques in the management of ruptured HCC are discussed.

Matched MeSH terms: Carcinoma, Hepatocellular/pathology; Liver Neoplasms/pathology

Comparison of B-scan sonographic measurements of optic cup with fundus photographic measurements

Ali NA, Subrayan V, Reddy SC, Othman F

J Clin Ultrasound, 2009 Jun;37(5):285-9.

PMID: 19280658 DOI: 10.1002/jcu.20570

To compare the measurements of the optic cup diameter with B-scan sonography with fundus photography in patients with clear ocular media and to propose a solution for the clinical problem of determining the cup-disc ratio in eyes with opaque ocular media.

Matched MeSH terms: Glaucoma/pathology; Optic Disk/pathology

Renal ischemic injury affects renal hemodynamics and excretory functions in Sprague Dawley rats: involvement of renal sympathetic tone

Salman IM, Sattar MA, Abdullah NA, Ameer OZ, Yam MF, Kaur G, et al.

Ren Fail, 2010 Jan;32(1):96-102.

PMID: 20113274 DOI: 10.3109/08860220903389196

The role of renal sympathetic nerves in the pathogenesis of ischemic acute renal failure (ARF) and the immediate changes in the renal excretory functions following renal ischemia were investigated. Two groups of male Sprague Dawley (SD) rats were anesthetized (pentobarbitone sodium, 60 mg kg(-1) i.p.) and subjected to unilateral renal ischemia by clamping the left renal artery for 30 min followed by reperfusion. In group 1, the renal nerves were electrically stimulated and the responses in the renal blood flow (RBF) and renal vascular resistance (RVR) were recorded, while group 2 was used to study the early changes in the renal functions following renal ischemia. In post-ischemic animals, basal RBF and the renal vasoconstrictor reperfusion to renal nerve stimulation (RNS) were significantly lower (all p < 0.05 vs. control). Mean arterial pressure (MAP), basal RVR, urine flow rate (UFR), absolute and fractional excretions of sodium (U(Na)V and FE(Na)), and potassium (U(K)V and FE(K)) were higher in ARF rats (all p < 0.05 vs. control). Post-ischemic animals showed markedly lower glomerular filtration rate (GFR) (p < 0.05 vs. control). No appreciable differences were observed in urinary sodium to potassium ratio (U(Na)/U(K)) during the early reperfusion phase of renal ischemia (p > 0.05 vs. control). The data suggest an immediate involvement of renal sympathetic nerve action in the pathogenesis of ischemic ARF primarily through altered renal hemodynamics. Diuresis, natriuresis, and kaliuresis due to impaired renal tubular functions are typical responses to renal ischemia and of comparable magnitudes.

Matched MeSH terms: Kidney/pathology; Kidney/physiopathology; Sympathetic Nervous System/physiopathology*; Reperfusion Injury/pathology; Reperfusion Injury/physiopathology*

Cutaneous larva migrans: a neglected disease and possible association with the use of long socks

Hamat RA, Rahman AA, Osman M, Unyah NZ, Abdullah WO, Isa NH

Trans R Soc Trop Med Hyg, 2010 Feb;104(2):170-2.

PMID: 19732927 DOI: 10.1016/j.trstmh.2009.07.019

Cutaneous larva migrans is a common parasitic skin disease that can be easily prevented by wearing 'protective' footwear. However, this has been under-emphasized in terms of what constitutes the protective footwear. Even though the disease resolves spontaneously, the significant duration of the disease along with severity of pruritus make treatment unavoidable. Here, we present a very long-standing creeping eruption, which puzzled many attending clinicians handling the case, and the possibility of long socks as a causal effect on the development of cutaneous larva migrans infection.

Matched MeSH terms: Foot Dermatoses/pathology; Larva Migrans/pathology

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