Displaying all 17 publications

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  1. Choon SE, Mathew M, Othman BS
    Med J Malaysia, 2000 Jun;55(2):174-9.
    PMID: 19839145
    The demographic characteristics, risk behaviourand prevalence of other sexually transmitted diseases (STDs) were determined in 132 HIV-infected individuals seen in a Dermatology cum Genitourinary Clinic, Hospital Sultanah Aminah Johor Bahru. Sixty-one (46.2%) were Malays, 37.9% Chinese, 10.6% Indians and 5.3% were of other ethnic groups. The male to female ratio was 4.5:1. Most of the patients (82.5%) were between 20 to 40 years-old. Seventy (53.0%) were single, 34.1% were married and 7.5% were divorcees. The majority of them (97.7%) were heterosexual. Fifty seven (53.3%) of our male patients patronised commercial workers. Eighty-one (61.8%) were not intravenous drug users (IVDU). Of the 50 IVDUs, 24 had multiple sexual exposures. Fifty-three (48.2%) of the 109 patients screened for STDs had one or more other STDs. Thirty-four patients (31.9%) reported one STD in the past and 3.6% reported two STDs in the past. Fifty-six patients (42.4%) had developed AIDS. Thirteen had passed away. The main mode of transmission of HIV infection in this population is through heterosexual intercourse and the prevalence of STDs is high. These findings indicate a need to advocate responsible sexual behaviour and to detect as well as treat STDs early to prevent the sexual transmission of HIV.

    Study site: Dermatology cum Genitourinary Clinic, Hospital Sultanah Aminah Johor Bahru
  2. Jacob M, Rajathi P, Mathew M, Fenn SM
    Indian J Pathol Microbiol, 2023;66(2):388-391.
    PMID: 37077093 DOI: 10.4103/ijpm.ijpm_714_21
    Papilliferous keratoameloblastoma is an extremely rare variant of ameloblastoma, a benign odontogenic tumor, with only seven cases reported in the English language literature. This variant presents with the metaplastic transformation of stellate reticulum-like cells to the extent of forming papillary structures exhibiting superficial keratinization of varying thickness. This paper describes the pathognomonic macroscopic features of this tumor observed during gross examination under the stereo zoom microscope that differentiate it from the other odontogenic tumors which have not been explored in the previously documented cases. Also, in this paper, a detailed comparison of the macroscopic features observed under the stereo zoom microscope during gross examination with the microscopic features of the histologic section has been described proving to be useful in the histological differential diagnosis of the keratinizing variants of ameloblastoma.
  3. Thomas AR, Mathew M, Nettemu SK, Mayya A
    Cureus, 2023 Nov;15(11):e49717.
    PMID: 38161818 DOI: 10.7759/cureus.49717
    The pulp and the periodontium are inherently interconnected, both anatomically and functionally. Conditions affecting the periodontium and the pulp can create challenges in diagnosis, treatment strategizing, and predicting outcomes. This case report outlines the combination of resection and regeneration techniques utilizing mineral trioxide aggregate (MTA) and bone grafting to address a persistent periapical lesion in a maxillary premolar. The treatment led to the effective alleviation of the patient's symptoms and successful regeneration.
  4. Mathew M, Nayak V, Nettemu SK, Ong TYD
    BMJ Case Rep, 2024 Jun 25;17(6).
    PMID: 38925668 DOI: 10.1136/bcr-2024-260402
  5. Selvamani M, Bindiya PK, Bhojaraju N, Bastian TS, Suhana HS, Mathew M
    J Oral Maxillofac Pathol, 2019 9 14;23(2):295-299.
    PMID: 31516240 DOI: 10.4103/jomfp.JOMFP_277_18
    Aim: The aim of this study was to analyze and identify differences in the palatal rugae patterns and genderwise distributions in three different populations (Kerala, Mahe and Puducherry).

    Materials and Methods: Ninety maxillary study models (30 from each group including males and females) were examined in the age group ranging from 18 to 25 years. The palatal rugae pattern was analyzed for shape.

    Results: After analyzing the rugae patterns among the groups, the most common pattern was the wavy pattern (53.57%) followed by curved (18.22%) and straight (13.66%). The least was circular (1.3%). When compared between sex, the most common pattern was found to be wavy (male - 54.3% and female - 53.09%), while the curved pattern was more common among the females (21.09%) than males (13.97%). The straight pattern was more common among the males (18.8%) than females (10.18%). The least common pattern was found to be the circular in both sexes which accounted for around 1%.

    Conclusion: This study shows no two palates are identical in terms of their rugae pattern. Palatal rugae possess unique characteristics as they are absolutely individualistic. Study also confirms that the "wavy" type of palatal rugae pattern was the most predominant among these three populations.

  6. Mathew M, Makhankova A, Menier D, Sautter B, Betzler C, Pierson B
    Sci Rep, 2020 04 28;10(1):7141.
    PMID: 32346046 DOI: 10.1038/s41598-020-64119-9
    During the Miocene, extensive carbonate deposition thrived over wide latitudinal ranges in Southeast Asia despite perturbations of the global climate and thermohaline circulation that affected the Asian continent. Nevertheless, the mechanisms of its emergence, adaptability in siliciclastic-dominated margins and demise, especially in southern South China Sea (SCS), are largely speculative and remains enigmatic along with a scarcity of constraints on paleoclimatic and palaeoceanographic conditions. Here we show, through newly acquired high-resolution geophysical data and accurate stratigraphic records based on strontium isotopic dating, the evolution of these platforms from ~15.5-9.5 Ma is initially tied to tectonics and eustasy, and ultimately, after ~9.5 Ma, to changes in the global climate patterns and consequent palaeoceanographic conditions. Our results demonstrate at least two paleodeltas that provided favourable substratum of elevated sand bars, which conditioning the emergence of the buildups that inadvertently mirrored the underlying strata. We show unprecedented evidences for ocean current fluctuations linked to the intensification of the Asian summer monsoon winds resulting in the formation of drifts and moats, which extirpated the platforms through sediment removal and starvation. This work highlights the imperative role of palaeoceanography in creating favourable niches for reefal development that can be applicable to carbonate platforms elsewhere.
  7. Menier D, Mathew M, Pubellier M, Sapin F, Delcaillau B, Siddiqui N, et al.
    Sci Rep, 2017 03 28;7(1):457.
    PMID: 28352115 DOI: 10.1038/s41598-017-00620-y
    Empirical models have simulated the consequences of uplift and orographic-precipitation on the evolution of orogens whereas the effects of these forcings on ridgelines and consequent topography of natural landscapes remain equivocal. Here we demonstrate the feedback of a terrestrial landscape in NW Borneo subject to uplift and precipitation gradient owing to orographic effect, and leading to less-predictable flooding and irreversible damages to life and property. Disequilibrium in a large catchment recording the lowest rainfall rates in Borneo, and adjacent drainage basins as determined through χ, a proxy for steady-state channel elevation, is shown to result in dynamic migration of water divide from the windward-side of the orogen towards the leeward-side to attain equilibrium. Loss of drainage area in the leeward-side reduces erosion rates with progressive shortening resulting in an unstable landscape with tectonic uplift, gravity faults and debris flows.14C dating of exhumed cut-and-fill terraces reveal a Mid-Pleistocene age, suggesting tectonic events in the trend of exhumation rates (>7 mm a-1) estimated by thermochronology, and confirmed by morphotectonic and sedimentological analyses. Our study suggests that divide migration leads to lowered erosion rates, channel narrowing, and sediment accretion in intermontane basins on the leeward-side ultimately resulting in enhanced flooding.
  8. Bankur PK, Mathew M, Almalki SA, Jalaluddin M, Jayanti I, Durgaraju M
    J Contemp Dent Pract, 2019 Sep 01;20(9):1041-1044.
    PMID: 31797826
    AIM: The aim of the present study was to evaluate the antibacterial efficacy of various concentrations of Eucalyptus globulus leaf extract on periodontal pathogens.

    MATERIALS AND METHODS: Matured, healthy and disease-free leaves of Eucalyptus globulus were collected. The leaves were washed under tap water and finally dried in an oven at a temperature of 45°C for 48 hours. The dried plants were ground in an electric blender to make them into a powder. The powder was mixed with 100% ethanol and kept it inside a shaker overnight at 35°C. The mixture was centrifuged for 10 minutes at 2,500 rpm. Three different concentrations (10%, 50%, and 100% v/v) were used as antibacterial agents. Chlorhexidine (0.2%) was considered as positive control and dimethyl formamide was considered as negative control against P. gingivalis and A. actinomycetemcomitans. The disc diffusion method was used to determine the extract's antibacterial activity against the test organisms. A digital Vernier caliper was used to measure the diameter of antibacterial activity showing the zone of inhibition in millimeters.

    RESULTS: Eucalyptus globulus with 100% concentration showed a maximum zone of inhibition against A. actinomycetemcomitans and P. gingivalis (5.38 ± 0.32 mm, 4.82 ± 0.11 mm) followed by 50% and 10% accordingly. The negative control of dimethyl formamide showed a zone of inhibition of 0.48 ± 0.96 mm and 0.63 ± 0.20 mm against A. actinomycetemcomitans and P. gingivalis. The positive control of 0.2% chlorhexidine showed a zone of inhibition of 8.46 ± 1.02 mm and 7.18 ± 0.54 mm against A. actinomycetemcomitans and P. gingivalis. The ANOVA test showed a highly significant antibacterial efficacy in 0.2% chlorhexidine and 100% concentration Eucalyptus globulus.

    CONCLUSION: A significant maximum zone of inhibition against A. actinomycetemcomitans and P. gingivalis was showed by 100% concentration of Eucalyptus globulus.

    CLINICAL SIGNIFICANCE: Other than the systemic diseases treatment, Eucalyptus globulus also serves as an effective promising alternative to antibiotics in the prevention of oral infections because of the natural phytochemicals existing in them.

  9. Mathew M, Makhankova A, Menier D, Sautter B, Betzler C, Pierson B
    Sci Rep, 2020 Jun 04;10(1):9348.
    PMID: 32493945 DOI: 10.1038/s41598-020-66550-4
    An amendment to this paper has been published and can be accessed via a link at the top of the paper.
  10. Ghoshal A, O'Carroll RE, Ferguson E, Shepherd L, Doherty S, Mathew M, et al.
    J Health Psychol, 2021 Dec 29.
    PMID: 34963351 DOI: 10.1177/13591053211064985
    Although medical mistrust (MM) may be an impediment to public health interventions, no MM scale has been validated across countries and the assessment of MM has not been explored using item response theory, which allows generalisation beyond the sampled data. We aimed to determine the dimensionality of a brief MM measure across four countries through Mokken analysis and Graded Response Modelling. Analysis of 1468 participants from UK (n = 1179), Ireland (n = 191), India (n = 49) and Malaysia (n = 49) demonstrated that MM items formed a hierarchical, unidimensional measure, which is very informative about high levels of MM. Possible item reduction and scoring changes were also demonstrated. This study demonstrates that this brief MM measure is suitable for international studies as it is unidimensional across countries, cross cultural, and shows that minor adjustments will not impact on the assessment of MM when using these items.
  11. Hosadurga R, Kyaw Soe HH, Peck Lim AT, Adl A, Mathew M
    J Family Med Prim Care, 2020 Feb;9(2):925-932.
    PMID: 32318447 DOI: 10.4103/jfmpc.jfmpc_811_19
    CONTEXT: Cardiovascular diseases (CVD) are one of the leading causes of premature deaths among noncommunicable disease. Hypertension increases the risk of cardiovascular events. In addition to well-known risk factors for hypertension like obesity, lack of physical activity, studies have shown independent association between tooth loss and increased blood pressure and stroke. However, the relevant literature is not conclusive.

    AIMS: Aim of our study was to investigate the association between tooth loss and increased blood pressure among adult patients.

    METHODS AND MATERIAL: A cross-sectional study among 270 adults aged 20-59 years was conducted. The dependent variables were systolic blood pressure (SBP) and diastolic blood pressure (DBP). The main exploratory variable was the number of self-reported natural teeth for each dental arch. They were recorded as 10 or more natural teeth, less than 10 natural teeth, and no natural teeth. Data were analyzed using descriptive statistics, independent t-test, ANOVA, and multiple linear regression analysis.

    RESULTS: Mean SBP was 125.3 mmHg and DBP was 78.9 mmHg. Moreover, 29.3% of participants had hypertension, 8.9% were edentulous, 22.8% had lost more than 10 teeth, and 68.3% had lost less than 10 teeth. Increased SBP was seen with increased tooth loss among participants. After adjusting for all covariates, no significant association between tooth loss and SBP and DBP was seen.

    CONCLUSIONS: The mean SBP was higher among the participants who were edentulous than partially edentulous. However, there was no significant association between tooth loss and SBP and DBP after adjusting for confounding factors.

  12. Singh VP, Nettem S, Kyaw Soe HH, Babji NAB, Sahari AIB, Yusof LSBM, et al.
    Work, 2022;73(3):969-976.
    PMID: 35988242 DOI: 10.3233/WOR-210519
    BACKGROUND: Dental professionals have been reported to be constantly exposed to work-related musculoskeletal disorders with symptoms often started as early as the student phase. Risk perception may play an important role in modifying risk at work.

    OBJECTIVE: To assess the influence of gender, academic level, and the presence of painful symptoms on the perception of risk factors at work contributing to musculoskeletal symptoms among dental students of Melaka, Malaysia.

    METHODS: A cross-sectional survey of 183 clinical year dental students based on a convenience sample. The data were collected using the Nordic Musculoskeletal Questionnaire and Job Factor Questionnaire for assessment of musculoskeletal symptoms and risk factors at work respectively. Study data were evaluated using percentage, median, Cochran's Q test, Bonferroni correction, multiple linear regression analysis and Mann-Whitney U Test. The analysis was interpreted considering a 95 % confidence interval and significant level at P 

  13. Nayak V, Kumar S, Madhuri S, Kannaiyan K, Mathew M, Kyaw Soe HH, et al.
    Cureus, 2023 Dec;15(12):e51085.
    PMID: 38274929 DOI: 10.7759/cureus.51085
    BACKGROUND: The routine oral and maxillofacial procedure involving the surgical removal of impacted mandibular third molars comes with inherent risks to nearby anatomical structures. Proximity of mandibular third molar roots to the inferior alveolar nerve (IAN) poses a significant risk for injury, prompting the need for reliable assessment methods. Radiographic indicators, particularly those observed on intraoral periapical radiographs (IOPARs), offer a dependable means to evaluate proximity.

    OBJECTIVES: This study seeks to examine the closeness between the mandibular canal and the roots of mandibular third molars using IOPARs and to assess the incidence of postoperative neurosensory disorders.

    METHODS: A cohort of 100 subjects aged 18 to 25, presenting for partially erupted/ impacted mandibular third molar removal, underwent IOPAR examinations. Data analysis employed IBM SPSS Statistics for Windows, Version 12 (Released 2004; IBM Corp., Armonk, New York, United States), calculating frequencies, percentages, means, standard deviations, and ranges. Radiographic signs of proximity were evaluated, and a standardized surgical procedure was performed under local anesthesia. Postoperative neurosensory disorders were assessed using various methods.

    RESULTS: Of the evaluated subjects, darkening of the root (52%) was the most prevalent radiographic sign, followed by interruption of the white line of the canal (20%). The prevalence of radiographic signs varied, with none of the patients experiencing narrowing of the root. Postsurgical paraesthesia assessment revealed no nerve sensitivity alterations in any patient.

    CONCLUSION: Preoperative radiographic examination is imperative for determining the relationship between mandibular third molar roots and the inferior alveolar canal, aiding in preventing IAN damage during extraction. Contrary to radiographic signs, there was no observed association between impacted mandibular third molar radiographic signs and the occurrence of postoperative neurosensory disorders.

  14. Jacob M, Sahu S, Singh YP, Mehta Y, Yang KY, Kuo SW, et al.
    Indian J Crit Care Med, 2020 Nov;24(11):1028-1036.
    PMID: 33384507 DOI: 10.5005/jp-journals-10071-23653
    Introduction: Fluid therapy in critically ill patients, especially timing and fluid choice, is controversial. Previous randomized trials produced conflicting results. This observational study evaluated the effect of colloid use on 90-day mortality and acute kidney injury (RIFLE F) within the Rational Fluid Therapy in Asia (RaFTA) registry in intensive care units.

    Materials and methods: RaFTA is a prospective, observational study in Asian intensive care unit (ICU) patients focusing on fluid therapy and related outcomes. Logistic regression was performed to identify risk factors for increased 90-day mortality and acute kidney injury (AKI).

    Results: Twenty-four study centers joined the RaFTA registry and collected 3,187 patient data sets from November 2011 to September 2012. A follow-up was done 90 days after ICU admission. For 90-day mortality, significant risk factors in the overall population were sepsis at admission (OR 2.185 [1.799; 2.654], p < 0.001), cumulative fluid balance (OR 1.032 [1.018; 1.047], p < 0.001), and the use of vasopressors (OR 3.409 [2.694; 4.312], p < 0.001). The use of colloids was associated with a reduced risk of 90-day mortality (OR 0.655 [0.478; 0.900], p = 0.009). The initial colloid dose was not associated with an increased risk for AKI (OR 1.094 [0.754; 1.588], p = 0.635).

    Conclusion: RaFTA adds the important finding that colloid use was not associated with increased 90-day mortality or AKI after adjustment for baseline patient condition.

    Clinical significance: Early resuscitation with colloids showed potential mortality benefit in the present analysis. Elucidating these findings may be an approach for future research.

    How to cite this article: Jacob M, Sahu S, Singh YP, Mehta Y, Yang K-Y, Kuo S-W, et al. A Prospective Observational Study of Rational Fluid Therapy in Asian Intensive Care Units: Another Puzzle Piece in Fluid Therapy. Indian J Crit Care Med 2020;24(11):1028-1036.

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