Displaying all 18 publications

  1. Salina H., Lim P.S., Gendeh B.S.
    Hereditary Hemorrhagic Telangiectasia, also known as Osler-Weber-Rendu Syndrome is an autosomal
    dominant disorder causing systemic abnormalities of the vascular structure. There are multiple arteriovenous malformations present in the skin and mucosal surface of the nail beds, nose, gastrointestinal tract, lungs and brain. Epistaxis is the common presentation symptom, which may require multiple hospital admissions and blood transfusions. It is extremely rare disease in our population. We report 4 cases of HHT who presented to us with moderate to severe epistaxis and how we managed these patients.
  2. Noorizan Y, Salina H
    Med J Malaysia, 2010 Mar;65(1):70-1.
    PMID: 21265255 MyJurnal
    A pregnant lady in her third trimester presented with a rapidly growing right-sided nasal mass associated with epistaxis and nasal obstruction for two months. Examination showed a non tender, protruding mass completely occluding her right nostril. Wide surgical excision was done under local anaesthesia. Histopathology revealed capillary haemangioma. In a gravid patient with a rapidly growing intranasal lesion, capillary haemangioma should be considered as a differential diagnosis. Due to the rapidity of growth, presentation with epistaxis and its macroscopic appearance which often mimics malignancy; histologic confirmation is crucial.
  3. Gendeh BS, Salina H
    Med J Malaysia, 2007 Dec;62(5):368-9.
    PMID: 18705467
    The purpose of this retrospective study is to determine whether there is a correlation among overweight, gender and the risk of development of spontaneous cerebrospinal fluid (CSF) rhinorrhoea. The clinical data of eight patients diagnosed with spontaneous cerebrospinal fluid rhinorrhoea who had been treated at our tertiary referral centre between 1998 and 2007 were assessed. Demographically, seven patients were female and one male with ages ranging from 14 to 53 years with a mean age of 43.6 years. This observation revealed that all patients were overweight with a mean body mass index (BMI) of 32.5 kg/m2. This study suggests that there is a trend of increasing BMI to the risk of developing a spontaneous CSF rhinorrhoea.
  4. Norhafizah S, Salina H, Goh BS
    Eur Ann Allergy Clin Immunol, 2020 05;52(3):121-130.
    PMID: 31668057 DOI: 10.23822/EurAnnACI.1764-1489.119
    Summary: Introduction.The prevalence of allergic rhinitis in children with persistent otitis media with effusion in different countries varies between 82% to 93%. Many risk factors of otitis media with effusion has been studied and proven. However, its association with allergic rhinitis remains controversial. Objective. The main objective of this study is to determine the prevalence of allergic rhinitis in children with persistent otitis media with effusion. This study is also aimed to identify the risk factors of otitis media with effusion, common allergens associated with allergic rhinitis and determine the hearing threshold of children with otitis media with effusion. Methods.A hundred and thirty children were recruited. History taking, physical examination and hearing assessment were done in the first visit. Those with allergic rhinitis underwent skin prick test and treated with intranasal corticosteroid and antihistamine. A second examination and hearing assessment were then repeated after 3 months. Results.The prevalence of allergic rhinitis in children with persistent otitis media with effusion in this study was noted to be 80.3%. Among these children, dust mites appeared to be the most common allergen (87.7%). Another risk factor appeared to be families with more than 4 members per-household (96%). It is noted that that otitis media with effusion caused a hearing loss up to 33 dB. However, there was a statistically significant improvement of the hearing threshold during second visit after commencement of allergy treatment. It was also noted that the hearing threshold in allergic rhinitis group was significantly impaired compared to the non-allergic rhinitis group. Conclusions.Allergic rhinitis and larger family household appeared to be common risk factors in children with persistent otitis media with effusion. There is significant hearing loss noted in children suffering from otitis media with effusion and allergic rhinitis. The hearing threshold improved remarkably with medical therapy. This study hence clarifies the controversy on the association between allergic rhinitis and otitis media with effusion.
  5. Azman M, Hamizan AW, Salina H
    Med J Malaysia, 2021 08;76(Suppl 4):49-51.
    PMID: 34558560
    The COVID-19 pandemic has affected the entrance evaluation for postgraduate studies (PGS) in various medical specialties. The PGS in otorhinolaryngology (ORL) continue to be relevant amidst the pandemic, with more than 150 applicants this year. We share here our recent experiences in managing ORL entrance examinations during the height of the COVID-19 pandemic. It is possible to conduct virtually the multi-institutional, multi-faceted evaluation for PGS entrance during pandemic situations whilst conforming to the already established format and standards.
  6. Syuhada, O., Shalini, P., Lim, W.K., Ammar, A., Suria Hayati, M.P., Aneeza Khairiyah, W.H., et al.
    Medicine & Health, 2016;11(1):56-61.
    Eosinophil-type nasal polyp (NP) is common in Western population. This aim of
    this study was to determine the histology type of NP among different Malaysian
    ethnic groups. A total of 122 chronic rhinosinusitis with nasal polyposis (CRSwNP)
    patients were retrospectively enrolled and demographic data was recorded. The
    histological slides were retrieved. The number of eosinophils and non-eosinophils
    were counted and average number of inflammatory cells for each high power
    field was calculated. Eosinophil-predominant was seen in 32.8% of patients and
    67.2% was non-eosinophil-predominant. Phenotypes of NP significantly showed an association with ethnicity (x² = 8.322; p < 0.05). A total of 78.9% of Chinese
    nasal polyps showed non-eosinophil predominant, while Malay and Indian nasal
    polyps revealed 71.9% and 40.7% of non-eosinophilic phenotype, respectively.
    Our study showed that Malaysian population had a non-eosinophilic phenotype
    of nasal polyps. There was a significant association in Malaysian ethnicity with the
    highest percentage in Chinese population.
  7. Gendeh BS, Salina H, Selladurai B, Jegan T
    Med J Malaysia, 2007 Aug;62(3):234-7.
    PMID: 18246914 MyJurnal
    Craniofacial resection is commonly performed in the surgical resection of sinonasal tumours involving anterior skull base. It entails a bicoronal scalp flap with lateral rhinotomy or an extended lateral rhinotomy to expose the anterior skull base. Transfacial approach is necessary in the resection of the nasal part of the tumour. The choice of surgical approach is based heavily on the surgeon's experience and training. The results of endoscopic-assisted craniofacial resection for sinonasal tumours performed in our center in eight patients from 1998 to 2005 were reviewed. There were seven males and one female with age ranging from 18 to 62 years (mean 42.4 years). There was each a case of mature teratoma, poorly differentiated squamous cell carcinoma, undifferentiated squamous cell carcinoma, olfactory neuroblastoma, fibrous dysplasia, inverted papilloma and two cases of sinonasal neuroendocrine carcinoma. The mean follow up duration for these eight patients post surgery was 21.4 months. Out of eight patients, five underwent surgery with no adverse complications. The complications encountered were a cerebrospinal leak and a postoperative transient V and VI cranial nerve palsy. One patient with sinonasal undifferentiated carcinoma died of lung metastasis at 11 months post-surgery. The endoscopic-assisted craniofacial resection is a highly useful surgical technique to avoid the unsightly facial scar of the lateral rhinotomy or the Weber-Ferguson incision, postoperative paranasal sinuses infection and avoidance of tracheostomy in selected cases. We found that this approach has lower morbidity rate in selected cases.
  8. Siti, N. I., Kavireshna, K., Zafirah, M. R., Foo, Y. I. W., Rabiatul Adawiyah, R., Salina, H., et al.
    Medicine & Health, 2017;12(2):259-274.
    Model tiga dimensi (3D) menyerupai ciri-ciri persekitaran tisu asli, justeru
    morfologi dan isyarat-isyarat sel daripada kultur 3D selalunya lebih menyerupai
    fisiologi asal berbanding sel kultur dua dimensi (2D). Diketahui juga, rembesan
    sel mempunyai kesan parakrin kepada pertumbuhan sel-sel lain. Dalam kajian
    ini, pengkulturan fibroblast hidung menggunakan system kultur sel 3D telah
    dioptimumkan dan kesan bahan rembesan (BR) daripada kultur 3D terhadap kadar
    pertumbuhan dan perlindungan sel telah dikaji. Fibroblas hidung dipencilkan
    daripada turbinate hidung manusia. Mikrosfera yang sesuai telah dipilih melalui
    pengkulturan fibroblast pemindahan ke-3 pada pelbagai jenis mikro sferapolisterin
    PolyGEM™. Kemudian, sel-sel telah dikulturkan pada mikrosfera yang terpilih
    menggunakan system kultur 3D dan media terkondisi (MT) telah dikumpulkan.
    Media terkondisi tiga dimensi (MT3D) telah ditambah kepada fibroblast untuk
    mengkaji kadar perlekatan sel, kadar proliferasi, dan perlindungan sel terhadap
    kesitotoksikan Centella asiatica. Asai protein asid bicinchonic dijalankan untuk
    mengetahui kuantiti protein di dalam BR. Elektroforesis gel poliakrilamida-Sodium
    Dodesil Sulfat (SDS-PAGE) telah dilakukan untuk memperoleh profil awal protein
    dan membandingkan profil MT3D dengan protein media terkondisi dua dimensi
    (MT2D). Kajian ini menunujukkan MT3D tidak menggalakkan perlekatan dan
    proliferasi sel secara signifikan. BR didapati memberikan perlindungan sel yang
    signifikan pada fibroblast hidung terhadap kesitotoksikan Centella asiatica. MT3D
    mempunyai kepekatan protein yang lebih tinggi berbanding MT2D. SDS-PAGE
    menunjukkan MT3D mempunyai 3 jalur ekslusif manakala MT2D mempunyai 4 jalur eksklusif. Kajian masa depan harus dijalankan keatas penggunaan BR
    fibroblast hidung untuk perlindungan sel terhadap agen-agen yang memudaratkan
    di alam sekitar dan produk herba yang sitotoksik.
  9. Fadzilah I, Salina H, Khairuzzana B, Rahmat O, Primuharsa Putra SH
    Ear Nose Throat J, 2014 Jun;93(6):E33-5.
    PMID: 24932827
    Schwannomas of the nasal cavity and paranasal sinuses are quite rare, especially in the nasal vestibule. We report the case of a 61-year-old woman who presented with a 2-month history of progressively worsening right-sided epistaxis and nasal blockage. Rigid nasoendoscopy showed a mobile, smooth, globular mass occupying the right nasal vestibule. The mass arose from the lateral nasal wall and impinged on the anterior part of the middle turbinate posteriorly. Computed tomography of the paranasal sinuses showed a 3.8 × 1.7-cm enhancing mass in the right nostril. The mass obliterated the nasal cavity and caused mild deviation of the septum. The preoperative histopathologic examination showed positivity for vimentin and S-100 protein, suggesting a diagnosis of schwannoma. The patient underwent an intranasal laser-assisted excision biopsy. The histopathologic examination confirmed the diagnosis of schwannoma. Postoperative recovery was uneventful, and no recurrence was seen in the follow-up period.
  10. Sazafi MS, Salina H, Asma A, Masir N, Primuharsa Putra SH
    Acta Otorhinolaryngol Ital, 2013 Dec;33(6):428-30.
    PMID: 24376301
    We report a case of keratoacanthoma in a non-sun-exposed nasal vestibule of an 84-year-old man. He presented with a progressively growing left nasal mass that had been present for 8 months. Examination showed a non-tender protruding mass arising from medial vestibular wall of the left nostril. Histopathology indicated it was a keratoacanthoma. In an elderly patient with a history of a progressively growing mass in the nose, a differential diagnosis of malignancy should be ruled out, and histological conformation is essential. To our knowledge, only a very small number of cases of nasal vestibular keratoacanthoma have been reported.
  11. Asma A, Azmi MN, Mazita A, Marina MB, Salina H, Norlaila M
    PMID: 22468245 DOI: 10.1007/s12070-011-0132-y
    Neuropathy is frequently a late complication of diabetes mellitus. Auditory neuropathy and microangiopathy of inner ear are the possible causes of hearing loss in diabetics. To study the correlation between glycaemic control and hearing threshold in patients with type 2 diabetes mellitus and to determine the differences of hearing threshold between groups treated with different modality. This single blind randomized controlled study was performed at the Department of Medicine and Department of Otorhinolaryngology, Hospital Universiti Kebangsaan Malaysia (UKM) between 1st May 2003 and 31st September 2004. This study was approved by Research Ethics Committee (code number FF-137). Subjects were randomized into two groups. Group 1 were patients treated with conventional oral hypoglycemic agents. The patients in group 2 were those treated with insulin injection. The subjects were seen 4 weekly for 3 months. Audiometric test were performed in all subjects at each visit. Blood were taken for fasting blood glucose, Hb1Ac, and fructosamine at every visit to determine the glycaemic controls of the subject. They were 11 patients (22 ears) treated with oral hypoglycemic agents and 17 patients treated (34 ears) with subcutaneous insulin. There is no significant difference between mean pure tone threshold before and after treatment at all frequencies in both groups. There is also no significance different in fasting glucose level and fructosamine. However, there is significant difference HbA1c levels between the two groups after treatment (P 
  12. Goh BS, Faizah AR, Salina H, Asma A, Saim L
    Med J Malaysia, 2010 Sep;65(3):196-8.
    PMID: 21939167
    This is a retrospective review of congenital cholesteatoma cases that were managed surgically. There were 5 cases. The age of presentation ranged from 5 to 18 year old. Three patients presented with complication of the disease. Three patients had intact tympanic membrane, two had perforation at the anterior superior quadrant. All patients had cholesteatoma medial to tympanic membrane. Four cases had extensive ossicular erosion with preoperative hearing worse than 40 dB. Four cases underwent canal wall down mastoid surgery and one underwent canal wall up surgery. One patient had recurrence which required revision surgery. In conclusion, congenital cholesteatoma presented late due to the silent nature of disease in its early stage. Extensive disease, ossicular destruction with risk of complication at presentation were marked in our study. Hence, more aggressive surgical intervention is recommended in the management of congenital cholesteatoma.
  13. Salina H, Abdullah A, Mukari SZ, Azmi MT
    Eur Arch Otorhinolaryngol, 2010 Apr;267(4):495-9.
    PMID: 19727788 DOI: 10.1007/s00405-009-1080-y
    Transient-evoked otoacoustic emission (TEOAE) is a well-established screening tool for universal newborn hearing screening. The aims of this study are to measure the effects of background noise on recording of TEOAE and the duration required to complete the test at various noise levels. This study is a prospective study from June 2006 until May 2007. The study population were newborns from postnatal wards who were delivered at term pregnancy. Newborns who were more than 8-h old and passed a hearing screening testing using screening auditory brainstem response (SABRe) were further tested with TEOAE in four different test environments [isolation room in the ward during non-peak hour (E1), isolation room in the ward during peak hour (E2), maternal bedside in the ward during non-peak hour (E3) and maternal bedside in the ward during peak hour (E4)]. This study showed that test environment significantly influenced the time required to complete testing in both ears with F [534.23] = 0.945; P < 0.001 on the right ear and F [636.54] = 0.954; P < 0.001 on the left. Our study revealed that TEOAE testing was efficient in defining the presence of normal hearing in our postnatal wards at maternal bedside during non-peak hour with a specificity of 96.8%. Our study concludes that background noise levels for acceptable and accurate TEOAE recording in newborns should not exceed 65 dB A. In addition, when using TEOAE assessment in noisy environments, the time taken to obtain accurate results will greatly increase.
  14. Aidayanti MD, Salina H, Gendeh BS, Farah DZ, Faezah MZ
    Med J Malaysia, 2018 08;73(4):249-252.
    PMID: 30121689 MyJurnal
    Endoscopic sinus surgery (ESS) is a standard treatment for rhinosinusitis, which failed optimum medical therapy. Iatrogenic cerebrospinal fluid (CSF) rhinorrhoea can occur during ESS warrants early repair of the leakage. The common sites for CSF leakage are cribriform plate, fovea ethmoidalis, and anterior ethmoid sinuses. We present five cases of iatrogenic CSF rhinorrhoea due to ESS and its management.
  15. Shaariyah MM, Salina H, Dipak B, Majid MN
    Ann Saudi Med, 2010 9 25;30(6):475-7.
    PMID: 20864791
    Migration of a foreign body from the hypopharynx to the subcutaneous tissue of the neck is a rare event. We report a case of a 48-year-old male who accidentally swallowed a fish bone which was not identified intraoperatively. The patient then presented with migration of the bone to the soft tissue of the neck. We conclude that careful assessment of the patient with a foreign body in the throat is crucial to avoid fatal complications.
  16. Wong DKC, Gendeh HS, Thong HK, Lum SG, Gendeh BS, Saim A, et al.
    Med J Malaysia, 2020 09;75(5):574-581.
    PMID: 32918429
    INTRODUCTION: Multiple anecdotal reports suggest that smell and taste loss were early subclinical symptoms of COVID-19 patients. The objective of this review was to identify the incidence of smell and taste dysfunction in COVID-19, determine the onset of their symptoms and the risk factors of anosmia, hyposmia, ageusia or dysgeusia for COVID-19 infection.

    METHODS: We searched the PubMed and Google Scholar on 15th May 2020, with search terms including SARS-COV-2, coronavirus, COVID-19, hyposmia, anosmia, ageusia and dysgeusia. The articles included were cross sectional studies, observational studies and retrospective or prospective audits, letters to editor and short communications that included a study of a cohort of patients. Case reports, case-series and interventional studies were excluded.

    DISCUSSION: A total of 16 studies were selected. Incidence of smell and taste dysfunction was higher in Europe (34 to 86%), North America (19 to 71%) and the Middle East (36 to 98%) when compared to the Asian cohorts (11 to 15%) in COVID-19 positive patients. Incidence of smell and taste dysfunction in COVID-19 negative patients was low in comparison (12 to 27%). Total incidence of smell and taste dysfunction from COVID-19 positive and negative patients from seven studies was 20% and 10% respectively. Symptoms may appear just before, concomitantly, or immediately after the onset of the usual symptoms. Occurs predominantly in females. When occurring immediately after the onset of the usual symptoms, the median time of onset was 3.3 to 4.4 days. Symptoms persist for a period of seven to 14 days. Patients with smell and taste dysfunction were reported to have a six to ten-fold odds of having COVID-19.

    CONCLUSION: Smell and taste dysfunction has a high incidence in Europe, North America, and the Middle East. The incidence was lower in the Asia region. It is a strong risk factor for COVID-19. It may be the only symptom and should be added to the list of symptoms when screening for COVID- 19.

  17. Ameen SA, Salina H, Zahedi FD, Primuharsa-Putra SH, Masir N
    Iran J Otorhinolaryngol, 2019 May;31(104):191-195.
    PMID: 31223601
    Introduction: Angiomyolipoma (AML), a benign mesenchymal tumor that commonly arises from the kidney, may be associated with tuberous sclerosis complex and perivascular epithelioid cell tumors (PEComas). Nasal angiomyolipoma is very rare and usually occurs in elderly individuals with epistaxis and nasal obstruction.

    Case Report: We report a rare case of nasal angiomyolipoma in a young male. To the best of our knowledge, this is the first documented case of angiomyolipoma originating from the posterior end of the inferior turbinate, clinically mimicking juvenile nasopharyngeal angiofibroma (JNA). The tumor was removed completely via coblator-assisted endoscopic sinus surgery. The patient was asymptomatic at a 2-year follow-up.

    Conclusion: Nasal AML located in the posterior nasal cavity in a male patient can mimic the presentation of JNA. A computed tomography scan of the paranasal sinuses played an important role in differentiating nasal AML from JNA. The coblator-assisted endoscopic technique is useful in controlling intraoperative hemostasis in the removal of a suspicious vascular tumor.

  18. Khairuddin NK, Salina H, Gendeh BS, Wan Hamizan AK, Lund VJ
    Med J Malaysia, 2018 02;73(1):1-6.
    PMID: 29531195
    OBJECTIVE: To assess the quality of life (QoL) and recurrence of disease in patients with eosinophilic (ECRSwNP) and non-eosinophilic chronic rhinosinusitis with nasal polyposis (non-ECRSwNP) post endoscopic sinus surgery (ESS).

    METHODOLOGY: A cross-sectional comparative study was carried out in the Otorhinolaryngology - HNS Department, Universiti Kebangsaan Malaysia Medical Center (UKMMC). Subjective assessments of nasal symptoms and quality of life (QoL) using SNOT-22 and Visual Analogue Scale (VAS) and objective endoscopic assessment was undertaken using a modified Hadley endoscopic examination.

    RESULTS: There was no significant statistical difference in the quality of life between the ECRSwNP and non-ECRSwNP groups as evidenced by the SNOT-22 score and the VAS comparison (p>0.05). However, there was a significant difference in terms of recurrence of disease with the presence of nasal polyps on endoscopic examination. (p = 0.016) CONCLUSION: In conclusion, we found that there is no significant difference in QoL between ECRSwNP and non- ECRSwNP. There is higher frequency of recurrence of nasal polyps amongst ECRSwNP.

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