Displaying publications 1 - 20 of 127 in total

  1. Pan KL, Ting SS, Mohamad AWK, Lee WG, Wong CC, Rasit AH
    Med J Malaysia, 2003 Dec;58(5):752-7.
    PMID: 15190663
    Improvements in the overall treatment of patients with aggressive, large tumours involving the bone have made it possible to preserve and salvage limbs instead of amputating them. Each patient is unique in his clinical presentation and social circumstance. The different reconstructive options available allow us to choose the most appropriate method suited to the particular patient and with minimal delay, even when resources are limited. The patient and the relatives actively participate in the choice. The early experience of the different techniques for reconstructing these bone defects at our hospital are presented in this paper.
    Matched MeSH terms: Bone Neoplasms/surgery*
  2. Dutt AK, Dhillon DS, Omar bin Din
    Med J Malaya, 1969 Sep;24(1):71-3.
    PMID: 4243847
    Matched MeSH terms: Bone Neoplasms*
  3. Rasit AH, Sharaf I, Rahman HA
    Med J Malaysia, 2001 Jun;56 Suppl C:86-8.
    PMID: 11814259
    Ewing's sarcoma is a rare malignant tumor of the foot in children. We report a case of Ewing's sarcoma of the talus in a four-year-old Chinese girl to highlight the initial difficulty in diagnosis and the clinical course of the disease. She was initially diagnosed as osteomyelitis of the talus and died eight months after presentation with pleural and spinal metastases. To the best of our knowledge, Ewing's sarcoma of the talus in a young child has never been reported in Malaysia.
    Matched MeSH terms: Bone Neoplasms/pathology*; Bone Neoplasms/radiography*
  4. Sharma DN, Gairola M, Mohanti BK, Rath GK
    Med J Malaysia, 1999 Jun;54(2):210-5.
    PMID: 10972031
    From June 1993 to September 1995, 132 case files of patients who received palliative radiotherapy (RT) for skeletal metastases were reviewed. Majority of the patients (75/132) was in the age range of 41-60 years. Common sites of metastases were the vertebrae (86 patients) and the pelvic bones (40 patients). The major primary tumors encountered were as follows: multiple myeloma (30), breast cancer (25) and prostate cancer (20). Pain was the commonest symptom of presentation. Doses of palliative RT ranged from 8-40 Gy in different fractionation schedules. Ninety-four patients showed more than 50% symptomatic response, 26 had no response and 12 were lost to follow up immediately after the treatment. Single fraction treatments resulted in almost similar responses compared to various multiple fraction treatments. To conclude, short course radiation therapy regimes are optimum in our local circumstances where RT resources are limited and patients have to travel long distances to attend hospital.
    Matched MeSH terms: Bone Neoplasms/radiotherapy*; Bone Neoplasms/secondary
  5. Ibrahim S, Sundari MN, Masir N
    Med J Malaysia, 1999 Jun;54(2):261-3.
    PMID: 10972039
    We report a case of a sixteen-month old boy with osteosarcoma of the left humerus. To the best of our knowledge this is the youngest case reported in Malaysia. This case illustrates that osteosarcoma although rare does occur in a very young child. The child died six weeks after presentation due to disseminated disease.
    Matched MeSH terms: Bone Neoplasms/diagnosis*; Bone Neoplasms/pathology
  6. Lopez CG, Ganesan S, Dutt AK, Omar bin Din
    Med J Malaya, 1969 Dec;24(2):154-7.
    PMID: 4244143
    Matched MeSH terms: Bone Neoplasms/etiology*
  7. Sallehuddin, A., Saw, A., George, J., Sengupta, S.
    Malays Orthop J, 2008;2(1):12-16.
    Purpose: To evaluate the usefulness of ultrasound guidance in percutaneous needle biopsy for musculoskeletal tumours.
    Methods: Forty-five consecutive patients underwent ultrasound-guided needle biopsy. An additional group of 50 patients who underwent needle biopsy without ultrasound guidance was retrospectively selected as historical control. The sample was considered adequate when a diagnosis can be made, and diagnostic when the diagnosis is similar to the final report based on the excised tumour.
    Results: Adequacy of the biopsy samples was 84% in ultrasound-guided group as compared 76% in the group with no ultrasound guidance. Diagnostic accuracy was 64% in the ultrasound-guided group and 52% in the group without ultrasound guidance. Both of these differences were not statistically significant.
    Conclusions: Ultrasound guidance did not provide a significant advantage in the biopsy of musculoskeletal tumours. Diagnostic accuracy seems to improve with the use of larger 14 gauge biopsy needle but further evaluation is necessary.
    Matched MeSH terms: Bone Neoplasms*
  8. Noh BJ, Han CS, Park JS, Lee J, Kim YW, Park YK
    Malays J Pathol, 2018 Aug;40(2):161-167.
    PMID: 30173234
    Primary bone lymphoma (PBL) is an uncommon type of extranodal lymphoma involvement. An anaplastic large-cell lymphoma (ALCL) is an extremely rare type of PBL, and it remains unclear whether ALCLs that primarily involve the bone exhibit favourable or unfavourable biological behaviour, and whether they are similar to ALCLs in general, or not. We reported a case of ALK-positive ALCL with primary bone involvement, and reviewed the clinicopathological features of 22 previously reported cases. An ALCL with primary bone involvement mostly affects younger patients with a preponderant towards the involvement of axial-bone. The prognosis of an ALCL that primarily involves bone is unfavourable, compared with PBL generally. The ALK-positive ALCLs in PBLs had less decedents than the ALK-negative ALCLs with a statistical non-significance (p=0.198).
    Matched MeSH terms: Bone Neoplasms/pathology*
  9. Lim PJ, Peh WC
    Med J Malaysia, 2014 Oct;69(5):231-3.
    PMID: 25638239
    The scapula is a flat, triangular bone overlying the posterior chest wall and forming the posterior aspect of the shoulder girdle. To the best of our knowledge, there is no previous description of a notch of the medial aspect of the superior border of the scapula in the literature. The imaging findings of a supero-medial scapula border notch mimicking a bone tumour are presented in this case report.
    Matched MeSH terms: Bone Neoplasms
  10. Rahmat K, Wastie M, Abdullah B
    Biomed Imaging Interv J, 2007 Oct;3(4):e52.
    PMID: 21614300 MyJurnal DOI: 10.2349/biij.3.4.e52
    Primary bone lymphoma is an uncommon tumour accounting for approximately 4-5% of extra nodal lymphoma and less than 1% of all Non-Hodgkin's lymphoma. The radiographic appearance of primary bone lymphoma is variable. As lesions frequently resemble other disease processes namely chronic osteomyelitis and metastases, further imaging evaluation and histopathological examination allow early identification for appropriate treatment. The authors present a case of anaplastic large cell lymphoma of bone presenting with multifocal osseus involvement.
    Matched MeSH terms: Bone Neoplasms
  11. Hazmy W
    Med J Malaysia, 2001 Jun;56 Suppl C:89-90.
    PMID: 11814260
    The author reports a case of a 11-year old child presented with peroneal nerve entrapment secondary to proximal fibular osteochondroma, with complete recovery of function following the excision of the tumor.
    Matched MeSH terms: Bone Neoplasms/complications*; Bone Neoplasms/radiography; Bone Neoplasms/surgery*
  12. Hoe TS, Sivanantham M, Phang KS, Yogeswary S, Foo LS
    Med J Malaysia, 1994 Sep;49(3):289-91.
    PMID: 7845282
    Matched MeSH terms: Bone Neoplasms/diagnosis*; Bone Neoplasms/pathology; Bone Neoplasms/therapy
  13. Mawardi M, Hussin P
    Malays Fam Physician, 2018;13(3):38-39.
    PMID: 30800233
    Matched MeSH terms: Bone Neoplasms
  14. Choong, C. Y. L., Chan, H. Z., Azuhairy, A., Anwar Hau, M., Zulkiflee, O.
    Malays Orthop J, 2014;8(2):55-58.
    Conventional chondrosarcomas rarely metastasize and it is extremely unusual to see multicentric- behaviour in malignant cartilage tumour. We report a 40 year old lady with presentation of two non-contiguous metachronous foci of low to intermediate grade of chondrosarcoma over left pelvic bone and right scalp respectively in the absence of pulmonary or visceral metastasis.
    Matched MeSH terms: Bone Neoplasms
  15. Abdul Rahim, N.I.H., Ngah, N.A., Ramanathan, A., George, T., Ismail, S.M.
    Ann Dent, 2011;18(1):24-29.
    Osteosarcoma is a primary malignant neoplasm of the bone. Osteosarcoma of the jaws especially those of maxilla is rare. The diagnosis of osteosarcomas is difficult and challenging. In this case report we highlight a rare case of osteosarcoma of the maxilla in a 29 year old male patient which was highly aggressive and was initially diagnosed as rhabdomyosarcoma. This case highlights the difficulty in diagnosing osteosarcoma merely from incisional biopsy specimens which may not be representative of the whole tumour. Limited clinical information at incisional biopsy also adds to the difficulty in arriving at the definitive diagnosis. We further discuss the treatment modalities followed in this case.
    Matched MeSH terms: Bone Neoplasms
  16. Noor Khairiah AK, Mohamad Nazrulhisham MN, John G
    Med J Malaysia, 2018 04;73(2):116-118.
    PMID: 29703878 MyJurnal
    Primary osteosarcoma of the spine is indeed rare and only several sporadic cases have been reported. It tends to occur in a slightly older age group than those with appendicular skeleton tumours. We present here an unusual case of aggressive lumbosacral osteosarcoma in a young teenager complicated by extensive dural spread, skip lesions and intravascular extension. Although a histopathological examination is mandatory to establish the diagnosis, this case emphasises the need of imaging to ascertain the full extent of disease spread especially in deciding the type of treatment to be instituted and to evaluate the response to the treatment.
    Matched MeSH terms: Bone Neoplasms
  17. Nayak SB, Kumar N, Sirasanagandla SR, Srinivas SP, Pamidi N, Shetty SD
    Anat Cell Biol, 2018 Jun;51(2):136-138.
    PMID: 29984059 DOI: 10.5115/acb.2018.51.2.136
    Osteochondromas develop as cartilaginous nodules in the periosteum of bones. They are the commonest benign tumors of the skeleton, generally observed in the long bones. Rarely, they are also found in the axial skeleton, flat bones of skull and facial bones. During a regular dissection, we came across a solitary osteochondroma in posterior surface of the body of the right pubic bone. Histopathology of the bony projection confirmed the typical features of the osteochondroma. The symptomatic osteochondromas are usually evaluated during radiographic examination. Though, the observed osteochondroma is relatively smaller its unusual location is remarkable and knowledge of occurrence of such nodules is clinically important during the diagnosis and planning of treatment.
    Matched MeSH terms: Bone Neoplasms
  18. Makhadmeh GN, Abdul Aziz A
    Artif Cells Nanomed Biotechnol, 2018;46(sup3):S1043-S1046.
    PMID: 30449196 DOI: 10.1080/21691401.2018.1528982
    BACKGROUND: Achieved Silica Nanoparticles (SiNPs) to encapsulate the photosensitizer [Protoporphyrin IX (PpIX)] in photodynamic therapy (PDT) application was reported in this research.

    MATERIALS AND METHODS: Cytotoxicity for five different concentrations of encapsulated and naked PpIX was measured. Optimum concentration and optimum exposure time of encapsulated and naked PpIX that needed to destroy the cells (Osteosarcoma cells) was measured.

    RESULTS: The results showed that the encapsulated PpIX has more efficacy compared to the naked PpIX and the applicability of the encapsulated PpIX-SiNPs was proved on osteosarcoma cells.

    CONCLUSION: The results established the important in-vitro photodynamic effectiveness of PpIX-SiNP, which may open a new application for PpIX in its clinical and in-vitro studies.

    Matched MeSH terms: Bone Neoplasms/drug therapy*; Bone Neoplasms/metabolism; Bone Neoplasms/pathology
  19. Pan KL, Mourougayah V, Jayamalar T
    Med J Malaysia, 2003 Dec;58(5):783-5.
    PMID: 15190672
    We present an elderly patient with a squamous cell carcinoma over the subcutaneous aspect of the leg involving the tibia. En bloc resection of the tumour together with a 10 centimetre segment of the tibia was done. The resected bone was autoclaved, replaced in its original position and stabilized with bone cement and a locked nail. This allowed early ambulation with minimal cost.
    Matched MeSH terms: Bone Neoplasms/surgery*
  20. Narayanan V, Jayapalan RR, Singh Sidhu A, Koh KMR
    J Craniofac Surg, 2019 2 27;30(3):841-842.
    PMID: 30807473 DOI: 10.1097/SCS.0000000000005185
    Exophytic lesions involving the face present with an undesirable esthetic deformity and usually necessitate surgical excision. Conventional open excision techniques may lead to scar formation or pigmentation issues postoperatively. Minimally invasive endoscope-assisted surgery will be able to overcome these problems. However, this technique is not widely used because of the limited optical cavity working space, which hinders good visualization. We describe a technique to improve the optical cavity workspace to enable adequate endoscope-assisted surgical excision of forehead lesions in 2 cases. Foley's catheter and ribbon gauze were used in both cases to gain optical cavity workspace. The surgical technique is described in detail. One case had a frontal osteoma, whereas other was a nodular fasciitis of the forehead, confirmed by histology. Postoperative follow-up showed good outcomes at 1 year with no recurrences. Both patients were satisfied with the surgical and cosmetic outcomes. Endoscopic excision of a forehead lesion using the described technique is both safe and reliable. It is an excellent method for excising benign growths over the forehead while being cosmetically acceptable.
    Matched MeSH terms: Bone Neoplasms/surgery*
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