MyMedR

Nail bed and flap reconstructions for acute fingertip injuries - A case review and report of a chemical burn injury

Gunasagaran J, Sian KS, Ahmad TS

J Orthop Surg (Hong Kong), 2019 4 5;27(2):2309499019839278.

PMID: 30943852 DOI: 10.1177/2309499019839278

Nail bed injuries were commonly found concomitantly with fingertip injuries. Reconstruction of fingertip including the nail bed should be attempted at acute stage. Aim of the surgery was to restore as much finger length and achieve normal nail growth. In chemical burns, the initial presentation might not reflect the exact extent of injury. Appropriate acute management must be initiated while waiting for demarcation. We report a case of young stewardess who presented with fingertip chemical burn injury. Surgical debridement was done on third day post-injury. A cross-finger flap to cover skin defect and split-thickness nail bed grafting from the remnant of injured finger were done. Excellent functional and cosmetic outcome was achieved in 6 months. Surgical treatment in a chemical burn was similar to traumatic injury. Nail bed graft was the best option for nail bed reconstruction. In cases of soft tissue loss, advancement or pedicle flaps are beneficial.

Matched MeSH terms: Burns, Chemical

Fulltext Corrosive oesophageal stricture in Malaysian adults

Krishnan MMS, Tan KC

Med J Malaysia, 1983 Dec;38(4):325-6.

PMID: 6599992

M. M. Sudhakar Krishnan, MS, FRCS (Edin & Glasg).
Department of Surgery, University Hospital, Kuala Lumpur, Malaysia

Matched MeSH terms: Burns, Chemical/complications*

Oesophageal replacement with colon in corrosive stricture

Wai NC

Med J Malaya, 1969 Sep;24(1):49-57.

PMID: 4243844

Matched MeSH terms: Burns, Chemical*

Cultivated oral mucosal epithelial transplantation (COMET) and penetrating keratoplasty in long-standing severe ocular surface injury

Lim IH, Alias R, Umapathy T, Samsudin A

Med J Malaysia, 2019 Oct;74(5):433-435.

PMID: 31649222

Ocular chemical injury is a true ophthalmic emergency requiring immediate medical intervention. Damages can be devastating and potentially resulting in blindness, corneal perforation and phthisis bulbi. We describe here a successful treatment outcome in a patient who sustained Roper-Hall Grade 4 injury to both eyes. Patient received medical therapy followed by serial ocular surgeries with eventual visual recovery in one eye from counting finger to 6/15 after a decade. In conclusion, after maximum medical therapy, a carefully planned serial surgeries of cultivated oral mucosal epithelial transplantation (COMET) and PK has proven beneficial for this patient with advanced limbal stem cell deficiency (LSCD).

Matched MeSH terms: Burns, Chemical

Caustic strictures of the oesophagus

Skene-Smith H

Br J Radiol, 1975 Aug;48(572):646-8.

PMID: 810200

Twenty-two cases of corrosive oesophageal strictures were reviewed and divided into annular, short segment and long segment lesions. The lower third of the oeseophagus was involved in all the long segment strictures, but with sparing of the extreme distal portion in most. Irregularity of the stricture walls with an appearance similar to reported cases of intramural diverticulosis is a common finding but smooth strictures can also occur.

Matched MeSH terms: Burns, Chemical/complications; Burns, Chemical/radiography*

Bovine pericardium in treating large corneal perforation secondary to alkali injury: a case report

Khanna RK, Mokhtar E

Indian J Ophthalmol, 2008 8 20;56(5):429-30.

PMID: 18711278

To describe use of a locally processed bovine pericardium (BP) to cover a large central corneal perforation following alkali injury and discuss postoperative outcome. A 27-year-old Malay male patient presented two weeks after alkali splashed in his left eye while working. A clinical diagnosis of left central corneal ulcer with limbal ischemia following alkali injury with secondary infection was made. After failed medical therapy, we performed a Gunderson conjunctival flap under local anesthesia that retracted after one week and resulted in a large central corneal perforation with surrounding stromal thinning. The perforation was covered with a locally processed BP xenograft (Lyolemb) supplied by the National Tissue Bank, University Sains Malaysia. Nine months follow-up showed a well-taken graft without any exposure/dehiscence and minimal inflammation. Amniotic membrane transplantation when used as a patch graft needs an urgent tectonic graft to promote corneal stability in patients with severe corneal thinning. The use of processed BP can be a viable option in treating such cases.

Matched MeSH terms: Burns, Chemical/etiology; Burns, Chemical/pathology; Burns, Chemical/surgery*

A case of facial burn due to the misuse of garlic face mask for acne

Hisham A, Mohamed Sukur S, Basiron N

Australas J Dermatol, 2018 Nov;59(4):336-337.

PMID: 29377074 DOI: 10.1111/ajd.12789

Matched MeSH terms: Burns, Chemical/etiology*

Fulltext Anti-inflammatory and antioxidant effects of Tualang honey in alkali injury on the eyes of rabbits: experimental animal study

Bashkaran K, Zunaina E, Bakiah S, Sulaiman SA, Sirajudeen K, Naik V

BMC Complement Altern Med, 2011;11:90.

PMID: 21982267 DOI: 10.1186/1472-6882-11-90

Alkali injury is one of the most devastating injuries to the eye. It results in permanent unilateral or bilateral visual impairment. Chemical eye injury is accompanied by an increase in the oxidative stress. Anti-inflammatory and antioxidant agents play a major role in the treatment of chemical eye injuries. The purpose of this study is to evaluate the anti-inflammatory (clinical and histopathological) and antioxidant effects of Tualang honey versus conventional treatment in alkali injury on the eyes of rabbits.

Matched MeSH terms: Burns, Chemical/drug therapy*; Burns, Chemical/pathology

Corneal regeneration by induced human buccal mucosa cultivated on an amniotic membrane following alkaline injury

Man RC, Yong TK, Hwei NM, Halim WHWA, Zahidin AZM, Ramli R, et al.

Mol Vis, 2017;23:810-822.

PMID: 29225457

Various clinical disorders and injuries, such as chemical, thermal, or mechanical injuries, may lead to corneal loss that results in blindness. PURPOSE: The aims of this study were to differentiate human buccal mucosa (BMuc) into corneal epithelial-like cells, to fabricate engineered corneal tissue using buccal mucosal epithelial cells, and to reconstruct a damaged corneal epithelium in a nude rat model.

Methods: BMuc were subjected to 10 d of induction factors to investigate the potential of cells to differentiate into corneal lineages.

Results: Corneal stem cell markers β1-integrin, C/EBPδ, ABCG2, p63, and CK3 were upregulated in the gene expression analysis in induced BMuc, whereas CK3 and p63 showed significant protein expression in induced BMuc compared to the uninduced cells. BMuc were then left to reach 80% confluency after differential trypsinization. The cells were harvested and cultivated on a commercially available untreated air-dried amniotic membrane (AM) in a Transwell system in induction medium. The corneal constructs were fabricated and then implanted into damaged rat corneas for up to 8 weeks. A significant improvement was detected in the treatment group at 8 weeks post-implantation, as revealed by slit lamp biomicroscopy analysis. The structure and thickness of the corneal layer were also analyzed using histological staining and time-domain optical coherence tomography scans and were found to resemble a native corneal layer. The protein expression for CK3 and p63 were continuously detected throughout the corneal epithelial layer in the corneal construct.

Conclusions: In conclusion, human BMuc can be induced to express a corneal epithelial-like phenotype. The addition of BMuc improves corneal clarity, prevents vascularization, increases corneal thickness and stromal alignment, and appears to have no adverse effect on the host after implantation.

Matched MeSH terms: Burns, Chemical/metabolism; Burns, Chemical/physiopathology; Burns, Chemical/surgery*

Cannon's disease: clinical and diagnostic implications: a case report

Ram S, Siar CH

Dent Update, 2004 Nov;31(9):557-9.

PMID: 15612463

Cannon's disease or white sponge naevus is a relatively rare genetically determined skin disorder. It is inherited as an autosomal dominant trait that displays a high degree of penetrance and expressivity. This article describes cases of Cannon's disease in a mother and her son.

Matched MeSH terms: Burns, Chemical/diagnosis

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