Displaying publications 1 - 20 of 151 in total

  1. Jemaima, C.H., Muhammad Syamil, M.S.
    Medicine & Health, 2018;13(1):3-11.
    Glaucoma is a group of diseases which result in a progressive loss of retinal ganglion cells, producing characteristic optic nerve head appearance with corresponding visual loss. The aetiology remains unclear until today. Previous authors had tried to associate its pathology in relation to intracranial pressure level. We review the literature on interrelation of intraocular pressure (IOP) and intracranial pressure (ICP) which gives rise to the study of translaminar pressure gradient (TLPG) in postulating its causal factor towards glaucoma. Several studies had demonstrated that ICP was reduced in patients with glaucoma, and in sequence with normal or raised IOP, leads to increased level of TLPG. The increased TLPG which acts across the lamina cribrosa may cause a posteriorly bowed lamina cribrosa, therefore leading to glaucomatous changes. This review also explores the current available methods in
    measuring ICP accurately. Further studies are needed to elucidate possible disease mechanism in keeping with IOP-ICP relationship, thus confirming the findings of
    previous authors.
    Keywords: Glaucoma, intracranial, intraocular, pressure, pathophysiology, translaminar
    Matched MeSH terms: Glaucoma
  2. Schroeder H
    Malayan Medical Journal, 1937;12:147-8.
    Matched MeSH terms: Glaucoma
  3. Lee RM, Samsudin A, Bouremel Y, Brocchini S, Khaw PT
    Invest Ophthalmol Vis Sci, 2015 Dec;56(13):8026.
    PMID: 26720450 DOI: 10.1167/iovs.15-18495
    Matched MeSH terms: Glaucoma/surgery*; Glaucoma Drainage Implants*
  4. Adlina AR, Alisa-Victoria K, Shatriah I, Liza-Sharmini AT, Ahmad MS
    PMID: 25540578 DOI: 10.2147/OPTH.S71136
    There are limited data concerning the optic disc topography in normal-tension glaucoma (NTG) and primary open-angle glaucoma (POAG) patients living in Southeast Asian countries. This study aims to compare optic disc parameters in patients with NTG and POAG in Malaysia and to discuss the results in comparison with studies of NTG and POAG in other Asian countries.
    Matched MeSH terms: Glaucoma, Open-Angle; Low Tension Glaucoma
  5. Yip VCH, Wong HT, Yong VKY, Lim BA, Hee OK, Cheng J, et al.
    J. Glaucoma, 2019 07;28(7):e132-e133.
    PMID: 31135585 DOI: 10.1097/IJG.0000000000001289
    Matched MeSH terms: Glaucoma*
  6. Samsudin A, Eames I, Brocchini S, Khaw PT
    J. Glaucoma, 2016 Jan;25(1):e39-45.
    PMID: 25719236 DOI: 10.1097/IJG.0000000000000243
    PURPOSE: ExPress devices are available as P50 and P200 models, the numbers related to their luminal diameters in μm. We compared their Poiseuille's Law-based theoretical resistance values with experimental values and correlated these with their luminal dimensions derived from electron microscopy.

    METHODS: Scanning electron microscopy was performed on P50 and P200 devices. Bench-top flow studies were performed to find the resistances of the devices. Devices were also incorporated into a perfused, ex vivo porcine sclera model to test and compare their control of pressure, with and without overlying scleral flaps, and with trabeculectomies.

    RESULTS: The luminal dimensions of the P200 device were 206.4±3.3 and 204.5±0.9 μm at the subconjunctival space and anterior chamber ends, respectively. Those of the P50 device were 205.0±5.8 and 206.9±3.7 μm, respectively. There were no significant differences between the P200 and P50 devices (all P>0.05). The resistances of the P200 and P50 devices were 0.010±0.001 and 0.054±0.002 mm Hg/μL/min, respectively (P<0.05). Equilibrium pressures with overlying scleral flaps were 17.81±3.30 mm Hg for the P50, 17.31±4.24 mm Hg for the P200, and 16.28±6.67 mm Hg for trabeculectomies (P=0.850).

    CONCLUSIONS: The luminal diameters of both devices are externally similar. The effective luminal diameter of the P50 is much larger than 50 μm. Both devices have low resistance values, making them unlikely to prevent hypotony on their own. They lead to similar equilibrium pressures as the trabeculectomy procedure when inserted under the scleral flap.

    Matched MeSH terms: Glaucoma/physiopathology; Glaucoma/surgery; Glaucoma Drainage Implants*
  7. Ang GS, Tey A, Ng WS, Subrayan V
    Med J Malaysia, 2007 Aug;62(3):259-60.
    PMID: 18246923
    Patients with bleeding diatheses can present in a variety of clinical situations. When these patients manifest with ocular complications, their management can be challenging. We describe a case of acute angle closure glaucoma secondary to subretinal haemorrhage, with myelodysplasia as a predisposing factor.
    Matched MeSH terms: Glaucoma, Angle-Closure/drug therapy; Glaucoma, Angle-Closure/etiology*; Glaucoma, Angle-Closure/pathology; Glaucoma, Angle-Closure/surgery
  8. Premsenthil M, Salowi MA, Siew CM, ak Gudom I, Kah T
    BMC Ophthalmol, 2012;12:64.
    PMID: 23241197 DOI: 10.1186/1471-2415-12-64
    To report a case of spontaneous malignant glaucoma in an Asian female. To propose the term "positive vitreous pressure glaucoma" to reflect the pathophysiology, treatment and prognosis of the condition.
    Matched MeSH terms: Glaucoma, Angle-Closure/physiopathology; Glaucoma, Angle-Closure/surgery*
  9. Abdul Rahim A, Ismail S, Ahmad Tajudin LS, Ahmad MS
    Med J Malaysia, 2013 Aug;68(4):338-42.
    PMID: 24145263 MyJurnal
    There are limited data in the literature on the optic disc topography in normal tension glaucoma (NTG) patients in Asian countries, especially in Southeast Asia. This study is aimed at comparing optic disc topography in NTG patients and a control group in Malaysia, and we discuss the literature on NTG studies in other Asian populations. A comparative cross-sectional study was conducted in two hospitals with glaucoma services in Malaysia from November 2010 to February 2012. A total of 109 eyes of 109 Malay patients were included in this study: 32 NTG patients and 77 subjects in the control group. All participants underwent a thorough ocular examination, including visual acuity, subjective refraction, anterior segment and fundus examinations, Humphrey visual field 24-2, intraocular pressure measurement, gonioscopy examination and fundus photography. Optic disc topography was assessed using the Heidelberg Retinal Tomograph III by an identified masked investigator in each hospital. NTG patients had a notably larger disc area (2.65 (0.41) vs 2.19 (0.43) mm(2), respectively), larger cupping (1.54 (0.43) vs 0.63 (0.40) mm(2), respectively), smaller retinal rim areas (1.12 (0.41) vs 1.56 (0.33) mm(2), respectively), higher cup volume (0.47 (0.28) vs 0.11 (0.19) mm(3), respectively), reduced rim volume (0.23 (0.13) vs 0.41 (0.16) mm(3), respectively), higher cup to disc area ratio (0.58 (0.14) vs 0.27 (0.15), respectively), higher linear cup to disc ratio (0.76 (0.09) vs 0.49 (0.17) mm(2), respectively), higher mean cup depth (0.37 (0.09) vs 0.22 (0.09) mm, respectively), higher maximum cup depth (0.77 (0.16) vs 0.59 (0.20) mm, respectively), higher mean of cup shape measure (-0.04 (0.06) vs -0.16 (0.07), respectively), and thinner mean retinal nerve fibre layer thickness (0.15 (0.15) vs 0.24 (0.07) mm, respectively) compared to the control group (p<0.05). In conclusion, most of the optic disc parameters were significantly different in NTG patients compared to healthy individuals in Malaysia. Our findings are comparable to those reported in NTG studies in other Asian countries.
    Matched MeSH terms: Low Tension Glaucoma*
  10. Salim NL, Azhany Y, Abdul Rahman Z, Yusof R, Liza-Sharmini AT
    PMID: 26064735 DOI: 10.1155/2015/249419
    Fungal endophthalmitis is rare but may complicate glaucoma drainage device surgery. Management is challenging as the symptoms and signs may be subtle at initial presentation and the visual prognosis is usually poor due to its resistant nature to treatment. At present there is lesser experience with intravitreal injection of voriconazole as compared to Amphotericin B. We present a case of successfully treated Aspergillus endophthalmitis following Baerveldt glaucoma drainage device implantation with intravitreal and topical voriconazole.
    Matched MeSH terms: Glaucoma; Glaucoma Drainage Implants
  11. Sharif FM, Selvarajah S
    Med J Malaysia, 1997 Mar;52(1):17-25.
    PMID: 10968049
    A clinical audit was conducted for a 4-year period at the Universiti Kebangsaan Malaysia (UKM) Ophthalmology Department in which 61 eyes of adult patients with primary glaucoma underwent trabeculectomies without antimetabolites. At a 2-year follow-up duration, successful trabeculectomies as defined by intraocular pressure below 20 mm Hg without additional glaucoma medication were 62% for primary open-angle glaucoma, 48% for primary acute angle-closure glaucoma and 43% for chronic angle-closure glaucoma. 50.8% of eyes were without complications while 49.2% had complications. Shallow anterior chamber (22.9%) and hyphaema (19.7%) were the two commonest complications.
    Matched MeSH terms: Glaucoma/surgery*
  12. KIAT RL
    Med J Malaya, 1957 Jun;11(4):302-7.
    PMID: 13482567
    Matched MeSH terms: Glaucoma/therapy*
  13. Azhany Y, Norhayati A, Siti Raihan I, Liza Sharmini AT
    Malays Fam Physician, 2014;9(2):48-52.
    PMID: 25883765 MyJurnal
    To determine the clinical presentations, management and outcome of lens-induced glaucoma (LIG) in Hospital Universiti Sains Malaysia.
    Matched MeSH terms: Glaucoma
  14. Agarwal R, Agarwal P
    Indian J Ophthalmol, 2012 Jul;60(4):255-61.
    PMID: 22824592 DOI: 10.4103/0301-4738.98700
    Glaucoma, a neurodegenerative disease, is currently being treated by modulation of one of its primary risk factors, the elevated intraocular pressure. Newer therapies that can provide direct neuroprotection to retinal ganglion cells are being extensively investigated. Tumor necrosis factor-α, a cytokine, has been recognized to play an important role in pro and antiapoptotic cellular events. In this paper we review the relevant literature to understand (1) The association of increased expression of tumor necrosis factor-α with glaucomatous neurodegeneraion, (2) Modulation of tumor necrosis factor-α expression by exposure to various risk factors of glaucoma, (3) Downstream cellular signaling mechanisms following interaction of tumor necrosis factor-α with its receptors and (4) Role of tumor necrosis factor-α as a possible target for therapeutic intervention in glaucoma. Literature was reviewed using PubMed search engine with relevant key words and a total of 82 English language papers published from 1990 to 2010 are included in this review.
    Matched MeSH terms: Glaucoma/complications*; Glaucoma/metabolism; Glaucoma/pathology
  15. Ramli R, Idris MYI, Hasikin K, A Karim NK, Abdul Wahab AW, Ahmedy I, et al.
    J Healthc Eng, 2017;2017:1489524.
    PMID: 29204257 DOI: 10.1155/2017/1489524
    Retinal image registration is important to assist diagnosis and monitor retinal diseases, such as diabetic retinopathy and glaucoma. However, registering retinal images for various registration applications requires the detection and distribution of feature points on the low-quality region that consists of vessels of varying contrast and sizes. A recent feature detector known as Saddle detects feature points on vessels that are poorly distributed and densely positioned on strong contrast vessels. Therefore, we propose a multiresolution difference of Gaussian pyramid with Saddle detector (D-Saddle) to detect feature points on the low-quality region that consists of vessels with varying contrast and sizes. D-Saddle is tested on Fundus Image Registration (FIRE) Dataset that consists of 134 retinal image pairs. Experimental results show that D-Saddle successfully registered 43% of retinal image pairs with average registration accuracy of 2.329 pixels while a lower success rate is observed in other four state-of-the-art retinal image registration methods GDB-ICP (28%), Harris-PIIFD (4%), H-M (16%), and Saddle (16%). Furthermore, the registration accuracy of D-Saddle has the weakest correlation (Spearman) with the intensity uniformity metric among all methods. Finally, the paired t-test shows that D-Saddle significantly improved the overall registration accuracy of the original Saddle.
    Matched MeSH terms: Glaucoma
  16. Tan HK, Ahmad Tajuddin LS, Lee MY, Ismail S, Wan-Hitam WH
    PMID: 26065503 DOI: 10.1097/APO.0000000000000058
    PURPOSE: To determine the mean central corneal thickness (CCT) and the relationship between the CCT and visual field progression in primary angle closure (PAC) and primary angle closure glaucoma (PACG).
    DESIGN: A combined cross-sectional and prospective study on PAC and PACG.
    METHODS: A total of 35 eyes were included in the study for each group of normal control, PAC, and PACG patients from eye clinics in Kota Bharu, state of Kelantan, Malaysia, from January 2007 to November 2009. The PAC and PACG patients were divided into thin and thick CCT groups. They were followed up for 12 to 18 months for visual field progression assessment with their mean Advanced Glaucoma Intervention Study (AGIS) score.
    RESULTS: The CCT was 516.8 ± 26.0 µm for PAC and 509.7 ± 27.4 µm for PACG. Both were significantly thinner compared with the control group with CCT of 540 ± 27.8 µm (P < 0.001). There was a statistically significant increase in the mean AGIS score after 12.9 ± 1.7 months of follow-up in the thin CCT group for PACG (P = 0.002). However, no significant increase in the mean AGIS score was found for the thick CCT group in PACG and for both thin and thick CCT in PAC.
    CONCLUSIONS: The PAC and PACG had statistically significant thinner CCT compared with the controls. Thin CCT was associated with visual field progression based on the mean AGIS score in PACG.

    Study site: eye
    clinics in Kota Bharu, Kelantan
    Matched MeSH terms: Glaucoma, Open-Angle/diagnosis*; Glaucoma, Open-Angle/physiopathology; Glaucoma, Angle-Closure/diagnosis*; Glaucoma, Angle-Closure/physiopathology
  17. Peng HB, Zahary MN, Tajudin LS, Lin CL, Teck CM, Sidek MR, et al.
    Kobe J Med Sci, 2007;53(1-2):49-52.
    PMID: 17582204
    The Prostaglandin F2alpha (PGF2alpha) receptor gene has been found to play an important role in reducing the intraocular pressure of the glaucomatous patients. Variations of the PGF2alpha receptor gene may be responsible for the differences in the response to an antiglaucoma drug, Latanoprost. A combined method of denaturing High Performance Liquid Chromatography (dHPLC) and sequencing was applied to detection of the PGF2alpha receptor gene variant among the 76 Malaysian patients with glaucoma, and a novel single nucleotide polymorphism (SNP), IVS -97A>T, was identified. According to the genotyping analysis, 36.8% of the subjects were heterozygous for the variant allele T, while 9.2% homozygous. The frequency of variant allele T was 0.28. Although with a limited number of samples, our data suggested that this polymorphism is common in the Malaysian patients with glaucoma.
    Matched MeSH terms: Glaucoma/genetics*
  18. Loh KY, Ogle J
    Med J Malaysia, 2004 Oct;59(4):562-8, quiz 569.
    PMID: 15779599
    Visual impairment among the elderly is a major health problem. With advancing age, the normal function of eye tissues decreases and there is an increased incidence of ocular pathology. Demographic studies have shown that age is the best predictor of blindness and visual impairment. The most common causes of age related visual impairment in the elderly are presbyopia, cataracts, age related macular degeneration, primary open angle glaucoma and diabetic retinopathy. Untreated visual impairment leads to physical handicap, increased incidence of fall, depression, social isolation and dependency. Active screening for visual loss in the elderly should be part of the health examination. The elderly should be encouraged to come for formal 1-2 yearly eye assessment for early detection of visual impairment and to treat all associated problems in order to prevent permanent visual loss.
    Matched MeSH terms: Glaucoma, Open-Angle/etiology
  19. Selvarajah S
    Med J Malaysia, 1998 Mar;53(1):42-5.
    PMID: 10968136
    The records of all the glaucoma patients seen at the General Hospital Kuala Lumpur over a five year period were analysed. The racial, age and sex distribution of patients with primary open angle glaucoma and primary angle closure glaucoma was determined. The causes of secondary glaucoma were analysed. As no previous records of glaucoma statistics are available in Malaysia, it is hoped that these findings will form an initial mosaic to build on in the future.
    Matched MeSH terms: Glaucoma/epidemiology*
  20. Ooi, Edwin I.L., Safinaz, M.K., Ropilah, A.R
    This was a 28-year-old mentally-challenged girl with underlying congenital Rubella syndrome. She was bilaterally aphakic after congenital cataract surgery. She then developed bilateral aphakic glaucoma and had to undergo multiple glaucoma filtering surgeries. The most recent procedure she had undergone for her left eye was a second Ahmed valve implantation with an overlying sclera patch. Postoperatively, intraocular pressure was well controlled. However, nine months later, slit lamp examination revealed the tube was adherent to the overlying cornea with surrounding deep and superficial cornea vascularization. Siedel test was negative and intraocular pressure was normal. Subsequently the tube was removed but the plate was left in situ.
    Matched MeSH terms: Glaucoma; Glaucoma Drainage Implants
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